Minerva gastroenterology最新文献

IF 3 4区医学

Minerva gastroenterology Pub Date : 2024-09-01 Epub Date: 2023-06-16 DOI: 10.23736/S2724-5985.23.03206-0

Patricia A Skat-Rørdam, Johanna Eliasson, Mette Skalshøi Kjær, Palle Bekker Jeppesen, Henriette Ytting

{"title":"Health-related quality of life in patients with primary biliary cholangitis: a cross-sectional study from a single centre in Denmark.","authors":"Patricia A Skat-Rørdam, Johanna Eliasson, Mette Skalshøi Kjær, Palle Bekker Jeppesen, Henriette Ytting","doi":"10.23736/S2724-5985.23.03206-0","DOIUrl":"10.23736/S2724-5985.23.03206-0","url":null,"abstract":"Background: The impact of primary biliary cholangitis (PBC) on health-related quality of life (HRQOL) is poorly understood. The aim of this study was to compare HRQOL in Danish patients with PBC to the general population and to assess associations to clinical and laboratory data.Methods: We conducted a single-centre, cross-sectional questionnaire study in patients with PBC using the SF-36 and EQ-5D-5L. Clinical and paraclinical data were obtained from patients' healthcare records. SF-36 scores were compared to an age- and gender-matched Danish general population. A general linear model was used to explore which variables were associated with main SF-36 scores.Results: Sixty-nine patients with PBC were included. Compared to the Danish general population, patients with PBC had a significantly lower HRQOL in the domains bodily pain, general health, vitality, social functioning, mental health and mental component summary score. No clinical characteristics (gender, age at inclusion, concurrent autoimmune hepatitis, pruritus or cirrhosis) or biochemical markers were significantly associated with main SF-36 scores (physical and mental component summary).Conclusions: The study is the first to report on HRQOL in a well-characterized PBC patient population from Denmark. Danish patients with PBC had a significantly impaired HRQOL compared to the general population with the greatest impairment in mental aspects. Reductions in HRQOL were independent of clinical characteristics and biochemical markers why HRQOL should be considered as an independent outcome.","PeriodicalId":18653,"journal":{"name":"Minerva gastroenterology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9639131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serrated polyps <10 mm cannot reliably be characterized by i-Scan without magnification at routine colonoscopy. 在常规结肠镜检查中，小于 10 毫米的锯齿状息肉在没有放大镜的情况下无法通过 i-Scan 进行可靠定性。

IF 3 4区医学

Minerva gastroenterology Pub Date : 2024-09-01 Epub Date: 2023-06-30 DOI: 10.23736/S2724-5985.23.03420-4

Sabrina Gg Testoni, Chiara Notaristefano, Giuliano F Bonura, Maria Napolitano, Dario Esposito, Edi Viale, Lorella Fanti, Francesco Azzolini, Giulia M Cavestro, PierAlberto Testoni

{"title":"Serrated polyps <10 mm cannot reliably be characterized by i-Scan without magnification at routine colonoscopy.","authors":"Sabrina Gg Testoni, Chiara Notaristefano, Giuliano F Bonura, Maria Napolitano, Dario Esposito, Edi Viale, Lorella Fanti, Francesco Azzolini, Giulia M Cavestro, PierAlberto Testoni","doi":"10.23736/S2724-5985.23.03420-4","DOIUrl":"10.23736/S2724-5985.23.03420-4","url":null,"abstract":"Background: Colorectal lesions (CRLs) <10 mm found at colonoscopy tend towards \"diagnose-and-leave\" or \"resect-and-discard\" strategies based on real-time Kudo glandular pit-pattern's assessment using i-Scan. However, i-Scan has not yet been validated for Kudo's classification. We aimed to assess whether, in routine colonoscopy, i-Scan without magnification and optical enhancement (M-OE) reliably differentiates hyperplastic polyps (HPs) from other serrated lesions (SLs) and conventional adenomas (CAs), and, among SLs, HPs from sessile serrated lesions (SSLs) and traditional or unknown serrated adenomas (TSAs, USAs), in Kudo type II CRLs<10 mm, according to ASGE Preservation and Incorporation of Valuable endoscopic Innovations (PIVI) recommended negative predictive value (NPV) threshold for adenomas.Methods: Prospectively recorded CRLs over 12 months, classified according to Kudo pit-pattern using i-Scan, were retrospectively compared with histology.Results: Overall, 898 ≤5-mm and 704 6- to 9-mm CRLs were included. Type II pit-pattern was found in 76.6% and 38.7% of HPs and SSLs-TSAs/CAs (P<0.000001), and in 84.1% and 26.6% of SLs and CAs (P<0.000001). Among SLs, it was found in 81.9% and 86.6% of HPs and SSLs-TSAs. In CRLs≤5 mm, HPs were prevalent over other SLs (P=0.00001); in CRLs 6-9 mm, CAs were prevalent (P<0.000001). About 77% of SLs in right colon were SSLs-TSAs; 82% in left colon were HPs. PIVI ≥90% NPV threshold for adenomas was reached for CRLs 6-9mm (92.1%), nearly achieved for CRLs≤5 mm (88.2%), and not reached for SLs independently on the size.Conclusions: A strategy of \"diagnose-and-leave\" or \"resect-and-discard\" cannot be recommended for SLs<10 mm with Kudo type II pit-pattern using i-Scan, especially in right colon, if M-OE unavailable.","PeriodicalId":18653,"journal":{"name":"Minerva gastroenterology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9699628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of prognostic factors and model establishment of long-term postoperative effect in children with hepatoblastoma. 肝母细胞瘤患儿的预后因素分析及术后长期疗效模型的建立

IF 3 4区医学

Minerva gastroenterology Pub Date : 2024-09-01 Epub Date: 2023-06-16 DOI: 10.23736/S2724-5985.23.03462-9

Junjie Lin, Yuanqi Wang, Shiming Shi, Wenzong Gao, Juntao Xie, Juncheng Liu, Hong Jiang, Li Zhou

引用次数: 0

Brunner's gland hamartoma misdiagnosed as a case of duodenal malignancy. 被误诊为十二指肠恶性肿瘤的布鲁纳腺火腿肠瘤。

IF 3 4区医学

Minerva gastroenterology Pub Date : 2024-09-01 Epub Date: 2023-09-15 DOI: 10.23736/S2724-5985.23.03524-6

Zhe Wang, Xiaoming Zhu, Zhenying Yue, Jun Lu, Guozheng Pan, Faping You

引用次数: 0

The impact of comprehensive nursing intervention on the psychological status and quality of life of patients with severe acute myeloid leukemia. 综合护理干预对重症急性髓性白血病患者心理状态和生活质量的影响。

IF 3 4区医学

Minerva gastroenterology Pub Date : 2024-09-01 Epub Date: 2023-05-10 DOI: 10.23736/S2724-5985.23.03417-4

Mengtian Zong, Wei Chen

引用次数: 0

Study on the application of multi-nursing specialty group in the treatment of recurrence after resection of multiple colorectal polyps by the method of removing turbidity from liver. 多学科护理专业组在肝去浊法治疗多发性大肠息肉切除术后复发中的应用研究。

IF 3 4区医学

Minerva gastroenterology Pub Date : 2024-09-01 Epub Date: 2023-07-13 DOI: 10.23736/S2724-5985.23.03505-2

Jing Hu, Wenxiao Chi, Na Zhang

引用次数: 0

Performance of serum-based biomarkers in fibrosis prediction of chronic hepatitis B patients in real life practice. 基于血清的生物标志物在实际生活中预测慢性乙型肝炎患者纤维化的性能。

IF 3 4区医学

Minerva gastroenterology Pub Date : 2024-09-01 Epub Date: 2023-06-13 DOI: 10.23736/S2724-5985.23.03347-8

Fadi Abu Baker, Randa Taher Natour, Yael Kopelman, Abdel H Alkilani, Saif Abu Mouch

{"title":"Performance of serum-based biomarkers in fibrosis prediction of chronic hepatitis B patients in real life practice.","authors":"Fadi Abu Baker, Randa Taher Natour, Yael Kopelman, Abdel H Alkilani, Saif Abu Mouch","doi":"10.23736/S2724-5985.23.03347-8","DOIUrl":"10.23736/S2724-5985.23.03347-8","url":null,"abstract":"Background: Few studies have addressed the performance and diagnostic accuracy of laboratory-based markers for fibrosis prediction in chronic hepatitis B (CHB) patients yielding heterogeneous results. We aimed to study the performance of the FIB-4 and neutrophil-to-lymphocyte ratio (NLR) markers for the differentiation between significant and non-significant hepatic fibrosis in real-life practice.Methods: We prospectively recruited CHB patients attending the hepatology clinic to undergo shear wave elastography (SWE) and blood tests. The predictive accuracy of FIB-4 and NLR for liver fibrosis was assessed by receiver operating characteristics (ROC) analysis.Results: Overall, 174 fully characterized CHB patients with an average age of 50.2±11.2 (29-86 years) and a male predominance (65.2%) were included. Of these, 23% had significant fibrosis (≥F2) per SWE (>7.1KPA). A significant and linear correlation was found between the SWE score and FIB-4 values (r=0.572; P<0.001). A lower cut-off of 1.43 has yielded an AUROC of 0.76, with a sensitivity of 68.8%, specificity of 79.8%, diagnostic accuracy of 78.5%, and NPV of 96%. On the contrary, NLR values were similar between significant and minimal fibrosis and were not found to be correlated with significant fibrosis (r=0.54, P=0.39).Conclusions: FIB4 has a moderate performance and may have a valuable role in excluding significant fibrosis in CHB patients in daily practice.","PeriodicalId":18653,"journal":{"name":"Minerva gastroenterology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9994572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between intestinal microflora and obesity. 肠道微生物菌群与肥胖之间的关系

IF 3 4区医学

Minerva gastroenterology Pub Date : 2024-09-01 Epub Date: 2023-03-21 DOI: 10.23736/S2724-5985.23.03379-X

Maryana Savytska, Marko Kozyk, Kateryna Strubchevska, Kateryna Yosypenko, Tetyana Falalyeyeva, Nazarii Kobyliak, Luigi Boccuto, Rinaldo Pellicano, Sharmila Fagoonee, Emidio Scarpellini, Ludovico Abenavoli

{"title":"Association between intestinal microflora and obesity.","authors":"Maryana Savytska, Marko Kozyk, Kateryna Strubchevska, Kateryna Yosypenko, Tetyana Falalyeyeva, Nazarii Kobyliak, Luigi Boccuto, Rinaldo Pellicano, Sharmila Fagoonee, Emidio Scarpellini, Ludovico Abenavoli","doi":"10.23736/S2724-5985.23.03379-X","DOIUrl":"10.23736/S2724-5985.23.03379-X","url":null,"abstract":"Obesity has become one of modern society's most serious health problems. Studies from the last 30 years revealed a direct relationship between imbalanced energy intake and increased healthcare costs related to the treatment or management of obesity. Recent research has highlighted significant effects of gut microbial composition on obesity. We aimed to report the current knowledge on the definition, composition, and functions of intestinal microbiota. We have performed an extensive review of the literature searching for the following key words: metabolism, gut microbiota, dysbiosis, and obesity. There is evidence that an association between intestinal microbiota and obesity exists at any age. There are complex genetic, metabolic, and inflammatory mechanisms involved in the pathogenesis of obesity. Revision of indications for use of probiotics, prebiotics, and antibiotics in obese patients should be considered. Microbial composition of the gut may be an important factor involved in the development of obesity. Changes in the gut microbiota may result in changes in human metabolism and weight loss.","PeriodicalId":18653,"journal":{"name":"Minerva gastroenterology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9141569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical value of zinc combined with folic acid in the treatment of infantile diarrhea. 锌联合叶酸治疗婴儿腹泻的临床价值。

IF 3 4区医学

Minerva gastroenterology Pub Date : 2024-09-01 Epub Date: 2023-07-21 DOI: 10.23736/S2724-5985.23.03516-7

Shu Hua

引用次数: 0

Study on the involvement of plasma exosomal lncRNA in pathogenesis and diagnostic value of Kawasaki disease. 关于血浆外泌体 lncRNA 参与川崎病发病机制及诊断价值的研究

IF 3 4区医学

Minerva gastroenterology Pub Date : 2024-06-01 Epub Date: 2023-05-26 DOI: 10.23736/S2724-5985.23.03453-8

Xuehong Ji, Xianmin Wang, Guixia Li, Xia Xiao, Li Hu, Xing Zhang

引用次数: 0