M. Aljaafari, M. Alhosani, A. Abushelaibi, K. Lai, S. Lim
{"title":"Essential Oils: Partnering with Antibiotics","authors":"M. Aljaafari, M. Alhosani, A. Abushelaibi, K. Lai, S. Lim","doi":"10.5772/INTECHOPEN.86575","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.86575","url":null,"abstract":"Essential oils (EO) are volatile, non-lipid-based oils produced as a plant defense mechanism. Studies from our group have validated the potential usefulness of EOs to synergistically and additively work with antibiotics. In this book chapter, we aim to outline some background on the EOs and their uses and applications, to discuss the different mechanisms of action in partnering with antibiotics, and, finally, to explore their potential use against multidrug-resistant bacteria. Applications of EO in therapy will enable the revival of previously sidelined antibiotics and enhance the development of new drug regimens to better mitigate what may be the biggest health challenge by year 2050.","PeriodicalId":183791,"journal":{"name":"Essential Oils - Oils of Nature","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130427195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Nazzaro, F. Fratianni, A. d’Acierno, R. Coppola, F. Ayala-Zavala, A. G. Cruz, V. Feo
{"title":"Essential Oils and Microbial Communication","authors":"F. Nazzaro, F. Fratianni, A. d’Acierno, R. Coppola, F. Ayala-Zavala, A. G. Cruz, V. Feo","doi":"10.5772/INTECHOPEN.85638","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.85638","url":null,"abstract":"The World Health Organization highlighted the increase in the resistance to conventional antibiotics for most pathogens and observed also a decrease of the threshold for all mechanisms of cell-cell microbial communication, leading to the formation of biofilms and to the increase of microbial pathogenicity. Scientific community is therefore oriented to the identification and study of alternative substances to antibiotics. In such context, substances of vegetal source, such as essential oils (EOs), always used in traditional medicine, stimulated— particularly in recent decades—the scientific world to discover and identify substances, intended as a mixture or single components capable to fight pathogenic microorganisms. From this point of view, the study of plants is very interesting and offers many interesting ideas and results. This brief chapter describes the basis of the microbial communication, until the formation of biofilm, and some mechanisms through which essential oils, or some of their main components, may decrease or inactivate the complex mechanisms that lead to pathogenicity, both of prokaryotes and eukaryotes.","PeriodicalId":183791,"journal":{"name":"Essential Oils - Oils of Nature","volume":"4629 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117204039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}