Medicinski arhiv最新文献

{"title":"TGF-β1 Effects on Total Collagen of the New Zealand Rabbit's Urethral Wall (Oryctolagus cuniculus) in Animal Models of Urethral Stricture.","authors":"Paksi Satyagraha,&nbsp;Hamid Hunaif Dhofi Alluza,&nbsp;I Made Udiyana Indradiputra,&nbsp;Athaya Febriantyo Purnomo,&nbsp;Pradana Nurhadi,&nbsp;Kenty Wantri Anita,&nbsp;Yuyun Yueniwati,&nbsp;Happy Kurnia Permatasari,&nbsp;Basuki Bambang Purnomo","doi":"10.5455/medarh.2023.77.189-193","DOIUrl":"https://doi.org/10.5455/medarh.2023.77.189-193","url":null,"abstract":"<p><strong>Background: </strong>Currently, animal models of urethral stricture are not standardized. Transforming Growth Factor Beta 1 (TGF-β1) regulates extracellular matrix deposition in homeostatic and pathological responses.</p><p><strong>Objective: </strong>The aim of this study was to present the potential model to be developed as a urethral stricture.</p><p><strong>Methods: </strong>True experimental laboratory research was conducted by using Male New Zealand rabbits (<i>Oryctolagus cuniculus</i>), which were divided into 5 groups; control, placebo, and 3 treatment groups (TGF-β1 injection of 1 µg, 2 µg, 4 µg). Urethrography, histopathological analysis, and evaluation of total collagen formation of the urethral wall were performed after 6 weeks.</p><p><strong>Results: </strong>An increase in the dose of TGF-β1 decreased the mean rabbit's urethral lumen diameter (29.3% in the 2µg group and 34% in the 4µg group) compared to controls. Three rabbits decreased as much as ≤ 50% in urethral lumen diameter. Significant increases in total collagen density in the periluminal and peripheral urethral spongiosum were noted by increasing doses of TGF-β1. The percentage of urethral lumen diameter has a strong negative correlation with periluminal total collagen density (r = -0,798; p = 0,000) and very strong negative correlation with peripheral spongiosa total collagen density (r = -0,748, p = 0,000).</p><p><strong>Conclusion: </strong>TGF-β1 plays a role in changing total collagen compositions of the rabbit's urethral wall, decreasing the urethral lumen diameter. Further research with increasing doses of TGF-β1 is needed to determine the effective dose of TGF-β1 in inducing urethral stricture.</p>","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":"77 3","pages":"189-193"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/79/00/medarch-77-189.PMC10495137.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10596788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dilemma of Blunt Abdominal Trauma in Patients with Crohn's Disease, Can Intestinal Perforation be Missed?","authors":"Mohammed S Foula,&nbsp;Dhuha N Boumarah,&nbsp;Aqilah Alabbad,&nbsp;Motaz AlQahtani,&nbsp;Ali H Alsaffar,&nbsp;Mamoun Nabri,&nbsp;Saeed Alshomimi","doi":"10.5455/medarh.2023.77.231-236","DOIUrl":"https://doi.org/10.5455/medarh.2023.77.231-236","url":null,"abstract":"<p><strong>Background: </strong>Isolated intestinal injury after blunt abdominal trauma is a rare challenging clinical entity. Patients with Crohn's disease (CD) are considered more prone to spontaneous intestinal perforation rather than normal population However, spontaneous intestinal perforation remains rare. In the literature, there are few cases reports discussing intestinal perforation after blunt abdominal trauma in CD patients.</p><p><strong>Objective: </strong>Herein, we report a young male patient with CD who had missed traumatic intestinal perforation along with literature review of similar cases.</p><p><strong>Case presentation: </strong>A young male patient, known to have CD, was brought to the emergency department after a road traffic accident. He had mild tenderness over his right iliac fossa with no signs of peritonitis. His chest X-rays revealed right-sided pneumothorax. His pan-computed tomography revealed thickened terminal ileum and minimal collection between the intestinal loops that were interpreted as interval regression of his Crohn's disease. On the second day, he remained hemodynamically-stable with no signs of peritonitis but his chest X-rays showed air under diaphragm. A repeated CT showed pneumoperitoneum, air foci around the terminal ileum and mild free fluid. An ileal perforation was found around 25 cm from the ileo-cecal valve. The involved ileal segment was completely resected with double-barrel ileostomy.</p><p><strong>Conclusion: </strong>Traumatic intestinal injury in patients with Crohn's disease represent both diagnostic and management dilemma. Inaccurate interpretation of radiological signs may lead to a delayed or missed diagnosis and surgical intervention. Abdominal CT scan should be routinely repeated, within 24 hours, for such patients, regardless absence of symptoms or signs suggestive of intestinal perforation.</p>","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":"77 3","pages":"231-236"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/19/c0/medarch-77-231.PMC10495144.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10578749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Thorough Analysis of The Effects and Complications of Two Different Suturing Techniques in Hypospadias Repair Using Tubularized-Incised Plate Urethroplasty: a Meta-Analysis.","authors":"Lalu Muhammad Editia Subihardi,&nbsp;Ida Bagus Gde Tirta Yoga Yatindra,&nbsp;Llham Akbar Rahman,&nbsp;Muhammad Rifki Setiawan,&nbsp;Dimas Panca Andhika,&nbsp;Mohammad Ayodhia Soebadi","doi":"10.5455/medarh.2023.77.194-201","DOIUrl":"https://doi.org/10.5455/medarh.2023.77.194-201","url":null,"abstract":"<p><strong>Background: </strong>Hypospadias is a male congenital anomaly that requires urethroplasty via the tubularized-incised plate (TIP) technique. This technique is simple, and the results are promising, although it has few postoperative complications, including the associated suture technique.</p><p><strong>Objective: </strong>Comparing the continuous and interrupted suturing techniques on the TIP procedure for hypospadias repair.</p><p><strong>Methods: </strong>This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The authors thoroughly searched electronic databases of PubMed, Scopus, ScienceDirect, and Web of Science. The compared endpoints were the total complication, wound infection, meatal stenosis, glans dehiscence, and urethral stricture presented as risk ratio (RR), with mean operating time as mean difference (MD), in 95% confidence intervals (CIs). All statistical analyses were performed using Revman 5.4.</p><p><strong>Results: </strong>Ten eligible studies were included, totalling 1,894 patients. Pooled RR showed no significant difference in overall complication, surgical site infection, meatal stenosis, glans dehiscence, and urethral stricture between continuous and interrupted sutures. In subgroup analysis, the interrupted suture had fewer complications when using polyglactin material (RR: 1.51, 95% CI 1.07 to 2.14; p = 0.02). The continuous suture showed lesser mean operative time than the interrupted suture (MD: -6 .67, 95% CI -12.52 to -0.82; p = 0.03).</p><p><strong>Discussion and conclusion: </strong>No significant complication difference existed between continuous and interrupted suturing techniques. Fewer complications were obtained when using interrupted sutures with polyglactin material. However, continuous suture required less mean operative time.</p>","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":"77 3","pages":"194-201"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e9/14/medarch-77-194.PMC10495135.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10596783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seroprevalence of Varicella Zoster Virus in the Eastern Province of Saudi Arabia in Post-vaccination Era","authors":"Reem Dossary","doi":"10.5455/medarh.2023.77.358-362","DOIUrl":"https://doi.org/10.5455/medarh.2023.77.358-362","url":null,"abstract":"Background: Varicella zoster virus (VZV) is a highly contagious virus causing two types of skin infections known as varicella and herpes zoster. Due to its high burden, vaccination is available in almost 42 counties worldwide including Saudi Arabia. Since its introduction, data on the impact of the vaccine from local and neighboring countries is lacking. Objective: This study was done to determine the seroprevalence of anti VZV IgG and IgM antibodies in post-vaccination era fifteen years after varicella vaccine introduction in routine childhood vaccination schedules. Methods: retrospective observational study over seven years on all individual tested for anti VZV IgG and IgM in a tertiary university hospital in the eastern province of Saudi Arabia between Jan 2014 to Dec 2020. Results: 83.69% (6820/8149) of tested population were seropositive with significantly lower positivity in children less than ten years old (44%). Yet no significant difference was found between males and females or among different nationalities tested. Conclusions: varicella continuous to be prevalent in the eastern province of Saudi Arabia fifteen years after the introduction of the vaccine but the level of anti VZV IgG detection is significantly lower in children below ten years of age. Further large-scale studies are needed to assess the impact of universal vaccination on the epidemiology of VZV.","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134980008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synchronous Malignant Peritoneal Mesothelioma and Sigmoid Adenocarcinoma: a Challenging Clinical Entity","authors":"Hefzi Alratrout, Dhuha Boumarah, Elham Alghusnah, Aqilah Alabbad, Ali Alsaffar, Noor Alsafwani, Mohammed Foula","doi":"10.5455/medarh.2023.77.400-404","DOIUrl":"https://doi.org/10.5455/medarh.2023.77.400-404","url":null,"abstract":"Background: Malignant peritoneal mesothelioma (MPM) represents a rare clinical entity. The synchronous existence of MPM with other malignancies as colonic adenocarcinoma have been rarely reported. Its diagnosis and management are challenging given its complexity and rarity. Objective: Herein, we report a case of epithelioid subtype of MPM occurring synchronously with sigmoid colonic adenocarcinoma, along with review of the literature. Case presentation: An elderly female patient was referred as case of rectosigmoid mass. She reported history of abdominal pain, per-rectal bleeding, anorexia, and significant weight loss. Her computed-tomography scan of the abdomen revealed a fistulizing sigmoid mass and multiple enlarged lymphnodes with omental nodulation. The colonoscopy revealed a large fungating mass and the endoscopic biopsies were reported as colonic adenocarcinoma. The patient was scheduled laparoscopic low anterior resection. However, the diagnostic laparoscopy revealed several nodules disseminated all over the peritoneum, suggestive of peritoneal mesothelioma. Therefore, the decision was changed to create transverse colostomy after examination obtaining multiple biopsies from the omental and peritoneal nodules. The histopathological revealed MPM and the final diagnosis was sigmoid adenocarcinoma with synchronous MPM. The patient was started on palliative chemotherapy (capecitabine) without active management of MPM because of her general condition. She was followed up with a good clinical course. Conclusion: MPM is an overlooked entity with vague clinical presentation. Synchronous MPM with colorectal cancer is rare with only few published case reports. Its diagnosis is challenging, and its management should be tailored according to the patient. This case is the first reported case in Saudi Arabia and the Middle East.","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":"305 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134981232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti Inflammatory Action of Allium Sativum Ethanol Extract to Prevent Lung Damage in Smoker Rat Model.","authors":"Maya Savira,&nbsp;Dina Keumala Sari,&nbsp;Yetty Machrina,&nbsp;Sry Suryani Widjaja,&nbsp;Adrien Jems Akiles Unitly,&nbsp;Syafruddin Ilyas,&nbsp;Jelita Siregar,&nbsp;Pandiaman Pandia,&nbsp;M Rusda,&nbsp;Mustafa M Amin","doi":"10.5455/medarh.2023.77.178-182","DOIUrl":"https://doi.org/10.5455/medarh.2023.77.178-182","url":null,"abstract":"<p><strong>Background: </strong>Smoking is the leading cause of death in worldwide and is known as one of the risk factors in the development and pathogenesis of several diseases and most are respiratory and cardiovascular diseases. Secondhand smoke (SHS) exposure is associated with negative health consequences including respiratory tract infection, asthma, and cancer. One of the pathogenesis that has known to cause these diseases is inflammation. Garlic (<i>Allium sativum</i>) is a medicinal herb that contains <i>Allicin</i> and other active constituents that are known to have anti-inflammatory ability by suppressing the expression and production of proinflammatory cytokines that will cause inflammation.</p><p><strong>Objective: </strong>The aim of this study is; to analyze the anti-inflammatory action of <i>Allium sativum</i> ethanol extract to prevent lung damage in the smoker rat model.</p><p><strong>Methods: </strong>This is a case-control study with five groups of rats each group contains of three rats. The five groups were negative control (KN), 10 days (10d) smoker (K1), 20 days (20d) smoker (K2), 20d smoker treated with <i>Allium sativum</i> for 10 days (K3) and 20d smoker treated with <i>Allium sativum</i> for 20 days (K4). After 20 days all animals were sacrificed and histological preparation of lung organs was observed under a microscope with 100 dan 400 times magnification and then captured by photomicrograph for analyzed.</p><p><strong>Results: </strong>There were improvements in lung structure both in group K3 and K4 . there was a decrease of leucocytes and inflammatory cells infiltration that covered almost all alveolar surface to 10-20% surface area and the dilated alveoli decrease from more than 50% to less than 30% area. The bronchus was clean in both two groups compared to the groups that were not treated with <i>Allium sativum</i>.</p><p><strong>Conclusion: </strong>This study shows that <i>Allium sativum</i> ethanol extract has the ability to prevent lung damage in the smoker rat model.</p>","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":"77 3","pages":"178-182"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e4/98/medarch-77-178.PMC10495143.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10596786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Correlation Between the D-Dimer Values and Anatomical Distribution of Pulmonary Embolism","authors":"Spomenka Kristic, Amela Begic, Sandra Zubovic, Amila Basic, Haris Kuric","doi":"10.5455/medarh.2023.77.354-357","DOIUrl":"https://doi.org/10.5455/medarh.2023.77.354-357","url":null,"abstract":"Background: Pulmonary Embolism (PE) represents a life-threatening medical emergency that, given the serious complications, requires urgent application of anticoagulant therapy. In addition to other factors that are taken into account when choosing a therapy for treatment of PE, the anatomical distribution of thrombi is also considered–whether it is a central, lobar, segmental or subsegmental PE. D-dimer is an intermediate product of degradation of fibrin molecules and its values in the plasma are increased in the case of PE, but also in other diseases. Objective: To determine whether there is a difference in D-dimer values in subjects with different anatomical distribution of PE. Methods: The study included 100 subjects with diagnosed PE by using MSCT and/or V/P SPECT and with measured values of D-dimer. Results: Out of 100 subjects, PE was not diagnosed in 37 subjects, while 63 subjects PE was diagnosed. All subjects with diagnosed PE were divided into 3 groups regarding the anatomical localization of thrombus: lobar, segmental or subsegmental. Average D-dimer values were calculated for all 3 groups. Statistical analysis showed that there was no significant difference in D-dimer values between subjects with different anatomical distribution of PE. Conclusion: There is no significant difference in D-dimer values between subjects with different anatomical distribution od PE–lobar, segmental and subsegmental PE.","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134979747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idiopathic Osteosclerosis and Condensing Osteitis in a Sample of the Lebanese Population: A Digital Panoramic Based Study","authors":"Elie Hayek, Elie Maalouf, Jean Nassar, Fadi AbiLamaa, Georges Aoun","doi":"10.5455/medarh.2023.77.396-399","DOIUrl":"https://doi.org/10.5455/medarh.2023.77.396-399","url":null,"abstract":"Background: Idiopathic osteosclerosis (IO) is an area of enlarged bone production in the jaw that usually appears radiopaque and round, elliptical, or irregular in shape. Condensing osteitis (CO) is a focalized osseous reaction leading to periapical sclerotic bone growth. Objective: The aim of this study was to investigate the prevalence, localization, shape, and dental relationship of IO and CO in a group of Lebanese patients and to correlate these findings to age and gender. Methods: 520 digital panoramic radiographs of patients (215 men and 305 women) ranging in age from 18 to 77 (mean age 40.89 years) who visited the Faculty of Dental Medicine, Lebanese University, for dental treatment were included in this study and assessed for IO and CO. The prevalence of the two lesions according to gender and age, as well as their localization, and dental relationship, were recorded and saved in an Excel sheet. Results: Among the 520 radiographs, 47 (9%) showed IO, and 30 (5.8%) showed CO. Both lesions are more frequent among females in their third decade and are essentially found in the mandible, mainly in relation to the root apices. Conclusion: Within the limits of this study, we concluded that in our sample of the Lebanese population, the prevalence of IO and CO is low and supports the theory that IO can be defined as developmental variations of normal bony architecture unrelated to a local stimulant, and CO could be considered reactive bone formations related to pulpitis, deep restoration, or caries.","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":"305 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134980834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Analysis from A Single Center Perspective On Complications After Fixing Distal Radius Fracture In Pediatric Population","authors":"Ammar Alomran, Abdulaziz Alhawas, Ahmed Almulhim, Mohammad Alfehaid, Arwa Alumran, Abdullah Alkharashi, Noof Alabdulwahab, Reem Alalwan","doi":"10.5455/medarh.2023.77.384-390","DOIUrl":"https://doi.org/10.5455/medarh.2023.77.384-390","url":null,"abstract":"Background: The Distal radius fractures in the pediatric age group have similar complications to any other fracture. One interpretation of the high fracture incidence in the distal third of the radius is the relative weakness of the metaphyseal part. Objective: The aim of this study is to provide an evaluation of Surgical complications of distal radius through satisfactory reduction and proper fixation by K-wires through bone growth plates. Methods: A retrospective single-center study in a tertiary hospital in Eastern Saudi Arabia from 2000 to 2021, using the hospital’s electronic records system. The Inclusion criteria of this study involve all distal radius fracture cases who underwent surgical fixation by k-wire or plating system and are up to 14 years old. The exclusion criteria include loss of follow-up, incomplete data, and age of more than 14 years. Results: the study included 103 patients. The side of injury was almost equally distributed between the left and right sides. The odds of having at least one complication increase by 2.5 folds if the site of fracture is at the diaphysis. Further, if the distance of the fracture line to the epiphysis is more than 20 mm, the odds of reporting at least one complication post-procedure is 4.4 times higher than if it was at the level of the epiphysis. The majority of diaphyseal fractures required less than 6 weeks for radiological healing, which is significantly different from other sites which were evaluated. Conclusion: Complications of distal radius fracture due to Surgical intervention could be confounded by the complexity of the fracture itself. In our study, we found the distance of the fracture from the physis was inversely proportional to the likelihood of complications. For a comprehensive appreciation of physeal plate, we recommend extended follow-up for those who present with signs of severe distal radius fracture, especially in case of associated ulnar fracture.","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134980401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Single-Center Experience on the Treatment Outcomes of Patients with COVID-19-Pleural Disorders: Lessons for the Future","authors":"Alma Pasalic, Ilijaz Pilav, Veljko Maric, Kenan Kadic, Meho Dapcevic, Ademir Hadzismailovic, Alen Pilav, Enisa Ademovic, Orhan Custovic","doi":"10.5455/medarh.2023.77.345-349","DOIUrl":"https://doi.org/10.5455/medarh.2023.77.345-349","url":null,"abstract":"Background: Pleural disorders in novel coronavirus disease 2019 (COVID-19), responsible for the deaths of more than 6.7 million people worldwide, are relatively uncommon and underappreciated findings. The severity of the pleural disease in these patients correlates with the treatment outcome and overall prognosis. Objective: We aim to review our experience with treatment modalities and prognosis in 45 patients with COVID-19, who were treated at our Clinic between April 2020 and October 2021. Methods: We conducted a retrospective, single-center, cross-sectional study. Demographic data, the type of thoracosurgical intervention(s), and treatment outcome for 45 patients included in this study were recorded for every patient. We analyzed the type and number of treatment modalities according to the pleural disorder, and the outcome of the treatment. Results: Pneumothorax was the most common COVID-19-related pleural disorder, followed by the pleural effusion. Tube thoracostomy was the mainstay of treatment, performed in 84.4% of patients with unilateral pleural complications. In total, 20% of our patients were on mechanical ventilation, and all of them had a fatal outcome. We found statistical significance in comparison to the percentage of fatal outcomes between patients treated with and without mechanical ventilation (p=0.000). Conclusion: COVID-19-related pleural disorders are prognostic markers of disease progression. Mechanically ventilated patients who require tube thoracostomy have an unfavorable prognosis.","PeriodicalId":18421,"journal":{"name":"Medicinski arhiv","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135158383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}