Magyar onkologia最新文献

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[Fertility preservation in testicular cancer patients]. [保留睾丸癌患者的生育能力]。
Magyar onkologia Pub Date : 2021-03-17 Epub Date: 2019-08-14
Tamás Martin, Magdolna Dank, Krisztina Biró, Zsófia Küronya, Fruzsina Gyergyay, Krisztián Nagyiványi, Barna Budai, Katinka Fűrész, Lajos Géczi
{"title":"[Fertility preservation in testicular cancer patients].","authors":"Tamás Martin,&nbsp;Magdolna Dank,&nbsp;Krisztina Biró,&nbsp;Zsófia Küronya,&nbsp;Fruzsina Gyergyay,&nbsp;Krisztián Nagyiványi,&nbsp;Barna Budai,&nbsp;Katinka Fűrész,&nbsp;Lajos Géczi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Germ cell tumors of the testicle account for 1% of all tumors. Testicular cancer (TC) is the most common malignancy in men aged 15-35 years. Patients with TC have an excellent survival rate but often have not yet attempted to father children, and fertility is one of the main concerns of survivors, therefore it is important to preserve it. The most commonly used method is sperm banking. Retrospective analysis of the Hungarian data showed that in case of testicular cancer spermatogenesis is more impaired in the more advanced disease. No correlation was found among the histological types and the proportion of azoo- and oligozoospermia. The parameters of testicular cancer and non-Hodgkin lymphoma patients were worse compared to the normal population. Sperm cryopreservation prior to initiating life-saving cancer treatment offers men the best chance to father children and should be offered to all men with testicular cancer before chemotherapy, since cytostatic therapy may lead to infertility.</p>","PeriodicalId":18175,"journal":{"name":"Magyar onkologia","volume":"65 1","pages":"53-57"},"PeriodicalIF":0.0,"publicationDate":"2021-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25487154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Linac-based stereotactic ablative radiotherapy for pancreatic cancer with intrafractional triggered imaging]. [基于linac的胰腺癌立体定向消融放疗伴术内触发显像]。
Magyar onkologia Pub Date : 2021-03-17 Epub Date: 2021-01-25
Katalin Kisiván, Dóra Erdélyesi, Dávid Gutyina, Péter Sajti, Dániel Gugyerás, Andrea Farkas, Csaba Glavák, Zoltán László, Éva Somogyiné Ezer, Károly Máhr, Zsolt Szabó, Helga Szabó, Zsolt Cselik, Ákos Gulybán, Melinda Petőné Csima, Zsolt Káposztás, Ferenc Lakosi
{"title":"[Linac-based stereotactic ablative radiotherapy for pancreatic cancer with intrafractional triggered imaging].","authors":"Katalin Kisiván,&nbsp;Dóra Erdélyesi,&nbsp;Dávid Gutyina,&nbsp;Péter Sajti,&nbsp;Dániel Gugyerás,&nbsp;Andrea Farkas,&nbsp;Csaba Glavák,&nbsp;Zoltán László,&nbsp;Éva Somogyiné Ezer,&nbsp;Károly Máhr,&nbsp;Zsolt Szabó,&nbsp;Helga Szabó,&nbsp;Zsolt Cselik,&nbsp;Ákos Gulybán,&nbsp;Melinda Petőné Csima,&nbsp;Zsolt Káposztás,&nbsp;Ferenc Lakosi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Our aim was to present different treatment strategies (non-gated [NG], respiratory-gated [RG] and deep inspiration breath-hold [DIBH] technique) of linac-based stereotaxic ablative radiotherapy (SABR) for pancreatic cancer in terms of use of marker, abdominal compression, image quality, and time efficiency. From October 2016 to October 2020 14 patients were treated with VMAT-based SABR (NG: 6/14, 8/14 RG RT including 3/8 DIBH SABR). Treatment verification consisted of 3D/4D CBCTs. For intrafractional tumor visualization (11/14) different type of fiducials were used. The average treatment time was the shortest with NG RT, followed by DIBH and RG RT. However, the best image quality was achieved with DIBH technique. The Krippendorff's agreement test among three independent RTTs showed that DIBH CBCT (Cone Beam CT) can produce sufficient image quality for OARs and can be used to reliably determine OARs position related to safety zone (PRV). Overall, marker-based DIBH SABR with intrafractional tumor visualization appears to be the best technique on linac at present.</p>","PeriodicalId":18175,"journal":{"name":"Magyar onkologia","volume":"65 1","pages":"6-13"},"PeriodicalIF":0.0,"publicationDate":"2021-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25497232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The effects of normal tissue objective parameters on lung stereotactic body radiotherapy dose distributions]. [正常组织客观参数对肺立体定向放疗剂量分布的影响]。
Magyar onkologia Pub Date : 2021-03-17 Epub Date: 2020-03-17
Mercédesz Gerdán, Tamás Pócza, Csaba Polgár, Tibor Major
{"title":"[The effects of normal tissue objective parameters on lung stereotactic body radiotherapy dose distributions].","authors":"Mercédesz Gerdán,&nbsp;Tamás Pócza,&nbsp;Csaba Polgár,&nbsp;Tibor Major","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In treatment planning of small-sized lung tumors treated with stereotactic body radiotherapy (SBRT) in Eclipse treatment planning system with the Normal tissue objective (NTO) tool sharp dose gradients beyond the target volume can be achived. NTO has 5 variable parameters, so it is difficult to know which settings are optimal. The purpose of this study was to characterize the effects of changing NTO parameters on lung SBRT dose distributions. Ten lung SBRT cases were replanned using different NTO parameters. Dose calculation was performed using AAA and AXB algorithms as well. Differences between AAA and AXB plans were statistically significant. Plans were evaluated based on plan quality metrics. According to this analysis the fall-off of 0.15 and the priority of 500 have satisfied our institutional criteria best. Using NTO during planning is recommended in clinical practice.</p>","PeriodicalId":18175,"journal":{"name":"Magyar onkologia","volume":"65 1","pages":"14-22"},"PeriodicalIF":0.0,"publicationDate":"2021-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25497233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
["The phlebotomist" - venous punction and venous access obtaining in the department of oncology]. [“抽血师”-肿瘤科静脉穿刺和静脉通路的获取]。
Magyar onkologia Pub Date : 2021-03-17 Epub Date: 2020-12-06
Anita Szabó, Erzsébet Csikósné Mácsok, Béla Pikó
{"title":"[\"The phlebotomist\" - venous punction and venous access obtaining in the department of oncology].","authors":"Anita Szabó,&nbsp;Erzsébet Csikósné Mácsok,&nbsp;Béla Pikó","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The protection of the veins in patients with malignancies is of high importance (regarding both blood taking and the drug administration). In order to prevent any unnecessary injury, every phlebotomy needs to have a sophisticated indication and requires skilled hands and adequate mentality. For the administration of cytostatic treatment, insertion of cannula is necessary, in most of the cases through a peripheral vein. Recently with more successful treatment possibilities, patients undergo many subsequent types of treatment. Thus, more examinations and diagnostic procedures (e.g. blood taking, radiologic examinations) are needed. Therefore, the need for central venous catheter or Porth-a-Cath device is increasing. Our report demonstrates general guidelines of blood taking and our everyday practice.</p>","PeriodicalId":18175,"journal":{"name":"Magyar onkologia","volume":"65 1","pages":"89-95"},"PeriodicalIF":0.0,"publicationDate":"2021-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25487080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Biological dose estimation for photons of different qualities in radiation therapy]. [放射治疗中不同质量光子的生物剂量估计]。
Magyar onkologia Pub Date : 2021-03-17 Epub Date: 2020-11-27
Gyöngyi Farkas, Gábor Székely, Tamás Pócza, Zsuzsa S Kocsis, Dalma Mihály, Márta Kun-Gazda, Csilla Pesznyák, Tibor Major, Csaba Polgár, Zsolt Jurányi
{"title":"[Biological dose estimation for photons of different qualities in radiation therapy].","authors":"Gyöngyi Farkas,&nbsp;Gábor Székely,&nbsp;Tamás Pócza,&nbsp;Zsuzsa S Kocsis,&nbsp;Dalma Mihály,&nbsp;Márta Kun-Gazda,&nbsp;Csilla Pesznyák,&nbsp;Tibor Major,&nbsp;Csaba Polgár,&nbsp;Zsolt Jurányi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Flattening filter free mode (FFF) has been introduced in radiotherapy during the past decades, however, not much has been reported on its radiobiological effect. The purpose of our study was to compare the radiobiological effects of flattening filter and flattening filter free photon beams on chromosomal aberrations in peripheral blood lymphocytes. In our study the blood of the same healthy donor was irradiated with linear accelerator using both conventional flattening filter (FF) and FFF photon beams at dose rate of 3.57-23.08 Gy/min, using 6 or 10 MV. The dose-response calibration curves for dicentric + ring chromosomes induced by irradiation were fitted with linear-quadratic model. CABAS (Chromosomal Aberration Calculation Software) was used to prepare the curves. The coefficients and equations of the curves were calculated and compared with the results of other authors. We found significant differences in the number of aberrations at different irradiation parameters. Based on our results, FFF mode has a 10-20% higher biological effect than FF mode. These results can be used during radiotherapy or to estimate the biological doses in case of an accidental exposure to radiation.</p>","PeriodicalId":18175,"journal":{"name":"Magyar onkologia","volume":"65 1","pages":"30-37"},"PeriodicalIF":0.0,"publicationDate":"2021-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25487151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Mutagen sensitivity and risk of second cancer in young patients with head and neck squamous cell cancer]. 【年轻头颈部鳞状细胞癌患者诱变原敏感性及二次癌风险分析】。
Magyar onkologia Pub Date : 2021-03-17 Epub Date: 2019-07-10
Botond Bukovszky, János Fodor, Gábor Székely, Zsuzsa S Kocsis, Ferenc Oberna, Tibor Major, Zoltán Takácsi-Nagy, Csaba Polgár, Zsolt Jurányi
{"title":"[Mutagen sensitivity and risk of second cancer in young patients with head and neck squamous cell cancer].","authors":"Botond Bukovszky,&nbsp;János Fodor,&nbsp;Gábor Székely,&nbsp;Zsuzsa S Kocsis,&nbsp;Ferenc Oberna,&nbsp;Tibor Major,&nbsp;Zoltán Takácsi-Nagy,&nbsp;Csaba Polgár,&nbsp;Zsolt Jurányi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Head and neck cancer patients are at high risk for secondary primary cancer (SPC) development. Mutagen hypersensitivity may be associated with elevated risk of SPC. A survey was made of SPC among 124 young (≤50 years) patients with squamous cell carcinoma of the head and neck who were enrolled in a pretreatment mutagen sensitivity investigation during 1996-2006. Mutagen sensitivity was assessed by exposing lymphocytes to bleomycin in vitro and quantitating the bleomycin-induced chromatid breaks per cell (b/c). Patients were classified as hypersensitive (>1 b/c) or not hypersensitive (≤1 b/c). The mean follow-up time was 64 months (range: 5-244 months). Eighteen patients (15%) developed a SPC. The 10-year estimated rate of SPC for hypersensitive (n=65) or not hypersensitive (n=59) patients were 17% and 30%, respectively (p=0.4272). Thirty-nine percent of SPC was developed after 10-year follow-up. The 5-year cancer-specific survival was 17% following the development of SPC. According to our findings, mutagen hypersensitivity does not increase the risk of developing SPC.</p>","PeriodicalId":18175,"journal":{"name":"Magyar onkologia","volume":"65 1","pages":"39-45"},"PeriodicalIF":0.0,"publicationDate":"2021-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25487152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The role of low grade glioma prognostic factors in therapeutic choices - summary of international literature and recommendations with conclusions]. [低级别胶质瘤预后因素在治疗选择中的作用——国际文献综述及建议结论]。
Magyar onkologia Pub Date : 2021-03-17 Epub Date: 2020-08-24
László Szivos, József Virga, Álmos Klekner, Péter Árkosy
{"title":"[The role of low grade glioma prognostic factors in therapeutic choices - summary of international literature and recommendations with conclusions].","authors":"László Szivos,&nbsp;József Virga,&nbsp;Álmos Klekner,&nbsp;Péter Árkosy","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Our knowledge on low grade gliomas has grown extensively recently. Both molecular alterations and clinical trials unraveling their clinical significance are difficult to get familiar with. Thus, efforts made to reach any consensus are of upmost importance, so that multidisciplinary teams involved in patient management can make up-to-date, individually-tailored therapeutic plans. Our aims were to synthesize all the molecular and clinical investigations, recommendations and guidelines related to low grade gliomas in Hungarian language, and to define low and high risk prognostic groups with different therapeutic strategies. The roles of 21 molecular pathological markers and their significance levels in low grade gliomas are summarized in this paper. Data from relevant literature, as well as recommendations of neuro-oncological organizations were included. This summary could help to integrate diverse therapeutic plans of the past decades in low grade gliomas. Moreover, this paper may serve as a source for future revisions when updating low and high risk groups in low grade gliomas.</p>","PeriodicalId":18175,"journal":{"name":"Magyar onkologia","volume":"65 1","pages":"59-70"},"PeriodicalIF":0.0,"publicationDate":"2021-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25487155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Psychological phenomena and symptoms in active and complex oncology care: challenges of interventions and rehabilitation opportunities.] [积极和复杂肿瘤治疗中的心理现象和症状:干预的挑战和康复机会]
Magyar onkologia Pub Date : 2021-03-17 Epub Date: 2020-12-14
Péter Kovács, Zsófia Esperger, Dóra Horváth, Katalin Lacsán, Dániel Patyi, Nóra Stefanovits, Lili Zsoldos, Orsolya Horváth
{"title":"[Psychological phenomena and symptoms in active and complex oncology care: challenges of interventions and rehabilitation opportunities.]","authors":"Péter Kovács,&nbsp;Zsófia Esperger,&nbsp;Dóra Horváth,&nbsp;Katalin Lacsán,&nbsp;Dániel Patyi,&nbsp;Nóra Stefanovits,&nbsp;Lili Zsoldos,&nbsp;Orsolya Horváth","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>According to research, almost every second oncology patient experiences intense distress during their oncology treatment. The development of new medical treatment options in cancer care allows longer survival for cancer patients. Because of this, quality of life becomes an increasingly important factor during treatments. Psycho-oncological interventions include all psychosocial interventions that are designed to positively influence the patient's psychosocial adaptation and adjustment to diagnosis, treatment, and survivorship. Interventions also promote rehabilitation progress and help the emotional integration of disease-related crisis and trauma. Psycho-oncological therapies are supposed to manage cancer-related distress and other psychosocial problems by specific types of treatments or interventions. It is crucial for the medical system to deal with the psychosocial aspects of cancer care in order to identify and deal with patients' needs for better compliance and adherence to treatment. The key of personalized holistic rehabilitation is multidisciplinary teamwork during the whole healing process: sharing the emotional experience also helps to prevent healthcare workers' burnout.</p>","PeriodicalId":18175,"journal":{"name":"Magyar onkologia","volume":"65 1","pages":"78-88"},"PeriodicalIF":0.0,"publicationDate":"2021-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25487157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Secondary lung cancer risk after breast cancer radiation therapy. The benefits substantially overweight the minimal disadvantages]. 乳腺癌放疗后继发肺癌的风险。好处很大,超重,缺点最小]。
Magyar onkologia Pub Date : 2021-03-17 Epub Date: 2020-11-23
Tamás Nagykálnai, László Landherr
{"title":"[Secondary lung cancer risk after breast cancer radiation therapy. The benefits substantially overweight the minimal disadvantages].","authors":"Tamás Nagykálnai,&nbsp;László Landherr","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Considerable evidence supports the rationale for postoperative radiotherapy after breast cancer surgery. Moreover, local tumour control affects survival too. High-dose irradiation is inherently associated with an increased risk of secondary malignancies in the long run. This radiobiological phenomenon raises the question whether it is worth taking this hazard, and the exact level of the risk of a secondary malignancy should be clarified. Answering these questions is important, regarding the large population size of breast cancer survivors, as well as patients' improving survival rates and time. The postoperative radiation load to the ipsilateral lung tissue can be reduced, but it is still significant. The current literature review aims to evaluate the risk of secondary lung cancer associated with breast cancer- specific radiotherapy. Published evidence suggests that the benefits of postoperative radiotherapy following breast cancer surgery are much higher than the minimal risk of secondary lung cancer associated with this management strategy.</p>","PeriodicalId":18175,"journal":{"name":"Magyar onkologia","volume":"65 1","pages":"46-52"},"PeriodicalIF":0.0,"publicationDate":"2021-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25487153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The adjuvant killing effect of modulated electro-hyperthermia combined with chemotherapy on B16F10 melanoma cells]. [调制电热联合化疗对B16F10黑色素瘤细胞的辅助杀伤作用]。
Magyar onkologia Pub Date : 2021-03-17 Epub Date: 2020-02-21
Enikő Major, Anett Benedek, Marcell A Szász, Zoltán Benyó, Andrea Balogh
{"title":"[The adjuvant killing effect of modulated electro-hyperthermia combined with chemotherapy on B16F10 melanoma cells].","authors":"Enikő Major,&nbsp;Anett Benedek,&nbsp;Marcell A Szász,&nbsp;Zoltán Benyó,&nbsp;Andrea Balogh","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Our aim was to detect the effect of modulated electro-hyperthermia (mEHT) on cell viability and to examine if hyperthermia can augment the cell killing effect of various chemotherapeutic agents. B16F10 melanoma cells were treated for 30, 60, 90 and 120 minutes with mEHT using LabEHY100 (OncothermTM). Cell viability was measured using MTT assay and apoptosis by annexin V/7-AAD staining using flow cytometry 24 hours post-treatment. For analyzing gene expression with qPCR cells were harvested after 60 minutes treatment. In combined protocols, cells were treated with paclitaxel (40 nM), dacarbazine (40 μM) or nutlin-3a (10 μM) after mEHT. mEHT induced nuclear translocation of p53 which in turn regulates pro- and anti-apoptotic gene expression accounting for decreased cell viability. In combination with chemotherapy, mEHT augmented the cell killing effect of dacarbazine or nutlin-3a but not that of paclitaxel determined 48 hours post-treatment. The sensitizing effect on chemotherapeutics demonstrate the efficiency of mEHT as an adjuvant modality in cancer treatment.</p>","PeriodicalId":18175,"journal":{"name":"Magyar onkologia","volume":"65 1","pages":"71-77"},"PeriodicalIF":0.0,"publicationDate":"2021-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25487156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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