{"title":"LRRK2 and GBA1 in Lewy body diseases: neuropathological subtypes at opposite ends of a spectrum?","authors":"Vedika Jha,Lorraine V Kalia","doi":"10.1186/s13024-026-00939-z","DOIUrl":"https://doi.org/10.1186/s13024-026-00939-z","url":null,"abstract":"","PeriodicalId":18800,"journal":{"name":"Molecular Neurodegeneration","volume":"91 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexandra N Trelle,Karly A Cody,Tran T Nguyen,Joseph R Winer,Skylar Weiss,Isha Sai,Tyler Ward,Gloria Cheng,Divya Channappa,Justin Mendiola,Amal Al-Rajhi,Keerthana Raghuraman,Sharon J Sha,Edward N Wilson,Tony Wyss-Coray,Holden T Maecker,Anthony D Wagner,Elizabeth C Mormino
{"title":"Plasma proteomic signatures of preclinical Alzheimer's disease in clinically unimpaired older adults.","authors":"Alexandra N Trelle,Karly A Cody,Tran T Nguyen,Joseph R Winer,Skylar Weiss,Isha Sai,Tyler Ward,Gloria Cheng,Divya Channappa,Justin Mendiola,Amal Al-Rajhi,Keerthana Raghuraman,Sharon J Sha,Edward N Wilson,Tony Wyss-Coray,Holden T Maecker,Anthony D Wagner,Elizabeth C Mormino","doi":"10.1186/s13024-026-00941-5","DOIUrl":"https://doi.org/10.1186/s13024-026-00941-5","url":null,"abstract":"","PeriodicalId":18800,"journal":{"name":"Molecular Neurodegeneration","volume":"4 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147739061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Li Yang,Jianting Sheng,Shaohua Qi,Zheng Yin,Michael Chan,Yuliang Cao,Hong Zhao,Zhihao Wan,Bill Chan,Ju Young Ahn,Xiaohui Yu,Matthew Vasquez,Shan Xu,Xianlin Han,Weiming Xia,Willa A Hsueh,Stephen T C Wong
{"title":"Obesity-driven phosphatidylethanolamine dysregulation impairs neuroimmune crosstalk and accelerates Alzheimer's pathogenesis.","authors":"Li Yang,Jianting Sheng,Shaohua Qi,Zheng Yin,Michael Chan,Yuliang Cao,Hong Zhao,Zhihao Wan,Bill Chan,Ju Young Ahn,Xiaohui Yu,Matthew Vasquez,Shan Xu,Xianlin Han,Weiming Xia,Willa A Hsueh,Stephen T C Wong","doi":"10.1186/s13024-026-00943-3","DOIUrl":"https://doi.org/10.1186/s13024-026-00943-3","url":null,"abstract":"","PeriodicalId":18800,"journal":{"name":"Molecular Neurodegeneration","volume":"15 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147684814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sheelakumari Raghavan, Scott A Przybelski, Robel K Gebre, Audrey Low, Mingzhao Hu, Robert I Reid, B Gwen Windham, Heather J Wiste, Angela J Fought, Michael G Kamykowski, Aivi T Nguyen, Melissa E Murray, Val J Lowe, Clifford R Jr Jack, Ronald C Petersen, Jonathan Graff-Radford, Prashanthi Vemuri
{"title":"Regional diffusion imaging measures to disentangle SVD-related hypertensive arteriopathy versus cerebral amyloid angiopathy.","authors":"Sheelakumari Raghavan, Scott A Przybelski, Robel K Gebre, Audrey Low, Mingzhao Hu, Robert I Reid, B Gwen Windham, Heather J Wiste, Angela J Fought, Michael G Kamykowski, Aivi T Nguyen, Melissa E Murray, Val J Lowe, Clifford R Jr Jack, Ronald C Petersen, Jonathan Graff-Radford, Prashanthi Vemuri","doi":"10.1186/s13024-026-00942-4","DOIUrl":"https://doi.org/10.1186/s13024-026-00942-4","url":null,"abstract":"","PeriodicalId":18800,"journal":{"name":"Molecular Neurodegeneration","volume":" ","pages":""},"PeriodicalIF":17.5,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andy P Tsai,Amara K Martin,Andrew Mi,Ava E Yeh,Eduardo Ramirez Lopez,Tony Wyss-Coray
{"title":"PLCG2 signaling and genetic resilience in Alzheimer's disease.","authors":"Andy P Tsai,Amara K Martin,Andrew Mi,Ava E Yeh,Eduardo Ramirez Lopez,Tony Wyss-Coray","doi":"10.1186/s13024-026-00935-3","DOIUrl":"https://doi.org/10.1186/s13024-026-00935-3","url":null,"abstract":"","PeriodicalId":18800,"journal":{"name":"Molecular Neurodegeneration","volume":"58 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147518438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Na Wang, Gefei Yu, Zhen Wang, Alla Alnobani, Suren Jeevaratnam, Xue Zhang, Mehan McReynolds, Yuzhou Chang, Fangfang Qi, William Tauer, Cassandra Rosenberg, Melissa Wren, Tadafumi C Ikezu, Yuka A Martens, Minghui Wang, Bin Zhang, Gregory W Carter, Michael Sasner, David M Holtzman, Junmin Peng, Long-Jun Wu, Takahisa Kanekiyo, Chia-Chen Liu, Guojun Bu
{"title":"Molecular characterization of humanized APOE mouse models reveals source and genotype dependent differences.","authors":"Na Wang, Gefei Yu, Zhen Wang, Alla Alnobani, Suren Jeevaratnam, Xue Zhang, Mehan McReynolds, Yuzhou Chang, Fangfang Qi, William Tauer, Cassandra Rosenberg, Melissa Wren, Tadafumi C Ikezu, Yuka A Martens, Minghui Wang, Bin Zhang, Gregory W Carter, Michael Sasner, David M Holtzman, Junmin Peng, Long-Jun Wu, Takahisa Kanekiyo, Chia-Chen Liu, Guojun Bu","doi":"10.1186/s13024-026-00940-6","DOIUrl":"https://doi.org/10.1186/s13024-026-00940-6","url":null,"abstract":"","PeriodicalId":18800,"journal":{"name":"Molecular Neurodegeneration","volume":" ","pages":""},"PeriodicalIF":17.5,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexandra Beilina, Jae-Hyeon Park, Natalie Landeck, Ruth Chia, Jinhui Ding, Xylena Reed, Hannah Bailey, Changyoun Kim, Alice Kaganovich, Dominic J Acri, Janet Brooks, Alexandra Mann, Kareem A Zaghloul, Elise Marsan, J Raphael Gibbs, Alex DeCasien, Mark R Cookson
{"title":"Inflammatory signaling differentially changes chromatin accessibility and gene expression of the PD- associated kinase LRRK2 between human and mice.","authors":"Alexandra Beilina, Jae-Hyeon Park, Natalie Landeck, Ruth Chia, Jinhui Ding, Xylena Reed, Hannah Bailey, Changyoun Kim, Alice Kaganovich, Dominic J Acri, Janet Brooks, Alexandra Mann, Kareem A Zaghloul, Elise Marsan, J Raphael Gibbs, Alex DeCasien, Mark R Cookson","doi":"10.1186/s13024-026-00938-0","DOIUrl":"10.1186/s13024-026-00938-0","url":null,"abstract":"","PeriodicalId":18800,"journal":{"name":"Molecular Neurodegeneration","volume":" ","pages":""},"PeriodicalIF":17.5,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147481187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paula J Bice, Kwangsik Nho, Nilüfer Ertekin-Taner, Andrew J Saykin
{"title":"Systems biology of Alzheimer's Disease: a scoping review of key pathways and mechanisms.","authors":"Paula J Bice, Kwangsik Nho, Nilüfer Ertekin-Taner, Andrew J Saykin","doi":"10.1186/s13024-026-00934-4","DOIUrl":"10.1186/s13024-026-00934-4","url":null,"abstract":"","PeriodicalId":18800,"journal":{"name":"Molecular Neurodegeneration","volume":" ","pages":""},"PeriodicalIF":17.5,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13032323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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