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The Impact of Medical Nutritional Therapy on the Efficacy of Premix Insulin in Glycemic Control in Patients with Type 2 Diabetes. 药物营养治疗对预混胰岛素控制2型糖尿病患者血糖效果的影响
Materia Socio-Medica Pub Date : 2023-03-01 DOI: 10.5455/msm.2023.35.13-17
Senada Husaric, Azra Avdic Salihovic, Nedzad Kadric, Samra Iljazovic-Topic, Jasmina Pasic, Anida Divanovic
{"title":"The Impact of Medical Nutritional Therapy on the Efficacy of Premix Insulin in Glycemic Control in Patients with Type 2 Diabetes.","authors":"Senada Husaric,&nbsp;Azra Avdic Salihovic,&nbsp;Nedzad Kadric,&nbsp;Samra Iljazovic-Topic,&nbsp;Jasmina Pasic,&nbsp;Anida Divanovic","doi":"10.5455/msm.2023.35.13-17","DOIUrl":"https://doi.org/10.5455/msm.2023.35.13-17","url":null,"abstract":"<p><strong>Background: </strong>Medical nutritional therapy (MNT) is a key component in the treatment of Diabetes mellitus (DM). MNT is completely individual and should be present in the treatment of diabetes from the very beginning, continuously with pharmacological therapy, taking into account lifestyle, dietary habits and the type of antidiabetic therapy. Mistakes that are made when planning the diet are the absence of individual adjustment of the diet, which means that the number and time of meals, as well as the amount of UH per meal, is not adjusted to the patients' oral or insulin therapy according to their pharmacokinetics and pharmacodynamics.</p><p><strong>Objective: </strong>This study investigated the effect of MNT with reduced carbohydrate content (MNT M-ADA) on the efficacy of human and analogue premix insulin in patients with T2DM.</p><p><strong>Methods: </strong>Subjects were randomized into two groups (human and analog premix insulins), and then each group into two subgroups of 30 subjects each. One subgroup each on therapy with human and analog biphasic insulins was educated about MNT and learned to count UH, and then they applied MNT M-ADA for 24 weeks, unlike the other two subgroups. In this review, we present only the subgroup analysis on human and analog premix insulins that applied MNT M-ADA (200 g UH/day). Efficacy outcomes in the analysis of these subgroups were estimated changes in each subgroup from baseline to end point (week 24) and differences between subgroups at the end of the study in levels of glycated hemoglobin (HbA1c), self-measured glucose values (SMBG) and frequency of hypoglycemia.</p><p><strong>Results: </strong>Both subgroups of subjects with MNT M-ADA improved glycemic control, which was assessed by improvements in HBA1C, SMBG levels, without an increase in the frequency of hypoglycemia, but at the end of the study there was no statistically significant difference in the mentioned parameters between the subgroups.</p><p><strong>Conclusion: </strong>The effectiveness of MNT M-ADA in people with T2DM did not depend on the type of insulin, both insulin regimens are effective if the amount of ingested UH is taken into account.</p>","PeriodicalId":18358,"journal":{"name":"Materia Socio-Medica","volume":"35 1","pages":"13-17"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e4/68/MSM-35-13.PMC10122531.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9743700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of the Temporary Contracting and Visiting Doctor Program in Supporting the Health System during and after COVID-19 Pandemic in Saudi Arabia. 临时签约和访问医生计划在沙特阿拉伯COVID-19大流行期间和之后支持卫生系统的作用。
Materia Socio-Medica Pub Date : 2023-03-01 DOI: 10.5455/msm.2023.35.53-57
Faisal S Alenezi, Aeshah I Alsagheir, Lamya M Alzubaidi, Wijdan S Al-Saedi, Saleh S Alharbi, Muna H Hassanein, Tareef Y Alaama
{"title":"The Role of the Temporary Contracting and Visiting Doctor Program in Supporting the Health System during and after COVID-19 Pandemic in Saudi Arabia.","authors":"Faisal S Alenezi,&nbsp;Aeshah I Alsagheir,&nbsp;Lamya M Alzubaidi,&nbsp;Wijdan S Al-Saedi,&nbsp;Saleh S Alharbi,&nbsp;Muna H Hassanein,&nbsp;Tareef Y Alaama","doi":"10.5455/msm.2023.35.53-57","DOIUrl":"https://doi.org/10.5455/msm.2023.35.53-57","url":null,"abstract":"<p><strong>Background: </strong>Adequate supply of health workforce with proper skills is essential to deliver appropriate health services in normal times and during disasters.</p><p><strong>Objective: </strong>To describe the role of the Saudi Temporary Contracting and Visiting Doctors Program in the provision of critical care during COVID-19 pandemic, and in the clearance of the surgical backlog thereafter.</p><p><strong>Methods: </strong>We reviewed reports of General Directorate of Health Services and Saudi Ministry of Health annual statistical books to obtain the following data: number of temporary healthcare professionals contracted from 2019 to 2022; number of intensive care unit beds before and during COVID-19 pandemic; volume of elective surgeries before, during and after COVID-19 pandemic.</p><p><strong>Results: </strong>In 2020, intensive care unit beds increased from 6341 to 9306 in governmental hospitals in response to COVID-19 pandemic. A total of 3539 temporary healthcare professionals were recruited from April to August 2020 to contribute towards staffing the added beds. During the recovery period from COVID-19 pandemic, 4322 and 4917 temporary health care professionals were recruited in 2021and 2022 respectively. Elective surgeries volume increased from 5074 in September 2020 to 17533 in September 2021 to 26242 in September 2022, surpassing the volume of surgeries in pre-COVID-19 period.</p><p><strong>Conclusions: </strong>In response to COVID-19 pandemic, and through the existing temporary contracting program, the Saudi Ministry of Health was able to recruit temporary staff of verified credentials in a timely manner, to supplement the existing staff, for activation of the newly added intensive care unit beds, and for clearing the resulting surgical backlog.</p>","PeriodicalId":18358,"journal":{"name":"Materia Socio-Medica","volume":"35 1","pages":"53-57"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a2/15/MSM-35-53.PMC10122529.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9743701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cognitive Imapirment in Multiple Sclerosis: Relation to Dysability, Duration and Type of Disease. 多发性硬化症的认知功能障碍:与残疾、病程和疾病类型的关系。
Materia Socio-Medica Pub Date : 2023-03-01 DOI: 10.5455/msm.2023.35.23-27
Selma Sabanagic-Hajric, Amra Memic-Serdarevic, Gorana Sulejmanpasic, Dzenita Salihovic-Besirovic, Avdo Kurtovic, Nermina Bajramagic, Enra Mehmedika-Suljic
{"title":"Cognitive Imapirment in Multiple Sclerosis: Relation to Dysability, Duration and Type of Disease.","authors":"Selma Sabanagic-Hajric,&nbsp;Amra Memic-Serdarevic,&nbsp;Gorana Sulejmanpasic,&nbsp;Dzenita Salihovic-Besirovic,&nbsp;Avdo Kurtovic,&nbsp;Nermina Bajramagic,&nbsp;Enra Mehmedika-Suljic","doi":"10.5455/msm.2023.35.23-27","DOIUrl":"https://doi.org/10.5455/msm.2023.35.23-27","url":null,"abstract":"<p><strong>Background: </strong>Cognitive dysfunctions are often presented as a symptom in multiple sclerosis which is associated with both structural and functional imapirments of neuronal networks in the brain.</p><p><strong>Objective: </strong>The aim of the study was to evaluate the influence of dysability, duration and type of disesase on cognitive functions in multiple sclerosis patients.</p><p><strong>Methods: </strong>This study included 60 MS patients treated at the Department of Neurology, Clinical Center University of Sarajevo. Inclusion criteria were clinically definite diagnosis of multiple sclerosis, 18 years of age or older and were able to give written informed consent. Cognitive function was evaluated by the Montreal Cognitive Assessment (MoCa) screening test. Mann-Whitney and Kruskal-Wallis test were used for comparisons between clinical characteristics and MoCa test scores.</p><p><strong>Results: </strong>Out of 63.33% of patients had EDSS <=4.5. Disease lasted longer than 10 years in 30% of patients. 80% had relapsing-remitting MS and 20% had secondary progressive MS. 84,2 % of patients with EDSS ≤ 4.5 had cognitive dysfunction. Higher disability (rho=0,306, p<0,05), progressive type of disease (rho=0,377, p< 0,01) and longer disease duration (rho=0,282, p<0,05) were associated with worse overall cognitive functions. Level of disability showed statistical significant correlation with the executive functions and language domains of cognition (p<0.01). Longer disease duration was significant correlated with executive functions (p<0,01) and language domains (p<0,01), while progressive type of disease was signifacant correlated only with executive functions domain (p<0,01). MoCa score variables did not show a statistically significant difference in relation to the number of relapses per year and the use of imunoterapy. Statistically significant negative correlation was obtained between executive functions domain and level of disability, disease duration and progressive type of disease, while language domain significantly correlated only with disability level and progressive type of disease.</p><p><strong>Conclusion: </strong>High percentage of MS patients has cognitive impairment. Patients with higher disability were presented with lower cognitive abilities, especially in executive functions and language domains. Higher frequency of cognitive impairment were presented in progessive forms of disaese and longer disease duration with strong influence on executive functions domains of cognition.</p>","PeriodicalId":18358,"journal":{"name":"Materia Socio-Medica","volume":"35 1","pages":"23-27"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/41/25/MSM-35-23.PMC10122534.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9743703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frequency of Urinary Tract Infection When Diagnosing Vesico Uretheral Reflux in Children in Tuzla Canton. 图兹拉县儿童在诊断膀胱尿道反流时尿路感染的发生率
Materia Socio-Medica Pub Date : 2023-03-01 DOI: 10.5455/msm.2023.35.4-7
Evlijana Zulic, Devleta Hadzic, Almira Cosickic, Nedima Atic, Amela Selimovic, Dzenana Ostrvica
{"title":"Frequency of Urinary Tract Infection When Diagnosing Vesico Uretheral Reflux in Children in Tuzla Canton.","authors":"Evlijana Zulic, Devleta Hadzic, Almira Cosickic, Nedima Atic, Amela Selimovic, Dzenana Ostrvica","doi":"10.5455/msm.2023.35.4-7","DOIUrl":"10.5455/msm.2023.35.4-7","url":null,"abstract":"<p><strong>Background: </strong>Vesicoureteral reflux (VUR) represents the return of urine from the bladder into the ureter and the renal canal system. Reflux can occur only on one or both kidneys. VUR most often occurs due to an incompetent ureterovesical junction, which consequently leads to hydronephrosis and dysfunction of the lower parts of the urinary system.</p><p><strong>Objective: </strong>The aim of the study was to determine the frequency of urinary infection when diagnosing vesicouretheral reflux in children in the Tuzla Canton, in the five-year period from 01.01.2016 to 01.01.2021.</p><p><strong>Methods: </strong>Through a retrospective study, we analyzed data from 256 children with vesiocouretheral reflux (VUR), examined in the Nephrology Outpatient Clinic, Clinic for Children's Diseases, University Clinical Center Tuzla, in the period from 01.01.2016 to 01.01.2021, from early neonatal to 15 years of age. The age and gender of children, the most common symptoms of urinary tract infections during the detection of VUR, and the degree of VUR were analyzed.</p><p><strong>Results: </strong>From 256 children with VUR, 54% were male and 46% female. The highest prevalence of VUR was in the age group 0-2 years, and the lowest in the age of children > 15 years. There was no statistically significant difference between the groups of our respondents in relation to age groups, nor in relation to the gender of the children. Statistically significantly more children were without nonspecific symptoms and with asymptomatic bacteriuria in the group without UTI symptoms in children with VUR compared to the group with UTI symptoms in children with VUR. Pathological urine culture between the groups was without a statistically significant difference.</p><p><strong>Conclusion: </strong>Although urinary tract infection in children is common, the possibility of permanent consequences should always be kept in mind if VUR is not diagnosed and treated in time.</p>","PeriodicalId":18358,"journal":{"name":"Materia Socio-Medica","volume":"35 1","pages":"4-7"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/71/6b/MSM-35-4.PMC10122522.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9759188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Behavioral and Knowledge Patterns Regarding the Use of Antibiotics Among Urban and Rural Population in Bosnia and Herzegovina-a Cross-sectional Study. 波斯尼亚和黑塞哥维那城乡居民使用抗生素的行为和知识模式--一项横断面研究。
Materia Socio-Medica Pub Date : 2023-03-01 DOI: 10.5455/msm.2023.35.33-41
Monika Glibić, Leonora Bedeković, Mirko Maglica, Ilija Marijanović, Damir Vukoja
{"title":"Behavioral and Knowledge Patterns Regarding the Use of Antibiotics Among Urban and Rural Population in Bosnia and Herzegovina-a Cross-sectional Study.","authors":"Monika Glibić, Leonora Bedeković, Mirko Maglica, Ilija Marijanović, Damir Vukoja","doi":"10.5455/msm.2023.35.33-41","DOIUrl":"10.5455/msm.2023.35.33-41","url":null,"abstract":"<p><strong>Background: </strong>Antimicrobial resistance imposes one of the leading global health issues and is strongly associated with the overuse and misuse of antimicrobials.</p><p><strong>Objective: </strong>The present study aimed to determine the level of knowledge, attitudes, and behavior regarding the use of antibiotics among urban and rural population in the southeastern European country of Bosnia and Herzegovina.</p><p><strong>Methods: </strong>A cross-sectional questionnaire-based study was conducted by convenience sampling technique among people who visited health centers, malls, and also online. In total, 1057 questionnaires were completed, of which 920 were completed in the city of Mostar (i.e. urban area), while 137 in the municipality of Grude (i.e., rural area). Descriptive statistical analysis was performed to process the results.</p><p><strong>Results: </strong>Participants from Mostar had better knowledge about antibiotics (p = 0.031) and a higher level of education (p = 0.001). Women showed markedly better knowledge in the group of urban area responders (p = 0.004). Improper use of antibiotics was more common among respondents from Grude; they tend to use antibiotics more frequently and almost half of them are prone to self-medication (p = 0.017). Overall, those classified with adequate knowledge showed less tendency to irregular antibiotic intake. Having a medical worker in a family was significantly associated with better knowledge regarding antibiotics, while educational level was not.</p><p><strong>Conclusion: </strong>Although a significant number of respondents showed adequate knowledge about the use of antibiotics, there were noticeable irregular behavioral patterns, while significant differences between urban and rural population were detected as well. Further analysis is required to access the whole specter of the issue and to initiate policies directed toward reducing inappropriate use of antibiotics and bacterial resistance to these medications.</p>","PeriodicalId":18358,"journal":{"name":"Materia Socio-Medica","volume":"35 1","pages":"33-41"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b9/b5/MSM-35-33.PMC10122528.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9743697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of Post-LASIK Ectasia. lasik术后扩张的处理。
Materia Socio-Medica Pub Date : 2023-03-01 DOI: 10.5455/msm.2023.35.73-78
Maja Bohac, Alma Biscevic, Melisa Ahmedbegovic-Pjano, Mateja Jagic, Doria Gabric, Selma Lukacevic, Ivana Mravicic
{"title":"Management of Post-LASIK Ectasia.","authors":"Maja Bohac,&nbsp;Alma Biscevic,&nbsp;Melisa Ahmedbegovic-Pjano,&nbsp;Mateja Jagic,&nbsp;Doria Gabric,&nbsp;Selma Lukacevic,&nbsp;Ivana Mravicic","doi":"10.5455/msm.2023.35.73-78","DOIUrl":"https://doi.org/10.5455/msm.2023.35.73-78","url":null,"abstract":"<p><strong>Background: </strong>Corneal ectasia is a sight-threatening complication of corneal refractive surgery characterized by progressive steepening and thinning of the cornea and subsequent loss of best-corrected visual acuity.</p><p><strong>Objective: </strong>To report the clinical outcomes following treatment of post-laser in situ keratomileusis (LASIK) induced ectasia.</p><p><strong>Methods: </strong>This is a retrospective case series of 7 patients (10 eyes) which developed post-LASIK ectasia. In these cases of postoperative ectasia, the presented clinical signs were either forme fruste keratoconus, thin cornea, posterior elevation map value > +15.0µm, or residual stromal bed < 300µm. All cases were treated with either collagen crosslinking (CXL) alone or combined with PRK or CXL and phakic intraocular implant using the Dresden protocol and a slight modification thereof. In all cases, the flap was created using the Moria M2 mechanical microkeratome (average flap thickness 118.15±12.88µm), and refractive error was corrected using the Wavelight Allegretto excimer laser.</p><p><strong>Results: </strong>Average preoperative corrected visual acuity (CDVA) was 0.75 (±0.26) Snellen. Postoperative CDVA significantly increased to 0.86 (±0.13) Snellen (p=0.04, paired t-test). One eye lost three lines of its baseline CDVA (before ectasia), while all other eyes regained lines of CDVA. All cases remained stable during the follow-up.</p><p><strong>Conclusion: </strong>Several surgical procedures are used for the management of corneal ectasia. However, the best surgical approach should be determined based on the state of progression of the disease. Although ectasia remains a potentially devastating complication after refractive surgery, most patients can regain functional visual acuity with appropriate management, and corneal transplantation is infrequently indicated.</p>","PeriodicalId":18358,"journal":{"name":"Materia Socio-Medica","volume":"35 1","pages":"73-78"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d0/8b/MSM-35-73.PMC10122526.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9743699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Acquisition of New Philips Affiniti 30 Vascular Color Doppler Ultrasound Device - Cost Benefit Analysis to Reduce Cardiosurgical Patients' Treatment. 收购新的飞利浦Affiniti 30血管彩色多普勒超声设备-成本效益分析,以减少心脏手术患者的治疗。
Materia Socio-Medica Pub Date : 2023-03-01 DOI: 10.5455/msm.2023.35.65-72
Alen Karic, Adisa Oprasic-Dzordic, Ervin Busevac, Alma Krajnovic, Nabil Naser, Izet Masic
{"title":"Acquisition of New Philips Affiniti 30 Vascular Color Doppler Ultrasound Device - Cost Benefit Analysis to Reduce Cardiosurgical Patients' Treatment.","authors":"Alen Karic,&nbsp;Adisa Oprasic-Dzordic,&nbsp;Ervin Busevac,&nbsp;Alma Krajnovic,&nbsp;Nabil Naser,&nbsp;Izet Masic","doi":"10.5455/msm.2023.35.65-72","DOIUrl":"https://doi.org/10.5455/msm.2023.35.65-72","url":null,"abstract":"<p><strong>Background: </strong>Cerebrovascular accidents (CVI) are considered the second most serious complication in cardiac surgery patients with a frequency of 10%. By preventing complications of surgical treatment, using a Color Doppler ultrasound (CDU) device, in the population of cardiac surgery patients, the unplanned costs of prolonged postoperative treatment would be reduced.</p><p><strong>Objective: </strong>To prove that the acquisition and use of the newly developed CDU device \"Affinit 30\" is completely economical, profitable and medically justified.</p><p><strong>Methods: </strong>Numerical parameters of the treatment of cardiovascular patients were analyzed (number of procedures, number of days in the intensive care unit, cost of additional consultative services of the clinic for radiology and neurology), and the calculated economic value of the potential investment, as well as the cost of preventing surgical complications, by purchasing and installing a new modern CDU device.</p><p><strong>Results: </strong>The profitability of the investment was assessed using the economic parameters Net Present Value (NPV) of the investment, Internal rate of return (IRR) and Profitability Index (PI). A mathematical calculation with the given parameters yields NPV = 948,850 KM and IRR of 273% when applied to the given parameters. The PI value is 12.6, which matches the previously calculated NPV and IRR values.</p><p><strong>Conclusion: </strong>The acquisition and use of the newly developed CDU device \"Affinit 30\" is economically profitable and medically justified. This is shown by the calculated values of the economic parameters Net Present Value of the investment (NPV), Internal rate of return (IRR) and the Profitability Index (PI).</p>","PeriodicalId":18358,"journal":{"name":"Materia Socio-Medica","volume":"35 1","pages":"65-72"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d9/d7/MSM-35-65.PMC10122532.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9743696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pregabalin in the Treatment of Peripheral and Central Chronic Neuropathic Pain. 普瑞巴林治疗外周和中枢慢性神经性疼痛。
Materia Socio-Medica Pub Date : 2023-03-01 DOI: 10.5455/msm.2023.35.42-47
Besim Prnjavorac, Suljo Kunic, Natasa Pejanovic-Skobic, Nermina Polimac Gorana, Dragana Zirojevic, Samra Kadic Vukas, Merita Tiric Campara, Amira Skopljak
{"title":"Pregabalin in the Treatment of Peripheral and Central Chronic Neuropathic Pain.","authors":"Besim Prnjavorac,&nbsp;Suljo Kunic,&nbsp;Natasa Pejanovic-Skobic,&nbsp;Nermina Polimac Gorana,&nbsp;Dragana Zirojevic,&nbsp;Samra Kadic Vukas,&nbsp;Merita Tiric Campara,&nbsp;Amira Skopljak","doi":"10.5455/msm.2023.35.42-47","DOIUrl":"https://doi.org/10.5455/msm.2023.35.42-47","url":null,"abstract":"<p><strong>Background: </strong>Pregabalin is a first-line therapy of pain with additional positive effects on the states of depression and anxiety that often occur in patients with chronic pain, thus improving their quality of life.</p><p><strong>Objective: </strong>The aim of this study was to demonstrate the efficacy of pregabalin in reducing neuropathic pain and improving quality of life in patients with peripheral and central chronic neuropathic pain in Bosnia and Herzegovina. Also, the aim was to monitor the safety of therapy with pregabalin.</p><p><strong>Methods: </strong>The study included patients with neuropathic pain lasting more than 3 months. Based on the underlying disease, patients were divided into 5 groups: DM-patients with diabetes mellitus, M-patients after stroke, D-patients with lower back pain, MS-patients with multiple sclerosis, and P group-patients with spinal cord injury. During the baseline visit, the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) was used to assess neuropathic pain. During two follow-up visits (1.5 and 3 months after baseline), the 36-Item Short-Form Health Survey (SF 36) was used to assess the effectiveness of therapy on quality of life. The safety of the treatment was evaluated by monitoring the incidence of adverse drug reactions.</p><p><strong>Results: </strong>The study included 125 patients. During treatment with pregabalin, there was a statistically significant reduction in pain intensity in the DM, M, D and MS groups. In group P, the decrease in pain intensity was not statistically significant (p = 0.070). There was a significant improvement in different parameters of the quality of life in all analyzed groups, with the most prominent effects in the DM group. The effectiveness of treatment was rated as \"good\" and \"very good\" in more than 70% of subjects in each group. The expected side effects of treatment were recorded in 27.1% of patients in the DM group, in 20.0% in the M group and in 22.2% in the MS group. Unexpected side effects of treatment were observed in one patient (2.1%) in the DM group. Assessment of tolerability of the applied treatment showed \"good\" and \"very good\" response in 68.7% of patients in DM group, 73.3% in M group, 74.5% in D group, 88.9% in MS group and 85.8% in P group.</p><p><strong>Conclusion: </strong>Pregabalin is a safe and effective drug in treatment of neuropathic pain of different etiology.</p>","PeriodicalId":18358,"journal":{"name":"Materia Socio-Medica","volume":"35 1","pages":"42-47"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3e/ef/MSM-35-42.PMC10122530.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9759187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Domestic Violence During Women's Life in Developing Countries. 发展中国家妇女生活中的家庭暴力。
Materia Socio-Medica Pub Date : 2023-03-01 DOI: 10.5455/msm.2023.35.58-64
Christaki Christaki, Orovou Orovou, Dagla Dagla, Sarantaki Sarantaki, Moriati Moriati, Kirkou Kirkou, Antoniou Antoniou
{"title":"Domestic Violence During Women's Life in Developing Countries.","authors":"Christaki Christaki,&nbsp;Orovou Orovou,&nbsp;Dagla Dagla,&nbsp;Sarantaki Sarantaki,&nbsp;Moriati Moriati,&nbsp;Kirkou Kirkou,&nbsp;Antoniou Antoniou","doi":"10.5455/msm.2023.35.58-64","DOIUrl":"https://doi.org/10.5455/msm.2023.35.58-64","url":null,"abstract":"<p><strong>Background: </strong>The lack of information relating to the definitive factors causing domestic violence has resulted in the lack of sound and effective programs; this makes the need for further research in domestic violence more imperative.</p><p><strong>Objective: </strong>The aim of this systematic review is to investigate the factors and impacts of domestic violence in developing countries.</p><p><strong>Methods: </strong>This study is a significant contribution to the existing literature, based on the use of data from the international literature of the last ten years and the evaluation of the degree that the domestic violence affects the lives of women both at an individual as well as a community level. Studies related to the scope of this review from international databases (Google Scholar, PubMed and Scopus) were used. The inclusion criteria comprised studies in English, published between 2012 and 2022 and studies which, apart from the prevalence or types of domestic violence investigated social factors related to violence in women of different ages in developing countries.</p><p><strong>Results: </strong>The results of the study showed that partners-husbands are the main perpetrators of domestic violence. The prevalence of domestic violence ranged between 29.4% and 73.78%, with the highest prevalence observed in Bangladesh.</p><p><strong>Conclusion: </strong>The factors affecting domestic violence were the young age of marriage, the low education level, non-proper execution of household chores, financial issues, patriarchic families, non-proper cooking according to the husband's desire, dowry issues, giving birth to a girl, poverty, women's work but also women's unemployment, other children in the family and their neglect according to the husband, husband's unemployment and the personal experiences of domestic violence for both partners. In addition, significant risk factors were the husband's addiction to substances and the wife's refusal for sex.</p>","PeriodicalId":18358,"journal":{"name":"Materia Socio-Medica","volume":"35 1","pages":"58-64"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/60/a1/MSM-35-58.PMC10122524.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9743698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Genetically Homogeneous or Heterogeneous Population - Distribution of the Recessive Allele in Selected Qualitative Characteristics of Selected Working-Age Population Sample. 遗传上同质或异质的群体——在选定的工作年龄群体样本中选定的质量特征中隐性等位基因的分布。
Materia Socio-Medica Pub Date : 2023-03-01 DOI: 10.5455/msm.2023.35.8-12
Azra Metovic, Jasmin Musanovic, Almira Lujinovic, Esad Pepic, Jelena Prstojevic-Kovacevic
{"title":"Genetically Homogeneous or Heterogeneous Population - Distribution of the Recessive Allele in Selected Qualitative Characteristics of Selected Working-Age Population Sample.","authors":"Azra Metovic,&nbsp;Jasmin Musanovic,&nbsp;Almira Lujinovic,&nbsp;Esad Pepic,&nbsp;Jelena Prstojevic-Kovacevic","doi":"10.5455/msm.2023.35.8-12","DOIUrl":"https://doi.org/10.5455/msm.2023.35.8-12","url":null,"abstract":"<p><strong>Background: </strong>The genetic structure of each population can be explained according to the frequency of genes and their allelic variants, genotypes, and phenotypes.</p><p><strong>Objective: </strong>To analyze the genetic heterogeneity of the working-age population from the area of Sarajevo Canton based on classic genetic markers. The studied parameters of genetic heterogeneity were assessed by the relative frequency of the recessive allele for static-morphological traits (earlobe shape, chin shape, hairiness of the middle digital phalanx, bending of the distal phalanx of the little finger and digital index) and dynamic-morphological traits (rolling of the tongue into a groove, extensibility of the proximal thumb knuckle, extensibility of the distal thumb knuckle, the way the forearms are crossed, and the way the fists are made).</p><p><strong>Results: </strong>The results of the t-test showed a significant difference in the manifestation of the recessive homozygote for the observed parameters of qualitative variation in the subsamples of men and women. Only for two traits (attached earlobe and hyperextensibility of the distal knuckle of the thumb). The selected sample represent a relatively genetically homogenous population.</p><p><strong>Conclusion: </strong>This study serves as a valuable source of data for future research and the formation of a genetic database in Bosnia and Herzegovina.</p>","PeriodicalId":18358,"journal":{"name":"Materia Socio-Medica","volume":"35 1","pages":"8-12"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ec/21/MSM-35-8.PMC10122533.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9743702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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