Malaria Journal最新文献

{"title":"Determinants of malaria infection among under five children in Gursum district of Somali region, Eastern Ethiopia.","authors":"Dejene Edessa Gobe, Ahmed Mohammed, Abdurezak Adem, Kebede Deribe, Afona Chernet, Solomon Yared","doi":"10.1186/s12936-024-05206-4","DOIUrl":"https://doi.org/10.1186/s12936-024-05206-4","url":null,"abstract":"<p><strong>Background: </strong>Despite significant efforts to control malaria infections in recent years, new infection rates continue to pose a major public health challenge in sub-Saharan Africa, including Ethiopia. This study aims to identify the key factors of malaria infection among children under five years (U5) in the Gursum district of Somali region, Eastern Ethiopia.</p><p><strong>Methods: </strong>An institution-based case-control study was conducted over two months, from June to July 2020. The study included 247 participants, divided into 82 cases and 165 controls, with a case-to-control ratio of 1:2. It focused on households with children under the age of five who received care at three health centers within the district. The investigation involved identifying Plasmodium species using rapid diagnostic tests and microscopic blood film examination. A logistic regression model was employed to analyze the factors affecting the outcome, using statistical software STATA-13/15. Odds ratios and the corresponding confidence intervals were calculated to identify potential predictors in the logistic regression model.</p><p><strong>Results: </strong>A multivariate analysis identified five exposures significantly associated with malaria positivity among children: living near a source of water [adjusted odds ratio (AOR) = 3.60 (1.73-7.48)], residing in rural areas [AOR = 3.58 (1.56-8.21)], living in houses with openings or holes in the walls that facilitate mosquito entry [AOR = 5.00 (2.22-11.28)], and not receiving malaria health information [AOR = 2.12 (1.06-4.21)]. Additionally, proximity to malaria vector breeding habitats [AOR = 4.74 (2.27-9.90)] was significant for malaria positivity. These five factors emerged as the primary determinants of malaria positivity among U5 children in the Gursum district.</p><p><strong>Conclusion: </strong>The study indicates that critical factors contributing to malaria positivity among U5 children in the Gursum district are related to a lack of awareness, housing conditions, and proximity to vector breeding sites. Therefore, social mobilization and targeted malaria interventions at the community level are essential for reducing disease transmission, particularly among the most vulnerable children.</p>","PeriodicalId":18317,"journal":{"name":"Malaria Journal","volume":"23 1","pages":"393"},"PeriodicalIF":2.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Willingness to pay for a mosquito bite prevention 'forest pack' in Cambodia: results of a discrete choice experiment.","authors":"Joshua Yukich, Dyna Doum, David J McIver, Jason H Richardson, Siv Sovannanoroth, Neil F Lobo, Allison Tatarsky","doi":"10.1186/s12936-024-05224-2","DOIUrl":"https://doi.org/10.1186/s12936-024-05224-2","url":null,"abstract":"<p><strong>Background: </strong>Progress towards malaria elimination in the Greater Mekong Subregion has left much of the residual malaria transmission concentrated among forest-exposed populations for whom traditional domicile focused malaria vector control is unlikely to be effective. New tools to protect these populations from vector biting outdoors are needed.</p><p><strong>Methods: </strong>Alongside implementation research on the deployment of a \"forest pack\" consisting of a volatile pyrethroid (transfluthrin)-based spatial repellent (VPSR), a picaridin-based topical repellent and etofenprox treatment of clothing, an assessment was made of participant willingness to pay for the forest packs and variants of the packs using a discrete choice experiment.</p><p><strong>Results: </strong>Participants showed willingness to pay for forest packs consistent with full-cost recovery for VPSR devices. The inclusion of a full malaria season's worth of VPSR devices increased the willingness to pay for a forest pack by 15% (p = 0.061). At a price of approximately 10 USD, approximately 50% of participants were willing to pay for a forest pack which included a full season's worth of VPSR.</p><p><strong>Conclusion: </strong>Forest packs which include VPSR are likely to be acceptable to the target forest-exposed populations, and those which include VPSR products may even have potential for commercial sales or some cost-recovery.</p>","PeriodicalId":18317,"journal":{"name":"Malaria Journal","volume":"23 1","pages":"392"},"PeriodicalIF":2.4,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilot introduction of long-lasting insecticidal nets and hammock nets in the indigenous Comarca of Guna Yala, Panama.","authors":"A Oscar E González, Carmen Perez, Tania Blanco, Cipriano Ayarza, Santiago Chérigo, Mario Ávila, Lucía Fernández Montoya, Nicholas A Presley, Bernardo García Espinosa, Mariela Mosquera Renteria","doi":"10.1186/s12936-024-05208-2","DOIUrl":"https://doi.org/10.1186/s12936-024-05208-2","url":null,"abstract":"<p><strong>Background: </strong>After almost 70 years of using indoor residual spraying (IRS) as the primary intervention for malaria vector control, the Republic of Panama wanted to evaluate the operational feasibility and acceptability of distributing long-lasting insecticidal hammock nets (LLIHNs) and long-lasting insecticidal nets (LLINs) in the country.</p><p><strong>Methods: </strong>A pilot study conducted in 2019 distributed LLINs and LLIHNs to cover all sleeping spaces in 15 high burden localities of the indigenous Comarca of Guna Yala and measured retention, coverage, use and physical deterioration, washing and drying practices, as well as people's satisfaction with product characteristics post-distribution.</p><p><strong>Results: </strong>Overall, 89.9% of enumerated sleeping spaces were covered during the campaign. Monitoring post-distribution showed that 82.7% of the population received messages about the campaign before it happened and 92.4% claimed to know the purpose of the net and how to care for and repair it. Mild adverse reactions, specifically skin irritation associated with the insecticide in LLINs and LLIHNs, were reported by 38.4% of households. Two years after distribution, 86.3% of the LLIHN/LLINs were retained. Use was very high right after distribution (85%) but decreased to 57% six months after distribution and to 38% two years after distribution. The main reason for not using the LLIHN/LLINs was the reported absence of mosquitoes. Two years post-distribution, LLIHN/LLINs were preserved in good physical condition (4% torn), very few were washed with insecticide-damaging products (chlorine or detergent) (9%) or dried under the sun (15%), and LLIHN/LLINs were washed on average less than once every two months. The average number of people per sleeping space was 1.34.</p><p><strong>Conclusion: </strong>Although the distribution of LLIHN/LLINs was operationally feasible and LLIHN/LLINs were initially well-accepted and cared for by these communities, use decreased drastically over the two years of follow up after distribution. Hence, should there be future LLIHN/LLIN distributions in this area, sufficient resources and efforts need to be allocated to promoting LLIHN/LLIN use. Further investigation into the reasons for low LLIHN/LLIN use are needed to guide such efforts.</p>","PeriodicalId":18317,"journal":{"name":"Malaria Journal","volume":"23 1","pages":"383"},"PeriodicalIF":2.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasmodium falciparum and Schistosoma mansoni coinfections among the general population in Ethiopia: a systematic review and meta-analysis.","authors":"Abebaw Setegn, Gashaw Azanaw Amare, Wagaw Abebe, Wassie Alemayehu Damtie, Gebremariam Wulie Geremew, Abaynesh Fentahun Bekalu, Tekletsadik Tekleslassie Alemayehu, Fentahun Megabiaw, Yenesew Mihret Wondmagegn, Zufan Yiheyis Abriham, Yilkal Abebaw Wassie, Getasew Kibralew, Getu Girmay, Muluneh Assefa, Berihun Agegn Mengistie","doi":"10.1186/s12936-024-05192-7","DOIUrl":"https://doi.org/10.1186/s12936-024-05192-7","url":null,"abstract":"<p><strong>Background: </strong>Due to the overlapping endemic regions and the high burden of both infections, coinfection with Plasmodium falciparum and Schistosoma mansoni poses distinct public health concerns that require coordinated, multifaceted interventions. There are epidemiological studies on the coinfection of these two parasites in Ethiopia, and the results differ and are inconsistent from one region to another. Thus, the goal of this systematic review and meta-analysis was to ascertain Ethiopia's pooled prevalence of P. falciparum and S. mansoni coinfection.</p><p><strong>Methods: </strong>The preferred reporting item review and meta-analysis guidelines were followed in this study. PubMed, Google Scholar, Research4Life, Scopus, African-Wider, and EMBASE were the primary search databases. The final analysis included six studies in total. Stata software version 11 was used for analysis after Microsoft Excel was used to extract the data. The critical appraisal tool developed by the Joanna Briggs Institute was used to evaluate the methodological quality of the studies. Publication bias was checked via a funnel plot, Begg's test, and Egger's test. The pooled prevalence of P. falciparum and S. mansoni coinfection was estimated via a random effect model via the Der Simonian-Laird method. The heterogeneity of the studies was evaluated via I² statistical tests.</p><p><strong>Results: </strong>The pooled prevalence of P. falciparum and S. mansoni coinfections in Ethiopia was 10.496% (95% CI 6.134, 14.859). Subgroup analysis of geopolitical regions revealed that the highest and lowest pooled prevalence rates of coinfection were 11.808% (95% CI 0.304, 23.312) and 8.600% (95% CI 5.755, 11.445), respectively, in the Amhara and Benishangul Gumuz regions.</p><p><strong>Conclusions: </strong>This study highlights the substantial prevalence of P. falciparum and S. mansoni coinfection in Ethiopia's general population, with considerable geographical variation. Targeted and intensive public health interventions are necessary because it has the highest incidence in the Amhara region, and ongoing efforts are needed to address the relatively lower but still considerable prevalence in the Benishangul Gumuz region. These results direct future research, integrated control strategy design, and resource allocation to successfully manage Ethiopia's combined burden of malaria and schistosomiasis.</p>","PeriodicalId":18317,"journal":{"name":"Malaria Journal","volume":"23 1","pages":"382"},"PeriodicalIF":2.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing under-five mortality in Tanzania: insights from a 60-years data analysis on economic and health indicators.","authors":"Mohamed K Mwanga, Silas Mirau, Jean M Tchuenche, Isambi S Mbalawata","doi":"10.1186/s12936-024-05213-5","DOIUrl":"https://doi.org/10.1186/s12936-024-05213-5","url":null,"abstract":"<p><strong>Background: </strong>Under-five mortality in Tanzania remains a persistent issue, significantly affecting both the health and economic sectors. Despite various interventions, the under-five mortality rate (U5MR) remains high, impeding progress toward global health targets. This study investigates the factors influencing under-five mortality in Tanzania, focusing on the gross domestic product (GDP), malaria incidence, access to water, and access to sanitation.</p><p><strong>Methods: </strong>The study employed data sets for Tanzania U5MR, GDP, access to water and sanitation, and malaria incidences from the World Bank for the years 1960-2020. Missing values are generated through the linear trend at point method. To analyses the data, correlation analysis and Bayesian linear regression are employed.</p><p><strong>Results: </strong>The analysis reveals significant relationships between the gross domestic product (GDP), malaria incidence, access to water, access to sanitation and under-five mortality. Furthermore, an increase in malaria incidences increase under-five mortality by 0.14 (14%), while access to water and sanitation exhibit an uncertain relationship. On the other hand, results show that an increase in the GDP lowers the likelihood of U5MR.</p><p><strong>Conclusion: </strong>These findings underscore the importance of economic development and public health interventions in reducing the child mortality rate. The study provides valuable insights for policymakers aiming to achieve Sustainable Development Goal (SDG) Target 3.2 by 2030, which aims for all countries to accomplish U5MR of 25 or less deaths per 1000 live births. By highlighting the relationships between these variables, the study contributes practical evidence to support efforts towards SDG 3.2, emphasizing the need for targeted interventions in both health and infrastructure sectors.</p>","PeriodicalId":18317,"journal":{"name":"Malaria Journal","volume":"23 1","pages":"378"},"PeriodicalIF":2.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of novel mosquito bite prevention tools on Anopheles minimus landing and key secondary endpoints: semi-field evaluations in Thailand.","authors":"Élodie A Vajda, Amanda Ross, Manop Saeung, Arissara Pongsiri, David J McIver, Allison Tatarsky, Nakul Chitnis, Jeffrey Hii, Jason H Richardson, Michael Macdonald, Sarah J Moore, Neil F Lobo, Theeraphap Chareonviriyaphap, Alongkot Ponlawat","doi":"10.1186/s12936-024-05188-3","DOIUrl":"https://doi.org/10.1186/s12936-024-05188-3","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The Greater Mekong Subregion (GMS) aims to eliminate all human malaria by 2030 and is making substantial progress toward this goal, with malaria increasingly confined to forest foci. These transmission foci are predominantly inhabited by ethnic minorities, local populations, and rural mobile and migrant populations working in mining and agriculture. The recommendations of the World Health Organization (WHO) on malaria elimination states that small population groups which constitute a large proportion of the malaria transmission reservoir should benefit from targeted strategies to reduce transmission overall. These population groups are exposed to malaria vector bites during the day due to Anopheles daytime biting, and during the night, due to low bed net use and open sleeping structures. Such characteristics limit the effectiveness of the WHO core vector control strategies [indoor residual spraying (IRS), insecticide-treated nets (ITNs)], which target indoor resting and indoor feeding mosquitoes. Interventions that target daytime and outdoor resting or biting mosquitoes, and which complement IRS and ITNs and drug strategies, may hasten a decline in the malaria burden.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study evaluated two transfluthrin- and one metofluthrin-based volatile pyrethroid spatial repellents (VPSRs), and etofenprox insecticide-treated clothing (ITC) with and without a topical repellent in a semi-field system (SFS) at two research sites in Thailand, across two trial rounds. The study estimated the protective efficacies of the vector control tools against two pyrethroid-susceptible Anopheles minimus strains in the form of 15 interventions, including a combined VPSR and ITC intervention. The interventions' modes of action were studied by measuring their impact on mosquito landing, and on key life history traits known to affect vectoral capacity (knockdown, post-exposure blood feeding, and 24-h mortality) using a block-randomized crossover design. The odds ratio (OR) for each intervention compared to the control on each outcome was estimated.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;All interventions substantially reduced An. minimus landings and prevented more than 50% mosquito landings when new (VPSRs) or unwashed (treated clothing). In addition to landing reduction, all interventions decreased post-exposure blood feeding, induced knockdown and increased mortality at 24 h. The VPSR interventions were generally more protective against landing than the treated clothing intervention. The combined intervention (VPSR + ITC) provided the greatest protection overall.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This SFS evaluation indicates an effect of these VPSR and ITC interventions in reducing An. minimus landing for the user, and indicates their potential for community protection by secondary modes of action. This study demonstrates the utility of SFS trials in the evaluation of bite prevention tools and emphasizes the need f","PeriodicalId":18317,"journal":{"name":"Malaria Journal","volume":"23 1","pages":"387"},"PeriodicalIF":2.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of caregiver's malaria-related knowledge on the use of insecticide-treated net among children under-five: a cross-sectional study.","authors":"Emmanuel Kumah","doi":"10.1186/s12936-024-05203-7","DOIUrl":"https://doi.org/10.1186/s12936-024-05203-7","url":null,"abstract":"<p><strong>Background: </strong>Malaria remains a critical public health challenge globally, particularly in sub-Saharan Africa where it significantly contributes to morbidity and mortality among children under-five. In Ghana, efforts to promote the use of insecticide-treated nets (ITNs) as a preventive measure have been substantial but utilization rates remain suboptimal. This study examines the influence of caregivers' malaria-related knowledge on ITN use among children under the age of five years in a rural district of Ghana.</p><p><strong>Methods: </strong>A community-based cross-sectional study was conducted in the Ahafo Ano South West District, Ghana, between June and October 2023. A total of 442 caregivers (mothers) of children under-five were selected using a two-stage sampling process. Data were collected through structured interviews and analysed using bivariate and multivariable logistic regression models to determine the association between caregivers' malaria-related knowledge and ITN use among children.</p><p><strong>Results: </strong>Out of 442 caregivers, 436 (98.6%) completed the survey. ITN use among children under-five the night before the survey was reported by 73.8% of caregivers. Overall, 36.8% of caregivers had good malaria-related knowledge, 41.2% had satisfactory knowledge, and 21.9% had poor knowledge. Multivariable analysis showed that caregivers with good malaria-related knowledge were 12 times more likely to use ITNs for their children (AOR = 12.06, 95% CI 2.30-53.20) compared to those with poor knowledge. Other significant predictors included education on ITN use, ITN ownership, child's age, and use of alternative malaria prevention methods.</p><p><strong>Conclusion: </strong>This study highlights the critical role of caregiver malaria-related knowledge in promoting ITN use among children under-five in rural Ghana. Caregivers with better knowledge were significantly more likely to use ITNs, emphasizing the need for targeted health education programs. Such interventions should enhance awareness of malaria risks and ITN benefits, empower caregivers to use ITNs effectively, and reduce barriers to ITN access. These findings provide valuable insights for policymakers aiming to improve ITN utilization and reduce malaria morbidity and mortality in vulnerable populations.</p>","PeriodicalId":18317,"journal":{"name":"Malaria Journal","volume":"23 1","pages":"374"},"PeriodicalIF":2.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The status of insecticide resistance of Anopheles coluzzii on the islands of São Tomé and Príncipe, after 20 years of malaria vector control.","authors":"Maria Correa, Janete Lopes, Carla A Sousa, Gustavo Rocha, Robin Oriango, Andreia Cardetas, Joao Viegas, Anthony J Cornel, Gregory C Lanzaro, João Pinto","doi":"10.1186/s12936-024-05212-6","DOIUrl":"https://doi.org/10.1186/s12936-024-05212-6","url":null,"abstract":"<p><strong>Background: </strong>Insecticide-based malaria vector control has been implemented on the islands of São Tomé and Príncipe (STP) for more than 20 years. During this period malaria incidence was significantly reduced to pre-elimination levels. While cases remained low since 2015, these have significantly increased in the last year, challenging the commitment of the country to achieve malaria elimination by 2025. To better understand the reasons for increasing malaria cases, levels and underlying mechanisms of insecticide resistance in the local Anopheles coluzzii populations were characterized.</p><p><strong>Methods: </strong>Mosquito larval collections were performed in the rainy and dry seasons, between 2022 and 2024, in two localities of São Tomé and one locality in Príncipe. Susceptibility to permethrin, α-cypermethrin, pirimiphos-methyl and DDT was assessed using WHO bioassays and protocols. Intensity of resistance and reversal by PBO pre-exposure were determined for pyrethroid insecticides. The kdr locus was genotyped by PCR assays in subsamples of the mosquitoes tested.</p><p><strong>Results: </strong>Anopheles coluzzii populations were fully susceptible to pirimiphos-methyl, but high levels of resistance to pyrethroids and DDT were detected, particularly in São Tomé rainy season collections. Increasing the pyrethroid and DDT dosages to 5 <math><mo>×</mo></math> and 10 <math><mo>×</mo></math> did not restore full susceptibility in all populations. Pre-exposure to PBO resulted into partial reversal of the resistance phenotype suggesting the presence of cytochrome P450 oxidases-mediated metabolic resistance. The L1014F knockdown resistance mutation was present in An. coluzzii on both islands but at much higher frequency in São Tomé where it was associated with the resistant phenotype.</p><p><strong>Conclusions: </strong>Future vector control interventions should consider the use of non-pyrethroid insecticides or combination with synergists to overcome the high levels of pyrethroid resistance. Alternative control methods not dependent on the use of insecticides should be additionally implemented to achieve malaria elimination in STP.</p>","PeriodicalId":18317,"journal":{"name":"Malaria Journal","volume":"23 1","pages":"390"},"PeriodicalIF":2.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of surveillance data in detecting malaria outbreaks in an epidemic-prone region in Kenya: findings from an investigation of a suspected outbreak in Nandi County.","authors":"Geoffrey Kongo Githinji, Fredrick Ouma Odhiambo, Clara Muyaku Andala, Daniel Chepkwony, James Kibet Sang, Maurice Owiny, Japhet Ruto, Elvis Omondi Oyugi, Fredrick Odhiambo","doi":"10.1186/s12936-024-05216-2","DOIUrl":"https://doi.org/10.1186/s12936-024-05216-2","url":null,"abstract":"<p><strong>Background: </strong>Approximately 70% of the Kenyan population is at risk for malaria, including 19 million people in highland epidemic-prone and seasonal transmission areas. Surveillance data showed a 288% increase in malaria cases and an incidence rate of 10.5 per 1000 population between January and May 2021 in Nandi County. We investigated the increased incidence of malaria in Nandi County.</p><p><strong>Methods: </strong>We abstracted demographic and clinical data from the laboratory register in health facilities with high malaria burden. Key informant interviews using a structured questionnaire collected healthcare worker perceptions on malaria interventions and personnel capacity. We calculated means and medians for continuous variables and frequency and proportions for categorical variables. Data quality assessment (DQA) was conducted to evaluate timeliness and completeness, data accuracy, and overall system assessment.</p><p><strong>Results: </strong>We reviewed 19,526 records from 12 health facilities. Females contributed 61% cases (11,862). A majority of cases, 21% (4111), were between the age group 15-24 years. Of the 19,498 tested, 2662 tested positive (test positivity rate, TPR = 13.7%). Microscopy accounted for 39% (1041) and RDT for 61% (1620) of tests conducted, with some patients being double tested using both tests. Kapsabet County Referral contributed 26% (5051) suspected cases, TPR 3.2%, and Chemase Health Centre TPR was 33.2%. Facilities experienced major RDTs stock-outs in the preceding 3 months while three (30%) of the 10 facilities assessed conducted laboratory Internal Quality Control (IQC) programmes. Of the 12 facilities assessed, four (33%) facilities had an over-reporting of suspected cases in the monthly summary, while three (25%) facilities were over-reported in the online tool. On reporting confirmed malaria cases, over-reporting was noted in three (25%) facilities in both the monthly summaries and the online tool. Data completeness was 77% and timeliness 93%.</p><p><strong>Conclusion: </strong>The increase in malaria cases in Nandi County displayed a seasonal pattern that coincided with either the long or short rainy seasons, the investigation did not reveal an active outbreak at the time of the inquiry. Sub-county hospitals in Tinderet and Aldai sub-counties had malaria cases exceeding both the alert and action thresholds at specific times during the year under review, suggesting a potential occurrence of unidentified outbreaks, while several other facilities had an increase of cases reaching alert thresholds, indicating upsurges. In healthcare settings, we noted there were problems with data quality. We advised routine data review, analysis, and feedback; mentorships for data analysis and on the job and support supervision; mentorships for malaria diagnosis; and installation of laboratory quality assurance.</p>","PeriodicalId":18317,"journal":{"name":"Malaria Journal","volume":"23 1","pages":"372"},"PeriodicalIF":2.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review of evidence for the impact and effectiveness of the 1-3-7 strategy for malaria elimination.","authors":"Nihal Sogandji, Anna Stevenson, Michael Y Luo, Gao Qi, Richard J Maude","doi":"10.1186/s12936-024-05200-w","DOIUrl":"https://doi.org/10.1186/s12936-024-05200-w","url":null,"abstract":"<p><strong>Background: </strong>The 1-3-7 approach to eliminate malaria was first implemented in China in 2012. It has since been expanded to multiple countries, but no systematic review has examined the evidence for its use. A systematic review was conducted aiming to evaluate the impact and effectiveness of the strategy and identify key challenges and variations in its implementation across different countries.</p><p><strong>Methods: </strong>PUBMED, Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, CABS Abstracts, LILACS, Global Health, Medrxiv, Biorxiv were searched for all studies containing 1-3-7 and articles included if they contained information on 1-3-7 impact, effectiveness, challenges and/or adaptations for implementation in different countries.</p><p><strong>Results: </strong>31 studies were included from China (19), Thailand (6), Myanmar (2), Tanzania (1), Cambodia (1), India (1) and Vietnam (1). During 1-3-7 implementation, malaria cases in China decreased by 99.1-99.9%, in Thailand by 66.9% during 2013-19, 65,1% in Cambodia during 2015-17 and 30.3% in India during 2015-16, with some differences in implementation. It was not possible to separate the impact of 1-3-7 from that due to other contemporaneous interventions. Implementing the 1-3-7 policy was largely effective, with reporting within 1 day in 99.8-100% of individuals in China and 36-100% in other countries, investigation within 3 days in 81.5-99.4% in China and 79.4-100% in other countries, and foci investigation within 7 days in 90.1-100% in China and 83.2-100% in other countries. Adaptations to 1-3-7 were described in 5 studies, mostly adjustment of the timing and/or definitions of each component. Key challenges identified included those related to staffing, equipment, process, and patient-provided information.</p><p><strong>Conclusion: </strong>Overall, the 1-3-7 approach was effectively implemented with a concomitant decrease in cases in malaria elimination settings, however, it was not possible to quantify impact as it was not implemented in isolation. Implementing adequate measures for testing, reporting, treatment, and containment is crucial for its success, which is dependent on the availability of resources, infrastructure, staffing, and consistent compliance across regions and throughout the year. However, achieving this nationally and maintaining compliance, especially at borders with malaria-affected countries, poses significant challenges.</p>","PeriodicalId":18317,"journal":{"name":"Malaria Journal","volume":"23 1","pages":"371"},"PeriodicalIF":2.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}