Medicinski arhiv最新文献

{"title":"Intravitreal Sustained-release Dexamethasone Implant in Treatment for Chronic Macular Edema in Syphilis Infection: a Case Report","authors":"Azra Mehmedovic, Vernesa Drino, Alma Biscevic, Melisa Pjano","doi":"10.5455/medarh.2023.77.405-408","DOIUrl":"https://doi.org/10.5455/medarh.2023.77.405-408","url":null,"abstract":"Background: Macular edema results from many conditions, such as diabetic retinopathy, macular degeneration, inflammatory diseases, cataract operation, trauma, and tumors. Specifically, the capillary filtration rate should equal the speed of fluid removal from extracellular retinal tissue, such as the glial and retinal pigment epithelium cells layer (RPE). Once these forces are imbalanced, fluid accumulates in cystoid spaces within the inner layers of the retina. Objective: The main purpose of this case report is to show that macular edema caused by any inflammation, either bacteria, virus, or autoimmune origin, can be treated successfully, even if it is chronic. Case report: A 31-year-old man has been reported to our clinic with symptoms of blurry vision in the left eye, which occurred during the last year. Essential examinations included CDVA, IOP measurement, slit-lamp examination, indirect ophthalmoscopy, and OCT scan that showed significant macular edema (central foveal thickness of 353 microns). We initiated laboratory searches, such as blood, serology, and immunology testing for the next three months after his first visit, together with prescribed topical and periocular corticosteroid therapy. The test to VDRL (venereal disease research laboratory) for Syphilis and Toxocariasis came positive. We took the best decision and recommended further treatment with the intravitreal application of Dexamethasone Implant 0.7mg. One week after the intravitreal application of corticosteroids on the control exam, there were normal findings on the posterior segment with no macular edema (central foveal thickness of 269 microns). Conclusion: It is unexclusive that infection by Treponema pallidum (TP) causes isolated macular edema without any other symptoms on the anterior segment of the eye. It has indirect action on the macula, not just causing papilledema, retinal vasculitis, retinochoroiditis, and inflammatory disc edema, as expected. TP or the bacteria transmembrane protein (treponemal ligands) directly acting on vascular endothelial cells of the RPE cells, will be the key to the most certain mechanism of this condition. It is related to the possibility of the secretion of cytokines and the interactions between immune cells indirectly.","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134979772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology, Etiology, Timing and Severity of Open Fracture - a Five Years Review From a Tertiary Trauma Center, Eastern Province, Saudi Arabia","authors":"Abdulaziz Alhavas, Mohannad Alghamdi","doi":"10.5455/medarh.2023.77.391-395","DOIUrl":"https://doi.org/10.5455/medarh.2023.77.391-395","url":null,"abstract":"Background: Open fractures are severe injuries resulting from the bone breaking through the skin, and they have a negative impact on patients' physical, mental, and financial well-being as well as that of the healthcare system. The incidence of open fractures varies globally. These injuries can lead to prolonged disability, increased healthcare costs, and psychological distress. The Gustilo-Anderson classification system is used to classify open fractures into three categories which surgeons use as an index for the severity of an injury and as a prognostic tool. Management involves a multidisciplinary approach, focusing on preventing infection, promoting wound healing, and restoring function. Objective: The objective of this study is to provide statistics on the epidemiology of open fractures presented to the emergency department to be used later to create management protocols. Methods: This 5-year retrospective observational analysis of open fracture patients at King Fahad Hospital, a tertiary trauma care institute in Alkhobar from 2018-2023, aimed to understand socio-demographics, injury mechanisms, fracture patterns, and timing. Data were collected electronically, and found 373 cases which were reviewed, and only 138 open fractures fit our inclusion and exclusion criteria and were added to the study. Results: The study analyzed 138 openly fractured bones in 132 patients aged 2 to 68. Most bones affected were in the lower extremities, the most common being the forefoot bones. The most common mode of injury was a motorbike, followed by MVA. The most common Gustilo type was type 2, with no significant correlation between gender and severity. Musculoskeletal system injury was the highest associated system. Furthermore, we observe a slight increase in cases in Winter/Fall weather seasons. Conclusion: Total amount of 84.8% of patients with open fractures are men, compared to 15.2% of women. The average age of patients is 25.6 ± 15.6 years. Motorbike accidents, then MVA, are the two leading causes of open fractures. Weather seasons, especially in fall and winter, may also contribute to an increase in open fractures. We found that type 2 is the most common Gustilo type among the injured bones (59.1%).","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134979961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative Hypoalbuminemia as a Predictor of Severe Postoperative Complications in Patients Undergoing Whipple Pancreatoduodenectomy","authors":"Emir Ahmetasevic, Sefik Hasukic, Mirha Agic, Selmira Brkic","doi":"10.5455/medarh.2023.77.350-353","DOIUrl":"https://doi.org/10.5455/medarh.2023.77.350-353","url":null,"abstract":"Background: Pancreaticoduodenectomy (PD) known as Whipple procedure is still one of the most complex abdominal surgeries used for treatment of periampullary tumors. PD is often followed with postoperative complications (pancreatic, biliar or intestinal fistula, haemorrhage, intraabdominal abscess, delayed gastric empting. Severe postoperative complications (SPC) can be reason for reoperation and reason of bad outcome of treatment and life treathening condition. Objective: To investigate predicitive value of preoperative hypoalbuminemia for severe postoperative complications (SPC) in patients who have undergone Whipple pancreaticoduodenetomy (PD). However, no similiar study has been ever reported from our country until now. Methods: In this retrospective-prospective study, 100 patients who have had Whipple pancreaticoduodenectomy for malignant periampullary tumors at the Department for Surgery of University Clinic Center Tuzla, Bosnia and Herzegovina were enrolled, from january of 2009 to decembre of 2021. All patients were preoperatively analysed according to serum albumine levels and presensce of hypolabuminemia (serum albumine levels <32g/l). Serum albumine biochemical test were done 1-2 days preoperatively. Clavien Dindo classification was used for determination patients with SPC. Patients who did not have SPC belonged to (I-II) Clavien Dindo group of patients while those who had SPC belonged to( III-V) Clavien Dindo group of patients. Results: Out of 100 patients who have undergone pancreaticoduodenetomy, in 55 (55%) patients postoperative complications were noticed. Mortality rate was 18 (18%) and reoperation has been done in 20 cases (20%). SPC were noticed in 19 patients and most often were: delayed gastric emptying (20%), pancreatic fistula (13%) and intraabdominal collections (9%). Hypoalbuminemic patients had a significantly higher rate of severe postoperative complications ( p<0.05). Using hypoalbuminemia-SPC correlation analaysis, there is confirmed statistically significant correlation between hypoalbuminemia and SPC (ρ= 0.236; p<0.05). Conclusion: Preoperative hypoalbuminemia can be used as predictor and prognostic factor for severe postoperative complications after Whipple pancreaticoduodenectomy. Identification and optimization of serum albumin level prior to Whipple pancreatoduodenectomy may improve surgical outcomes.","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135159754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect Of Continuously Dutasteride Monotherapy on The Expression Of Protein Kinase C-Alpha Enzyme In BPH Model Of Wistar Strain Rattus Novergicus Rat.","authors":"Besut Daryanto, I Gusti Lanang Andi Suharibawa, Athaya Febriantyo Purnomo, Pradana Nurhadi, Viera Wardhani","doi":"10.5455/medarh.2023.77.202-206","DOIUrl":"10.5455/medarh.2023.77.202-206","url":null,"abstract":"<p><strong>Background: </strong>Benign prostate hyperplasia (BPH) is frequently found in the elderly and significantly impacts the quality of life. One of the risk factors that induce BPH is the androgen hormone. One of the effective medications in reducing the severity of Lower Urinary Tract Symptoms caused by BPH is the α-adrenergic receptor 5α-reductase inhibitor.</p><p><strong>Objective: </strong>The study aims to see the effect of long-term dutasteride on the expression of the PKC-α enzyme in prostatic stromal tissue in the BPH Model of Wistar strain Rattus norvegicus rats.</p><p><strong>Method: </strong>This study was an experimental, post-test-only, control group design that used randomization in sample selection. The objective is to measure the expression of PKC-α enzyme from prostate tissue of an adult male Wistar Strain of Rattus Novergicus rat that was given testosterone to induce BPH and given dutasteride in 1,3 and 6 days continuously. Data is shown in mean±SD, and all of the data were analyzed using the software SPSS 21st version with the One Way ANOVA Statistical method after fulfilling the normality test and variant homogeneity test. Data analysis with confidence rate 95% and a=0,05.</p><p><strong>Results: </strong>There was a decrease of PKC-α enzyme and prostate weight in dutasteride monotherapy in 1,3,6 days compared to the positive control, and the lowest value was on the sixth day (SD ± 2876.8). There was a constant decrease of PKC-α enzyme from the first day until the sixth day.</p><p><strong>Conclusion: </strong>In conclusion, long-term dutasteride monotherapy could significantly decrease the level of PKC-α enzyme. There was no upregulation of the PKC-α enzyme in the long term of dutasteride monotherapy.</p>","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":"77 3","pages":"202-206"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/88/fc/medarch-77-202.PMC10495133.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10229900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indoor Aeroallergen Sensitization and Associated Factors in Hospitalized Children with Asthma Exacerbations","authors":"Nguyen Thao, To Kien, Tran Tuan, Nguyen Duc, Phan Hoang, Le Vu","doi":"10.5455/medarh.2023.77.338-344","DOIUrl":"https://doi.org/10.5455/medarh.2023.77.338-344","url":null,"abstract":"Background: Allergic asthma represents the most popular phenotype of childhood asthma and is characterized by eosinophilic airway inflammation associated with specific immunoglobulin E (IgE) antibodies sensitization to various allergens, as evidenced by serology or skin prick test.2 Sensitization to indoor aeroallergens is associated with severe asthma and severe asthma exacerbations. Objective: This study aimed to identify the prevalence of aeroallergen sensitization and its associated factors in children with an asthma exacerbation in Vietnam. Methods: A cross-sectional study was conducted at Children’s Hospital 1, Ho Chi Minh City (HCMC). Children who were aged 3 to 15 and admitted to the hospital with moderate or severe asthma exacerbation were recruited to the study. Data was collected from interviews and medical records. SPT was used to identify aeroallergen sensitization. The association between school-age, living area, and passive smoking with the odds of aeroallergen sensitization was assessed using a multivariable logistic regression. Results: The prevalence of aeroallergen sensitization was 82.6% and this figure in school-age children was higher than that in preschool-age ones (93.8% vs 72.1%, p=0.001). School-age, living in HCMC, and passive smoking significantly increased the odds of aeroallergen sensitization in asthmatic children with adjusted OR [95%CI] as 6.9 [2.1-23.3], 4.1 [1.5-11.5], and 2.9 [1.0-8.4], respectively. Asthmatic children with aeroallergen sensitization required more hours to resolve an asthma exacerbation than those without (22.4 vs 15.2, p=0.006). Conclusion: Aeroallergen sensitization was common in hospitalized children with moderate or severe asthma exacerbation. It is necessary to establish environmental policy and screening practices of aeroallergen sensitization to improve the quality of asthma management for Vietnamese children.","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135159965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of Cyclophilin and Phospholipase Enzyme in Women Infected with Toxoplasmosis.","authors":"Noor Abdul Redah Al-Kremy,&nbsp;Maher Ali Al-Qrashy","doi":"10.5455/medarh.2022.76.443-446","DOIUrl":"https://doi.org/10.5455/medarh.2022.76.443-446","url":null,"abstract":"<p><strong>Background: </strong>Toxoplasma gondii, a protozoan parasite with a worldwide distribution, is considered to infect one-third of all humans. many species. The intracellular parasite Toxoplasma gondii causes toxoplasmosis. Numerous physiological abnormalities are documented in toxoplasmosis-infected women.</p><p><strong>Objective: </strong>This study aims to demonstrate the connection between cyclophilins, the phospholipase enzyme, and latent toxoplasmosis.</p><p><strong>Methods: </strong>The research was carried out between January 2022 and June 2022. out of 150 patients had blood samples drawn, 250 had serum samples drawn from women with toxoplasma gondi infection, and 50 had healthy samples drawn from Hila city, Iraq. To exclude subjects who had any medical disorders, information from the subjects was gathered via an interviewer-managed questionnaire. ELISA was used to examine the serum. Results: About 250 samples from women with infertility were infected with Toxoplasma gondii overall (24%) Enzyme-Linked Immunosorbent Assay was utilized to evaluate the levels of phospholipase and cyclophilin, while automated VIDAS family instruments were employed to determine the qualitative and quantitative anti-Toxoplasma-IgG-tests (ELISA). Since there was a substantial difference in the statistical analysis and a significant difference in the cyclophilin protein, parasite infection changed the quantity of the enzyme phospholipase.</p><p><strong>Conclusion: </strong>This study put forth the theory that toxoplasmosis infection. Our investigation showed that patients with toxoplasma Gondi infection had higher levels of cyclophilins and phospholipase than control subjects.</p>","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":"76 6","pages":"443-446"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/70/65/medarch-76-443.PMC10019867.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9515058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Contributes to Palliative Care Practice in Cancer Patients in Indonesia.","authors":"Sry Suryani Widjaja,&nbsp;Rusdiana Rusdiana,&nbsp;Vito Filbert Jayalie,&nbsp;Rina Amelia","doi":"10.5455/medarh.2022.76.464-468","DOIUrl":"https://doi.org/10.5455/medarh.2022.76.464-468","url":null,"abstract":"<p><strong>Background: </strong>Palliative care has an important role in cancer treatment. It has been established in Indonesia for years, however, palliative care does not give significant improvements which may due to the numerous components of palliative care.</p><p><strong>Objective: </strong>This research aims to identify factors affecting palliative care in Indonesia.</p><p><strong>Methods: </strong>This article is a literature review which was conducted through a systematic search from four online databases: Cochrane, Pubmed, Embase, EbscoHOST. The search revealed 45 studies then selected using PRISMA 2020 algoritm, leaving 8 studies to be analyzed. The factors affecting palliative care in Indonesia were then grouped into three points of view: the patients and caregiver; healthcare provider, further divided into healthcare personnel and system; as well as healthcare system. By knowing these factors it is expected that we can achieve optimal implementation palliative care in Indonesia, especially in cancer patient.</p><p><strong>Results: </strong>The factors influencing palliative care in Indonesia can be grouped into patients, healthcare provider and healthcare system.</p><p><strong>Conclusion: </strong>Palliative care improvement in Indonesia can be enhanced to achieve optimal implementation in cancer treatment.</p>","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":"76 6","pages":"464-468"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f1/e5/medarch-76-464.PMC10019868.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9515061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nurses' Knowledge and Practices Regarding the Prevention of Deep Vein Thrombosis in Saudi Arabia: Descriptive Cross-Sectional Study.","authors":"Hessa Abdulatif Alyousef,&nbsp;Sahar Elmetwally A Badawi,&nbsp;Yasser A Elghoneimy,&nbsp;Rana Ali Alameri,&nbsp;Abdulwahab Meteb Almutairi","doi":"10.5455/medarh.2022.76.447-453","DOIUrl":"https://doi.org/10.5455/medarh.2022.76.447-453","url":null,"abstract":"<p><strong>Background: </strong>Deep venous thrombosis (DVT) is a prevalent fatal problem and a major cause of avoidable death among morbid hospitalized patients. It is estimated that up to 900,000 people in the United States are affected each year. Additionally, around 60,000 to 100,000 Americans die annually of DVT.</p><p><strong>Objective: </strong>To assess studied nurses' knowledge and practice regarding Deep venous thrombosis prevention.</p><p><strong>Methods: </strong>A descriptive cross-sectional research design was used in this study at King Fahad Hospital of the University in the Kingdom of Saudi Arabia, using a self-administered questionnaire. A total of 67 nurses from medical and surgical units were included in the study. Data were coded and analyzed using SPSS 23.0 version.</p><p><strong>Results: </strong>According to the results, the knowledge and practice of nurses were found to be high. Total knowledge score regarding prevention of deep venous thrombosis (72.8±9.6), regarding studied nurses, score for each subcategory: general knowledge category (70.6±15.5), deep venous thrombosis risk factors category (66.5±13.1), and deep venous thrombosis prevention category (90.1±10.5). in addition, a statically significance association between nurses' years of experience (p=0.026), previous Deep venous thrombosis education (p=0.012), and total knowledge score regarding the prevention of deep venous thrombosis. Concerning the self-reported practice, the majority of the studied nurses have shown a very high practice score. Yet, there was no statically significant association between the sociodemographic characteristic and practice. Furthermore, a positive association between total knowledge and reported practice score but statically insignificant (p=0.075).</p><p><strong>Conclusion: </strong>Based on the result of the study, most of the studied nurses' level of knowledge and practice concerning the prevention of deep vein thrombosis ranged between high and very high.</p>","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":"76 6","pages":"447-453"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3d/d0/medarch-76-447.PMC10019885.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9140070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between Intensity of Vimentin Immuno-expression in Young Women with Triple Negative Breast Cancer and Its Cliniocopathological Parameters.","authors":"Fitriani Lumongga,&nbsp;Ridha Dharmajaya,&nbsp;Kamal Basri Siregar,&nbsp;Delyuzar,&nbsp;Diah Rini Handjari,&nbsp;Nelva Karmila Jusuf,&nbsp;Delfitri Munir,&nbsp;Asrul","doi":"10.5455/medarh.2022.76.454-457","DOIUrl":"https://doi.org/10.5455/medarh.2022.76.454-457","url":null,"abstract":"<p><strong>Background: </strong>Young breast cancer patients (≤40 years) have different unifying oncogenic signaling pathways when compared to older people. Vimentin is a filament intermediate. Vimentin expression has an important role in epithelial-to-mesenchymal transition (EMT) and cancer progression.</p><p><strong>Objective: </strong>The aim of this study was to assess the correlation between vimentin intensity and clinicopathological parameters in patients with triple negative breast cancer aged 40 years.</p><p><strong>Methods: </strong>Samples were taken from 45 paraffin blocks of patients with young woman with triple negative invasive breast cancer NOS type that met the inclusion criteria, immunohistochemical examination was performed with vimentin. Vimentin intensity was assessed using ImageJ analysis.</p><p><strong>Results: </strong>Samples were taken from paraffin blocks of patients with triple negative invasive breast cancer NOS type that met the inclusion criteria, immunohistochemical examination was performed with vimentin. Vimentin intensity was assessed using ImageJ analysis.</p><p><strong>Conclusion: </strong>This study shows that vimentin intensity is strongly associated with tumor progression, tumor mass size and tumor invasion so that it can be used as a prognostic factor in young triple negative breast cancer patients.</p>","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":"76 6","pages":"454-457"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/87/1f/medarch-76-454.PMC10019877.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9144543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 Vaccinations: Medical, Ethical and Legal Aspects.","authors":"Farouq Ahmad Faleh Alazzam,&nbsp;Hisham Jadallah Mansour Shakatreh,&nbsp;Zaid Ibrahim Yousef Gharaibeh,&nbsp;Khaled Khalaf Abed Rabbo Aldrou,&nbsp;Ahed J Alkhatib","doi":"10.5455/medarh.2022.76.413-418","DOIUrl":"https://doi.org/10.5455/medarh.2022.76.413-418","url":null,"abstract":"<p><strong>Background: </strong>Following the consideration of COVID-19 as pandemic by the World Health Organization (WHO), developing new vaccinations against COVID-19 was the dream of humanity. Leading companies competed to achieve this task. Several vaccinations have been developed relatively quickly.</p><p><strong>Objective: </strong>The aim of the present study was to review the literature regarding medical, ethical, and legal aspects of COVID-19 vaccination.</p><p><strong>Methods: </strong>Literature was reviewed regarding various issues of COVID-19 vaccinations.</p><p><strong>Results and discussion: </strong>The main findings showed that a dilemma exists in literature regarding the ethics in general in keeping the rights of individuals to retain their rights to receive the vaccine and considering receiving the vaccination as compulsory.</p><p><strong>Conclusion: </strong>As the disease has become pandemic with high mortality rates, keeping the safety of the community has received the priority on individual rights, and many countries considered compulsory vaccinations.</p>","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":"76 6","pages":"413-418"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8f/99/medarch-76-413.PMC10019883.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9499442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}