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Non-opiate pharmacotherapy options for the management of pain in older adults 老年人疼痛管理的非阿片类药物治疗选择
Mental Health Clinician Pub Date : 2015-05-22 DOI: 10.9740/MHC.2015.05.091
Nakia Duncan, Rebecca J. Mahan, S. J. Turner
{"title":"Non-opiate pharmacotherapy options for the management of pain in older adults","authors":"Nakia Duncan, Rebecca J. Mahan, S. J. Turner","doi":"10.9740/MHC.2015.05.091","DOIUrl":"https://doi.org/10.9740/MHC.2015.05.091","url":null,"abstract":"Abstract Pain is highly prevalent, costly, and disabling in later life, especially when undertreated. In this article, we aim to describe the risks and benefits of non-opioid medication options for the management of pain in adults aged 65 years and older in order to provide additional options in a practitioner's tool box when designing a pain management regimen for an older adult. Non-opiate pharmacologic therapies, such as acetaminophen, nonsteroidal anti-inflammatory drugs, topicals, and antidepressants have an important role in pain management of older adults. When designing a pain regimen, taking an individualized approach that considers the patient's functional status, comorbidities, and treatment goals will maximize pain management.","PeriodicalId":18691,"journal":{"name":"Mental Health Clinician","volume":"1 1","pages":"91-101"},"PeriodicalIF":0.0,"publicationDate":"2015-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89247965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Known unknowns: A review of opioid-induced hyperalgesia 已知未知:阿片类药物引起的痛觉过敏的综述
Mental Health Clinician Pub Date : 2015-05-22 DOI: 10.9740/MHC.2015.05.138
Dan McGraw
{"title":"Known unknowns: A review of opioid-induced hyperalgesia","authors":"Dan McGraw","doi":"10.9740/MHC.2015.05.138","DOIUrl":"https://doi.org/10.9740/MHC.2015.05.138","url":null,"abstract":"Abstract Opioid-induced hyperalgesia (OIH) is a relatively new paradigm that has added to the already growing uncertainty surrounding long-term opioid treatment. OIH is the oversensitization to sti...","PeriodicalId":18691,"journal":{"name":"Mental Health Clinician","volume":"49 1","pages":"138-143"},"PeriodicalIF":0.0,"publicationDate":"2015-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72921432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Review of antidepressants in the treatment of neuropathic pain 抗抑郁药物治疗神经性疼痛的研究进展
Mental Health Clinician Pub Date : 2015-05-22 DOI: 10.9740/MHC.2015.05.123
Elizabeth P. Baltenberger, Whitney M. Buterbaugh, B. Martin, Christopher J Thomas
{"title":"Review of antidepressants in the treatment of neuropathic pain","authors":"Elizabeth P. Baltenberger, Whitney M. Buterbaugh, B. Martin, Christopher J Thomas","doi":"10.9740/MHC.2015.05.123","DOIUrl":"https://doi.org/10.9740/MHC.2015.05.123","url":null,"abstract":"Abstract Introduction: Neuropathy is a pathological pain disorder characterized by burning, stabbing, and cramping sensations. There are multiple etiologies for this pain such as diabetes, vascular disorders, and chemotherapy treatment. Neurotransmitters, such as norepinephrine and serotonin, are thought to play a part in the modulation of this pain. The objective of this review is to summarize the current literature to support the efficacy and impact of adverse events of the various classes of antidepressants utilized in the treatment of neuropathic pain. Methods: A Medline/Pubmed search was conducted to identify randomized clinical trials within the last 12 years examining the efficacy and safety of antidepressants for the treatment of neuropathy. Systematic reviews and meta-analyses were also included. Results: Antidepressants are commonly used in the treatment of neuropathy, with meta-analyses supporting the use of tricyclic antidepressants and selective norepinephrine serotonin reuptake inhibitors. T...","PeriodicalId":18691,"journal":{"name":"Mental Health Clinician","volume":"7 1","pages":"123-133"},"PeriodicalIF":0.0,"publicationDate":"2015-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77490927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
A review of the clinical utility of serum clozapine and norclozapine levels 血清氯氮平和去氯氮平水平的临床应用综述
Mental Health Clinician Pub Date : 2015-03-20 DOI: 10.9740/MHC.2015.03.068
J. Ellison, R. Dufresne
{"title":"A review of the clinical utility of serum clozapine and norclozapine levels","authors":"J. Ellison, R. Dufresne","doi":"10.9740/MHC.2015.03.068","DOIUrl":"https://doi.org/10.9740/MHC.2015.03.068","url":null,"abstract":"Abstract Treatment refractory schizophrenia is a serious issue affecting at least 30% of all patients with schizophrenia despite the continued emergence of new agents aimed at treating this disease...","PeriodicalId":18691,"journal":{"name":"Mental Health Clinician","volume":"3 1","pages":"68-73"},"PeriodicalIF":0.0,"publicationDate":"2015-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78434047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Pharmacogenomics of lamotrigine: a possible link to serious cutaneous adverse reactions 拉莫三嗪的药物基因组学:与严重皮肤不良反应的可能联系
Mental Health Clinician Pub Date : 2015-03-20 DOI: 10.9740/MHC.2015.03.078
Rebecca H Campbell, J. Beall
{"title":"Pharmacogenomics of lamotrigine: a possible link to serious cutaneous adverse reactions","authors":"Rebecca H Campbell, J. Beall","doi":"10.9740/MHC.2015.03.078","DOIUrl":"https://doi.org/10.9740/MHC.2015.03.078","url":null,"abstract":"Abstract Introduction: Lamotrigine's packaging contains a boxed warning for serious skin reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis. The purpose of this review is to summarize literature pertaining to HLA genetic polymorphisms that may increase susceptibility to serious skin reactions induced by lamotrigine. Methods: A literature search of PubMed/MEDLINE and Ovid IPA was conducted using the following search terms: lamotrigine, genetic polymorphism, pharmacogenetics, pharmacogenomics, predictive genetic testing, anticonvulsants, hypersensitivity, and HLA-B. Results: Three case-control studies were identified focusing on genetic polymorphisms that can cause direct susceptibility to serious skin reactions, such as HLA-B*1502. Other factors were also taken into consideration, such as age, concomitant medications, ethnicity, and smoking status. Most results were not statistically significant but rather hypothesis generating and were limited by small sample size and study desig...","PeriodicalId":18691,"journal":{"name":"Mental Health Clinician","volume":"120 1","pages":"78-81"},"PeriodicalIF":0.0,"publicationDate":"2015-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80141337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful clozapine rechallenge following clozapine-induced neuroleptic malignant syndrome 氯氮平诱导的抗精神病药恶性综合征后氯氮平再灌注成功
Mental Health Clinician Pub Date : 2015-03-20 DOI: 10.9740/MHC.2015.03.088
C. Ross
{"title":"Successful clozapine rechallenge following clozapine-induced neuroleptic malignant syndrome","authors":"C. Ross","doi":"10.9740/MHC.2015.03.088","DOIUrl":"https://doi.org/10.9740/MHC.2015.03.088","url":null,"abstract":"Abstract Neuroleptic malignant syndrome (NMS) is a potential life-threatening adverse effect of antipsychotics. Characteristic signs and symptoms of NMS include hyperthermia, muscle rigidity, alter...","PeriodicalId":18691,"journal":{"name":"Mental Health Clinician","volume":"6 1","pages":"88-90"},"PeriodicalIF":0.0,"publicationDate":"2015-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72834646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Clozapine-induced myocarditis may warrant cardiac monitoring protocol 氯氮平引起的心肌炎可能需要心脏监测方案
Mental Health Clinician Pub Date : 2015-03-20 DOI: 10.9740/MHC.2015.03.082
L. J. Miller, Rachel Grande
{"title":"Clozapine-induced myocarditis may warrant cardiac monitoring protocol","authors":"L. J. Miller, Rachel Grande","doi":"10.9740/MHC.2015.03.082","DOIUrl":"https://doi.org/10.9740/MHC.2015.03.082","url":null,"abstract":"Abstract Background: Myocarditis, or inflammation of the heart muscle, is a black box warning associated with the use of clozapine. Although the incidence of clozapine-induced myocarditis is only 0.015% to 1.2%, recent retrospective studies have found that up to 66% of clozapine patients develop nonspecific symptoms consistent with myocarditis. Because of the difficulty in distinguishing these symptoms (including fever, tachycardia, and fatigue) from clozapine dose titration, myocarditis may be difficult to recognize. If left undetected, the condition could be fatal. Patient Case: A 25-year-old Filipino male with a history of schizoaffective disorder, bipolar type, continued to endorse persistent and distressing command auditory and visual hallucinations despite therapy with olanzapine, 40 mg daily. Clozapine was initiated for refractory psychosis and titrated up to 125 mg over 17 days. On day 14, the patient reported “feeling sick,” having chills, a nonproductive cough, and fatigue; he was febrile and ta...","PeriodicalId":18691,"journal":{"name":"Mental Health Clinician","volume":"34 1","pages":"82-87"},"PeriodicalIF":0.0,"publicationDate":"2015-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76524067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Indicators of response to clozapine treatment 氯氮平治疗反应指标
Mental Health Clinician Pub Date : 2015-03-20 DOI: 10.9740/MHC.2015.03.074
Dongmi Kim
{"title":"Indicators of response to clozapine treatment","authors":"Dongmi Kim","doi":"10.9740/MHC.2015.03.074","DOIUrl":"https://doi.org/10.9740/MHC.2015.03.074","url":null,"abstract":"Abstract Since its initial landmark trial against chlorpromazine in 1988, clozapine has been the drug of choice for the treatment of refractory schizophrenia. However, variability in clinical response to clozapine treatment is unequivocal. In an effort to preselect patients who are most likely to benefit from clozapine, a number of patient and disease variables and select genetic differences have been studied for their association with positive treatment response to clozapine. Because of small trial sizes and the heterogeneity of study design, findings have resulted in no generalizable conclusion. Future pharmacogenetic studies hold the promise of antipsychotic treatment personalization.","PeriodicalId":18691,"journal":{"name":"Mental Health Clinician","volume":"21 1","pages":"74-77"},"PeriodicalIF":0.0,"publicationDate":"2015-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88884694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Clozapine underutilization in treatment-resistant schizophrenia 难治性精神分裂症氯氮平使用不足
Mental Health Clinician Pub Date : 2015-03-20 DOI: 10.9740/MHC.2015.03.063
Robert J. Stanton, Chris Paxos, W. Geldenhuys, B. Pharm., Jessica L. Boss, M. Munetz, A. Darvesh, M. Pharm
{"title":"Clozapine underutilization in treatment-resistant schizophrenia","authors":"Robert J. Stanton, Chris Paxos, W. Geldenhuys, B. Pharm., Jessica L. Boss, M. Munetz, A. Darvesh, M. Pharm","doi":"10.9740/MHC.2015.03.063","DOIUrl":"https://doi.org/10.9740/MHC.2015.03.063","url":null,"abstract":"Abstract It has been shown that up to one third of patients with schizophrenia do not respond to antipsychotic therapy. Thus, treatment-resistant schizophrenia (TRS) remains a major mental health care challenge. Clozapine has been shown to provide superior therapeutic benefits and is approved as first-line therapy for TRS. These benefits include improvement in both positive and negative symptoms, and reduction of suicidal behavior in patients with schizophrenia. Clozapine, however, remains significantly underused for TRS. A major reason for clozapine's underuse is its substantial adverse effect profile, mainly the risk of life-threatening agranulocytosis which necessitates regular hematologic monitoring. Another factor contributing to reduced clozapine prescribing is the increased use of other second-generation antipsychotics. In TRS patients, there is often a considerable delay in clozapine use, which is prescribed only after other unsuccessful second-generation antipsychotic trials. To combat this trend...","PeriodicalId":18691,"journal":{"name":"Mental Health Clinician","volume":"42 1","pages":"63-67"},"PeriodicalIF":0.0,"publicationDate":"2015-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88835298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Minimizing negative outcomes associated with potentially harmful lithium levels by means of pharmacist-led educational interventions in an inpatient psychiatric facility 在精神病住院病人中，通过药剂师主导的教育干预最小化与潜在有害锂水平相关的负面结果
Mental Health Clinician Pub Date : 2015-01-27 DOI: 10.9740/MHC.2015.01.029
Erika E Tillery
{"title":"Minimizing negative outcomes associated with potentially harmful lithium levels by means of pharmacist-led educational interventions in an inpatient psychiatric facility","authors":"Erika E Tillery","doi":"10.9740/MHC.2015.01.029","DOIUrl":"https://doi.org/10.9740/MHC.2015.01.029","url":null,"abstract":"Introduction: Studies examining educational interventions led by pharmacists to minimize negative outcomes associated with elevated and potentially harmful lithium levels in inpatient psychiatric f...","PeriodicalId":18691,"journal":{"name":"Mental Health Clinician","volume":"19 1","pages":"29-34"},"PeriodicalIF":0.0,"publicationDate":"2015-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81403368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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