Mediterranean Journal of Hematology and Infectious Diseases最新文献

{"title":"A case of Severe Gastrointestinal Toxicity after Allogeneic Hematopoietic Stem Cell Transplantation: Can We Improve the Evaluation of the \"Gut Fitness\"?","authors":"Gabriele Magliano, Enrico Morello, Mirko Farina, Vera Radici, Marco Galli, Giulia Brambilla, Michele Malagola, Domenico Russo, Daniele Avenoso","doi":"10.4084/MJHID.2025.054","DOIUrl":"10.4084/MJHID.2025.054","url":null,"abstract":"","PeriodicalId":18498,"journal":{"name":"Mediterranean Journal of Hematology and Infectious Diseases","volume":"17 1","pages":"e2025054"},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serological and Molecular Detection of <i>Rickettsia</i> spp in Patients with Meningeal Syndrome in Northern Algeria.","authors":"H Ghaoui, Ibrahim Nasir Adam, S Basher Nosiba, T Idres, S Temim, A Saad-Djaballah, I Bitam, N Achour","doi":"10.4084/MJHID.2025.046","DOIUrl":"10.4084/MJHID.2025.046","url":null,"abstract":"<p><strong>Background: </strong>Rickettsioses are considered emerging or re-emerging hematophagous arthropod-borne zoonosis. In addition, Meningeal syndromes are among the most common reasons for consultation in infectious disease emergencies.</p><p><strong>Objectives: </strong>Our study aimed to identify <i>Rickettsia</i> spp using IFA and qPCR for serological and molecular tests, respectively, in patients presenting with Meningeal Syndrome at the National Centre of Infectious Diseases El-HADI FLICI Hospital, Nicolle-Laveran department in Algiers.</p><p><strong>Methods: </strong>We collected 55 whole blood and 55 sera from patients with meningeal syndrome of various ages and genders, with a mean age of 24.03 (ranging from 2 to 50 years old).</p><p><strong>Results: </strong>The indirect immunofluorescence assay (IFA) for <i>Rickettsia spp</i> returned positive results in seven sera (7/55, 12.72%). We diagnosed four cases of Spotted Mediterranean Fever (MSF) caused by <i>R. conorii</i>, two cases of Murine Typhus caused by <i>R. typhi</i>, and one case of Flea-borne Spotted Fever caused by <i>R. felis</i>. Concerning the spinal tap, we reported that three patients were positive for <i>R. conorii</i>, where cerebrospinal fluid was opalescent, and there was a mixed cellular profile on cytology. These findings suggest a possible co-infection with <i>R. conorii</i> in patients with meningeal syndrome. Thus, the serological findings coupled with the Meningeal syndrome and the diverse clinical manifestations of both pathogens observed among these patients suggest a possible overlap in clinical expression.</p><p><strong>Conclusion: </strong>These results highlight the importance of heightened awareness among infectious disease specialists, particularly when faced with confirmed cases of Meningeal Syndrome that may exhibit clinical similarities with Rickettsial diseases, especially in regions where hematophagous arthropod-borne zoonoses are prevalent.</p>","PeriodicalId":18498,"journal":{"name":"Mediterranean Journal of Hematology and Infectious Diseases","volume":"17 1","pages":"e2025046"},"PeriodicalIF":2.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12240247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term Persistence of Dysplastic Features in Patients with Acute Promyelocytic Leukemia Treated with All-trans Retinoic Acid and Arsenic Trioxide.","authors":"Enrico Santinelli, Maria Rosaria Pascale, Luca Guarnera, Arianna Savi, Flavia Mallegni, Maria Luigia Catanoso, Carmelo Gurnari, Luca Maurillo, Maria Teresa Voso, Susanna Fenu","doi":"10.4084/MJHID.2025.038","DOIUrl":"https://doi.org/10.4084/MJHID.2025.038","url":null,"abstract":"","PeriodicalId":18498,"journal":{"name":"Mediterranean Journal of Hematology and Infectious Diseases","volume":"17 1","pages":"e2025038"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Multiple Myeloma in a Patient in Treatment for Chronic Lymphocytic Leukemia.","authors":"Mario Biglietto, Ugo Coppetelli, Luciano Fiori, Martina Gherardini, Raffaele Maglione, Alessandro Pulsoni, Azzurra Anna Romeo","doi":"10.4084/MJHID.2025.033","DOIUrl":"https://doi.org/10.4084/MJHID.2025.033","url":null,"abstract":"","PeriodicalId":18498,"journal":{"name":"Mediterranean Journal of Hematology and Infectious Diseases","volume":"17 1","pages":"e2025033"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Interesting Case of Rash in a Child with Febrile Neutropenia - Not Everything is a Medical Problem.","authors":"Anamika Bakliwal, Sanjeev Kumar Sharma","doi":"10.4084/MJHID.2025.036","DOIUrl":"https://doi.org/10.4084/MJHID.2025.036","url":null,"abstract":"","PeriodicalId":18498,"journal":{"name":"Mediterranean Journal of Hematology and Infectious Diseases","volume":"17 1","pages":"e2025036"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monoclonal Gammopathy of Neurological Significance: A Case Report and Insights on Treatment.","authors":"Mario Biglietto, Martina Gherardini, Raffaele Maglione, Azzurra Anna Romeo, Luciano Fiori, Piera Giovangrossi, Alessandro Pulsoni, Ugo Coppetelli","doi":"10.4084/MJHID.2025.034","DOIUrl":"https://doi.org/10.4084/MJHID.2025.034","url":null,"abstract":"","PeriodicalId":18498,"journal":{"name":"Mediterranean Journal of Hematology and Infectious Diseases","volume":"17 1","pages":"e2025034"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bladder Microbiota Snapshots Help to Monitor Urinary Tract Infections in Vulnerable Patients.","authors":"Giulia Santarelli, Delia Mercedes Bianco, Margherita Capriati, Maurizio Sanguinetti, Claudia Rendeli, Flavio De Maio","doi":"10.4084/MJHID.2025.028","DOIUrl":"https://doi.org/10.4084/MJHID.2025.028","url":null,"abstract":"","PeriodicalId":18498,"journal":{"name":"Mediterranean Journal of Hematology and Infectious Diseases","volume":"17 1","pages":"e2025028"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 Induces Prolonged Immunological Exhaustion Leading to Relapse of Hematological Malignancies Except in Hematopoietic Cell Transplant Recipients.","authors":"Suparno Chakrabarti, Snigdha Banerjee, Mahak Agarwal, Gitali Bhagawati, Nilanjan Saha, Sarita Rani Jaiswal","doi":"10.4084/MJHID.2025.042","DOIUrl":"https://doi.org/10.4084/MJHID.2025.042","url":null,"abstract":"","PeriodicalId":18498,"journal":{"name":"Mediterranean Journal of Hematology and Infectious Diseases","volume":"17 1","pages":"e2025042"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fecal Microbiota Transplantation as a Salvage Therapy for Concomitant Resistant Digestive Graft Versus Host Disease and Cryptosporidiosis in a Patient Post Hematopoietic Stem Cell Transplant: about a Case.","authors":"Thomas Finotto, Carole Chevenet, Amandine Fayard","doi":"10.4084/MJHID.2025.035","DOIUrl":"https://doi.org/10.4084/MJHID.2025.035","url":null,"abstract":"","PeriodicalId":18498,"journal":{"name":"Mediterranean Journal of Hematology and Infectious Diseases","volume":"17 1","pages":"e2025035"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematopoietic Stem Cell Transplantation in Severe Pediatric Sickle Cell Disease: Outcome and long-term complications, Saudi experience at King Faisal Specialist Hospital, Riyadh, Saudi Arabia.","authors":"Abdullah Al-Jefri, Fatema Al-Hashem, Khawar Siddiqui, Amal Al-Seraihy, Ali Al-Ahmari, Ibrahim Ghemlas, Awatif AlAnazi, Hawazen Al-Saedi, Saadiya Khan, Abdulrahman Al-Musa, Mahasen Saleh, Mouhab Ayas","doi":"10.4084/MJHID.2025.030","DOIUrl":"https://doi.org/10.4084/MJHID.2025.030","url":null,"abstract":"<p><strong>Background: </strong>Hematopoietic stem transplantation (HSCT) from matched related donors (MRD) is offered as a curative therapeutic option in children with Sickle cell disease (SCD).</p><p><strong>Objective: </strong>We wanted to assess the outcome and long-term complications observed in children undergoing HSCT at a single transplant center in Saudi Arabia.</p><p><strong>Patients and methods: </strong>One hundred and twenty-nine children were transplanted for severe Sickle cell disease (SCD) consecutively from 2006 to 2020 at our center. The main transplant indication was cerebral vasculopathy in 57 (43%), followed by the recurrent vaso-occlusive crisis (VOC) in 47 (36%). Median age at transplant was 9.1 years (range, 1.5-13.9 years). All patients received myeloablative conditioning with Busulfan, Cyclophosphamide, and Anti T-Lymphocyte Globulin (Grafalon®): BU/CY/ATG in 114 (88.4%), BU/CY in 13 (10%) and other in 2 (2%). Bone marrow was the main stem cell source in 123 (95%).</p><p><strong>Results: </strong>All patients showed granulocyte engraftment. Acute graft-versus-host-disease (aGVHD) and chronic GVHD were observed in 26 (20%) and 12 (9%) patients, respectively. At a median follow-up of 4.36 years (range, 0.13-15.5 years), 10-year overall survival (OS) and event-free survival (EFS) of 94% and 91% was observed. The OS and EFS were significantly better in patients receiving BU/CY/ATG when compared to BU/CY (OS: 97.4%±1.5%, vs. 76.2%±12.1 <i>P=0.003</i> and EFS: 94.7%±2.1% vs. 76.2%±12.1%, <i>P=0.019</i>).</p><p><strong>Conclusion: </strong>HSCT for children with sickle cell disease from fully matched siblings offers the best outcome using myeloablative conditioning. However, significant toxicities were observed secondary to myeloablative regimens, in particular long-term complications, which demands exploring the use of less toxic regimens.</p>","PeriodicalId":18498,"journal":{"name":"Mediterranean Journal of Hematology and Infectious Diseases","volume":"17 1","pages":"e2025030"},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}