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AGMATINE ADMINISTRATION ALLEVIATES NERVE DAMAGE AND IMPROVES NERVE FUNCTION IN METHOTREXATE INDUCED PERIPHERAL NEUROPATHY IN RATS 胍丁胺可减轻甲氨蝶呤诱导的周围神经病变大鼠的神经损伤，改善神经功能
Meandros Medical and Dental Journal Pub Date : 2024-09-17 DOI: 10.69601/meandrosmdj.1535051
Hatice Fulya Yılmaz, Özlem Bozkurt Girit
{"title":"AGMATINE ADMINISTRATION ALLEVIATES NERVE DAMAGE AND IMPROVES NERVE FUNCTION IN METHOTREXATE INDUCED PERIPHERAL NEUROPATHY IN RATS","authors":"Hatice Fulya Yılmaz, Özlem Bozkurt Girit","doi":"10.69601/meandrosmdj.1535051","DOIUrl":"https://doi.org/10.69601/meandrosmdj.1535051","url":null,"abstract":"Objective: Chemotherapeutic agents can produce neurodegenerative changes. This study was conducted to assess the therapeutic potential of agmatine, a neuromodulator, on methotrexate induced neurodegeneration in sciatic nerve. Materials and Methods: 40 male Wistar albino rats were assigned into four groups at random as control, methotrexate, agmatine and methotrexate-agmatine. Methotrexate was injected intraperitoneally at a 37.5 mg/kg/week dose for 3 weeks. Afterwards, agmatine was administered intraperitoneally twice a day at a 40 mg/kg dose for 7 days. Sciatic functional index, nociceptive pain perception and behavioral changes were analyzed every week. Nerve conduction velocity was evaluated. Apoptotic activity and mitophagy, histopathological changes in sciatic nerves were examined. Results: Methotrexate administration resulted in a prolonged escape time to the platform and decreased the time spent in the quadrant in the water maze test; elevated nociceptive latencies; decreased the number of frames passed in the open field test; reduced sciatic NCV and SFI score. Besides, methotrexate administration caused a reduction in myelin thickness and axon diameter in sciatic nerve and a more intense glial fibrillary acidic protein immunoreactivity. Methotrexate administration triggered an increase in the Bax/Bcl-2 protein expression ratio without changing the expression level of Parkin, indicating a slight apoptotic activation. agmatine administration improved methotrexate induced changes in behavioral performances, nociceptive pain perception, nerve conduction, SFI scores and histopathological changes. Conclusion: Agmatine has been demonstrated to possess a therapeutic potential in methotrexate induced degeneration and peripheral neuropathy in the rat sciatic nerve.","PeriodicalId":18332,"journal":{"name":"Meandros Medical and Dental Journal","volume":"25 3","pages":"317-336"},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://dergipark.org.tr/en/download/article-file/4153082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147900795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Awareness of Oral and Medical Healthcare Professionals in the Prevention, Diagnosis, and Management of Bisphosphonate-related Osteonecrosis of the Jaw 口腔和医疗保健专业人员对预防、诊断和管理与双膦酸盐相关的颌骨坏死的认识
IF 0.3
Meandros Medical and Dental Journal Pub Date : 2023-12-28 DOI: 10.4274/meandros.galenos.2023.93823
Yasemin Dedeoğlu, İlknur Özenci, Şebnem Dirikan İpçi, G. Cakar, C. Ahmedbeyli
{"title":"Awareness of Oral and Medical Healthcare Professionals in the Prevention, Diagnosis, and Management of Bisphosphonate-related Osteonecrosis of the Jaw","authors":"Yasemin Dedeoğlu, İlknur Özenci, Şebnem Dirikan İpçi, G. Cakar, C. Ahmedbeyli","doi":"10.4274/meandros.galenos.2023.93823","DOIUrl":"https://doi.org/10.4274/meandros.galenos.2023.93823","url":null,"abstract":"","PeriodicalId":18332,"journal":{"name":"Meandros Medical and Dental Journal","volume":"9 4","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139150673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determination of Trichomonas vaginalis Frequency Among Symptomatic Cases in Muğla Sıtkı Koçman Hospital Using Different Methods (Direct Microscopy, Culture, PCR and Immunochromatographic Method) 使用不同方法（直接显微镜检查法、培养法、聚合酶链反应法和免疫层析法）确定穆拉-谢特克-科奇曼医院有症状病例中的阴道毛滴虫感染率
IF 0.3
Meandros Medical and Dental Journal Pub Date : 2023-12-28 DOI: 10.4274/meandros.galenos.2023.04557
F. Sankur, S. Ertuğ, E. Malatyalı, Evren Tileklioğlu, İ. Yıldız, H. Ertabaklar
{"title":"Determination of Trichomonas vaginalis Frequency Among Symptomatic Cases in Muğla Sıtkı Koçman Hospital Using Different Methods (Direct Microscopy, Culture, PCR and Immunochromatographic Method)","authors":"F. Sankur, S. Ertuğ, E. Malatyalı, Evren Tileklioğlu, İ. Yıldız, H. Ertabaklar","doi":"10.4274/meandros.galenos.2023.04557","DOIUrl":"https://doi.org/10.4274/meandros.galenos.2023.04557","url":null,"abstract":"","PeriodicalId":18332,"journal":{"name":"Meandros Medical and Dental Journal","volume":"31 12","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139151540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between Newly Diagnosed Hypertensive Patients’ Dipping Status and Mean Neutrophil Volume 新诊断的高血压患者的浸润状态与平均中性粒细胞体积之间的关系
IF 0.3
Meandros Medical and Dental Journal Pub Date : 2023-12-28 DOI: 10.4274/meandros.galenos.2023.27880
Muhammet Salih Ateş, Muhammed Ulvi Yalçın, A. Tunçez, K. Demir, Nazif Aygül, B. Altunkeser
{"title":"Relationship between Newly Diagnosed Hypertensive Patients’ Dipping Status and Mean Neutrophil Volume","authors":"Muhammet Salih Ateş, Muhammed Ulvi Yalçın, A. Tunçez, K. Demir, Nazif Aygül, B. Altunkeser","doi":"10.4274/meandros.galenos.2023.27880","DOIUrl":"https://doi.org/10.4274/meandros.galenos.2023.27880","url":null,"abstract":"","PeriodicalId":18332,"journal":{"name":"Meandros Medical and Dental Journal","volume":"48 2","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139151246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glycated Albumin and Hba1c for the Diagnosis of Prediabetes in Obese and Non-obese Individuals 糖化白蛋白和 Hba1c 用于诊断肥胖和非肥胖者的糖尿病前期症状
IF 0.3
Meandros Medical and Dental Journal Pub Date : 2023-12-28 DOI: 10.4274/meandros.galenos.2023.25993
R. Abbasov, P. Demır, A. Şenat, T. Çandar, Reyhan Ersoy, leyla didem kozaci
{"title":"Glycated Albumin and Hba1c for the Diagnosis of Prediabetes in Obese and Non-obese Individuals","authors":"R. Abbasov, P. Demır, A. Şenat, T. Çandar, Reyhan Ersoy, leyla didem kozaci","doi":"10.4274/meandros.galenos.2023.25993","DOIUrl":"https://doi.org/10.4274/meandros.galenos.2023.25993","url":null,"abstract":"","PeriodicalId":18332,"journal":{"name":"Meandros Medical and Dental Journal","volume":"24 46","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139148517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differences in the Differential Expression of MicroRNAs Between Patients with Familial Multiple Sclerosis and Those with Sporadic Multiple Sclerosis 家族性多发性硬化症患者与散发性多发性硬化症患者的微RNA表达差异
IF 0.3
Meandros Medical and Dental Journal Pub Date : 2023-12-28 DOI: 10.4274/meandros.galenos.2023.71135
H. Güllüoğlu, Hasan Armağan Uysal, Turan Poyraz, Zekiye Altun, D. Kaya, P. Özçelik, E. İdiman
{"title":"Differences in the Differential Expression of MicroRNAs Between Patients with Familial Multiple Sclerosis and Those with Sporadic Multiple Sclerosis","authors":"H. Güllüoğlu, Hasan Armağan Uysal, Turan Poyraz, Zekiye Altun, D. Kaya, P. Özçelik, E. İdiman","doi":"10.4274/meandros.galenos.2023.71135","DOIUrl":"https://doi.org/10.4274/meandros.galenos.2023.71135","url":null,"abstract":"","PeriodicalId":18332,"journal":{"name":"Meandros Medical and Dental Journal","volume":"1 4","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139150041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Somatic PIK3CA Mutations Detected by Next-generation Sequencing in Breast Cancer Cases 对乳腺癌病例中通过新一代测序检测到的体细胞 PIK3CA 基因突变的评估
IF 0.3
Meandros Medical and Dental Journal Pub Date : 2023-12-28 DOI: 10.4274/meandros.galenos.2023.34356
I. Erdogdu, D. Gürel
{"title":"Evaluation of Somatic PIK3CA Mutations Detected by Next-generation Sequencing in Breast Cancer Cases","authors":"I. Erdogdu, D. Gürel","doi":"10.4274/meandros.galenos.2023.34356","DOIUrl":"https://doi.org/10.4274/meandros.galenos.2023.34356","url":null,"abstract":"","PeriodicalId":18332,"journal":{"name":"Meandros Medical and Dental Journal","volume":"16 6","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139151644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fractal Analysis of Nuclear Architecture in Oral Squamous Cell Carcinoma by Using Transmission Electron Microscopy: An Original Research 利用透射电子显微镜对口腔鳞状细胞癌的核结构进行分形分析：一项原创研究
IF 0.3
Meandros Medical and Dental Journal Pub Date : 2023-12-28 DOI: 10.4274/meandros.galenos.2023.33349
Supraja Salwaji, A. Ananthaneni, P. Kuberappa, B. Bagalad, M. Pasupuleti, V. Guduru
{"title":"Fractal Analysis of Nuclear Architecture in Oral Squamous Cell Carcinoma by Using Transmission Electron Microscopy: An Original Research","authors":"Supraja Salwaji, A. Ananthaneni, P. Kuberappa, B. Bagalad, M. Pasupuleti, V. Guduru","doi":"10.4274/meandros.galenos.2023.33349","DOIUrl":"https://doi.org/10.4274/meandros.galenos.2023.33349","url":null,"abstract":"","PeriodicalId":18332,"journal":{"name":"Meandros Medical and Dental Journal","volume":"33 5","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139149898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Cross-sectional View of Rational Antibiotic Use 合理使用抗生素的横断面视图
IF 0.3
Meandros Medical and Dental Journal Pub Date : 2023-12-28 DOI: 10.4274/meandros.galenos.2023.76993
Güliz Uyar Güleç, Gözde Çetinkaya
{"title":"A Cross-sectional View of Rational Antibiotic Use","authors":"Güliz Uyar Güleç, Gözde Çetinkaya","doi":"10.4274/meandros.galenos.2023.76993","DOIUrl":"https://doi.org/10.4274/meandros.galenos.2023.76993","url":null,"abstract":"","PeriodicalId":18332,"journal":{"name":"Meandros Medical and Dental Journal","volume":"30 43","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139148244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Periodontal Disease on Sleep Quality and Oral Health-related Quality of Life 牙周病对睡眠质量和口腔健康相关生活质量的影响
IF 0.3
Meandros Medical and Dental Journal Pub Date : 2023-12-28 DOI: 10.4274/meandros.galenos.2022.46873
R. S. Konathala, S. Gottumukkala, Kumar Pasupuleti Mohan, Swetha Pasupuleti, Bodedda Anusha, Gautami Penmetsa, Keerthi Vinnakota
{"title":"Impact of Periodontal Disease on Sleep Quality and Oral Health-related Quality of Life","authors":"R. S. Konathala, S. Gottumukkala, Kumar Pasupuleti Mohan, Swetha Pasupuleti, Bodedda Anusha, Gautami Penmetsa, Keerthi Vinnakota","doi":"10.4274/meandros.galenos.2022.46873","DOIUrl":"https://doi.org/10.4274/meandros.galenos.2022.46873","url":null,"abstract":"","PeriodicalId":18332,"journal":{"name":"Meandros Medical and Dental Journal","volume":"52 39","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139151056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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