A. Smer, O. Bheleel, Khalid Ellafi, A. Neihoum, Hanifa Alrabte, Omar Msalam
{"title":"The 8th Libyan Cardiac Society Congress Recommendations","authors":"A. Smer, O. Bheleel, Khalid Ellafi, A. Neihoum, Hanifa Alrabte, Omar Msalam","doi":"10.1055/s-0042-1758811","DOIUrl":"https://doi.org/10.1055/s-0042-1758811","url":null,"abstract":"","PeriodicalId":18106,"journal":{"name":"Libyan International Medical University Journal","volume":"10 1","pages":"063 - 066"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78041976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"2022: A Challenging Year for LIMUJ","authors":"A. S. Elhwuegi","doi":"10.1055/s-0043-1761299","DOIUrl":"https://doi.org/10.1055/s-0043-1761299","url":null,"abstract":"2022 was a transition year for the Libyan International Medical University Journal (LIMUJ). The transfer process from our old publisher (Medknow) to our new publisher (Thieme) was not smooth and took longer than expected. Besides, we were faced with many difficulties at the beginning that resulted in a loss of communication with many of our authors, readers, and referees; we apologize to them for any inconveniences they faced in reconnection with LIMUJ. However, our train now is back on track, and we hope for a smooth fast ride toward our goals.1 With Thieme, we have received 16 articles (excluding the editorials), 3 were rejected before review, two were rejected after review, and 11 articles were accepted after review with an acceptance rate of approximately 69%. The average review time from the first submission to the final decision was 33.6 days, and the average handling time after acceptance till article publication was 32.7 days. One of our short-term goals is to improve these indicators, the time for the reviewing process, and the time of production after acceptance. The articles accepted were from different countries including Libya (seven articles), Turkey (two articles), India (one article), and the United States (one article). The subjects of the accepted articles were of different diversities of the medical sciences, including coronavirus disease 2019 related complications like lung abscess,2 pulmonary mycosis,3 and vaccination status of healthcare workers in Turkey.4 In an ophthalmological study, different ocular parameters in Libyan subjects were reported.5 Another study was performed to examine the effect of intramuscular injection of vitamin D on serum 25-hydroxyvitamin D levels, glycemic control, and liver enzymes in Libyan patients suffering from type 2 diabetes mellitus with vitamin D deficiency.6 Animal studies included evaluation of the protective effects of doxycycline against vanadiuminduced hepatoxicity in rats,7 and central nervous system effects of the methanolic extract of the leaves of Capparis spinosa L.8 A clinicopathological characteristics of prostate lesions in surgical specimens of Libyan patients were prescribed in a retrospective study,9 and a review article provided information on the current state of antimicrobial resistance in Libya.10 Another original research article reported the magnitude of burnout among physicians in Benghazi-Libya,11 and a letter to the editor describing the 8th Libyan Cardiac Society Congress Recommendations.12 Publication in LIMUJ is still free, charging no processing or publication fees. It is open access under the terms of the Creative Commons permitting copying and reproduction so long as the work is properly cited. I always say that perfection is slow in onset but long in duration. We are aiming for near perfection, andwe hopewe can reach this aim with your help as an author, reader, and reviewer. Wishing you all a happy, healthy new year.","PeriodicalId":18106,"journal":{"name":"Libyan International Medical University Journal","volume":"1 1","pages":"037 - 038"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90085071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Khaled D. Alsaeiti, Abdelhdi Elkadiki, Mohamed Hamedh, R. M. Ezwaie, Sarah Muftah Younis, S. O. Elfigih
{"title":"Burnout among Physicians at Medical Departments in Benghazi-Libya","authors":"Khaled D. Alsaeiti, Abdelhdi Elkadiki, Mohamed Hamedh, R. M. Ezwaie, Sarah Muftah Younis, S. O. Elfigih","doi":"10.1055/s-0042-1758810","DOIUrl":"https://doi.org/10.1055/s-0042-1758810","url":null,"abstract":"Abstract Background Burnout syndrome is recognized as a global issue, and as medical practice is stressful, healthcare workers are found to be burnt out and exhausted very soon, which is reflected negatively on the medical staff well-being, patients' outcome, and the overall organizational performance. Aim This study is planned to assess the magnitude of burnout among physicians in Benghazi-Libya. Methods This cross-sectional study was carried out in 2020 on a total of 150 physicians working at different departments of internal medicine in Benghazi-Libya. The Maslach Burnout Inventory collection instrument was used to assess the three components of burnout syndrome: emotional exhaustion, depersonalization, and reduced personal accomplishment. High scores in emotional exhaustion and depersonalization and low scores in personal accomplishment are indicative of high burnout. The statistical analyses of the data were performed using the SPSS version 21. The level of statistical significance was considered as p -value less than 0.05. Results 60% of the respondents were females and 40% were males. About 14.7% had high emotional exhaustion, 92% had high depersonalization, and 87.3% had low personal accomplishment scores. Statistical analysis showed no significant relationship between gender and burnout. Alternatively, a significant association was found between degree certificate and emotional exhaustion, as moderate- and high-level burnout were more prevalent among MBCHB participants than those with masters and board degrees. No association was found between degree certificate and depersonalization or personal accomplishment. Conclusion Burnout is prevalent among internal medicine doctors in Benghazi, with the newly graduated medical personnel scoring higher rates of burnout than doctors with higher degrees. No relationship was found between gender and burnout.","PeriodicalId":18106,"journal":{"name":"Libyan International Medical University Journal","volume":"97 1","pages":"045 - 050"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80060170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preliminary Investigation into the Anticonvulsant, Sedative and Muscle Relaxant Effects of the Methanolic Extract of Capparis spinosa L. Leaves in Mice","authors":"A. Dugani, Sarah Saleh Khasheba, A. Auzzi","doi":"10.1055/s-0043-1760832","DOIUrl":"https://doi.org/10.1055/s-0043-1760832","url":null,"abstract":"Abstract Background Capparis spinosa L is a Mediterranean plant. In Libya, the plant grows in rocky areas and at high altitudes. It is commonly used by the inhabitants of the Mediterranean region in their kitchen and treatment of many diseases. Aim This study was undertaken to investigate the central nervous system depressant, anticonvulsant, and the muscle relaxant activities of orally administered methanolic extract from the leaves of C. spinosa L. (MECS) in mice. Methods The oral administration of three doses of the MECS in mice (500, 1000, and 2000 mg/kg) were evaluated in the picrotoxin (PC)-induced convulsion model, ketamine-induced sleep, and rota rod test. Diazepam was used as a reference drug for comparison. Results were analyzed using SPSS program version 16. Data are presented as mean ± SEM, and compared using one-way ANOVA followed by Duncan's test. The significance level was set at p < 0.05 Results Oral administration of MECS (1000 and 2000 mg/kg) significantly prolonged the onset of seizures ( p < 0.01) and produced dose-dependent protection against PC-induced seizures compared with the control group (12.5% and 50% protection, respectively). MECS significantly ( p < 0.05) and dose dependently reduced ketamine sleep latency (from 3.16 ± 0.16 to a minimum of 1.5 ± 0.22 minutes) and prolonged ketamine-induced sleeping time (from 11.33 ± 1.99 to a maximum of 33.33 ± 0.95 minutes). In the accelerated rotarod test, MECS significantly ( p < 0.01) decreased the riding time on the rotarod (from 128.83 ± 14.6 to a minimum of 1.83 ± 0.47 seconds) as compared with the normal saline control group. Conclusion The results showed that the MECS possesses anticonvulsant, sedative, and muscle relaxant properties in mice.","PeriodicalId":18106,"journal":{"name":"Libyan International Medical University Journal","volume":"18 1","pages":"057 - 062"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86011603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatih Uzer, Omer Yesil, Yasin Gokmen, Mehmet Reşit Sayan, Mucahit Cengiz
{"title":"Knowledge Levels, Attitudes, and Behaviors of Health Care Professionals regarding COVID-19 Vaccines","authors":"Fatih Uzer, Omer Yesil, Yasin Gokmen, Mehmet Reşit Sayan, Mucahit Cengiz","doi":"10.1055/s-0042-1747909","DOIUrl":"https://doi.org/10.1055/s-0042-1747909","url":null,"abstract":"\u0000 Background Shortly after the coronavirus disease 2019 (COVID-19) pandemic, vaccines were developed. Vaccination of the society in a short time may be the most important step in the fight against the pandemic. Health workers can be considered role models for society.\u0000 Aim We aimed to investigate the COVID-19 vaccination status of health care workers.\u0000 Methods The universe of our cross-sectional and descriptive study consisted of doctors, nurses, secretaries, interns, and other health care professionals. In the light of the literature, a questionnaire was prepared that questioned the attitudes and behaviors of the participants about vaccines. Face-to-face interviews were conducted during the visits. SPSS was used for statistical analysis.\u0000 Results A total of 806 volunteers, 51.4% (414) male and 48.6% (392) female, with a mean age of 32.7 ± 9.3 years, were included in the study. In total, 4.6% (37) of the participants in the study had not received any COVID-19 vaccine. Male participants were vaccinated statistically significantly more than female participants (p = 0.044). Of those vaccinated against COVID-19, 98.3% (774) had received at least two doses. Also, 26.9% (217) of health care workers had COVID-19 disease. The rate of those whose first-degree relatives had COVID-19 was 42.2% (340). A total of 87.3% (704) of health care workers reported that COVID-19 vaccines were safe. Also, 25.3% (204), 29.5% (238), and 35.0% (282) of the participants reported that state officials' vaccination in front of the media, social media news, and national media news, respectively, affected the decision to vaccinate.\u0000 Conclusion Although male health care workers have received more COVID-19 vaccines than female health care workers, vaccination rates of health care workers are at an acceptable level. Health workers comply with the calendar recommended by the ministry.","PeriodicalId":18106,"journal":{"name":"Libyan International Medical University Journal","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86668827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Axial Length, Anterior Chamber Depth, and Lens Thickness in Normal Libyan Eyes; Measured by the Aladdin Ocular Biometer","authors":"S. Bukhatwa, Masuod Suliman","doi":"10.1055/s-0042-1749116","DOIUrl":"https://doi.org/10.1055/s-0042-1749116","url":null,"abstract":"\u0000 Background: Ocular parameters as axial length (AL), anterior chamber depth (ACD), and lens thickness (LT) are important for refractive and cataract surgeries, and its normal data are important to be identified.\u0000 Aim: This study was carried out to obtain data about AL, ACD, and LT parameters in normal Libyans.\u0000 Methods: A cross-sectional study (first of July to end of August, 2021) was done in Benghazi teaching eye hospital on 106 nondiabetic volunteers aged between 17 and 75 years with no ophthalmic disease. Ocular parameters were measured using the Aladdin optical biometer that is a noninvasive machine and without the use of drugs. Descriptive statistics and data analysis were done by using SPSS version 23.0, IBM Corporation.\u0000 Results: The mean age was 35.36 ± 13.35 years, the mean AL was 23.79 ± 0.91 mm, the mean ACD was 2.96 ± 0.62 mm, and the mean LT was 3.67 ± 0.62 mm. There was no statistically significant difference between these parameters regarding gender or age.\u0000 Conclusion: This is the first study done on Libyan population to report the AL, ACD, and LT. It showed a comparable result with studies from other populations and that age and gender have no effect on these ocular parameters.","PeriodicalId":18106,"journal":{"name":"Libyan International Medical University Journal","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77570508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pulmonary Abscess as a Complication of SARS-CoV-2 Pneumonia","authors":"Fatih Uzer, Sukriye Oner, A. Çilli","doi":"10.1055/s-0042-1744043","DOIUrl":"https://doi.org/10.1055/s-0042-1744043","url":null,"abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease originated in the Wuhan region of China and spread all over the world. This disease typically starts as an acute viral disease, and it is characterized by lung infiltrates and elevation of inflammatory markers. The definitive diagnosis of the disease is confirmed by polymerase chain reaction (PCR) results. Although majority of patients with positive PCR results had mild disease, 5 to 14% of them are severely affected. It has been reported in the literature that a significant proportion of adult patients develops virus-related complications. Lung abscess is one of these complications that is a suppurative infection with an air-fluid level greater than 2 cm in diameter on chest X-ray. Although there is usually a single cavity, it can also be multifocal. It was reported as a possible late-term complication of SARS-CoV-2. We are presenting two cases with lung abscess after SARS-CoV-2 treatment.","PeriodicalId":18106,"journal":{"name":"Libyan International Medical University Journal","volume":"296 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77912168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Intramuscular Injection of Vitamin D on 25-Hydroxyvitamin D Levels, Glycaemic Control, and Liver Enzymes in Libyan Patients with Type 2 Diabetes Mellitus","authors":"Hafsa M. Alemam, M. Eljilani, A. Bashein","doi":"10.1055/s-0042-1749117","DOIUrl":"https://doi.org/10.1055/s-0042-1749117","url":null,"abstract":"\u0000 Background Vitamin D is a fat-soluble hormone that plays an important role in glycaemic control. In addition, it has a positive effect on improving liver enzyme function.\u0000 Aim This study was performed to examine the effect of intramuscular injection of vitamin D on serum 25-hydroxyvitamin D [25(OH)D] levels, glycemic control, and liver enzymes in Libyan patients suffering from type 2 diabetes mellitus (T2DM) with vitamin D deficiency.\u0000 Methods and Materials This cross-sectional study enrolled 100 T2DM (50 males and 50 females). Their serum 25(OH)D, fasting blood glucose (FBG), and liver enzymes were measured at the baseline and 12 weeks after treatment with vitamin D (200,000 IU) injection monthly for 3 months. Data analysis involved the estimation of mean ± standard error (SE) and comparison of means between pre and post-treatment values using paired t-test. Independent t-test was used to compare the means between males and females. The level of significance was set at p < 0.05.\u0000 Results Females had a lower 25(OH)D blood levels than males at baseline (7.03 ± 0.25 ng/mL versus 7.86 ± 0.26 ng/mL, respectively p < 0.02). 25(OH)D levels in both sexes was increased significantly from 7.45 ± 0.18 ng/mL to 26.69 ± 0.24 ng/mL after 12 weeks of vitamin D injections (p < 0.001), with no significant differences between male and females. FBG levels in both sexes was significantly decreased from 144.68 ± 1.84 mg/dL to 85.96 ± 0.34 mg/dL post treatment (p < 0.001). Alanine aminotransferase (ALT) was increased from 10.24 ± 0.17 U/L at baseline to 20.34 ± 1.15 U/L post treatment (p < 0.001). Similarly, aspartate aminotransferase (AST) was increased from 11.23 ± 0.21 to 20.57 ± 0.22 U/L (p < 0.001), and alkaline phosphatase (ALP) was decreased from 124.95 ± 1.15 U/L to 111.17 ± 1.27 U/L (p < 0.001). There were no significant differences between male and female liver enzymes either pre- or post-vitamin D injections\u0000 Conclusion Treatment with vitamin D injection showed a significant increase in 25(OH)D accompanied by decreased FBG and ALP levels and increased ALT and AST levels. Vitamin D levels should be monitored and adjusted in diabetic patients.","PeriodicalId":18106,"journal":{"name":"Libyan International Medical University Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89164340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Swain, K. Sharma, A. Ray, S. Vyas, Gagandeep Singh, M. Joshi, D. Jain, I. Xess, Sanjeev Sinha, N. Wig
{"title":"Post-COVID-19-Invasive Pulmonary Mycosis","authors":"S. Swain, K. Sharma, A. Ray, S. Vyas, Gagandeep Singh, M. Joshi, D. Jain, I. Xess, Sanjeev Sinha, N. Wig","doi":"10.1055/s-0042-1750711","DOIUrl":"https://doi.org/10.1055/s-0042-1750711","url":null,"abstract":"COVID-19 has been associated with myriad manifestations as well as adverse outcomes. One of the less commonly reported consequences of COVID-19 is the occurrence of secondary infections in patients suffering acutely from COVID-19 or in those recuperating. Secondary invasive fungal infections (IFIs) have also been observed earlier in other viral infections such as influenza, parainfluenza, and respiratory syncytial virus infections. Severe lung damage and immunologic derangement resulting from SARS-CoV-2 infection predispose to superinfections. Risk factors for secondary IFI includes immunologic derangement and immunoparalysis resulting from SARS-CoV-2 infection, neutropenia, or lymphopenia, poorly controlled diabetes, structural lung disease fungal colonization, and drugs such as corticosteroids or immunomodulators given as therapies for COVID-19. Invasive aspergillosis following COVID-19 is most commonly described fungal infection but other non-Aspergillus fungal infections (including mucormycosis) has also been reported. Herein we describe two interesting cases of secondary infections developing in patients beyond the acute phase of COVID-19 who had similar presentations but with different diagnoses and requiring different management strategies. Patient in case 1 developed COVID-19-associated subacute invasive pulmonary aspergillosis (SAIA) and patient in case 2 had COVID-19 associated pulmonary mucormycosis (CAPM). We have also described the various postulated immune-pathogenesis of the super-added fungal infections in COVID-19 patients.","PeriodicalId":18106,"journal":{"name":"Libyan International Medical University Journal","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76721137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Gassar, N. Mohamed, Fatema Abdullah Emtawel, Rehab Elfakhri, S. Haider
{"title":"Doxycycline: An Antibiotic Attenuates Oxidant Stress, Perturbation of Lipid Metabolites, and Antioxidants against Vanadium Toxicity in Rat Hepatocytes","authors":"E. Gassar, N. Mohamed, Fatema Abdullah Emtawel, Rehab Elfakhri, S. Haider","doi":"10.1055/s-0042-1751258","DOIUrl":"https://doi.org/10.1055/s-0042-1751258","url":null,"abstract":"\u0000 Background The liver is target following exposure to pentavalent vanadium (V5+). Doxycycline is an antioxidant that prevents the progression of disease through inhibition of lipid peroxidation.\u0000 Aim The present study was designed to evaluate the protective effects of doxycycline against vanadium-induced hepatoxicity.\u0000 Methods Sixty two male Sprague-Dawley rats (250–300 g) were equally divided into the following four groups: control group (received 0.2 mL of physiological saline), doxycycline control group (received 4 mg/kg body weight on day 1 and 2 mg/kg body weight daily thereafter), vanadium group (received elemental vanadium 1.5 mg/kg-body weight in distilled water), and concomitantly treated group (doxycycline + vanadium) received (doxycycline 4 mg/kg body weight on day 1 and 2 mg/kg body weight thereafter + vanadium 1.5 mg/kg body weight), all given orally for 10 consecutive days. The rats were sacrificed by decapitation 24 hours after the last dose. The liver was removed rapidly and processed for the evaluation of metabolic variables: phospholipids, cholesterol, cerebrosides, gangliosides, reduced glutathione (GSH), vitamin C, calcium, acetylcholinesterase enzyme, and lipid peroxidation.\u0000 Results Vanadium administration significantly reduced (−60 g) the body weight and significantly increased (+28%) the relative liver weight compared with controls. The rats exhibited neurological function deficits. Vanadium administration decreased the concentrations of metabolic variables compared with controls, cerebrosides (−50%), cholesterol (−39%), phospholipids (−18%), GSH (−45%), and inhibited acetylcholinesterase enzyme (–48%). Gangliosides (+ 38%), vitamin C (+ 20%), and calcium (+ 80%) were increased together with an enhancement (+64%) in lipid peroxidation. The combined treatment (vanadium and doxycycline) significantly increased (+25 g) the body weight and relative liver weight of rat was significantly reduced (+5%) compared with vanadium administered group. The levels of metabolic variables were significantly reversed in this group in the following order: cholesterol (+17%), phospholipids (+7%), vitamin C (−14%), acetylcholinesterase enzyme activity (−27%) together with inhibition (−16%) of lipid peroxidation. All levels were (p < 0.05). Doxycycline presented no effect on the levels of GSH, cerebrosides, and gangliosides.\u0000 Conclusion Results of this study suggested vanadium-induced oxidation of lipids and sphingolipids in hepatocytes and much of GSH was consumed against high production of reactive oxygen species. Doxycycline protected against vanadium-induced oxidative damage that could be attributed to its free radical scavenging effects on membrane-bound lipids and acetylcholinesterase enzyme.","PeriodicalId":18106,"journal":{"name":"Libyan International Medical University Journal","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82998766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}