Marmara Pharmaceutical Journal最新文献_第7页

Enhancement of solubility and dissolution of ibuprofen microparticle prepared by ultrasonic spray drying 超声喷雾干燥法提高布洛芬微粒的溶解度和溶出度

Marmara Pharmaceutical Journal Pub Date : 2017-12-01 DOI: 10.12991/MPJ.2017.30

Revika Rachmaniar, C. Panatarani, I. Joni, Marline Abdasah, T. Rusdiana

{"title":"Enhancement of solubility and dissolution of ibuprofen microparticle prepared by ultrasonic spray drying","authors":"Revika Rachmaniar, C. Panatarani, I. Joni, Marline Abdasah, T. Rusdiana","doi":"10.12991/MPJ.2017.30","DOIUrl":"https://doi.org/10.12991/MPJ.2017.30","url":null,"abstract":"Ibuprofen (IBU) is one of the most commonly used nonsteroidal anti-inflammatory drugs with high permeability and low solubility. The aims of this research is to improve the solubility and dissolution of the IBU by reducing particle size using ultrasonic spray drying method and utilizing watersoluble polymer (polyvinyl alcohol (PVA)) and surfactant (sodium lauryl sulphate (SLS)) for particles formulation. The results showed that increasing amount of PVA, smaller particle size of as-prepared IBU-PVA-SLS was obtained, 6.3-fold smaller than untreated IBU. The in vitro drug release study for simulated gastric fluid without enzymes (0.1 N HCl or Buffer pH 1.2) shows the dissolution of prepared IBU-PVA-SLS significantly increase 2.4-fold higher than untreated IBU for dissolution time of 30 minutes. While the solubility of the IBU-PVA-SLS was increased 4.7-fold compare to untreated IBU. In general, IBU possessing relatively high dissolution in intestinal fluid. In contrast, the finding of recent investigation on dissolution of IBU-PVA-SLS is significantly increase in gastric fluid, either due to smaller particles size or PVA-SLS. Thus, despite the PVA and SLS determine the particles formation during polymerization yielding smaller particle size, they also responsible for effective drug delivery system. It was concluded that PVA and SLS in ultrasonic spray drying technique for IBU preparation successfully reduces the particle size and effectively enhances the solubility and dissolution rate of poorly water-soluble IBU in 0.1 N HCl.","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"8 1","pages":"783-792"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83651419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Chemical composition, antioxidant, anticholinesterase and anti-urease activities of Sideritis pisidica Boiss. & Heldr. endemic to Turkey 甜菜黄螺旋体的化学成分、抗氧化活性、抗胆碱酯酶和抗脲酶活性。& Heldr。土耳其特有的

Marmara Pharmaceutical Journal Pub Date : 2017-12-01 DOI: 10.12991/MPJ.2017.13

Ebru Deveci, Gülsen Tel‐Çayan, H. Yıldırım, M. Duru

引用次数: 11

Plants Used as Painkiller in Folk Medicine in Turkey-I STOMACHACHE 土耳其民间医药中用作止痛药的植物——胃痛

Marmara Pharmaceutical Journal Pub Date : 2017-12-01 DOI: 10.12991/MPJ.2017.0

Meryem Seyda Erbay, S. Anıl, G. Melikoğlu

{"title":"Plants Used as Painkiller in Folk Medicine in Turkey-I STOMACHACHE","authors":"Meryem Seyda Erbay, S. Anıl, G. Melikoğlu","doi":"10.12991/MPJ.2017.0","DOIUrl":"https://doi.org/10.12991/MPJ.2017.0","url":null,"abstract":"There are many plants used by the public in the treatment of various diseases in Turkey.The folk remedies prepared with these plants from which treatment and how they used have been reached to day-to-day by transferring the generations. Ethnobotanic researches and traditional treatment methods are recorded and it is aimed to contribute to drug development studies.In this study, which was prepared by screening of ethnobotanical researches, 221 taxa which used in traditional treatment against stomachache in Turkey are reached and the scientific , local names, families, used parts of these taxa and the forms used in stomachache were compiled. According to the research done, families that are commonly used for stomachache are Lamiaceae (59 taxa), Asteraceae (28 taxa), Rosaceae (14 taxa), Apiaceae (12 taxa), Hypericaceae (8 taxa) and Fabaceae (7 taxa). The main reason why these family plants are used against stomach ache is that they contain essential oils with stomach related effect. The most commonly used parts of the plants for treatment are herba, leaf, flower, fruit, root and seed. The parts used may be prepared as decoction or infusion in the form of tea, eaten fresh or after being cooked, or by mixing with honey; the herba of some plants is made into mush then put on the stomach is used externally in the treatment of stomachache.","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"128 1","pages":"741-755"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76139267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Characterization of Sideritis trojana Bornm. essential oil and its antimicrobial activity 先天性特洛伊黄疸的特征。精油及其抑菌活性

Marmara Pharmaceutical Journal Pub Date : 2017-12-01 DOI: 10.12991/MPJ.2017.14

H. Kırmızıbekmez, N. Karaca, B. Demirci, Fatih Demirci

引用次数: 10

Development of a validated high-performance liquid chromatographic method for the determination of Lurasidone in pharmaceuticals 建立高效液相色谱法测定药物中鲁拉西酮的方法

Marmara Pharmaceutical Journal Pub Date : 2017-12-01 DOI: 10.12991/MPJ.2017.32

Sakine Atila Karaca, Duygu Yeniceli Uğur

引用次数: 3

Biosynthesis of copper nanoparticles using aqueous extract of Capparis spinosa fruit and investigation of its antibacterial activity 红椒果实水提物生物合成纳米铜及其抑菌活性研究

Marmara Pharmaceutical Journal Pub Date : 2017-12-01 DOI: 10.12991/MPJ.2017.31

Katrin Ebrahimi, Sima Shiravand, H. Mahmoudvand

{"title":"Biosynthesis of copper nanoparticles using aqueous extract of Capparis spinosa fruit and investigation of its antibacterial activity","authors":"Katrin Ebrahimi, Sima Shiravand, H. Mahmoudvand","doi":"10.12991/MPJ.2017.31","DOIUrl":"https://doi.org/10.12991/MPJ.2017.31","url":null,"abstract":"The present study was aimed to use the aqueous extract of Capparis spinosa to synthesize the copper nanoparticles and also evaluated their antibacterial activities again some pathogenic bacterial strains. UV-vis spectroscopy analyses, fourier transform of infrared (FTIR), scanning electron microscopy (SEM), and energy dispersive X-ray (EDX) were used to identify the synthesized nanoparticles. The antimicrobial activity of the synthesized copper nanoparticles was investigated using disk diffusion method and broth microdilution against some Gram-positive and Gram-negative bacteria. After adding the extract to the copper sulfate solution, the color of the solution changed from light blue to yellowish green. Existence of a maximum peak at the wavelength of 414 nm confirmed the formation of the copper nanoparticles. FTIR spectrum analysis showed that the factor groups created a coating extract on the surface of the nanoparticles. Scanning electron microscopy demonstrated the particle size between 17 and 41 nm. These findings showed that Staphylococcus aureus and Bacillus cereus as Gram-positive bacteria were most susceptible to synthesized copper nanoparticles in comparison with the Gram-negative bacteria (Klebsiella pneumoniae, and Escherichia coli). The obtained findings demonstrated that the aqueous extract of C. spinosa acts as a reviver and stabilizer factor. The synthesized copper nanoparticles demonstrated activity against both Grampositive and Gram-negative bacteria.","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"7 1","pages":"866-871"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85000552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

The action of monoterpenoids with promising antiparkinsonian activity on fertility of Drosophila melanogaster 具有抗帕金森活性的单萜类化合物对果蝇生育能力的影响

Marmara Pharmaceutical Journal Pub Date : 2017-12-01 DOI: 10.12991/MPJ.2017.29

M. Trushin, R. Khamidullina, O. Ardashov, K. Volcho, N. Salakhutdinov

引用次数: 0

Prescribing pattern of antidiabetic drugs in type 2 diabetic patients of Noakhali city in Bangladesh 孟加拉国Noakhali市2型糖尿病患者抗糖尿病药物的处方模式

Marmara Pharmaceutical Journal Pub Date : 2017-10-03 DOI: 10.12991/MPJ.2017.24

A. Chowdhury, Niloy Sen, Sujan Banik

{"title":"Prescribing pattern of antidiabetic drugs in type 2 diabetic patients of Noakhali city in Bangladesh","authors":"A. Chowdhury, Niloy Sen, Sujan Banik","doi":"10.12991/MPJ.2017.24","DOIUrl":"https://doi.org/10.12991/MPJ.2017.24","url":null,"abstract":"The aim of the study was to describe the recent trends in the prescription pattern of antidiabetic drugs and sociodemographic characteristics of type 2 diabetic patients in Noakhali city of Bangladesh. This hospital based prospective, cross-sectional study was carried out in three diabetic hospitals of Noakhali during the period of December, 2016 to February, 2017. A total of 200 outpatients were included in this study by following simple random procedure. Among 200 participants, 73.5% were treated with monotherapy and 26.5% were treated with polytherapy with the highest percentage (37.5%) of commonly prescribed group drugs of sulfonylureas, but lonely metformin (biguanide) was the most commonest (28%) drug among oral hypoglycemic agents. The most accounted fixed dose combination was sulfonylurea with biguanide, and biguanide with glucodiase inhibitors. The highly prescribed insulin preparations was insulin mixtures (11%) among the patients. Drugs were prescribed by traditional brand names (100%) of different local or foreign companies and 15% of prescription were contained at least one multivitamin supplement. It was focused from this study that oral hypoglycemic agents (OHA) yet dominate the prescribing pattern, but there was a shifting trend towards insulin preparation in the management of Type 2 diabetes mellitus.","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"12 1","pages":"1010-1014"},"PeriodicalIF":0.0,"publicationDate":"2017-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80364157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

In vitro gene silencing effect of chitosan/shRNA PDGF-D nanoparticles in breast cancer 壳聚糖/shRNA PDGF-D纳米颗粒在乳腺癌中的体外基因沉默作用

Marmara Pharmaceutical Journal Pub Date : 2017-10-03 DOI: 10.12991/MPJ.2017.21

Ceyda Ekentok, S. Turan, J. Akbuğa

{"title":"In vitro gene silencing effect of chitosan/shRNA PDGF-D nanoparticles in breast cancer","authors":"Ceyda Ekentok, S. Turan, J. Akbuğa","doi":"10.12991/MPJ.2017.21","DOIUrl":"https://doi.org/10.12991/MPJ.2017.21","url":null,"abstract":"Breast cancer is the most common cancer worldwide in women and it is highly malignant and fatal. PDGF-D plays role in regulation of many cellular processes such as angiogenesis. PDGF-D is overexpressed in many types of cancers and promote tumor growth and metastasis. Silencing of PDGF-D gene by using shRNA with an appropriate carrier system may decrease tumor growth and metastasis. In our study, we prepared chitosan nanoparticles loaded with five different shRNA plasmids targeting different exons of PDGF-D gene. Then, nanoparticles were characterized in vitro and transfection efficiency of these nanoparticles were investigated in breast cancer cell lines (MCF- 7, MDA-MB-231 and MDA-MB-435). The effects of single and multiple shRNA sequences, molecular weight of chitosan (150 kDa and 400 kDa) and the amount of shRNA (100 and 500 μg) on the characterization and transfection efficiencies of nanoparticles have been studied. Size of nanoparticles changed between 200-400 nm and approximately 95-100% encapsulation efficiency were obtained. Release of shRNA changed with the molecular weight of chitosan. It was obtained that formulation containing shRNA plasmid targeting PDGF-D exon 6 (NP1) has the highest silencing efficiency in MDA-MB-231 cell line. It was also evaluated that chitosan can be a suitable gene delivery system for shRNA targeting PDGF-D.","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"5 1","pages":"793-803"},"PeriodicalIF":0.0,"publicationDate":"2017-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85832770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Analytical and Sales Data Comparison of Reference Product of Insulin Aspart and its Biosimilar in Turkey 阿斯帕特胰岛素及其生物仿制药参比产品在土耳其的分析与销售数据比较

Marmara Pharmaceutical Journal Pub Date : 2017-06-24 DOI: 10.12991/marupj.323591

Onur Hakkı Dal, A. Sezer

{"title":"Analytical and Sales Data Comparison of Reference Product of Insulin Aspart and its Biosimilar in Turkey","authors":"Onur Hakkı Dal, A. Sezer","doi":"10.12991/marupj.323591","DOIUrl":"https://doi.org/10.12991/marupj.323591","url":null,"abstract":"Son yillarda ilac sanayinin ve ilac biyoteknolojisinin en populer konularindan biri biyobenzerlerdir. Uretimleri daha karmasik surecler iceren biyoteknolojik urunler, patentlerinin de bitmeye yaklasmasi veya bitmesi ile ilgi odagi olmaktadir. Jenerik urunler ile karsilastirildiginda karmasik surecler sadece uretim ile sinirli degildir. Gelistirme, klinik surecleri ve pazara erisim surecleri de zorlu ve maliyetlidir. Bu zorluklara ragmen biyobenzer gelistiren ve gelistirme calismalari devam eden bircok sirket bulunmaktadir. Jenerikler ile iliskili olarak gectigimiz uzun yillara ait net veriler olmasina ragmen biyobenzerler icin bircok baslik jeneriklere kiyasla yeni tartisilmaya baslanmistir. Bu basliklar arasinda biyobenzerlerin ekonomik katkisi, kamu maliyetine etkileri, hasta erisimi, klinik calismalar ve referans urun ile karsilastirma calismalarini sayabiliriz. Bu arastirma kapsaminda 1982 yilinda ilk onay alip, rekombinant DNA teknolojisi ile uretilmis biyolojik urun olan insulin iceren urunlerin kuresel ve Turkiye’deki satislari ele alinmistir. Arastirmada ayrica referans insulin aspart urunu ile insulin aspart biyobenzerinin analitik olarak karsilastirilmasi ele alinmistir, gelistirme ve ruhsat sureclerinde kullanilabilecek olasi basliklar irdelenmistir.","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"49 1","pages":"675-687"},"PeriodicalIF":0.0,"publicationDate":"2017-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82700423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0