Lymphokine research最新文献_第8页

Immunoenzymatic assessment of IL-1 beta mRNA by in situ hybridization using sulphonated probes. 用磺化探针原位杂交免疫酶评价IL-1 β mRNA。

Lymphokine research Pub Date : 1989-01-01

J Gerdes, H Herzbeck, C Schlüter, H D Flad

引用次数: 0

The role of cytokines in the immunopathology of tuberculosis, and the regulation of agalactosyl IgG. 细胞因子在肺结核免疫病理中的作用及对无乳酰IgG的调节。

Lymphokine research Pub Date : 1989-01-01

G A Rook, R A Attiyah, N Foley

{"title":"The role of cytokines in the immunopathology of tuberculosis, and the regulation of agalactosyl IgG.","authors":"G A Rook, R A Attiyah, N Foley","doi":"","DOIUrl":"","url":null,"abstract":"Tuberculosis is characterised by necrosis in the lesions and in skin-test sites, and by fever and weight loss. In contrast, other diseases with chronic T cell mediated responses, such as uncomplicated leprosy and sarcoidosis, have non-necrotising lesions with little systemic upset. Crude sonicates of M. tuberculosis and M. leprae prepare skin sites for TNF-mediated damage via a pathway which unexpectedly appears to involve CD8+ T cells, and both mycobacteria contain potent triggers of TNF release (lipoarabinomannan and peptidoglycan derivatives). These observations can partially explain the pathology of tuberculosis, but fail to explain why similar events do not normally occur in leprosy. It now seems likely that the answer lies in the existence of novel regulatory pathways. A recently recognised correlate (or consequence) of diseases characterised by T cell-dependent tissue-damaging pathology and cytokine release, is an increase in the level of agalactosyl IgG. This behaves like a T cell-dependent acute phase reactant, and is raised in tuberculosis, rheumatoid arthritis, and Crohn's disease, but not in sarcoidosis or uncomplicated leprosy. Thus it may act as a marker for a type of pathology of very broad significance, though its functional role remains obscure.","PeriodicalId":18130,"journal":{"name":"Lymphokine research","volume":"8 3","pages":"323-8"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13815891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporally different stimulation of TNF-alpha and PGE2 release from GM-CSF-primed macrophages. gm - csf引发巨噬细胞tnf - α和PGE2释放的时间差异刺激。

Lymphokine research Pub Date : 1989-01-01

S Heidenreich, J H Gong, H Renz, A Schmidt, M Nain, D Gemsa

引用次数: 0

Mechanisms which take part in regulation of the response to tumor necrosis factor. 参与肿瘤坏死因子反应调控的机制。

Lymphokine research Pub Date : 1989-01-01

D Wallach, H Holtmann, D Aderka, M Rubinstein, Y S Avni, I Sarov, H Engelman

引用次数: 0

The effect of tumor necrosis factor alpha on the activity of lipoprotein lipase in adipose tissue. 肿瘤坏死因子α对脂肪组织脂蛋白脂肪酶活性的影响。

Lymphokine research Pub Date : 1989-01-01

O Porat

{"title":"The effect of tumor necrosis factor alpha on the activity of lipoprotein lipase in adipose tissue.","authors":"O Porat","doi":"","DOIUrl":"","url":null,"abstract":"TNF alpha may play a critical role in many physiologic and pathophysiologic responses. It shows a bifunctional regulatory nature of both inhibiting tumor cell proliferation and enhancing growth and differentiation of other cells. TNF alpha acts as a mediator, binding to specific high affinity receptors to elicit biological responses. TNF alpha may be an essential local and systemic mediator in the pathogenesis of cachexia. By inhibiting the activity of lipogenic enzymes, it affects lipid mobilization from adipose tissue and adipocyte differentiation. The ability of TNF alpha to inhibit anabolic processes in adipocytes and preadipocytes is not unique and has been displayed, though to a lesser degree, by other cytokines such as LT, IFN-gamma, and IL-1. In infected animals, the effect of TNF alpha on LPL of inhibiting anabolic processes and enhancing secretion of FFA by adipocytes, may be important in providing additional energy needed by the immune system to combat invasion. However, the relationship between the suppression of the anabolic processes and the cytotoxicity is uncertain and prolonged action may lead to wasting. The evidence suggests that in the adipocyte, TNF alpha is the unique molecule that suppresses LPL through the selective inhibition of mRNA production. As a consequence of the decrease in the enzyme amounts, there is a reduction in TG-uptake and lipid deposition contributing to cachexia. Neutralizing the action of TNF alpha may reverse the cachectic processes and potentially improve the condition. Further research into the induction, synthesis and regulation of TNF alpha production is necessary. Modern molecular biology techniques should serve as useful models in understanding the regulation of TNF alpha functions in response to stimuli. Development of faster and more sensitive detection methods would improve the measurement of the low concentrations of cytokines.","PeriodicalId":18130,"journal":{"name":"Lymphokine research","volume":"8 4","pages":"459-69"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13823787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interleukin 1 stimulates production of LTC4 and other eicosanoids by macrophages. 白细胞介素1刺激巨噬细胞产生LTC4和其他类二十烷。

Lymphokine research Pub Date : 1989-01-01

S Censini, M Bartalini, A Tagliabue, D Boraschi

引用次数: 0

Interleukin 1 in rheumatoid arthritis: potentiation of immune responses within the joint. 类风湿关节炎中的白细胞介素1:关节内免疫反应的增强。

Lymphokine research Pub Date : 1989-01-01

J A Symons, T L McDowell, F S di Giovine, N C Wood, S J Capper, G W Duff

引用次数: 0

Comparative analysis of IL-2 and IL-3 induced tyrosine phosphorylation. IL-2和IL-3诱导酪氨酸磷酸化的比较分析。

Lymphokine research Pub Date : 1989-01-01

D K Ferris, J Willette-Brown, D Linnekin, W L Farrar

引用次数: 0

A role for interleukin 1 in the in vivo actions of tumor necrosis factor. 白细胞介素1在肿瘤坏死因子体内活动中的作用。

Lymphokine research Pub Date : 1989-01-01

P G Brouckaert, C Libert, B Everaerdt, N Takahashi, W Fiers

引用次数: 0

Activated human blood monocytes trigger the antitumor activity of blood polymorphonuclear cells. 活化的人血液单核细胞触发血液多形核细胞的抗肿瘤活性。

Lymphokine research Pub Date : 1989-01-01

I J Fidler, A Nii, J Y Tsao, S Davis, E S Kleinerman

{"title":"Activated human blood monocytes trigger the antitumor activity of blood polymorphonuclear cells.","authors":"I J Fidler, A Nii, J Y Tsao, S Davis, E S Kleinerman","doi":"","DOIUrl":"","url":null,"abstract":"The purpose of these studies was to determine whether human peripheral blood polymorphonuclear cells (PMNC) can be directly activated by lymphokines or bacterial products to lyse tumorigenic cells under in vitro conditions. Preparations of PMNC with different levels of purity were isolated by countercurrent elutriation. PMNC were incubated with recombinant interferon gamma and muramyldipeptide, with lipopolysaccharide, or with the synthetic lipopeptide CGP 31362. Only PMNC preparations containing 3-5% mononuclear cells lysed allogeneic melanoma cells. Homogeneous populations of PMNC did not. The addition of 5% monocytes to homogeneous populations of PMNC triggered PMNC-mediated tumor lysis. Cell-to-cell contact was not required in this process since culture supernatant of blood monocytes incubated with lipopolysaccharide (but not with medium) could trigger tumor cell lysis by PMNC. PMNC lysed both allogeneic tumorigenic (melanoma) and allogeneic nontumorigenic (fibroblast) cells, whereas activated monocytes lysed only tumorigenic cells. In conclusion, PMNC are triggered to lyse target cells by blood monocytes activated by bacterial products or by lymphokines.","PeriodicalId":18130,"journal":{"name":"Lymphokine research","volume":"8 4","pages":"427-37"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13950014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0