Medical Science Monitor : International Medical Journal of Experimental and Clinical Research最新文献_第7页

Comparative Analysis of Fused Deposition Modeling and Digital Light Processing Techniques for Dimensional Accuracy in Clear Aligner Manufacturing. 透明对准器制造尺寸精度的熔融沉积建模与数字光处理技术对比分析。

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research Pub Date : 2023-08-03 DOI: 10.12659/MSM.940922

Wojciech Grzebieluch, Magdalena Grajzer, Marcin Mikulewicz

{"title":"Comparative Analysis of Fused Deposition Modeling and Digital Light Processing Techniques for Dimensional Accuracy in Clear Aligner Manufacturing.","authors":"Wojciech Grzebieluch, Magdalena Grajzer, Marcin Mikulewicz","doi":"10.12659/MSM.940922","DOIUrl":"https://doi.org/10.12659/MSM.940922","url":null,"abstract":"BACKGROUND This study aimed to compare fused deposition modeling (FDM) and digital light processing (DLP) techniques in terms of dimensional accuracy for printing dental models used for the manufacture of clear dental aligners. MATERIAL AND METHODS Based on the intraoral scan of an adult patient, a sequence of 10 aligner models was created using BlueSkyPlan4. The test models (n=30) were fabricated with 2 desktop 3D printers: (DLP) and (FDM) printers. Two groups of samples were created (digitized using a desktop optical scanner). To calculate trueness (n=20) and precision (n=10), printed models were compared to the source files (REF). REF, DLP, and FDM files were superimposed and converted to point clouds. The cloud-to-cloud distances were calculated using CloudCompare software. Using the same algorithm, distortions of models were measured. Data were analyzed using one-way ANOVA and Tukey's post hoc test. RESULTS Significant differences were found between the trueness and precision of DLP and FDM groups. The average calculated trueness of DLP and FDM was 0.096 mm (0.021) (P<0.001) and 0.063 mm (0.024) (P<0.001), respectively. The average calculated precision of DLP and FDM was 0.027 mm (0.003) (P<0.001) and 0.036 mm (0.003) (P<0.001), respectively. A widening (0.158 mmfor DLP and 0.093 mmfor FDM, P=0.05) and twisting (0.03 mmfor DLP and 0.043 mmfor FDM, P=0.05) of the printed models was observed. CONCLUSIONS Both printers had sufficient precision for aligner models manufacturing. FDM showed a higher trueness and this device can be applied as an alternative to DLP. Polymerization shrinkage is a significant factor in decreasing the trueness of DLP printers.","PeriodicalId":18276,"journal":{"name":"Medical Science Monitor : International Medical Journal of Experimental and Clinical Research","volume":"29 ","pages":"e940922"},"PeriodicalIF":0.0,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f2/19/medscimonit-29-e940922.PMC10413909.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9977582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Alcohol Consumption, Smoking, and Diet on the Severity of Plaque Psoriasis: A Comprehensive Assessment using Clinical Scales and Quality of Life Measures. 饮酒、吸烟和饮食对斑块型银屑病严重程度的影响:使用临床量表和生活质量测量的综合评估

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research Pub Date : 2023-08-02 DOI: 10.12659/MSM.941255

Piotr Michalski, Veronica Palazzo-Michalska, Anna Michalska-Bańkowska, Mirosław Bańkowski, Beniamin Oskar Grabarek

{"title":"Impact of Alcohol Consumption, Smoking, and Diet on the Severity of Plaque Psoriasis: A Comprehensive Assessment using Clinical Scales and Quality of Life Measures.","authors":"Piotr Michalski, Veronica Palazzo-Michalska, Anna Michalska-Bańkowska, Mirosław Bańkowski, Beniamin Oskar Grabarek","doi":"10.12659/MSM.941255","DOIUrl":"https://doi.org/10.12659/MSM.941255","url":null,"abstract":"BACKGROUND This study aimed to evaluate the effects of alcohol intake, assessed using the Alcohol Use Disorder Identification Test (AUDIT) questionnaire, on the severity of plaque psoriasis using the Body Surface Area (BSA) and Psoriasis Area and Severity Index (PASI) scales, and quality of life using the Dermatology Life Quality Index (DLQI) questionnaire. MATERIAL AND METHODS The diagnosis of psoriasis was made based on the clinical picture. We enrolled 24 patients with psoriasis vulgaris, and the AUDIT test conducted at the time of follow-up indicated a possible risky/harmful pattern of alcohol consumption or alcohol dependence syndrome among the patients (>8 points). The comparison group consisted of 20 psoriatic patients and AUDIT <8 points. The BSA and PASI scales were used to determine the severity of psoriasis, and the DLQI questionnaire assessed patients' quality of life and how they felt during the week preceding the survey. RESULTS As the amount and frequency of alcohol consumed increased, the exacerbation of lesions measured according to the PASI and BSA scales was significantly higher (P<0.05), and the quality of life decreased (P<0.05). We noted that inadequate and excessive dietary intake of total protein, total fat, and assimilable carbohydrates were associated with statistically significantly higher values of BSA and PASI scores and, thus, more severe psoriatic lesions (P<0.05). CONCLUSIONS An unbalanced diet, alcohol abuse, and smoking negatively affect the course of psoriasis vulgaris, hence the importance of patient education.","PeriodicalId":18276,"journal":{"name":"Medical Science Monitor : International Medical Journal of Experimental and Clinical Research","volume":"29 ","pages":"e941255"},"PeriodicalIF":0.0,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a2/1c/medscimonit-29-e941255.PMC10405633.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10315969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: First Regulatory Approval for Allogeneic Pancreatic Islet Beta Cell Infusion for Adult Patients with Type 1 Diabetes Mellitus. 编辑:首次批准异体胰岛β细胞输注治疗成人1型糖尿病患者。

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research Pub Date : 2023-08-01 DOI: 10.12659/MSM.941918

Dinah V Parums

{"title":"Editorial: First Regulatory Approval for Allogeneic Pancreatic Islet Beta Cell Infusion for Adult Patients with Type 1 Diabetes Mellitus.","authors":"Dinah V Parums","doi":"10.12659/MSM.941918","DOIUrl":"https://doi.org/10.12659/MSM.941918","url":null,"abstract":"Type 1 diabetes mellitus affects adults and children, with an increasing number of newly-diagnosed cases each year. Type 1 diabetes involves a primary functional defect in pancreatic islet beta cells, resulting in secondary autoimmunity that results in T-cell-mediated beta cell death. However, pancreatic transplantation is a complex procedure, with complications that include transplant organ failure due to rejection or ischemia-reperfusion injury, safety issues of the duodenal-duodenal anastomosis technique, and the availability of segmental or whole organs. On June 28, 2023, the FDA Center for Biologics Evaluation and Research (CBER) approved Lantidra (donislecel), the first allogeneic (deceased donor) pancreatic islet cell therapy for the treatment of adults with type 1 diabetes who do not achieve target glycated hemoglobin levels because of repeated episodes of severe hypoglycemia, despite current management. This Editorial aims to highlight the increasing global health burden of type 1 diabetes, previous approaches to pancreatic transplant methods and introduces the first regulatory approval for allogeneic pancreatic islet beta cell infusion, a novel approach to transplantation.","PeriodicalId":18276,"journal":{"name":"Medical Science Monitor : International Medical Journal of Experimental and Clinical Research","volume":"29 ","pages":"e941918"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f8/d3/medscimonit-29-e941918.PMC10403990.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9942359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Pre-Transplant Parathyroidectomy on Graft Survival: A Comparative Study of Renal Transplant Patients (2005-2015). 移植前甲状旁腺切除术对移植物存活的影响:肾移植患者的比较研究(2005-2015)。

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research Pub Date : 2023-08-01 DOI: 10.12659/MSM.940959

Ming-Hsien Tsai, Mingchih Chen, Hung-Hsiang Liou, Tian-Shyug Lee, Yen-Chun Huang, Pei-Yang Liu, Yu-Wei Fang

{"title":"Impact of Pre-Transplant Parathyroidectomy on Graft Survival: A Comparative Study of Renal Transplant Patients (2005-2015).","authors":"Ming-Hsien Tsai, Mingchih Chen, Hung-Hsiang Liou, Tian-Shyug Lee, Yen-Chun Huang, Pei-Yang Liu, Yu-Wei Fang","doi":"10.12659/MSM.940959","DOIUrl":"https://doi.org/10.12659/MSM.940959","url":null,"abstract":"BACKGROUND Hyperparathyroidism poses significant risks for patients prior to kidney transplantation. However, the outcomes of patients who undergo parathyroidectomy before renal transplantation compared to those without such a procedure remain uncertain. This real-world data study aimed to examine the clinical outcomes of both patient groups. MATERIAL AND METHODS Using the Taiwan National Health Insurance Research Database, we conducted a retrospective cohort study on patients who underwent renal transplantation between January 2005 and December 2015. The patients were divided into two groups: a case group (n=294) with parathyroidectomy and a control group (n=588) without the need for parathyroidectomy before kidney transplantation. The groups were matched based on age, sex, dialysis vintage, and baseline characteristics at a 1:2 ratio. Hazard ratios (HR) were estimated using the Cox regression model. The main outcomes assessed were graft failure, mortality, and major adverse cardiovascular events (MACE) recorded until December 2019. RESULTS During a mean follow-up period of 6 years, a significant difference was observed in graft failure (HR 1.40; 95% confidence interval 1.10-1.79, p=0.007) between the two groups. After further adjustment, graft failure remained significant (HR 1.52; 95% CI 1.07-2.15, p=0.019). Additionally, machine learning-based feature selection identified the importance of parathyroidectomy (ranked 9 out of 11) before kidney transplantation in predicting subsequent graft failure. CONCLUSIONS Our study demonstrates that severe hyperparathyroidism requiring parathyroidectomy before kidney transplantation may contribute to poor post-transplant graft outcomes compared to patients who do not require parathyroidectomy.","PeriodicalId":18276,"journal":{"name":"Medical Science Monitor : International Medical Journal of Experimental and Clinical Research","volume":"29 ","pages":"e940959"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e1/db/medscimonit-29-e940959.PMC10403992.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9936272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Lactate/Albumin and Procalcitonin/Albumin Ratios as Predictors of 28-Day Mortality in ICU-Admitted Sepsis Patients: A Retrospective Cohort Study. 早期乳酸/白蛋白和降钙素原/白蛋白比率作为icu入院脓毒症患者28天死亡率的预测因素:一项回顾性队列研究

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research Pub Date : 2023-07-31 DOI: 10.12659/MSM.940654

Fuxing Li, Zhiqiang Ye, Junqi Zhu, Shumin Gu, Suqin Peng, Youling Fang, Longhua Hu, Jianqiu Xiong

{"title":"Early Lactate/Albumin and Procalcitonin/Albumin Ratios as Predictors of 28-Day Mortality in ICU-Admitted Sepsis Patients: A Retrospective Cohort Study.","authors":"Fuxing Li, Zhiqiang Ye, Junqi Zhu, Shumin Gu, Suqin Peng, Youling Fang, Longhua Hu, Jianqiu Xiong","doi":"10.12659/MSM.940654","DOIUrl":"https://doi.org/10.12659/MSM.940654","url":null,"abstract":"BACKGROUND Lactate/albumin (LA/ALB) and procalcitonin/albumin (PCT/ALB) ratios have been implicated in predicting mortality in sepsis patients. However, their prognostic value and relationship to sepsis severity require further investigation. This retrospective study aimed to assess the prognostic value of lactate/albumin (LA/ALB) and procalcitonin/albumin (PCT/ALB) ratios in septic patients admitted to the Intensive Care Unit (ICU). MATERIAL AND METHODS A total of 340 adult sepsis patients admitted to the ICU were included in the derivation cohort. LA/ALB and PCT/ALB ratios were calculated and analyzed in relation to sepsis severity and survival status. Additionally, a validation cohort of 75 sepsis patients from another medical center was selected. RESULTS In the derivation cohort, higher LA/ALB and PCT/ALB ratios and SOFA scores were significantly associated with increased mortality (P<0.001). The LA/ALB and PCT/ALB ratios positively correlated with SOFA score. Survival analysis revealed significantly higher 28-day mortality in sepsis patients with elevated PCT/ALB (≥0.256) and LA/ALB (≥0.079) ratios upon ICU admission. The constructed prediction model incorporating LA/ALB ratio, PCT/ALB ratio, and SOFA score yielded an AUC of 0.826, demonstrating good predictive ability. The associations between LA/ALB and PCT/ALB ratios and 28-day mortality in sepsis patients were validated in the validation cohort. CONCLUSIONS The LA/ALB and PCT/ALB ratios at ICU admission provide valuable prognostic information for predicting 28-day mortality in sepsis patients. Combining these ratios with SOFA score improves the assessment of prognosis in sepsis patients.","PeriodicalId":18276,"journal":{"name":"Medical Science Monitor : International Medical Journal of Experimental and Clinical Research","volume":"29 ","pages":"e940654"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/77/35/medscimonit-29-e940654.PMC10402292.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10301324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing Bone Grafting Outcomes: A Comprehensive Review of Antibacterial Artificial Composite Bone Scaffolds. 提高植骨效果:抗菌人工复合骨支架的综合综述。

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research Pub Date : 2023-07-30 DOI: 10.12659/MSM.939972

Yi Liu, Liuxing He, Lijia Cheng, Xinsong Li, Min Gao, Qinzhi Li, Jingjing Gao, Murugan Ramalingam

{"title":"Enhancing Bone Grafting Outcomes: A Comprehensive Review of Antibacterial Artificial Composite Bone Scaffolds.","authors":"Yi Liu, Liuxing He, Lijia Cheng, Xinsong Li, Min Gao, Qinzhi Li, Jingjing Gao, Murugan Ramalingam","doi":"10.12659/MSM.939972","DOIUrl":"https://doi.org/10.12659/MSM.939972","url":null,"abstract":"Bone defects and dysfunctions are prevalent among patients, resulting from various causes such as trauma, tumors, congenital malformations, inflammation, and infection. The demand for bone defect repair materials is second only to blood transfusions. Artificial bone composites offer numerous advantages for bone damage repair, including their availability, absence of rejection or immune reactions, high malleability, exceptional mechanical strength, and outstanding biocompatibility. However, bacterial infections frequently occur during bone transplantation or on graft material structures, leading to severe complications such as osteomyelitis and osteoporosis. Moreover, existing osteogenic materials alone are inadequate to address the challenges posed by traumatic infections, presenting a significant hurdle for clinicians in reconstructing infectious bone defects. Consequently, it is crucial to functionalize artificial bone composites to facilitate effective bone repair and regeneration. Notably, antibacterial capabilities play a critical role in preventing and treating infectious bone defects, and current research is focusing on the interface between artificial bone composites and antibacterial treatments. This article provides an extensive review of the current state of artificial composite bone scaffolds with antibacterial properties for infection prevention in bone grafting.","PeriodicalId":18276,"journal":{"name":"Medical Science Monitor : International Medical Journal of Experimental and Clinical Research","volume":"29 ","pages":"e939972"},"PeriodicalIF":0.0,"publicationDate":"2023-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a4/b6/medscimonit-29-e939972.PMC10399463.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9938370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the Puzzle of Central Serous Chorioretinopathy: Exploring Psychological Factors and Pathophysiological Mechanisms. 解开中枢浆液性脉络膜视网膜病变之谜:探索心理因素和病理生理机制。

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research Pub Date : 2023-07-29 DOI: 10.12659/MSM.941216

Antonio Sesar, Anita Pusic Sesar, Darija Jurisic, Katarina Cvitkovic, Ivan Cavar

{"title":"Unraveling the Puzzle of Central Serous Chorioretinopathy: Exploring Psychological Factors and Pathophysiological Mechanisms.","authors":"Antonio Sesar, Anita Pusic Sesar, Darija Jurisic, Katarina Cvitkovic, Ivan Cavar","doi":"10.12659/MSM.941216","DOIUrl":"https://doi.org/10.12659/MSM.941216","url":null,"abstract":"Central serous chorioretinopathy (CSCR) is a relatively common retinal disease involving the localized serous detachment of the neurosensory retina from the retinal pigment epithelium (RPE). Research suggests that individuals with a Type A personality, exhibiting traits such as competitiveness, urgency, aggression, and hostility, are significantly more prone to developing CSCR. Several studies have confirmed that a propensity to stress as well as different stressful events may predispose subjects to the development and recurrence of CSCR. Patients with CSCR are more depressive, report a higher level of anxiety and use more psychopharmacologic medications. Despite the research conducted on the topic, it remains unclear how a variety of psychological factors can contribute to dysfunction and pathological changes in the choroid and RPE. Some authors propose that increased levels of sympathetic neurotransmitters and glucocorticoids may alter the choroidal blood flow and increase the permeability of choriocapillaris in CSCR patients. It is generally accepted that hyperpermeable choroidal vessels are responsible for increased tissue hydrostatic pressure, which promotes RPE detachment, breaks the barrier function of the RPE and leads to subretinal fluid accumulation. Although the etiological factors and pathophysiological mechanisms have still not been fully clarified, CSCR is most likely a multifactorial disease involving disturbed interrelationships between biological and psychological factors. This comprehensive review aims to provide an up-to-date exploration of the psychological factors and pathophysiological mechanisms associated with CSCR.","PeriodicalId":18276,"journal":{"name":"Medical Science Monitor : International Medical Journal of Experimental and Clinical Research","volume":"29 ","pages":"e941216"},"PeriodicalIF":0.0,"publicationDate":"2023-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/12/34/medscimonit-29-e941216.PMC10395186.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9931877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emergency Response and Clinical Insights from a Non-Epicenter Hospital during the 2023 Turkey-Syria Earthquake: A Retrospective Analysis. 2023 年土耳其-叙利亚地震期间一家非震中医院的应急响应和临床见解：回顾性分析。

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research Pub Date : 2023-07-28 DOI: 10.12659/MSM.941226

Selahattin Gürü, Süeda Zaman, Mehmet Akif Karamercan

{"title":"Emergency Response and Clinical Insights from a Non-Epicenter Hospital during the 2023 Turkey-Syria Earthquake: A Retrospective Analysis.","authors":"Selahattin Gürü, Süeda Zaman, Mehmet Akif Karamercan","doi":"10.12659/MSM.941226","DOIUrl":"10.12659/MSM.941226","url":null,"abstract":"BACKGROUND The Turkey-Syria earthquake of February 6, 2023, impacted 11 provinces and necessitated widespread emergency medical support. Although not at the disaster's epicenter, Ankara Mamak State Hospital in Ankara, Turkey, offered critical multidisciplinary support. This retrospective study evaluates the factors that drove 124 admissions to the hospital's Emergency Department (ED) following the earthquake. MATERIAL AND METHODS We recorded patient demographic data, dates of arrival at the ED, provinces of origin, diagnoses, treatments, consultations during the ED visit, and patient outcomes. The majority of the 124 admissions were due to trauma and multi-organ damage, and the primary diagnostic tools were physical examination and radiological imaging. Of these patients, 85.5% (106) recovered and were discharged directly from the ED, 11 were admitted for continued care, and 7 were referred to another hospital. RESULTS The 124 cases consisted of adults injured within the first 20 days post-earthquake, with a mean age of 46.5±17.4 years, and a higher number of females. A peak in admissions was observed on the third and fourth days following the earthquake, with the most cases originating from the Hatay province. The most frequently injured body region was the lower extremity, and orthopedic consultations significantly outnumbered other surgical consultations. CONCLUSIONS Our findings underscore the vital role of robust, multidisciplinary disaster preparedness in all EDs, especially in regions prone to natural disasters.","PeriodicalId":18276,"journal":{"name":"Medical Science Monitor : International Medical Journal of Experimental and Clinical Research","volume":"29 ","pages":"e941226"},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d8/22/medscimonit-29-e941226.PMC10392225.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9979053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retracted: Upregulation of Serine Proteinase Inhibitor Clade B Member 3 (SERPINB3) Expression by Stromal Cell-Derived Factor (SDF-1)/CXCR4/Nuclear Factor kappa B (NF-κB) Promotes Migration and Invasion of Gastric Cancer Cells. 撤回：基质细胞衍生因子（SDF-1）/CXCR4/核因子卡巴B（NF-κB）上调丝氨酸蛋白酶抑制剂B族成员3（SERPINB3）的表达促进胃癌细胞的迁移和侵袭

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research Pub Date : 2023-07-28 DOI: 10.12659/MSM.941964

Jing Gong, Yongxi Song, Ling Xu, Xiaofang Che, Kezuo Hou, Tianshu Guo, Yu Cheng, Yunpeng Liu, Xiujuan Qu

引用次数: 0

Factors Associated with Severe Adenovirus Pneumonia in Children: A Retrospective Study from Guangzhou, China (2017-2019). 儿童严重腺病毒性肺炎的相关因素：中国广州的回顾性研究（2017-2019）。

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research Pub Date : 2023-07-27 DOI: 10.12659/MSM.939578

Yan Hong, Qiang Wang, Yongling Song, Guangming Liu, Jun Shen

{"title":"Factors Associated with Severe Adenovirus Pneumonia in Children: A Retrospective Study from Guangzhou, China (2017-2019).","authors":"Yan Hong, Qiang Wang, Yongling Song, Guangming Liu, Jun Shen","doi":"10.12659/MSM.939578","DOIUrl":"10.12659/MSM.939578","url":null,"abstract":"BACKGROUND Adenovirus infections are prevalent in children, typically presenting with mild or asymptomatic symptoms. However, some children develop severe pneumonia necessitating hospitalization. This retrospective study aimed to identify risk factors associated with severe adenovirus pneumonia in children. MATERIAL AND METHODS We screened consecutive children admitted for community-acquired pneumonia at the Emergency Department of Guangzhou Women's and Children's Medical Center between 2017 and 2019. Adenovirus infection was confirmed through rapid respiratory virus assay, RT-PCR assay from respiratory secretions, or serum IgM antibodies. According to Chinese guidelines, patients with pneumonia were classified into severe and mild groups. We assessed risk factors for severe adenovirus pneumonia by comparing clinical features and laboratory indicators, then included differing factors between the 2 groups in a logistic regression analysis. Data analysis was performed using SPSS 26.0 software. RESULTS Our study included 173 children diagnosed with adenovirus pneumonia (117 severe, 56 mild). The median age was 40 months, with 64 male patients. Univariate analysis and binary logistic regression analysis revealed that pleural effusion (13.449 [1.226-147.510], p=0.033), electrolyte disturbances (15.149 [2.724-84.246], p=0.002), oxygen therapy (258.219 [20.684-3223.548], p<0.001), bronchoscopy (26.781 [6.088-117.805], p<0.001), and steroid administration (6.584 [1.497-28.953], p=0.013) were associated with the severity of adenovirus pneumonia. CONCLUSIONS This single-center retrospective study identified pleural effusion, the need for bronchoscopy, oxygen therapy, and steroid treatment, along with impaired serum electrolytes, as factors associated with severe adenovirus pneumonia in children.","PeriodicalId":18276,"journal":{"name":"Medical Science Monitor : International Medical Journal of Experimental and Clinical Research","volume":"29 ","pages":"e939578"},"PeriodicalIF":0.0,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5d/a6/medscimonit-29-e939578.PMC10392226.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9979038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0