Bleeding, Thrombosis, and Vascular Biology最新文献_第6页

Is transient ischemic attack a minor stroke? 短暂性脑缺血发作是轻微中风吗?

Bleeding, Thrombosis, and Vascular Biology Pub Date : 2022-05-12 DOI: 10.4081/btvb.2022.31

Ettore Dolcetti, Antonio Bruno, D. Centonze

引用次数: 0

Are platelets more than a model of brain neurons? 血小板不仅仅是大脑神经元的模型吗?

Bleeding, Thrombosis, and Vascular Biology Pub Date : 2022-05-12 DOI: 10.4081/btvb.2022.29

I. Canobbio, S. Barbieri

引用次数: 1

The Von Willebrand factor-ADAMTS-13 axis: a two-faced Janus in bleeding and thrombosis 血管性血友病因子- adamts -13轴:出血和血栓形成的双面两面

Bleeding, Thrombosis, and Vascular Biology Pub Date : 2022-04-26 DOI: 10.4081/btvb.2022.11

S. Lancellotti, M. Sacco, M. Tardugno, A. Ferretti, R. De Cristofaro

{"title":"The Von Willebrand factor-ADAMTS-13 axis: a two-faced Janus in bleeding and thrombosis","authors":"S. Lancellotti, M. Sacco, M. Tardugno, A. Ferretti, R. De Cristofaro","doi":"10.4081/btvb.2022.11","DOIUrl":"https://doi.org/10.4081/btvb.2022.11","url":null,"abstract":"Von Willebrand factor (VWF), a blood multimeric protein with a very high molecular weight, plays a crucial role in the primary hemostasis, the physiological process characterized by the adhesion of blood platelets to the injured vessel wall. Hydrodynamic forces are responsible for the VWF multimers conformational transitions from a globular to a stretched linear conformation. These characteristics render this protein a valuable object to be investigated by mechanochemistry, the biophysical chemistry branch that studies the effects of shear forces on protein conformation. This review will focus on the structural elements of the VWF molecule involved in the biochemical response to shear forces. The stretched VWF conformation favors the interaction with the platelet GpIb and at the same time with ADAMTS-13, the zinc-protease that cleaves VWF in the A2 domain, limiting its prothrombotic capacity. It is important to consider the level or the function of VWF or ADAMTS-13 always in relation each other, keeping in mind that in many thrombotic forms of microangiopathies the reduction of the ratio between the ADAMTS-13 activity and the VWF level (lower than 0.5) can be a valuable parameter to predict a real thrombotic risk. Hence, a significant increase in VWF level alone, even without any reduction of ADAMTS-13 concentration, would still be responsible for a significant reduction of the ADAMTS-13/VWF ratio, which ultimately could reflect or predict a prothrombotic risk. Future studies will have to validate the concept whether ADAMTS-13/VWF ratio could a valuable and reliable biomarker to predict or confirm the presence of thrombotic risk in several morbid conditions.","PeriodicalId":186928,"journal":{"name":"Bleeding, Thrombosis, and Vascular Biology","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122199572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Gene transfer in hemophilia A: not cogent yet 血友病A的基因转移:尚不明确

Bleeding, Thrombosis, and Vascular Biology Pub Date : 2022-04-20 DOI: 10.4081/btvb.2022.32

P. Mannucci

引用次数: 1

Safety and efficacy of treatment with vitamin K antagonists in patients managed in a network of anticoagulation services or as routine general care 在抗凝服务网络中或作为常规一般护理的患者中使用维生素K拮抗剂治疗的安全性和有效性

Bleeding, Thrombosis, and Vascular Biology Pub Date : 2022-04-15 DOI: 10.4081/btvb.2022.9

G. De Girolamo, L. Sarti, Sonia Cecoli, K. Bonora, C. Ajolfi, F. Bellelli, V. Coluccio, G. Palareti, M. Marietta

{"title":"Safety and efficacy of treatment with vitamin K antagonists in patients managed in a network of anticoagulation services or as routine general care","authors":"G. De Girolamo, L. Sarti, Sonia Cecoli, K. Bonora, C. Ajolfi, F. Bellelli, V. Coluccio, G. Palareti, M. Marietta","doi":"10.4081/btvb.2022.9","DOIUrl":"https://doi.org/10.4081/btvb.2022.9","url":null,"abstract":"This is a retrospective, record-linkage study aimed at comparing the effectiveness and safety of two management models of vitamin K antagonists: a Network model (NAS), in which anticoagulation clinics and general practitioners (GP) share the same management software and database, and an individual General Practitioners model. Main outcomes were thromboembolic events (TE), major bleeding (MB) and all-cause mortality. Crude incidence rate and sub-distribution hazard ratio were calculated. Fine and Grey models were used to calculate SHR in multi-variable analysis. 9,418 patients in the NAS and 5,508 in the Routine General Care (RGC) cohort were included. Patients in the NAS cohort had a lower incidence of TE and mortality in respect to the RGC (sHR 0.76%, 95% CI 0.64-0.90 and 0.82%, 95% CI 0.75-0.89, respectively). More patients in the NAS than in the RGC cohort attained a Time in Therapeutic Range >60% (62.2% vs 35.7%, p<0.001). No statistically significant difference was found in MB incidence. This study shows that the NAS model for vitamin K antagonist oral anticoagulants management significantly improves the TTR and reduces the incidence of TE and mortality, without affecting the MB rate.","PeriodicalId":186928,"journal":{"name":"Bleeding, Thrombosis, and Vascular Biology","volume":"925 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133216508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Milvexian and other drugs targeting Factor XI: a new era of anticoagulation?

Bleeding, Thrombosis, and Vascular Biology Pub Date : 2022-04-15 DOI: 10.4081/btvb.2022.22

M. Donadini, W. Ageno

引用次数: 2

Moving beyond p-value 超越p值

Bleeding, Thrombosis, and Vascular Biology Pub Date : 2022-04-15 DOI: 10.4081/btvb.2022.30

A. Di Castelnuovo, L. Iacoviello

引用次数: 2

New perspectives for prevention of the post-thrombotic syndrome 预防血栓形成后综合征的新视角

Bleeding, Thrombosis, and Vascular Biology Pub Date : 2022-03-22 DOI: 10.4081/btvb.2022.20

P. Prandoni

{"title":"New perspectives for prevention of the post-thrombotic syndrome","authors":"P. Prandoni","doi":"10.4081/btvb.2022.20","DOIUrl":"https://doi.org/10.4081/btvb.2022.20","url":null,"abstract":"While on conventional anticoagulation, up to 50% of patients with one or more episodes of proximal deep vein thrombosis (DVT) can develop post-thrombotic (PTS) manifestations. The potential strategies for PTS prevention are the treatment of acute DVT with catheter-directed thrombolysis (CDT), the use of elastic compression stockings (ECS) and that of the direct oral anticoagulants (DOAC) in place of vitamin K antagonists (VKA) for the initial and long-term treatment of DVT. Based on the results of three randomized clinical trials, CDT cannot be recommended on a routine basis because of its invasiveness, the associated risk of major bleedings and the uncertainty about its efficacy. According to the results of a placebo-controlled randomized clinical trial, ECS are no longer recommended for PTS prevention on a routine basis. However, based on the results of a recent subanalysis of a prospective cohort study, patients with residual vein thrombosis and/or popliteal valve reflux at three months are likely to benefit from ECS for at least six months. Finally, following the demonstration that the inadequacy of VKA therapy plays a key role in the PTS development, several retrospective and prospective studies have shown that the use of DOACs for the initial and long-term treatment of DVT in place of VKAs reduces the risk of PTS by approximately 50%. In conclusion, the availability of DOACs and the potential of ECS in selected patients with proximal DVT are expected to play a key role for decreasing the rate and the severity of PTS in the forthcoming years.","PeriodicalId":186928,"journal":{"name":"Bleeding, Thrombosis, and Vascular Biology","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117335141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The night of randomized clinical trials where all patients are black: a need to estimate variability in treatment effects 所有患者都是黑人的随机临床试验之夜:需要评估治疗效果的可变性

Bleeding, Thrombosis, and Vascular Biology Pub Date : 2022-03-22 DOI: 10.4081/btvb.2022.24

G. de Gaetano, C. Cerletti, L. Iacoviello, M. Donati

引用次数: 0

An ecological alliance against air pollution and cardiovascular disease 一个对抗空气污染和心血管疾病的生态联盟

Bleeding, Thrombosis, and Vascular Biology Pub Date : 2022-03-22 DOI: 10.4081/btvb.2022.21

P. Mannucci

{"title":"An ecological alliance against air pollution and cardiovascular disease","authors":"P. Mannucci","doi":"10.4081/btvb.2022.21","DOIUrl":"https://doi.org/10.4081/btvb.2022.21","url":null,"abstract":"This narrative review article summarizes the strong available evidence that casually links indoor and outdoor air pollution to cardiovascular disease. It also discusses as a possible approach to mitigate this ubiquitous risk factor the use in the household of ornamental potted plants, and their variable degree of effectiveness for the removal of different indoor pollutants such as volatile organic compounds (formaldehyde, benzene, toluene, xylene). Thus, the choice of the plants should be tailored to the types and concentrations of the pollutants present in each household. Outdoor air is less polluted than indoor air in terms of concentrations of the gaseous (NO2) and particulate components (PM10, PM2.5, PM0.1), but it does hamper to a higher extent health because a large fraction of the population is inevitably exposed at the time of breezing. Being cognizant of the difficulties currently encountered in the attempts to mitigate the major sources of ambient air pollution (vehicle traffic and domestic heating) a strategy based upon a massive increase of green spaces in urban areas has been shown not only to positively mitigate air pollution but also improve life expectancy, general health and resilience.","PeriodicalId":186928,"journal":{"name":"Bleeding, Thrombosis, and Vascular Biology","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123576096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2