Mediterranean Journal of Hematology and Infectious Diseases最新文献

筛选
英文 中文
Immune Thrombotic Thrombocytopenic Purpura: Pathophysiology, Diagnosis, Therapy and Open Issues. 免疫性血栓性血小板减少性紫癜:病理生理学、诊断、治疗和未决问题。
IF 2 4区 医学
Mediterranean Journal of Hematology and Infectious Diseases Pub Date : 2024-07-01 eCollection Date: 2024-01-01 DOI: 10.4084/MJHID.2024.060
Silvia Maria Trisolini, Alessandro Laganà, Saveria Capria
{"title":"Immune Thrombotic Thrombocytopenic Purpura: Pathophysiology, Diagnosis, Therapy and Open Issues.","authors":"Silvia Maria Trisolini, Alessandro Laganà, Saveria Capria","doi":"10.4084/MJHID.2024.060","DOIUrl":"10.4084/MJHID.2024.060","url":null,"abstract":"<p><p>Immune thrombotic thrombocytopenic purpura (iTTP) is a life-threatening thrombotic microangiopathy characterized by microangiopathic hemolytic anemia, thrombocytopenia, and ischemic end-organ injury due to microvascular platelet-rich thrombi. iTTP pathophysiology is based on a severe ADAMTS13 deficiency, the specific von Willebrand factor (vWF)-cleaving protease, due to anti-ADAMTS13 autoantibodies. Early diagnosis and treatment reduce the mortality. Frontline therapy includes daily plasma exchange (PEX) with fresh frozen plasma replacement and immunosuppression with corticosteroids. Caplacizumab has recently been added to frontline therapy. Caplacizumab is a nanobody that binds to the A1 domain of vWF, blocking the interaction of ultra-large vWF multimers with the platelet and thereby preventing the formation of platelet-rich thrombi. Caplacizumab reduces mortality due to ischemic events, refractoriness, and exacerbations after PEX discontinuation. Until now, the criteria for response to treatment mainly took into account the normalization of platelet count and discontinuation of PEX; with the use of caplacizumab leading to rapid normalization of platelet count, it has been necessary to redefine the response criteria, taking into account also the underlying autoimmune disease. Monitoring of ADAMTS13 activity is important to identify cases with a low value of activity (<10IU/L), requiring the optimization of immunosuppressive therapy with the addition of Rituximab. Rituximab is effective in patients with refractory disease or relapsing disease. Currently, the use of Rituximab has expanded, both in frontline treatment and during follow-up, as a pre-emptive approach. Some patients do not achieve ADAMTS13 remission following the acute phase despite steroids and rituximab treatment, requiring an individualized immunosuppressive approach to prevent clinical relapse. In iTTP, there is an increased risk of venous thrombotic events (VTEs) as well as arterial thrombotic events, and most occur after platelet normalization. Until now, there has been no consensus on the use of pharmacological thromboprophylaxis in patients on caplacizumab because the drug is known to increase bleeding risk.</p>","PeriodicalId":18498,"journal":{"name":"Mediterranean Journal of Hematology and Infectious Diseases","volume":"16 1","pages":"e2024060"},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11232686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Advances in The Definition of the Molecular Alterations Occurring in Multiple Myeloma. 多发性骨髓瘤分子变异定义的最新进展。
IF 2 4区 医学
Mediterranean Journal of Hematology and Infectious Diseases Pub Date : 2024-07-01 eCollection Date: 2024-01-01 DOI: 10.4084/MJHID.2024.062
Ugo Testa, Elvira Pelosi, Germana Castelli, Giuseppe Leone
{"title":"Recent Advances in The Definition of the Molecular Alterations Occurring in Multiple Myeloma.","authors":"Ugo Testa, Elvira Pelosi, Germana Castelli, Giuseppe Leone","doi":"10.4084/MJHID.2024.062","DOIUrl":"10.4084/MJHID.2024.062","url":null,"abstract":"<p><p>Multiple myeloma (MM) is a disorder of the monoclonal plasma cells and is the second most common hematologic malignancy. MM initiation and progression are dependent upon complex genomic abnormalities. The current pathogenic model of MM includes two types of primary events, represented by chromosome translocations or chromosome number alterations resulting in hyperdiploidy. These primary molecular events are observed both in MM and in monoclonal gammopathy, its premalignant precursor. Subsequent genetic events allow the progression of monoclonal gammopathy to MM and, together with primary events, contribute to the genetic complexity and heterogeneity of MM. Newer therapies have considerably improved patient outcomes; however, MM remains an incurable disease and most patients experience multiple relapses. The dramatic progresses achieved in the analysis of the heterogeneous molecular features of different MM patients allowed a comprehensive molecular classification of MM and the definition of an individualized prognostic model to predict an individual MM patient's response to different therapeutic options. Despite these progresses, prognostic models fail to identify a significant proportion of patients destined to early relapse. Treatment strategies are increasingly. Based on disease biology, trials are enriched for high-risk MMs, whose careful definition and categorization requires DNA sequencing studies.</p>","PeriodicalId":18498,"journal":{"name":"Mediterranean Journal of Hematology and Infectious Diseases","volume":"16 1","pages":"e2024062"},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11232684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Congenital Dyserythropoietic Anemia Masked by Hemoglobin H Disease. 一个被血红蛋白 H 病掩盖的先天性红细胞生成障碍性贫血病例
IF 2 4区 医学
Mediterranean Journal of Hematology and Infectious Diseases Pub Date : 2024-07-01 eCollection Date: 2024-01-01 DOI: 10.4084/MJHID.2024.059
Guiping Liao, Ting Ting Lu, Changqing Wei, Bei Bei Yang, Manlv Wei, Qiuying Huang, Wuxia Qian, Xiaolin Yin
{"title":"A Case of Congenital Dyserythropoietic Anemia Masked by Hemoglobin H Disease.","authors":"Guiping Liao, Ting Ting Lu, Changqing Wei, Bei Bei Yang, Manlv Wei, Qiuying Huang, Wuxia Qian, Xiaolin Yin","doi":"10.4084/MJHID.2024.059","DOIUrl":"10.4084/MJHID.2024.059","url":null,"abstract":"","PeriodicalId":18498,"journal":{"name":"Mediterranean Journal of Hematology and Infectious Diseases","volume":"16 1","pages":"e2024059"},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11232676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is There a Better Therapeutic Time Window from Diagnosis to Treatment for Elderly Acute Myeloid Leukemia Patients Receiving Hypomethylating Agents? 接受低甲基化药物治疗的老年急性髓性白血病患者从诊断到治疗是否有更好的治疗时间窗?
IF 2 4区 医学
Mediterranean Journal of Hematology and Infectious Diseases Pub Date : 2024-07-01 eCollection Date: 2024-01-01 DOI: 10.4084/MJHID.2024.055
Matteo Molica, Luca Maurillo, Marco Rossi, Massimo Breccia, Carla Mazzone, Paolo de Fabritiis, Salvatore Perrone
{"title":"Is There a Better Therapeutic Time Window from Diagnosis to Treatment for Elderly Acute Myeloid Leukemia Patients Receiving Hypomethylating Agents?","authors":"Matteo Molica, Luca Maurillo, Marco Rossi, Massimo Breccia, Carla Mazzone, Paolo de Fabritiis, Salvatore Perrone","doi":"10.4084/MJHID.2024.055","DOIUrl":"10.4084/MJHID.2024.055","url":null,"abstract":"","PeriodicalId":18498,"journal":{"name":"Mediterranean Journal of Hematology and Infectious Diseases","volume":"16 1","pages":"e2024055"},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11232675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low Incidence of Anti-PF4/Heparin Antibodies in Patients with Acute Myelogenous Leukemia. 急性髓性白血病患者中抗PF4/肝素抗体的发生率较低。
IF 2 4区 医学
Mediterranean Journal of Hematology and Infectious Diseases Pub Date : 2024-07-01 eCollection Date: 2024-01-01 DOI: 10.4084/MJHID.2024.057
Ingvild Hausberg Sørvoll, Ingvild Jenssen Lægreid, Tom Sollid, Maria Therese Ahlen, Silje Johansen, Håkon Reikvam
{"title":"Low Incidence of Anti-PF4/Heparin Antibodies in Patients with Acute Myelogenous Leukemia.","authors":"Ingvild Hausberg Sørvoll, Ingvild Jenssen Lægreid, Tom Sollid, Maria Therese Ahlen, Silje Johansen, Håkon Reikvam","doi":"10.4084/MJHID.2024.057","DOIUrl":"10.4084/MJHID.2024.057","url":null,"abstract":"","PeriodicalId":18498,"journal":{"name":"Mediterranean Journal of Hematology and Infectious Diseases","volume":"16 1","pages":"e2024057"},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11232681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperbilirubinemia in ABO Minor Mismatch Transplantation. ABO小鼠错配移植中的高胆红素血症
IF 2 4区 医学
Mediterranean Journal of Hematology and Infectious Diseases Pub Date : 2024-07-01 eCollection Date: 2024-01-01 DOI: 10.4084/MJHID.2024.050
Guiping Liao, Changqing Wei, Qiuying Huang, Manlv Wei, Jing Li, Yaopeng Chen, Xiaolin Yin
{"title":"Hyperbilirubinemia in ABO Minor Mismatch Transplantation.","authors":"Guiping Liao, Changqing Wei, Qiuying Huang, Manlv Wei, Jing Li, Yaopeng Chen, Xiaolin Yin","doi":"10.4084/MJHID.2024.050","DOIUrl":"10.4084/MJHID.2024.050","url":null,"abstract":"","PeriodicalId":18498,"journal":{"name":"Mediterranean Journal of Hematology and Infectious Diseases","volume":"16 1","pages":"e2024050"},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11232679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Importance of Source Control in the Subgroup of Intra-Abdominal Infections for Septic Shock Patients: Analysis of 390 Cases. 脓毒症休克患者腹腔内感染亚群中病源控制的重要性:对 390 例病例的分析
IF 2 4区 医学
Mediterranean Journal of Hematology and Infectious Diseases Pub Date : 2024-07-01 eCollection Date: 2024-01-01 DOI: 10.4084/MJHID.2024.051
Uğur Önal, Deniz Akyol Seyhan, Olcay Buse Ketenoğlu, Merve Mert Vahabi, Dilşah Başkol Elik, Seichan Chousein Memetali, Gamze Şanlıdağ İşbilen, Cansu Bulut Avşar, Arda Kaya, Ayse Uyan-Önal, Nazlıhan Yalçın, Günel Guliyeva, Şükrü Dirik, Oğuzhan Acet, Damla Akdağ, Melike Demir Görür, Osman Bozbıyık, Berk Göktepe, Tufan Gümüş, İlkin Çankayalı, Kubilay Demirağ, Mehmet Uyar, Hilal Sipahi, Huseyin Aytac Erdem, Meltem Işıkgöz Taşbakan, Bilgin Arda, Şöhret Aydemir, Sercan Ulusoy, Oguz Resat Sipahi
{"title":"Importance of Source Control in the Subgroup of Intra-Abdominal Infections for Septic Shock Patients: Analysis of 390 Cases.","authors":"Uğur Önal, Deniz Akyol Seyhan, Olcay Buse Ketenoğlu, Merve Mert Vahabi, Dilşah Başkol Elik, Seichan Chousein Memetali, Gamze Şanlıdağ İşbilen, Cansu Bulut Avşar, Arda Kaya, Ayse Uyan-Önal, Nazlıhan Yalçın, Günel Guliyeva, Şükrü Dirik, Oğuzhan Acet, Damla Akdağ, Melike Demir Görür, Osman Bozbıyık, Berk Göktepe, Tufan Gümüş, İlkin Çankayalı, Kubilay Demirağ, Mehmet Uyar, Hilal Sipahi, Huseyin Aytac Erdem, Meltem Işıkgöz Taşbakan, Bilgin Arda, Şöhret Aydemir, Sercan Ulusoy, Oguz Resat Sipahi","doi":"10.4084/MJHID.2024.051","DOIUrl":"10.4084/MJHID.2024.051","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the epidemiology of septic shock (SS) associated with intraabdominal infections (IAI) as well as associated mortality and efficacy of early source control in a tertiary-care educational hospital.</p><p><strong>Methods: </strong>Patients who had SS with IAI and consulted by Infectious Diseases consultants between December 2013 and October 2022 during night shifts in our centre were analyzed retrospectively.</p><p><strong>Results: </strong>A total number of 390 patients were included. Overall, 30-day mortality was 42.5% on day 3, while day 14 and 30 mortality rates were 63.3% and 71.3%, respectively. Source control by surgical or percutaneous operation was performed in 123 of 390 cases (31.5%), and the mortality rate was significantly lower in cases that were performed source control at any time during SS (65/123-52.8% vs 213/267-79.8%, p<0.001). In 44 of 123 cases (35.7%), source control was performed during the first 12 hours, and mortality was significantly lower in this group versus others (24/44-54.5% vs 254/346-73.4%, p=0.009). On the other hand, female gender (p<0.001, odds ratio(OR)= 2.943, 95%CI=1.714-5.054), diabetes mellitus (p= 0.014, OR=2.284, 95%CI=1.179-4.424), carbapenem-resistant Gram-negative etiology (p=0.011, OR=4.386, 95%CI=1.398-13.759), SOFA≥10 (p<0.001, OR=3.036, 95%CI=1.802-5.114), lactate >3 mg/dl (p<0.001, OR=2.764, 95%CI=1.562-4.891) and lack of source control (p=0.001, OR=2.796, 95%CI=1.523-5.133) were significantly associated with 30-day mortality in logistic regression analysis.</p><p><strong>Conclusion: </strong>Source control has a vital importance in terms of mortality rates for IAI-related septic shock patients. Our study underscores the need for additional research, as the present analysis indicates that early source control does not manifest as a protective factor in logistic regression.</p>","PeriodicalId":18498,"journal":{"name":"Mediterranean Journal of Hematology and Infectious Diseases","volume":"16 1","pages":"e2024051"},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11232688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Rheumatoid Arthritis with Glucose-6-Phosphate Dehydrogenase Deficiency: Results from a Case-Control Study. 类风湿性关节炎与葡萄糖-6-磷酸脱氢酶缺乏症的关系:病例对照研究的结果
IF 2 4区 医学
Mediterranean Journal of Hematology and Infectious Diseases Pub Date : 2024-07-01 eCollection Date: 2024-01-01 DOI: 10.4084/MJHID.2024.056
Maria Pina Dore, Giovanni Mario Pes, Sandro Mereu, Jessica Piroddu, Lorenzo Cavagna, Gian Luca Erre
{"title":"Association of Rheumatoid Arthritis with Glucose-6-Phosphate Dehydrogenase Deficiency: Results from a Case-Control Study.","authors":"Maria Pina Dore, Giovanni Mario Pes, Sandro Mereu, Jessica Piroddu, Lorenzo Cavagna, Gian Luca Erre","doi":"10.4084/MJHID.2024.056","DOIUrl":"10.4084/MJHID.2024.056","url":null,"abstract":"","PeriodicalId":18498,"journal":{"name":"Mediterranean Journal of Hematology and Infectious Diseases","volume":"16 1","pages":"e2024056"},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11232680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hodgkin Lymphoma in Children: A 16-year Experience at the Children's Welfare Teaching Hospital of Baghdad, Iraq. 儿童霍奇金淋巴瘤:伊拉克巴格达儿童福利教学医院的 16 年经验。
IF 2 4区 医学
Mediterranean Journal of Hematology and Infectious Diseases Pub Date : 2024-07-01 eCollection Date: 2024-01-01 DOI: 10.4084/MJHID.2024.053
Anna Maria Testi, Mazin Faisal Al-Jadiry, Maria Luisa Moleti, Stefania Uccini, Amir Fadhil Al-Darraij, Raghad Majid Al-Saeed, Hasanein Habeeb Ghali, Ahmed Hatem Sabhan, Samaher Abdulrazzaq Fadhil, Safaa Abdulelah Al-Badri, Adil Rabeea Alsaadawi, Ameer Dh Hameedi, Manhal Hashim Shanshal, Yasir Saadoon Al-Agele, Fatimah Abdul Ridha Al-Saffar, Nihal Khalid Yaseen, Alfonso Piciocchi, Giovanni Marsili, Salma Abbas Al-Hadad
{"title":"Hodgkin Lymphoma in Children: A 16-year Experience at the Children's Welfare Teaching Hospital of Baghdad, Iraq.","authors":"Anna Maria Testi, Mazin Faisal Al-Jadiry, Maria Luisa Moleti, Stefania Uccini, Amir Fadhil Al-Darraij, Raghad Majid Al-Saeed, Hasanein Habeeb Ghali, Ahmed Hatem Sabhan, Samaher Abdulrazzaq Fadhil, Safaa Abdulelah Al-Badri, Adil Rabeea Alsaadawi, Ameer Dh Hameedi, Manhal Hashim Shanshal, Yasir Saadoon Al-Agele, Fatimah Abdul Ridha Al-Saffar, Nihal Khalid Yaseen, Alfonso Piciocchi, Giovanni Marsili, Salma Abbas Al-Hadad","doi":"10.4084/MJHID.2024.053","DOIUrl":"10.4084/MJHID.2024.053","url":null,"abstract":"<p><strong>Background: </strong>Childhood Hodgkin lymphoma (HL) is an eminently curable disease. Good outcomes can be achieved even in resource-limited settings, and the focus is increasingly on limiting long-term toxicity. Contemporary treatment incorporates a risk-stratified, response-adapted approach using multiagent chemotherapy with/without low-dose radiotherapy. Many developing countries continue to use ABVD-based regimens due to limited acute toxicity, cost, and ease of delivery.</p><p><strong>Objective: </strong>We herein report the outcomes of childhood HL diagnosed and treated in an Iraqi single centre over 16 years.</p><p><strong>Methods: </strong>Children ≤14 years old with biopsy-proven HL were enrolled. Most patients received ABVD chemotherapy or COPP/ABV when Dacarbazine was unavailable. Radiotherapy was not available.</p><p><strong>Results: </strong>Three hundred-three children were consecutively newly diagnosed with HL; 284 were considered eligible for the retrospective analysis (treatment refusals 9; deaths before therapy 5; initially diagnosed of non-Hodgkin lymphoma 5). ABVD scheme was administered to 184 children (65%), COPP/ABV to 83 (29%), and other schemes to the remaining 17 patients. Complete response (CR) was achieved in 277 (98%); 4 (1.4%) showed disease progression, and 1 had stable disease. Four patients in CR abandoned therapy and were in CR at the time of analysis, 2 died from infection. Relapse occurred in 42 patients (15%). The 15-year OS and EFS are 89.7% and 70.3%, respectively.</p><p><strong>Conclusion: </strong>In this single Centre, over 16 years, almost 90% of children suffering from HL survive, despite the numerous limitations in diagnostic procedures, shortage of chemotherapy, no radiotherapy facilities, absence of effective second-line treatments, and finally, therapy abandonment for social and financial reasons.</p>","PeriodicalId":18498,"journal":{"name":"Mediterranean Journal of Hematology and Infectious Diseases","volume":"16 1","pages":"e2024053"},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11232685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of Oxidative Stress and Inflammatory Indicators for Coronary Artery Disease in Kawasaki Disease. 川崎病冠状动脉疾病氧化应激和炎症指标的表达
IF 2 4区 医学
Mediterranean Journal of Hematology and Infectious Diseases Pub Date : 2024-07-01 eCollection Date: 2024-01-01 DOI: 10.4084/MJHID.2024.052
Yang Li, Suwei Lan, Haibo Zhang
{"title":"Expression of Oxidative Stress and Inflammatory Indicators for Coronary Artery Disease in Kawasaki Disease.","authors":"Yang Li, Suwei Lan, Haibo Zhang","doi":"10.4084/MJHID.2024.052","DOIUrl":"10.4084/MJHID.2024.052","url":null,"abstract":"<p><strong>Background: </strong>The paper was to investigate the clinical relevance of oxidative stress (OS) and inflammation-associated targets in coronary artery lesions (CALs) associated with Kawasaki disease (KD).</p><p><strong>Methods: </strong>The clinical data from 455 sufferers diagnosed with KD between February 2021 and June 2023 were gathered and divided into two groups: CAL and NCAL. The regression analysis was conducted to search for independent covariates for CALs related to OS and inflammation. The predictive nomogram was structured according to these risk factors. The properties of the model were estimated using calibration and receiver operating characteristic curves.</p><p><strong>Results: </strong>The levels of CRP, IL-6, PLT count, ESR, ox-HDL, MDA, and PLR were more elevated in CAL patients with KD; interestingly, HDL and superoxide dismutase (SOD) were low in the CAL group. Ascension of CRP, IL-6, ESR, ox-HDL, MDA, and PLR, and diminution of HDL and SOD were considered independent risk factors. The nomogram constructed using these factors demonstrated a satisfactory calibration degree and discriminatory power, with an area under the curve of 0.812. In the verification set, the area under the curve was found to be 0.799.</p><p><strong>Conclusion: </strong>The model was established according to 8 OS and inflammation-associated risk factors bound up with CALs in KD sufferers. It may be a usable approach for early diagnosis of CALs in KD.</p>","PeriodicalId":18498,"journal":{"name":"Mediterranean Journal of Hematology and Infectious Diseases","volume":"16 1","pages":"e2024052"},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11232689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信