Menoufia Medical Journal最新文献

{"title":"Urine-based detection of intestinal mucosal cell damage in neonates with suspected necrotizing enterocolitis","authors":"Fady Elgendy, Nouran Aboelkhair, Nesma El-Desokyc, Hanan Z El-Sayed","doi":"10.4103/mmj.mmj_271_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_271_22","url":null,"abstract":"Objectives To assess the diagnostic value of the urinary intestinal fatty acid-binding protein (iFABP) in neonatal necrotizing enterocolitis (NEC) in the early stage of the disease. Background NEC is a severe acute gastrointestinal disease affecting preterm newborns. iFABP has been associated with injury to the intestinal mucosa common to NEC. Patients and methods This cross-sectional study included 40 preterm neonates divided into two groups: group I included 20 preterm neonates with suspected NEC according to Modified Bell Staging Criteria for NEC and group II included 20 preterm neonates with non-NEC. All the included participants underwent full history taking, full examination, routine laboratory investigations, and assessment of urinary iFABP. Results The mean urinary iFABP level was 17.26 ± 3.69 ng/dl in group I and 8.39 ± 2.49 ng/ml in group II. This difference was significantly higher in the suspected NEC group (P = 0.001). The iFABP level at a cutoff more than 9.25 ng/ml had significant power of discrimination of NEC cases at an early stage (P = 0.001) with a sensitivity of 96.0% and specificity of 71.0%. Linear regression revealed that the sampling time was a significant measure for prediction of iFABP (P = 0.001). Conclusion There was an association between elevated iFABP levels in urine and NEC, suggesting that iFABP may be useful as a diagnostic biomarker for earlier identification of NEC.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"6 1","pages":"1835 - 1840"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81034035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of elective induction of labor at 39 weeks' gestational age on maternal and neonatal risk","authors":"I. Elnasr, M. Elsheikh, A. Elhalaby","doi":"10.4103/mmj.mmj_300_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_300_22","url":null,"abstract":"Objectives To compare elective induction of labor at 39 weeks' gestational age in uncomplicated pregnancies with expectant management of up to 41 weeks' gestation and induction of labor in undelivered mothers. Background Late-term and postterm pregnancies are associated with increased maternal and fetal risks, thus several studies have considered induction of labor between 39 and 41 weeks' gestational age. Patients and methods This study was a randomized case–control study on 194 pregnant women at 39 weeks for labor induction at Menoufia University Hospitals and Elsalam Specialized Hospital during the period between December 2020 and June 2022. Results In the present study, there was highly statistically significant (P < 0.001) increased Apgar score at 5 min in group A (interquartile range = 8–9) when compared with group B (interquartile range = 8–8) and statistically significant (P = 0.048) increased birth weight in group B when compared with group A. The cesarean section rate was statistically significant (P = 0.005) in group B (39.1%) than in group A (20.6%). Conclusion Labor induction at 39 weeks should be offered to low-risk women. That policy is associated with fewer cesarean section and other complications. If woman chooses spontaneous labor onset she should have regular fetal monitoring as several studies have suggested increased risk of perinatal death by increasing gestational age.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"263 1","pages":"1970 - 1976"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84772783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome predictors in the surgical management of intradural spinal tumors","authors":"Ibrahim Hegazy, E. Saleh, A. Azzab, A. El Naggar, Mohamed El tabl, A. Hanafy, Hossam Elnoamany, Hossam Habeb","doi":"10.4103/mmj.mmj_184_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_184_22","url":null,"abstract":"Objective To evaluate the different factors affecting the surgical outcome of intradural spinal tumors. Background Among the intradural spinal tumors, meningiomas, ependymomas, astrocytomas, and nerve sheath tumors are the most common. Early surgical intervention with the use of technical adjunctives and postoperative adjuvant therapy has improved the outcome. Patients and methods A prospective study was done on 30 consecutive patients with an age group ranging from 20 to 60 years. All patients underwent surgery for intradural spinal tumors at Menoufia University and Alexandria Armed Forces Hospital. Data were collected regarding histopathological diagnosis, clinical presentation, tumor location, operative data, and postoperative complications. A functional outcome was assessed using the modified McCormick Scale (MMS). Results There were 16 (53.3%) patients with extramedullary tumors and 14 (46.7%) patients with intramedullary tumors. Guided tissue regeneration (GTR) was achieved in 21 (70%) patients, mostly meningioma and ependymoma. Extramedullary locations are more likely to achieve GTR and are associated with better outcomes than those with intramedullary locations. The mean preoperative MMS (2.70 ± 0.88) showed marked improvement compared with the mean 2.20 ± 1.42, 2.0 ± 1.51, and 1.93 ± 1.51 immediately postoperatively, 6-month, and 1-year follow-up, respectively. The complication rate was 33.3% (10 patients), and cerebrospinal fluid leak was the most common complication. Conclusion The use of adjunctive (cavitron ultrasonic aspirator, IOM), the extramedullary location, low preoperative MMS, GTR, and low tumor grade were associated with better postoperative outcomes.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"49 1","pages":"1949 - 1954"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91255534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary C-reactive protein, mean platelet volume, and neutrophil-lymphocyte ratio as diagnostic markers of neonatal sepsis","authors":"S. Ragab, H. El-Sayed, S. El-deeb, Rehab El-Arabi","doi":"10.4103/mmj.mmj_208_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_208_22","url":null,"abstract":"Background Till now, salivary C-reactive protein (CRP), mean platelet volume (MPV), and neutrophil-lymphocyte ratio (NLR) have not been studied as markers for diagnosis of neonatal sepsis. Objectives To assess the applicability of salivary CRP, MPV, and NLR as diagnostic markers in preterm neonates with neonatal sepsis. Patients and methods A case–control study was conducted on 184 newborns from the neonatal ICU at Menoufia University Hospital and Qwesna General Hospital from 2021 to 2022. All selected newborns were divided into group I, which included 92 neonates diagnosed as having neonatal sepsis, and group II, which included 92 apparently healthy neonates. Full history taking; thorough clinical examination; laboratory investigations such as complete blood count, leukocyte count, platelet number, NLR, platelet-lymphocyte ratio, serum CRP, salivary CRP, and blood culture; and radiological investigation such as chest radiograph and cranial ultrasound were done. Results Salivary CRP, MPV, and NLR were significantly increased in the case group than the control group. The cutoff values of MPV, NLR, and salivary CRP were 8.4, 1.87, and 8.0, respectively, with sensitivity of 82.6, 97.8, and 98.9%, respectively, and specificity of 97.8, 98.9, and 100%, respectively, for detection of neonatal sepsis. Conclusion Salivary CPR, MPV, and NLR were significantly increased in neonatal sepsis than healthy neonates. However, platelet-lymphocyte ratio was not significant in neonatal sepsis.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"10 1","pages":"1810 - 1815"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73151602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of seroprevalence of dengue virus infection among patients visiting a tertiary-care center in Indore","authors":"M. Al-Mendalawi","doi":"10.4103/mmj.mmj_51_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_51_22","url":null,"abstract":"","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"25 1","pages":"2089 - 2089"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83229412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left ventricular mechanics before and after mitral valve replacement in patients with severe mitral regurgitation","authors":"Ahmed ElBekiey, S. Montaser, M. Ahmed, H. Eldeeb","doi":"10.4103/mmj.mmj_322_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_322_22","url":null,"abstract":"Objectives To study left ventricular (LV) mechanics in patients with severe mitral valve regurgitation (MR) before and after mitral valve replacement (MVR). Background Our study investigated the short-term follow-up of LV deformation mechanics twist and untwist and LV-global longitudinal strain as an LV function parameter affected by MVR in patients presented with severe mitral regurgitation. Patients and methods We assessed LV deformations by Speckle-tracking echocardiography in 30 patients who had preserved LV ejection fraction before, 1 week after, and 3 months after MVR surgery. Results Among the study population, 16 were men and the mean age was 54.9 ± 6.9 years. There was a significant decrease in LV ejection fraction, LV dimensions, and volumes during early follow-up, which recovered at 3-month follow-up. Right ventricular basal dimension, right ventricular systolic pressure, grade of tricuspid regurgitation, and functional capacity were significantly improved. There was significant deterioration of global longitudinal strain in the early postoperative period; however, it was improved 3 months later (P1 < 0.001, P2 < 0.001, and P3 < 0.001). There was a significant decrease regarding twist between preoperative, early, and late postoperative periods (P1 < 0.001, P2 < 0.001, and P3 < 0.001). There was a significant improvement regarding the untwist rate between preoperative and late postoperative periods (−103 ± 15.3 vs. −122.4 ± 15.3, P2 < 0.001). Conclusions In patients with severe MR, Speckle tracking is a useful technique for assessing LV deformation mechanics and detect subtle affection before conventional echocardiography.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"1 1","pages":"1635 - 1640"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82788403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunohistochemical expression of discoidin domain receptor 1 in keloid scar","authors":"R. Samaka, Amr El Meanawy, Mohammed A. Basha, Shimaa Abdel-Raouf","doi":"10.4103/mmj.mmj_275_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_275_22","url":null,"abstract":"Objectives To assess the role of discoidin domain receptor 1 (DDR1) in keloid scar. Background Keloid scars are formed of inert masses of collagen. Therefore, expression of collagen and DDR1 may determine the nature and extent of tissue scarring. Patients and methods This case–control study was carried out on 20 patients presented with keloid and 40 age-matched, sex-matched, and site-matched apparently normal skin from apparently healthy volunteers. Skin biopsies were sent to the Pathology Department of Faculty of Medicine, Menoufia University, for histopathological assessment and immunohistochemical staining of DDR1. Results Epidermal expression of DDR1 was positive in all keloid cases (lesional and perilesional). Its intensity was mild in all lesional biopsies and in only 20% of perilesional ones. Dermal expression was positive in all perilesional cases and in only 30% of lesional biopsies. A significant difference was found between lesional and perilesional keloid regarding DDR1 expression intensity in the epidermis and dermis (P < 0.001). A significant difference was found between lesional and perilesional keloid regarding DDR1 expression H-score in the epidermis and dermis (P < 0.001). A significant positive correlation was found between lesional epidermal and lesional dermal groups regarding keloid H-score (r = 0.552; P = 0.012). In control group, positive epidermal expression of DDR1 was found in all biopsies, with cytoplasmic localization and basal topography. Mild intensity was seen in 52.5% and moderate intensity was seen in 47.5%. The mean ± SD values of H-score were 81.50 ± 39.52. Positive dermal expression of DDR1 was found in all biopsies, with cytoplasmic localization and basal topography. Mild intensity was seen in 50% and moderate intensity was seen in 50%. The mean ± SD values of H-score were 82 ± 27.38. Conclusion DDR1 expression in keloid scar is suspected in early pathogenesis.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"5 1","pages":"1721 - 1725"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90853599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of condom use on sexual function","authors":"Mohammed Gaber, Shimaa Helal, Mohamed Abu Salem","doi":"10.4103/mmj.mmj_223_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_223_22","url":null,"abstract":"Objectives This work aimed to study the effect of condom use on the sexual function of males and females, who use condoms in their sexual relations in Egypt. Background Sexual health is a state of physical, emotional, mental, and social well-being, not merely the absence of disease, dysfunction, or infirmity. Sexual health requires a positive and respectful approach to sexuality and sexual relationships, as well as the possibility of having pleasurable and safe sexual experiences, free of coercion, discrimination, and violence. Patients and methods The current study was a cross-sectional study, which was carried out between October 2021 and January 2022 in the outpatient clinic of Menoufia University Hospital. The study included a questionnaire for 150 males and females, who use condoms in their sexual relationships. All study procedures were carried out and were approved by the Ethics Committee of Menoufia Faculty of Medicine. Results The condom decreased enjoyment in 46.7% of participants. Regarding condom problems, the condom slipped off in 27.3% followed by unsatisfied sex (23.3%) and dryness (22.7%) for females. For males, the unsatisfied sex was 34% followed by a slipped condom (20.7%) and loss of erection (20%). Participants of the study reported that 43.3% were obliged to use a condom because no other safe medical contraceptive method was available and 61.3% of their partners wanted to change the condom to a contraceptive method used by women. Unsatisfied sex with condom use was the main reason to shift to a contraceptive method used by wives in 37.3%. The majority of participants (83.3%) did not abuse their partners verbally on top of condom use. Conclusion Our study included condom discomfort and associated problems and reported problems of loss of sensation, erection problems, allergy to latex, condom size, dryness, and decreased sensation.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"11 1","pages":"1726 - 1734"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91145772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tadalafil versus tadalafil with sildosin in the management of symptomatic benign prostatic hyperplasia","authors":"M. Selim, M. Omar, Mohamed Mohamed, A. El-Din","doi":"10.4103/mmj.mmj_294_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_294_22","url":null,"abstract":"Objectives To compare the safety and efficacy of tadalafil versus tadalafil with silodosin in the treatment of patients with symptomatic benign prostatic hyperplasia (BPH) and their effect on erectile function. Background Lower urinary tract symptoms and erectile dysfunction are two commonly associated conditions in patients with BPH and lead to worsening of the quality of life in the male population. For such cases, alpha-blockers and phosphodiesterase five inhibitors are used. Patients and methods A total of 100 men, having lower urinary tract symptoms owing to BPH with moderate and severe international prostatic symptom score (IPSS), were randomly divided into four equal groups of 25 patients each. The IPSS and International index of erectile function-5 (IIEF-5) were scored for all patients together with measuring postvoid residual urine (PVR) and maximum urine flow rate (Q-MAX) at the first visit and then follow-up was done on the third, sixth, and 12th weeks, with same parameters added to inquiry about any adverse effects. Results Tadalafil monotherapy statistically improved IPSS, IIEF, and Q-MAX, with P value less than 0.001 in groups I and III. Moreover, it showed a statistically significant reduction in PVR in the same groups, with P value less than 0.001. The same findings were in groups II and IV receiving the combination therapy, with P value less than 0.001, with numerically better results in all aspects of the study. Conclusion All patients tolerated both protocols of treatment with no statistically significant adverse effects. The combination therapy was superior to monotherapy in all aspects regarding IPSS, IIEF, PVR, and Q-MAX.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"20 1","pages":"2081 - 2086"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82437183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of platelet indices in prediction of pulmonary embolism","authors":"Yasser M. Kamal, A. Kassem, Hasnaa Abo Elwafa, A. Abdel-baset","doi":"10.4103/mmj.mmj_247_22","DOIUrl":"https://doi.org/10.4103/mmj.mmj_247_22","url":null,"abstract":"Objectives To assess the platelet (PLT) indices, such as mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW), in pulmonary embolism (PE) prediction. Background PE is the third most frequent cardiovascular disease worldwide. The changes in PLT indices (MPV, PDW, and PCT) are gold standard markers for the pathogenesis in different cardiovascular diseases. Patients and methods A total of 100 patients with venous thromboembolism and 50 controls were recruited. Overall, 46 patients presented with first episode of deep venous thrombosis (DVT) without PE (group I) and 54 patients with PE (group II). Results MPV was significantly higher in patients with PE (10.72 ± 2.05 fl) than patients with DVT (9.25 ± 1.31 fl) (P = 0.02). Similarly, PDW was significantly higher in patients with PE (24.78 ± 6.76 fl) than patients with DVT (22.39 ± 4.33 fl), with P value of 0.04. The cutoff values of MPV and PDW for prediction of PE at presentation were 10 and 17.5 fl, respectively, with sensitivities of 77 and 83%, respectively, and specificities of 87 and 80%, respectively. PCT was significantly higher in the PE (0.25 ± 0.09 ng/ml) group and DVT (0.26 ± 0.07 ng/ml) group compared with the control (0.22 ± 0.04 ng/ml) group. PLT count was significantly lower in the PE group (229.39 ± 67.98 × 103/μl) than DVT (249.85 ± 54.7 × 103/μl) and control (279.13 ± 61.83 × 103/μl) groups. White blood cell were significantly higher in patients with PE (9.36 ± 3.67 × 109/l) than DVT (8.01 ± 2.53 × 109/l) and control (8 ± 2.37 × 109/l) groups. The highest values of MPV, PDW, right ventricular dimensions, pulmonary pressure, and cardiac troponin I level were significantly correlated to the severity of PE. MPV and PDW were directly related to thrombus size in Doppler ultrasonography finding in patients with DVT and to the level of obstruction of pulmonary vessels in computed tomography pulmonary angiogram for patients with PE. Conclusion The current study suggested that serial measurements of MPV, PDW, and PLT count are reliable markers for predicting the occurrence of acute PE in patients with first episode of acute proximal DVT.","PeriodicalId":18558,"journal":{"name":"Menoufia Medical Journal","volume":"65 1","pages":"1779 - 1786"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84488804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}