MatSciRN: Computational Studies of Inorganic & Organic Materials (Topic)最新文献_第2页

R11 Peptides Can Promote the Molecular Imaging of Spherical Nucleic Acids for the Bladder Cancer Margin Identification R11肽可促进球形核酸分子成像用于膀胱癌边缘鉴别

MatSciRN: Computational Studies of Inorganic & Organic Materials (Topic) Pub Date : 2021-04-14 DOI: 10.2139/ssrn.3825979

Minghai Ma, Pu Zhang, Xiao Liang, D. Cui, Qiuya Shao, Haibao Zhang, Mengzhao Zhang, Tao Yang, Lu Wang, Nan Zhang, Minxuan Jing, Lu Zhang, Weichao Dan, Rundong Song, Xi Liu, Jiatao Hao, Yuhang Chen, Lijiang Gu, Lei Wang, Jinhai Fan

{"title":"R11 Peptides Can Promote the Molecular Imaging of Spherical Nucleic Acids for the Bladder Cancer Margin Identification","authors":"Minghai Ma, Pu Zhang, Xiao Liang, D. Cui, Qiuya Shao, Haibao Zhang, Mengzhao Zhang, Tao Yang, Lu Wang, Nan Zhang, Minxuan Jing, Lu Zhang, Weichao Dan, Rundong Song, Xi Liu, Jiatao Hao, Yuhang Chen, Lijiang Gu, Lei Wang, Jinhai Fan","doi":"10.2139/ssrn.3825979","DOIUrl":"https://doi.org/10.2139/ssrn.3825979","url":null,"abstract":"One of the critical problems in bladder cancer (BC) management is local recurrence of disease. However, achieving accurate delineation of tumor margins intraoperatively remains extremely difficult due to the lack of effective tumor margin recognition technology. Herein, survivin molecular beacon (MB) and R11 peptides-linked spherical mucleic acids (SNAs) were synthesized as a nanoprobe (AuNP-MB@R11) for sensitive detection of BC margins. Physicochemical Properties proved that R11 peptides and survivin MB were successfully loaded onto the surface of SNAs. The AuNP-MB@R11 had good stability against nuclease, high sensitivity and specificity to detect survivin ssDNA in vitro experiment. In cytology, R11 peptides could increase BC targeting ability and membrane penetrability of SNAs. Notably, R11 peptides can significantly promote the disintegration of lysosome and release of SNAs to enhance the fluorescence imaging quality. The further RNA sequencing proved that some genes related with endocytosis and lysosome regulated significantly, such as AGPAT5, GPD1L, TREX1 and APEX1. In orthotopic BC models and a clinical sample from patient with BC, AuNP-MB@R11 showed a more legible cancerous fluorescence margin and offered remarkably improved detection effects compared to those achieved by SNAs. Thus, R11 peptides-linked SNAs presented a promising potential to identify the BC margin, which may help to improve the R0 resection rate in surgery and improve patient’s quality of life.","PeriodicalId":18279,"journal":{"name":"MatSciRN: Computational Studies of Inorganic & Organic Materials (Topic)","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77980928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Radiation Damage and Thermal Annealing in Tunnel Structured Hollandite Materials 隧道结构荷兰石材料的辐射损伤与热退火

MatSciRN: Computational Studies of Inorganic & Organic Materials (Topic) Pub Date : 2021-03-01 DOI: 10.2139/ssrn.3693589

Mingyang Zhao, Eric C. O’Quinn, N. Birkner, Yun Xu, M. Lang, K. Brinkman

{"title":"Radiation Damage and Thermal Annealing in Tunnel Structured Hollandite Materials","authors":"Mingyang Zhao, Eric C. O’Quinn, N. Birkner, Yun Xu, M. Lang, K. Brinkman","doi":"10.2139/ssrn.3693589","DOIUrl":"https://doi.org/10.2139/ssrn.3693589","url":null,"abstract":"Abstract Three tunnel structured hollandite samples (Cs1.33Ga1.33Ti6.67O16, Cs1.33Fe1.33Ti6.67O16, and Cs1.33Zn0.67Ti7.33O16) with demonstrated thermodynamic stability and chemical durability were synthesized and irradiated by a 1.1 GeV Au ion beam in order to study effects of B-site dopants on radiation stability. A crystalline-to-amorphous transformation induced by the high-energy ion irradiation was confirmed by complementary characterization techniques sensitive to different length-scales, such as powder X-ray diffraction, Raman spectroscopy and neutron total scattering. High-temperature oxide melt solution calorimetry was performed to determine the energy landscape before and after ion irradiation. Together, structural and thermodynamic analyses demonstrated distinctly different radiation responses of the hollandite with different B-site dopants; the Ga-substituted hollandite exhibited the smallest enthalpy of damage indicating the best radiation stability among the three samples. The hypothesized origin of the different radiation responses is the structural feature in the binary oxide form of the respective B-site dopants (e.g., Ga2O3 versus Fe2O3/ZnO for Ga and Fe/Zn dopants, respectively). Moreover, thermal analysis (i.e., differential scanning calorimetry) was conducted to investigate structural changes from the irradiation induced damaged states after thermal annealing. Results of thermal analysis revealed that the annealing-induced structural evolution of the radiation damaged hollandite structure is complex and decoupled at different length-scales. The long-range periodic structure (nanometers) was not recovered after thermal annealing and structural changes over a shorter range (≤ ∼3 A) occurred in multiple steps during the annealing process.","PeriodicalId":18279,"journal":{"name":"MatSciRN: Computational Studies of Inorganic & Organic Materials (Topic)","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76378788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Electrochemical Ammonia Synthesis from Nitrite Assisted by In-Situ Generated Hydrogen Atoms on Nickel Phosphide Catalyst 在磷化镍催化剂上原位生成氢原子辅助亚硝酸盐电化学合成氨

MatSciRN: Computational Studies of Inorganic & Organic Materials (Topic) Pub Date : 2021-02-24 DOI: 10.2139/ssrn.3792502

Xiao Yang, Lei Kang, Chuan-Jun Wang, Fulai Liu, Yong Chen

引用次数: 7

An Analysis of Effect of Water Hyacinth Carbonization Temperature on Fabrication and EMI Shielding Radar 水葫芦炭化温度对电磁干扰屏蔽雷达制作及屏蔽效果的影响分析

MatSciRN: Computational Studies of Inorganic & Organic Materials (Topic) Pub Date : 2021-02-10 DOI: 10.15587/1729-4061.2021.224219

A. M. Imammuddin, S. Suparman, W. Suprapto, A. A. Sonief

{"title":"An Analysis of Effect of Water Hyacinth Carbonization Temperature on Fabrication and EMI Shielding Radar","authors":"A. M. Imammuddin, S. Suparman, W. Suprapto, A. A. Sonief","doi":"10.15587/1729-4061.2021.224219","DOIUrl":"https://doi.org/10.15587/1729-4061.2021.224219","url":null,"abstract":"The need to increase the ability of water hyacinth composites as EMI radar protection is related to the carbonization process of organic materials. This research aimed to determine the effect of water hyacinth carbonization temperature on the effectiveness of fabrication and EMI shielding radar. The research method includes the preparations such as cutting, washing, and drying the water hyacinth. The drying process is carried out using an oven with a temperature of 70 °C for 4 days. Then the water hyacinth is mashed until it reaches the 80 mesh size. Then the carbonization process is carried out, with variations in carbonization temperature ranging from 500 °C, 600 °C, 700 °C, 800 °C, 900 °C and 1,000 °C, with a heat increase speed of 3 °C/minutes. After reaching the specified temperature, a holding time is then carried out for 1 hour. Furthermore, the composite composition of 30 % water hyacinth activated carbon powder and 70 % phenol-formaldehyde (PF) resin was molded using a hot press with a pressure of 300 kg/cm2 at 180 °C for 10 minutes. The results showed that the water hyacinth composite could be used as an EMI protection material at the X-Band frequency (8–12.5 GHz). Where the electrical conductivity and EMI SE increases with increasing carbonization temperature. Water hyacinth composites at a carbonization temperature of 1,000 °C showed the highest electrical conductivity and the highest EMI SE, respectively 4.64∙10-2 S/cm and 41.15 dB (attenuation 99.99 %) at a frequency of 8 GHz. The high absorption contribution is associated with the synergy combination of KCl and the pore structure of the goitre. KCl contributes to the magnetic properties and pore structure with high electrical conductivity values.","PeriodicalId":18279,"journal":{"name":"MatSciRN: Computational Studies of Inorganic & Organic Materials (Topic)","volume":"317 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80133829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three-Dimensional Printed Mulberry Anthocyanin Combined with Chitosan/Hydroxyethyl Cellulose Bilayer Films for Quality Preservation of Litchi 三维打印桑花青素复合壳聚糖/羟乙基纤维素双层膜在荔枝品质保鲜中的应用

MatSciRN: Computational Studies of Inorganic & Organic Materials (Topic) Pub Date : 2021-01-01 DOI: 10.2139/ssrn.3910231

Yan Li, Jingman Li, R. Xiong, Rui Lu, Md. Alomgir Hossen, Jianwu Dai, Suqing Li, Wen Qin, Yaowen Liu

{"title":"Three-Dimensional Printed Mulberry Anthocyanin Combined with Chitosan/Hydroxyethyl Cellulose Bilayer Films for Quality Preservation of Litchi","authors":"Yan Li, Jingman Li, R. Xiong, Rui Lu, Md. Alomgir Hossen, Jianwu Dai, Suqing Li, Wen Qin, Yaowen Liu","doi":"10.2139/ssrn.3910231","DOIUrl":"https://doi.org/10.2139/ssrn.3910231","url":null,"abstract":"In this study, a bilayer antibacterial chromogenic material has been prepared using chitosan (CS) and hydroxyethyl cellulose (HEC) as the inner substrates, mulberry anthocyanins (MA) as natural tracers, and titanium dioxide nanoparticles (nano-TiO2) as bacteriostatic agent for the outer layer. By investigating its apparent viscosity and suitability for three-dimensional (3D) printing, the optimal ratio of the substrates was determined to be CS:HEC = 3:3 (CH). The CH viscosity was observed to be moderate. The printing process was consistent with no breakage or clogging, and the printed image was of high stability, and not susceptible to collapse and diffusion. Scanning electron microscopy and infrared spectroscopy indicated that the intermolecular binding between the substances exhibited good compatibility. Nano-TiO2 was evenly distributed in the CH, and no agglomeration occurred. The inner membrane fill rates affected the overall performance of the chromogenic material, with strong inhibitory effects against Escherichia coli and Staphylococcus aureus at different temperatures, as well as strong color stability. The experimental results indicated that the double-layer antibacterial chromogenic material can, to a certain extent, extend the shelf life of litchi fruit and determine the extent of its freshness. Therefore, from this study, we can infer that the research and development of intelligent materials have a certain reference value.","PeriodicalId":18279,"journal":{"name":"MatSciRN: Computational Studies of Inorganic & Organic Materials (Topic)","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85386611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Convergence of Ni (Ii), Zn (Ii) and L-Glutamine Binary Complexes in Dimethylformamide-Aqueous Mixture Ni (Ii)、Zn (Ii)和l -谷氨酰胺二元配合物在二甲基甲酰胺水溶液中的收敛性

MatSciRN: Computational Studies of Inorganic & Organic Materials (Topic) Pub Date : 2021-01-01 DOI: 10.2139/ssrn.3868023

M. Mir, M. Ashraf, K. Andrews

引用次数: 0

A Slow Positron Beam Study of Helium Clustering in Oxide Dispersion Strengthened Steels 氧化物弥散强化钢中氦聚集的慢正电子束研究

MatSciRN: Computational Studies of Inorganic & Organic Materials (Topic) Pub Date : 2021-01-01 DOI: 10.2139/ssrn.3807772

V. Kršjak, J. Degmová, P. Hruška, S. Sojak, P. Noga, T. Shen, V. Sabelová, W. Egger, V. Slugen

{"title":"A Slow Positron Beam Study of Helium Clustering in Oxide Dispersion Strengthened Steels","authors":"V. Kršjak, J. Degmová, P. Hruška, S. Sojak, P. Noga, T. Shen, V. Sabelová, W. Egger, V. Slugen","doi":"10.2139/ssrn.3807772","DOIUrl":"https://doi.org/10.2139/ssrn.3807772","url":null,"abstract":"The present work provides an innovative approach to the experimental study of the radiation tolerance of oxide dispersion strengthened (ODS) steel comparing to its non-ODS variant. Inhomogeneous radiation damage, introduced by helium irradiation, was probed in a depth profile manner by a variable energy positron beam. Although numerous studies reporting the use of slow positron beam (SPB) experiments on ion-implanted materials have been published in the literature, only a few of them address the continuous distribution of microstructural damage introduced by ion beam. In this paper, we use SPB to probe a wide range of radiation damage in a single sample of each material. By evaluating positron diffusion in different parts of the Bragg peak, we were able to track the evolution of radiation-induced damage from a high density of small defects such as helium-vacancy clusters to large bubbles grown by coalescence. Combining with the transmission electron microscopy results and slow positron Doppler broadening spectroscopy, we offer new insight into different stages of microstructural bubble evolution in steels exposed to harsh radiation conditions. The obtained results show that the higher density of vacancy-type defects in the oxide dispersion strengthened steel, which act as recombination centres, suppress the formation of large defect agglomerations. While the TEM provides an indication of this effect in high displacement damage and helium production rates, positron annihilation spectroscopy elucidates the origin of this behaviour, improving the understanding of the fundamental mechanism of helium embrittlement.","PeriodicalId":18279,"journal":{"name":"MatSciRN: Computational Studies of Inorganic & Organic Materials (Topic)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79944321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of Steroid Hormones in Water Samples by Liquid Chromatography Electrospray Ionization Mass Spectrometry Using Parallel Reaction Monitoring 平行反应监测液相色谱-电喷雾电离质谱法测定水样中的类固醇激素

MatSciRN: Computational Studies of Inorganic & Organic Materials (Topic) Pub Date : 2021-01-01 DOI: 10.2139/ssrn.3929278

S. Molnár, Győző Kulcsár, P. Perjési

{"title":"Determination of Steroid Hormones in Water Samples by Liquid Chromatography Electrospray Ionization Mass Spectrometry Using Parallel Reaction Monitoring","authors":"S. Molnár, Győző Kulcsár, P. Perjési","doi":"10.2139/ssrn.3929278","DOIUrl":"https://doi.org/10.2139/ssrn.3929278","url":null,"abstract":"One of the negative consequences of the increased use of medicines is the potential reason for releasing various pharmaceutical residues into the environment. Continuous development of analytical methodologies to identify and quantify such chemicals in natural waters is of major importance to public health. This study aimed to set up a sufficiently sensitive LC-MS method to quantitate targeted androgens and estrogens in water samples. Method development was based on the official EPA Method 539:2010. In our experiments, estrogens were analyzed in the form of their dansyl derivatives. Such derivatization, using multiple reaction monitoring (MRM) mode, improved sensitivity of the original method for estrogens by one or two orders of magnitude. Using electrospray in positive ionization (HESI+) mode resulted in a robust, selective, and sensitive to quantify the targeted steroids with 10 pg L -1 method detection limit (MDL). The linearity of the method was good with correlation coefficients (R) in the range of 0.997-1.000 and with a calibration range of 5-1000 pg L -1 in drinking water. The method was successfully applied to analyze drinking water and mineral water samples collected in the area of Pécs (Baranya County, Hungary).","PeriodicalId":18279,"journal":{"name":"MatSciRN: Computational Studies of Inorganic & Organic Materials (Topic)","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85149480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Consideration on the One-Part Mixing Method of Alkali-Activated Material: Problems of the Sodium Silicate Solubility and Quick Setting 碱活化材料一组分混合法的思考:水玻璃溶解度及快速凝固问题

MatSciRN: Computational Studies of Inorganic & Organic Materials (Topic) Pub Date : 2021-01-01 DOI: 10.2139/ssrn.3940145

M. Rasuli, Y. Tajunnisa, Akifumi Yamamura, M. Shigeishi

{"title":"A Consideration on the One-Part Mixing Method of Alkali-Activated Material: Problems of the Sodium Silicate Solubility and Quick Setting","authors":"M. Rasuli, Y. Tajunnisa, Akifumi Yamamura, M. Shigeishi","doi":"10.2139/ssrn.3940145","DOIUrl":"https://doi.org/10.2139/ssrn.3940145","url":null,"abstract":"This research investigates the properties of alkali-activated materials (AAM) using sodium metasilicate, which has a SiO2:Na2O ratio of 1. This study was conducted to achieve the following three aims. To understand the solubility mechanism of granular sodium metasilicate pentahydrate (Na2SiO3.5H2O) when used in a one-part mixing method. Second, properties investigation of AAM when the sodium metasilicate aqueous solution is used as one of the alkaline materials and as a source of silica. Lastly, study the retardation effect of sucrose on AAM. This research used aluminum silicate precursors such as low calcium fly ash, slag, and micros silica, alkali activators such as NaOH pellets and Na2SiO3.5H2O, and standardized sand. The alkaline activators were first dissolved in water using a water bath shaker to achieve the alkaline solution. Sucrose, 2% by the weight of the solid precursor, was added to modify the precursors and alkali reaction process. The authors prepared four types of samples, M1, M2, M3, and M4, with the fly ash, slag, and silica fume ratios of 80:20:0, 70:30:0, 75:20:5 100:0:0, respectively. The research conducted solubility test of the alkaline materials, flowability, 7, 28, 56-day compressive and flexural tests and drying shrinkage test of mortar samples, and the setting tests of pastes with and without the sucrose. The results show that the dissolution time of the NaOH was much shorter while Na2SiO3.5H2O needed a solvent with a temperature of around 40°C to be fully dissolved. This problem solubility decreases the quality of AAM made by the one-part mixing method. The M4 had the highest, and M3 had the lowest flow rate among the mortar samples. M2 had the highest compressive and flexural strength of 43.4MPa and 6.1 MPa, respectively. The setting time test shows that sucrose retards the reaction process in AAM.","PeriodicalId":18279,"journal":{"name":"MatSciRN: Computational Studies of Inorganic & Organic Materials (Topic)","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88698141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decomposition Behavior of Solid Peroxides: Effect of Ph, Ions and Buffer Composition 固体过氧化物的分解行为:Ph、离子和缓冲成分的影响

MatSciRN: Computational Studies of Inorganic & Organic Materials (Topic) Pub Date : 2021-01-01 DOI: 10.2139/ssrn.3844701

Arghavan Rastinfard, Benjamin Dalisson, J. Barralet

引用次数: 0