Molecular & Cellular Epilepsy最新文献_第4页

Complex Roles of Notch Signaling in the Development of Temporal Lobe Epilepsy: Evidence and Speculation Notch信号在颞叶癫痫发展中的复杂作用:证据和推测

Molecular & Cellular Epilepsy Pub Date : 2014-02-15 DOI: 10.14800/MCE.22

Longze Sha, Qi Xu

{"title":"Complex Roles of Notch Signaling in the Development of Temporal Lobe Epilepsy: Evidence and Speculation","authors":"Longze Sha, Qi Xu","doi":"10.14800/MCE.22","DOIUrl":"https://doi.org/10.14800/MCE.22","url":null,"abstract":"The Notch pathway is well known as a master regulator of neural stem cells, but accumulating evidence suggest both novel and sophisticated roles for Notch signaling in adult brain. In the postnatal hippocampus, the regulatory function of Notch signaling on synaptic plasticity has been studied extensively. Mice with germline deletion of Notch1 or presenilins exhibited impaired long-term potentiation (LTP) and working memory, which could be understood as a consequence of disruptions in Notch-dependent neurite development and neuronal migration. Compared with long-term synaptic plasticity, recent studies have shown that Notch pathway is induced instantly by neuronal activity, suggesting a correlate of stimulus-dependent Notch activity and synaptic transmission. However, the role of those non-canonical functions of Notch signaling in neurological disorders has not been characterized so far. More recently, we have reported that Notch signaling activation led to an increase in epileptiform discharges in a mouse model of acute seizures. Temporal lobe epilepsy (TLE) is among the most frequent types of drug-resistant epilepsy, and the reorganization of neural circuits underlying the generation of recurrent seizures has been demonstrated, including impaired long-term potentiation of synaptic networks and disordered short-term synaptic responses. Here, focusing on the primary and new-emerging functions of Notch signaling, we review the complicated roles of Notch in the development of TLE and speculate some potential neuropathogenic mechanisms.","PeriodicalId":18603,"journal":{"name":"Molecular & Cellular Epilepsy","volume":"141 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85369301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Basic cellular and molecular mechanisms of refractory epilepsy: a review of current hypotheses 难治性癫痫的基本细胞和分子机制:当前假说综述

Molecular & Cellular Epilepsy Pub Date : 2014-01-15 DOI: 10.14800/MCE.17

E. Viteva

引用次数: 2

The γ2(R43Q) mutation linked to epilepsy affects GABAA receptor internalization 与癫痫相关的γ - 2(R43Q)突变影响GABAA受体内化

Molecular & Cellular Epilepsy Pub Date : 2014-01-15 DOI: 10.14800/MCE.24

S. Chaumont, M. Garret

引用次数: 0

Therapeutic mechanism of subthalamic nucleus stimulation for refractory epilepsy involved in melanocortin-4 receptor signaling 丘脑下核刺激治疗难治性癫痫的机制涉及黑素皮质素-4受体信号传导

Molecular & Cellular Epilepsy Pub Date : 2014-01-15 DOI: 10.14800/MCE.18

Hongbing Xiang

引用次数: 11

Levetiracetam – An Alternative Option in Preterm Neonates for Acute Seizure Management 左乙拉西坦-早产儿急性癫痫发作管理的另一种选择

Molecular & Cellular Epilepsy Pub Date : 2014-01-15 DOI: 10.14800/MCE.19

Batool F. Kirmani

{"title":"Levetiracetam – An Alternative Option in Preterm Neonates for Acute Seizure Management","authors":"Batool F. Kirmani","doi":"10.14800/MCE.19","DOIUrl":"https://doi.org/10.14800/MCE.19","url":null,"abstract":"800x600 Neonatal seizures occur in five of 1000 live births in North America and affect the future development of the child. Preterm neonates are more susceptible to seizures due to brain immaturity with the incidence of 11 of 1000 live births, much higher than neonatal seizures. Few medicines studied and approved to treat this subset of patients, management difficult. The only medicines approved by the FDA are phenytoin and Phenobarbital in the neonatal period. Failure of these agents due to lack of efficacy and undesirable side-effects led us to investigate the role of Intravenous Levetiracetam in preterm neonates, the most challenging group of patients in the pediatric population. In this research highlight, we will discuss the findings of our recent in preterm neonates. Normal 0 false false false EN-US ZH-CN X-NONE MicrosoftInternetExplorer4 \u0000st1:*{behavior:url(#ieooui) } \u0000 /* Style Definitions */ \u0000 table.MsoNormalTable \u0000 {mso-style-name:\"Table Normal\"; \u0000 mso-tstyle-rowband-size:0; \u0000 mso-tstyle-colband-size:0; \u0000 mso-style-noshow:yes; \u0000 mso-style-priority:99; \u0000 mso-style-parent:\"\"; \u0000 mso-padding-alt:0cm 5.4pt 0cm 5.4pt; \u0000 mso-para-margin:0cm; \u0000 mso-para-margin-bottom:.0001pt; \u0000 mso-pagination:widow-orphan; \u0000 font-size:10.0pt; \u0000 font-family:\"Times New Roman\",\"serif\";}","PeriodicalId":18603,"journal":{"name":"Molecular & Cellular Epilepsy","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90647290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Neonatal seizures and therapeutic hypothermia for hypoxic-ischemic encephalopathy. 新生儿癫痫和治疗性低温治疗缺氧缺血性脑病。

Molecular & Cellular Epilepsy Pub Date : 2014-01-01 DOI: 10.14800/mce.88

Dawn Gano, Sharon A Orbach, Sonia L Bonifacio, Hannah C Glass

引用次数: 11