Molecular and cellular pharmacology最新文献_第3页

Regulation of Aerobic Glycolysis by microRNAs in Cancer. 微rna在癌症中对有氧糖酵解的调控。

Molecular and cellular pharmacology Pub Date : 2011-12-31 DOI: 10.4255/MCPHARMACOL.11.17

P. Singh, Kamiya Mehla, M. Hollingsworth, Keith R. Johnson

引用次数: 65

Effects of Histone Deacetylase Inhibitors on Modulating H3K4 Methylation Marks - A Novel Cross-Talk Mechanism between Histone-Modifying Enzymes. 组蛋白去乙酰化酶抑制剂对H3K4甲基化标记的调节作用——组蛋白修饰酶之间的一种新的串导机制。

Molecular and cellular pharmacology Pub Date : 2011-12-01 DOI: 10.4255/MCPHARMACOL.11.06

Po-Hsien Huang, C. Plass, Ching S. Chen

引用次数: 21

MicroRNAs in glioblastoma multiforme: Profiling studies and therapeutic impacts 多形性胶质母细胞瘤中的microrna:分析研究和治疗影响

Molecular and cellular pharmacology Pub Date : 2011-12-01 DOI: 10.4255/MCPHARMACOL.11.14

D. Lebrun, Min Li

引用次数: 14

Evaluation of Anticancer Properties of Medicinal Plants from the Indian Sub-Continent 印度次大陆药用植物抗癌特性的评价

Molecular and cellular pharmacology Pub Date : 2011-02-28 DOI: 10.4255/MCPHARMACOL.11.04

A. Nawab, M. Yunus, A. Mahdi, Sanjay Gupta

引用次数: 62

MicroRNAs and Androgen Receptor 3' Untranslated Region: A Missing Link in Castration-resistant Prostate Cancer? microrna和雄激素受体3'非翻译区:去势抵抗性前列腺癌的缺失环节?

Molecular and cellular pharmacology Pub Date : 2011-01-01

Kavleen Sikand, Sailen Barik, Girish C Shukla

{"title":"MicroRNAs and Androgen Receptor 3' Untranslated Region: A Missing Link in Castration-resistant Prostate Cancer?","authors":"Kavleen Sikand, Sailen Barik, Girish C Shukla","doi":"","DOIUrl":"","url":null,"abstract":"The ligand-activated transcription factor, androgen receptor (AR) plays a central role in the development and progression of prostate cancer. Prostate cancer initiates as an androgen-dependent disease and further accumulation of multiple sequential genetic and epigenetic alterations transform it into an aggressive, castration-resistant prostate cancer (CRPC). The molecular basis of the transition from androgen-dependent prostate cancer to CRPC remains unclear. However, it is apparent that AR plays a pivotal role in this alteration. The recent discovery that microRNAs (miRNAs) can target the function of AR suggests a functional role of these non-coding RNAs in the pathogenesis of prostate cancer. miRNAs usually function by targeting the 3' untranslated region (UTR) of a mRNA by base-pairing interactions and modulate translation either by destabilizing the message or by repression of protein synthesis in actively translating ribosomes. Here, we discuss the potential molecular pathways through which AR targeting miRNAs may promote CRPC. Modulation of AR expression by miRNAs presents a novel therapeutic option for prostate cancer, albeit it will likely be used in combination with the existing therapies.","PeriodicalId":18748,"journal":{"name":"Molecular and cellular pharmacology","volume":"3 3","pages":"107-113"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315684/pdf/nihms348614.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30546936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Focus on α4β2* and α6β2* nAChRs for Parkinson's Disease Therapeutics. α4β2*和α6β2* nachr在帕金森病治疗中的应用

Molecular and cellular pharmacology Pub Date : 2011-01-01

Xiomara A Pérez, Maryka Quik

{"title":"Focus on α4β2* and α6β2* nAChRs for Parkinson's Disease Therapeutics.","authors":"Xiomara A Pérez, Maryka Quik","doi":"","DOIUrl":"","url":null,"abstract":"L-dopa is one of the best treatments for the motor symptoms of Parkinson's disease. However, its use is limited by the fact that it provides only symptomatic relief and chronic therapy leads to dyskinesias. There is therefore a continual search for novel therapeutic approaches. Nicotine, a drug that acts at nicotinic acetylcholine receptors (nAChRs), has been shown to protect against nigrostriatal damage and reduce L-dopa-induced dyskinesias. NAChRs may therefore represent novel targets for Parkinson's disease management. Since there are multiple nAChRs throughout the body, it is important to understand the subtypes involved in striatal function to allow for the development of drugs with optimal beneficial effects. Here we discuss recent work from our laboratory which indicates that α6β2* and α4β2* nAChRs are key in regulating striatal dopaminergic function. Experiments in parkinsonian rats using cyclic voltammetry showed that both α6β2* and α4β2* nAChR-mediated evoked-dopamine release in striatal slices is affected by nigrostriatal damage. These subtypes also appear to be important for neuroprotection against nigrostriatal damage and the nicotine-mediated reduction in L-dopa-induced dyskinesias in parkinsonian animal models. Our combined findings indicate that α4β2* and α6β2* nAChRs may represent useful therapeutic targets for Parkinson's disease.","PeriodicalId":18748,"journal":{"name":"Molecular and cellular pharmacology","volume":"3 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076673/pdf/nihms278255.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29821047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of MicroRNAs by Chemical Carcinogens and Anticancer Drugs in Human Cancer: Potential Inkling to Therapeutic Advantage. 化学致癌物和抗癌药物对人类癌症中microrna的调节:潜在的治疗优势。

Molecular and cellular pharmacology Pub Date : 2011-01-01 DOI: 10.4255/MCPHARMACOL.11.18

S. Haldar, A. Basu

{"title":"Modulation of MicroRNAs by Chemical Carcinogens and Anticancer Drugs in Human Cancer: Potential Inkling to Therapeutic Advantage.","authors":"S. Haldar, A. Basu","doi":"10.4255/MCPHARMACOL.11.18","DOIUrl":"https://doi.org/10.4255/MCPHARMACOL.11.18","url":null,"abstract":"The disorder of microRNAs (miRNAs) often referred as 'micromanagers of gene expression' has been implicated with a vast array of neoplasmthe discovery establishes an important connection with the etiology, diagnosis and potential therapy of human cancer. Indeed, the wide range of profiling studies enabled to create miRNA signatures of solid tumors as well as cancers of blood origin. MiRNAs have been observed to play a significant role in the regulation of gene expression-a critical aspect of many biological processes, including cell development, differentiation, apoptosis and proliferation. The differential expression levels of miRNAs in tumors and their normal counterpart have enabled scientists to designate their roles as oncomir or tumor suppressor. Interestingly, the diminishment of oncogenic or enhanced levels of tumor suppressor miRNAs (antagomirs) have been reported to modulate the sensitivity of cancer cells to anticancer agents. To the other end, carcinogenic chemicals either possess the ability of silencing beneficial tumor suppressive miRNAs or maintain the augmented levels of their oncogenic counterpart. In this article we provide a comprehensive overview on the modulation of these \"micromanaging oligos\" by cancer causing as well as cancer preventing agents.","PeriodicalId":18748,"journal":{"name":"Molecular and cellular pharmacology","volume":"13 1","pages":"135-141"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87668105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

MicroRNAs: Processing, Maturation, Target Recognition and Regulatory Functions. MicroRNAs:加工、成熟、目标识别和调控功能。

Molecular and cellular pharmacology Pub Date : 2011-01-01

Girish C Shukla, Jagjit Singh, Sailen Barik

引用次数: 0

Effects of Histone Deacetylase Inhibitors on Modulating H3K4 Methylation Marks - A Novel Cross-Talk Mechanism between Histone-Modifying Enzymes. 组蛋白去乙酰化酶抑制剂对H3K4甲基化标记的调节作用——组蛋白修饰酶之间的一种新的串导机制。

Molecular and cellular pharmacology Pub Date : 2011-01-01

Po-Hsien Huang, Christoph Plass, Ching-Shih Chen

引用次数: 0

Regulation of Aerobic Glycolysis by microRNAs in Cancer. 微rna在癌症中对有氧糖酵解的调控。

Molecular and cellular pharmacology Pub Date : 2011-01-01

Pankaj K Singh, Kamiya Mehla, Michael A Hollingsworth, Keith R Johnson

{"title":"Regulation of Aerobic Glycolysis by microRNAs in Cancer.","authors":"Pankaj K Singh, Kamiya Mehla, Michael A Hollingsworth, Keith R Johnson","doi":"","DOIUrl":"","url":null,"abstract":"One of the most common and profound biochemical phenotypes of animal and human cancer cells is their ability to metabolize glucose at high rates, even under aerobic conditions. Such alterations lead to establishment of tumor-specific metabolic machinery that is sufficient for supporting the biosynthetic and energy requirements of the tumor cells for facilitating rapid tumor growth and adaptation to new metastatic niches. These changes entail rapid glycolysis by the tumor cells, shifting the flux of glucose from tricarboxylic acid (TCA) cycle to glycolysis, resulting in generation of vast amounts of lactate, which is then secreted outside the tumor cells. This phenomenon is also termed as Warburg effect, as originally described by Otto Warburg. Several oncogenes and tumor suppressors have been implicated in altering tumor cell metabolism in order to facilitate tumor growth and metastasis. MicroRNAs mediate fine-tuning of the cancerassociated glycolytic pathways either directly or at the level of oncogenes. This article intends to review the mechanisms and pathways by which miRNAs regulate the aerobic glycolysis in cancer.","PeriodicalId":18748,"journal":{"name":"Molecular and cellular pharmacology","volume":"3 3","pages":"125-134"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392682/pdf/nihms348616.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30760367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0