Microcirculation, endothelium, and lymphatics最新文献_第4页

Rheological determinants and red cell lipidic pattern in essential obesity, in obese subjects with non-insulin-dependent diabetes mellitus (NIDDM) and in obese subjects with impaired glucose tolerance (IGT). 原发性肥胖、非胰岛素依赖型糖尿病(NIDDM)肥胖患者和糖耐量受损(IGT)肥胖患者的流变学决定因素和红细胞脂质模式

Microcirculation, endothelium, and lymphatics Pub Date : 1991-01-01

G Caimi, R Lo Presti, A Serra, A Catania, S D'Asaro, S Verga, S Buscemi, A Sarno

引用次数: 0

Endothelial cells are required for inhibition of contractile responses induced by reduction in extracellular magnesium and sodium ions in rat aortic smooth muscle [corrected]. 内皮细胞是抑制大鼠主动脉平滑肌细胞外镁离子和钠离子减少引起的收缩反应所必需的[修正]。

Microcirculation, endothelium, and lymphatics Pub Date : 1990-12-01

A Zhang, B T Altura, B M Altura

{"title":"Endothelial cells are required for inhibition of contractile responses induced by reduction in extracellular magnesium and sodium ions in rat aortic smooth muscle [corrected].","authors":"A Zhang, B T Altura, B M Altura","doi":"","DOIUrl":"","url":null,"abstract":"The possible importance of facilitation of sodium-calcium (Na(+)-Ca2+) exchange by removal of extracellular magnesium ions ([Mg2+]o) in expression of endothelium-dependent relaxation was investigated in aortic rings isolated from female rats. Simultaneous [Mg2+]o withdrawal (0 mM Mg2+) and reduction in extracellular Na+ (Total [Na+]o = 84 mM), by replacement of NaCl with isosmolar amounts of sucrose in normal Krebs-Ringer bicarbonate (NKRB), induced significant increases of basal tone of denuded rat aortic rings, but not in tissues with intact endothelium. These vascular effects were not affected by indomethacin, phentolamine or atropine in any of the tissues tested. Reintroduction of 1.2 mM Mg2+ or removal of extracellular Ca2+ ([Ca2+]o) from the Mg2+ and Na(+)-deficient incubation media induced complete relaxation of the denuded tissues. Methylene blue (10(-5) M), an inhibitor of endothelium-derived relaxant factor (EDRF), potentiated tension development in intact tissues. These results suggest that: (1) as in vascular muscle, Mg2+ plays an important role in Ca2+ homeostasis in endothelial cells (EC), probably via Na(+)-Ca2+ exchange; and (2) such Mg(+)-regulated internal Na(+)-dependent Ca2+ entry participates in the expression of endothelium-dependent relaxation.","PeriodicalId":18718,"journal":{"name":"Microcirculation, endothelium, and lymphatics","volume":"6 6","pages":"427-35"},"PeriodicalIF":0.0,"publicationDate":"1990-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12876583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CGRP-mediated changes in segmental resistances in the canine forelimb. cgrp介导的犬前肢节段阻力变化。

Microcirculation, endothelium, and lymphatics Pub Date : 1990-12-01

D E Dobbins

{"title":"CGRP-mediated changes in segmental resistances in the canine forelimb.","authors":"D E Dobbins","doi":"","DOIUrl":"","url":null,"abstract":"Calcitonin gene-related peptide (CGRP) is a 37 amino acid peptide which is found in high concentrations in the perivascular nerves innervating the resistance vessels of the peripheral circulation. In the current study we have infused CGRP at three infusion rates (.01, .1 and 1.0 micrograms/min into the brachial artery for thirty minutes at each infusion rate) in the isolated, innervated canine forelimb perfused at natural flow. We measured large artery and vein pressures, small artery and vein pressures and blood flows in both the skin and skeletal muscle circulations for the calculation of total and segmental (large artery, small vessel and large vein) vascular resistances. Infusion of the lowest dosage of CGRP produced slight vasodilation in some animals but did not significantly alter the mean resistances of all the animals as a group. The middle dosage resulted in a 55% decrease in total forelimb resistance and a small but significant decrease in systemic arterial pressure. The highest dosage of CGRP resulted in a 65% decrease in total forelimb resistance and a 34% decrease in systemic arterial pressure. The decreases in forelimb resistances were equally distributed between skin and muscle and were manifested in both large artery and small vessel resistances. The potent vasodilatory effects of CGRP and its concentration in perivascular nerves innervating the resistance vessels of the peripheral circulation suggests a potential role for CGRP in control of circulatory function under normal and/or pathophysiological conditions.","PeriodicalId":18718,"journal":{"name":"Microcirculation, endothelium, and lymphatics","volume":"6 6","pages":"465-81"},"PeriodicalIF":0.0,"publicationDate":"1990-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13254509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of O-(beta-hydroxy-ethyl)-rutosides (HR) on acute lymphoedema in rats' thighs, with and without macrophages. O-(β -羟基-乙基)-芦丁苷(HR)对有巨噬细胞和无巨噬细胞大鼠大腿急性淋巴水肿的影响。

Microcirculation, endothelium, and lymphatics Pub Date : 1990-12-01

J R Casley-Smith, J R Casley-Smith

引用次数: 0

Characterization of basement membranes of rat choroid plexus using the critical electrolyte concentration technique. 临界电解质浓度技术表征大鼠脉络膜丛基底膜。

Microcirculation, endothelium, and lymphatics Pub Date : 1990-12-01

J W Schmidley

引用次数: 0

Constriction of perfused lymphatics by acetylcholine, bradykinin and histamine. 乙酰胆碱、缓激肽和组胺对灌注淋巴的收缩。

Microcirculation, endothelium, and lymphatics Pub Date : 1990-12-01

D E Dobbins, M J Buehn, J M Dabney

{"title":"Constriction of perfused lymphatics by acetylcholine, bradykinin and histamine.","authors":"D E Dobbins, M J Buehn, J M Dabney","doi":"","DOIUrl":"","url":null,"abstract":"We have previously reported that perfused lymphatic vessels in the canine forelimb constrict in response to increased sympathetic nerve activity or local infusions of endogenous vasoconstrictor substances. In the present study we have assessed the effects of three endogenous vasodilators; acetylcholine, bradykinin and histamine on lymphatic vessel contractility. Each one of these agents, when infused intralymphatically, produced lymphatic constriction as evidenced by significant increases in lymphatic perfusion pressure. The threshold concentrations which produced lymphatic constriction were between 10(-6) and 10(-5) molar for acetylcholine and bradykinin and between 10(-5) and 10(-4) molar for histamine. Surgical exclusion of the lymph nodes and efferent lymph vessels from the perfused tissue did not significantly affect the observed response, indicating that the response occurs predominately in the prenodal segments of the lymphatic system. Infusion of acetylcholine and bradykinin into the arterial supply to the forelimb did not significantly alter lymphatic perfusion pressure, unlike the response seen when catecholamines are infused intra-arterially. Histamine displayed an unusual property in that it constricts lymph vessels upon initial administration but was thereafter completely ineffective. Constriction of lymphatic vessels by substances which are potent vasodilators clearly indicates that significant functional differences exist in endothelial cell/smooth muscle relationships between blood vessels and lymph vessels.","PeriodicalId":18718,"journal":{"name":"Microcirculation, endothelium, and lymphatics","volume":"6 6","pages":"409-25"},"PeriodicalIF":0.0,"publicationDate":"1990-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13254507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The inflammatory actions of platelet activating factor are blocked by levorotatory terbutaline. 左旋特布他林可阻断血小板活化因子的炎症作用。

Microcirculation, endothelium, and lymphatics Pub Date : 1990-12-01

D E Dobbins, M J Buehn, J M Dabney

{"title":"The inflammatory actions of platelet activating factor are blocked by levorotatory terbutaline.","authors":"D E Dobbins, M J Buehn, J M Dabney","doi":"","DOIUrl":"","url":null,"abstract":"Platelet activating factor (PAF), a potent vasoactive lipid, may play an important role in the inflammatory process. In this study, we infused PAF intra-arterially to characterize its edematogenic potency in the canine forelimb. We have also assessed the ability of the beta 2-receptor agonist l-terbutaline to block PAF-mediated edema formation. The infusion of PAF at .25 micrograms/min, .5 micrograms/min and 1 micrograms/min increased forelimb arterial pressures and, at the two higher dosages, significantly decreased systemic arterial pressure. PAF infusions increased transvascular fluid and macromolecular flux as indicated by significant increases in skin lymph flow, protein concentration and protein transport. The intra-arterial infusion of l-terbutaline at 1 micrograms/min significantly decreased forelimb arterial pressures but did not affect small vein pressure, systemic pressure or forelimb lymph parameters. The subsequent infusion of PAF at .5 micrograms/min, during the continued infusion of l-terbutaline, failed to significantly affect forelimb lymph parameters. These data indicate that PAF is significantly more potent as an edematogenic agent in the forelimb than histamine or bradykinin. Furthermore, the blockade of PAF-mediated edema formation by l-terbutaline suggests that beta 2-receptor agonists may be capable of antagonizing the inflammatory actions of a wide variety of putative inflammatory mediators.","PeriodicalId":18718,"journal":{"name":"Microcirculation, endothelium, and lymphatics","volume":"6 6","pages":"437-55"},"PeriodicalIF":0.0,"publicationDate":"1990-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13124296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of nifedipine on endothelin induced contractions of skeletal muscle arterioles of spontaneously hypertensive rats. 硝苯地平对内皮素诱导的自发性高血压大鼠骨骼肌小动脉收缩的影响。

Microcirculation, endothelium, and lymphatics Pub Date : 1990-08-01

L Lougee, C Hinojosa-Laborde, D R Harder, J H Lombard

{"title":"Effect of nifedipine on endothelin induced contractions of skeletal muscle arterioles of spontaneously hypertensive rats.","authors":"L Lougee, C Hinojosa-Laborde, D R Harder, J H Lombard","doi":"","DOIUrl":"","url":null,"abstract":"Endothelin is a potent vasoactive polypeptide isolated from cultured endothelial cells. However, there are relatively few studies of the action of endothelin on microvessels in vivo. To determine the effects of this compound on arterioles of normotensive and hypertensive rats, endothelin (1 x 10(-12) M to 1 x 10(-8) M) was dissolved in physiological salt solution and superfused over the cremaster muscle of 12-15 week old spontaneously hypertensive rats (SHR) and their normotensive Wistar-Kyoto (WKY) controls. Endothelin caused about a 55% constriction of second order arterioles and complete closure of most third order arterioles and all fourth order arterioles studied. SHR arterioles tended to be more sensitive to endothelin than those of WKY, although this difference was significant for only the third order arterioles. Endothelin induced contractions were significantly inhibited by 10(-6) M nifedipine in both WKY and SHR. These studies demonstrate that endothelin is a potent constrictor of skeletal muscle arterioles, and suggest that activator Ca2+ for endothelin induced contractions of these vessels enters the vascular smooth muscle cells through dihydropyridine sensitive calcium channels.","PeriodicalId":18718,"journal":{"name":"Microcirculation, endothelium, and lymphatics","volume":"6 4-5","pages":"355-68"},"PeriodicalIF":0.0,"publicationDate":"1990-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13431387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physiology and pathophysiology of pulmonary circulation. 肺循环的生理学和病理生理学。

Microcirculation, endothelium, and lymphatics Pub Date : 1990-08-01

R Mathew, B M Altura

引用次数: 0

Pulmonary vasculature in monocrotaline-induced hypertensive rats on magnesium therapy. 镁治疗对高血压大鼠肺血管的影响。

Microcirculation, endothelium, and lymphatics Pub Date : 1990-08-01

R Mathew, E S Gloster, B T Altura, B M Altura

引用次数: 0