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Biodiversity of Medicinal Plants from the Northern Black Sea Coastal Wetlands Part 2 - Durankulak Lake Protected Area 黑海北部滨海湿地药用植物的生物多样性。第2部分-杜兰库拉克湖保护区
Scripta Scientifica Pharmaceutica Pub Date : 2018-06-01 DOI: 10.14748/ssp.v1i1.5003
Dobri Ivanov, D. Cherneva
{"title":"Biodiversity of Medicinal Plants from the Northern Black Sea Coastal Wetlands Part 2 - Durankulak Lake Protected Area","authors":"Dobri Ivanov, D. Cherneva","doi":"10.14748/ssp.v1i1.5003","DOIUrl":"https://doi.org/10.14748/ssp.v1i1.5003","url":null,"abstract":"The present study aims to supplement the available research data on medicinal plants of the Durankulak Lake area. Survey results established a significant variety of medicinal plants: 112 species of higher plants referring to 34 families and 87 genera. The prevailing biological type is the herbaceous perennial type (67 species or 60 percent). Considering moisture and humidity as a factor, the mesophyte plants (presented by 48 species or 43%) occupy dominant position among the medicinal plants. Eurasian geo-elements (20 species or 18%) are predominant, followed by the Euro-Mediterranean (18 species or 16%), sub-Mediterranean (17 species or 15%). Among the medicinal plants there is only one Balkan endemic species. Medicinal plants of conservation significance represent 11.4% or 13 species. The established medicinal plants have more than 30 types of healing action, one fifth of which is used primarily for the treatment of gastrointestinal diseases. The species in which the above ground part (herba) is collected for plant substance constitute half of the established medicinal plants.","PeriodicalId":186809,"journal":{"name":"Scripta Scientifica Pharmaceutica","volume":"134 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115180454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Poisoning with Amanita phalloides (Vaill. ex Fr.) Link - 25-years retrospective analysis in Varna region, Bulgaria 毒伞毒伞中毒。(ex Fr.) Link -保加利亚瓦尔纳地区25年回顾性分析
Scripta Scientifica Pharmaceutica Pub Date : 2018-06-01 DOI: 10.14748/SSP.V1I1.5015
Dobri Ivanov, P. Marinov, S. Zlateva, T. Dimitrova
{"title":"Poisoning with Amanita phalloides (Vaill. ex Fr.) Link - 25-years retrospective analysis in Varna region, Bulgaria","authors":"Dobri Ivanov, P. Marinov, S. Zlateva, T. Dimitrova","doi":"10.14748/SSP.V1I1.5015","DOIUrl":"https://doi.org/10.14748/SSP.V1I1.5015","url":null,"abstract":"Fungal intoxications are important in the ethology of acute exogenous intoxications and A. phalloides mushrooms intoxications are the most important for clinical toxicology. Poisonings with A. phalloides mushrooms are infrequent, but they have high lethality due to their high toxicity. A retrospective analysis of poisonings with A. phalloides mushrooms in Varna region for a period of 25 years (1991-2015) was conducted and 147 patients have been registered. The frequency relative to all hospitalised patients with acute poisoning is 0.8%. Such intoxications are more common in males and the ratio of men to women is 1.62:1. The largest number of intoxications was registered in the age group of 45 to 60 years - 62 (42.2%). All intoxications occured following oral ingestion of A. phalloides mushrooms by mistake instead of edible mushrooms such as field mushroom - Agaricus campestris L. A lethal outcome was registered in 25 patients (17%). A. phalloides mushrooms account for 11.4% of the lethality in acute poisonings.","PeriodicalId":186809,"journal":{"name":"Scripta Scientifica Pharmaceutica","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124359600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of polyphenol supplementation to in vitro antioxidant potential of citrus juices 多酚对柑桔汁体外抗氧化能力的影响
Scripta Scientifica Pharmaceutica Pub Date : 2018-06-01 DOI: 10.14748/SSP.V1I1.5036
Agnieszka Synowiec-Wojtarowicz, Y. Kiselova, Dobri Ivanov, D. Ivanova, W. Bialik, Magdalena Kimsa-Dudek, K. Pawłowska-Góral
{"title":"Effects of polyphenol supplementation to in vitro antioxidant potential of citrus juices","authors":"Agnieszka Synowiec-Wojtarowicz, Y. Kiselova, Dobri Ivanov, D. Ivanova, W. Bialik, Magdalena Kimsa-Dudek, K. Pawłowska-Góral","doi":"10.14748/SSP.V1I1.5036","DOIUrl":"https://doi.org/10.14748/SSP.V1I1.5036","url":null,"abstract":"Food preparations containing substances with antioxidant activity have considerably aroused the interest of consumers, which has led to the marketing of a number of dietary supplements such as resveratrol, hesperidin or chlorogenic acid. On the other hand, natural antioxidants present in citrus fruit juices, together with dietary supplements, could contribute to an enhancement of their antioxidant properties and, in turn, alter their physiological impacts. The aim of the study was to evaluate the effect of supplementation of freshly squeezed citrus juices with resveratrol, hesperidin and chlorogenic acid on the in vitro antioxidant potential of the juices. The solutions of juices, selected polyphenols and the mixtures of solutions of juices and solution of polyphenols were analyzed to determine total polyphenol concentration using the Fast Blue method and total antioxidant potential by the ABTS method. As a result three different types of interactions were established: synergistic of chlorogenic acid which additionally increased the antioxidant potential by 35 - 38% over theoretical predictions, additive - after addition of resveratrol, and antagonistic - in the case of hesperidin. While the antioxidant potential was substantially higher in the mixture of mandarin juice with chlorogenic acid, the measured total polyphenol concentration decreased. Also a considerable decrease in the concentration of polyphenols was measured in the mixtures of mandarin and orange juices with resveratrol, all these possibly due to the sensitivity to other substances present in juices of the analytical method applied. A correlation between antioxidant potential of all examined solutions and total polyphenol concentration was found (r 2 = 0.8879).","PeriodicalId":186809,"journal":{"name":"Scripta Scientifica Pharmaceutica","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124709912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diltiazem-loaded Eudragit RS 100 microparticles for drug delivery: the challenge of viscosity 装载地尔硫卓的Eudragit rs100微颗粒用于药物递送:粘度的挑战
Scripta Scientifica Pharmaceutica Pub Date : 2018-05-31 DOI: 10.14748/SSP.V1I1.5004
I. Kolev, N. Ivanova, G. Alexieva, G. Tsutsumanova, V. Strashilov
{"title":"Diltiazem-loaded Eudragit RS 100 microparticles for drug delivery: the challenge of viscosity","authors":"I. Kolev, N. Ivanova, G. Alexieva, G. Tsutsumanova, V. Strashilov","doi":"10.14748/SSP.V1I1.5004","DOIUrl":"https://doi.org/10.14748/SSP.V1I1.5004","url":null,"abstract":"Strongly shape-dependent viscosity has been found in drug loaded and `empty` polymeric microspheres (drug delivery systems) made of pharmacopoeial Eudragit RS 100 representative. The dramatically increased viscosity of a layer of spherical particles deposited on the gold electrode surface of quartz resonators from water suspension leads to a large dynamic resistance and inability to sustain stable oscillations in a frequency measuring circuit. The viscosity is also affected by loading the polymer matrix with Diltiazem. Its adverse impact is removed by exposing the deposed layer to acetone vapor leading to `dissolving` the investigated spheres and changing their shape to a thin layered one.","PeriodicalId":186809,"journal":{"name":"Scripta Scientifica Pharmaceutica","volume":"153 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116415041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The study of phenolic compounds in Canna lily flowers using HPLC HPLC法研究美人蕉百合花中酚类化合物
Scripta Scientifica Pharmaceutica Pub Date : 2018-05-31 DOI: 10.14748/ssp.v1i1.3125
Svetlana Tymofieieva, O. Kyslychenko, I. Zhuravel
{"title":"The study of phenolic compounds in Canna lily flowers using HPLC","authors":"Svetlana Tymofieieva, O. Kyslychenko, I. Zhuravel","doi":"10.14748/ssp.v1i1.3125","DOIUrl":"https://doi.org/10.14748/ssp.v1i1.3125","url":null,"abstract":"Purpose . The purpose of our work was the research of phenolic compounds in canna lily ( Canna x hybrida Hort.) flowers for a further detailed study of canna lily plant raw material phytochemical composition. Materials and methods . Canna lily flowers of red color collected in Ukraine in summer 2014-2016 were chosen as the object of the study. Ethanol extracts obtained from dried flowers were used for the research. The extracts were analyzed using High Performance Liquid Chromatography (HPLC) technique on a liquid chromatograph equipped by diode-array detector Shimadzu HPLC-system, ser 20. HPLC technique was used to detect phenolic compounds in canna lily flowers. Results and conclusions . Rutin, neochlorogenic, chlorogenic, caffeic and rosemarinic acids were identified in canna lily flowers. The obtained experimental data can be used in the development of the standardization parameters of canna lily flowers.","PeriodicalId":186809,"journal":{"name":"Scripta Scientifica Pharmaceutica","volume":"110 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124685613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The unusual behavior of the Gibbs’ reagent versus Nitrofural 吉布斯试剂对硝基呋喃的异常反应
Scripta Scientifica Pharmaceutica Pub Date : 2018-05-30 DOI: 10.14748/SSP.V1I1.4996
I. Kolev, S. Ivanova
{"title":"The unusual behavior of the Gibbs’ reagent versus Nitrofural","authors":"I. Kolev, S. Ivanova","doi":"10.14748/SSP.V1I1.4996","DOIUrl":"https://doi.org/10.14748/SSP.V1I1.4996","url":null,"abstract":"The study covers a new qualitative analytic test (method) for detecting the semicarbazone chemotherapeutic Nitrofural . The combination of Gibbs` reagent and ammonia was successfully implemented for analyzing the drug. The main structural features of the obtained color products were determined by UV-VIS spectroscopy.","PeriodicalId":186809,"journal":{"name":"Scripta Scientifica Pharmaceutica","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117174202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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