Liver International最新文献

{"title":"TIPSEMS-VB Trial Reappraised: Infection Control, HE Prophylaxis, and Ischemic Hepatitis Considerations","authors":"Kaiyu Bian, Yujie Zhang, Xiang Ma","doi":"10.1111/liv.70244","DOIUrl":"https://doi.org/10.1111/liv.70244","url":null,"abstract":"","PeriodicalId":18101,"journal":{"name":"Liver International","volume":"45 8","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thigh Muscles and Metabolic Dysfunction-Associated Steatotic Liver Disease: Findings From the SCAPIS/IGT-Microbiota Study","authors":"Amar Osmancevic,&nbsp;Anders Gummesson,&nbsp;Matthew Allison,&nbsp;Joel Kullberg,&nbsp;Ying Li,&nbsp;Göran Bergström,&nbsp;Bledar Daka","doi":"10.1111/liv.70239","DOIUrl":"https://doi.org/10.1111/liv.70239","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>The relationship between skeletal muscle features and hepatic fat infiltration remains understudied. To address this knowledge gap, a cross-sectional observational study was conducted using data from two ancillary studies of the SCAPIS cohort.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>The study aimed to examine the relationship between skeletal thigh muscle radiodensity (Hounsfield Units, HU) and area (cm²), and metabolic dysfunction-associated steatotic liver disease (MASLD) and hepatic radiodensity (HU). Multivariable linear regression analyses were applied to data from 4620 participants (52% women) with a mean age of 57.9 years. Adjustments for confounders were computed in four theoretical models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Results showed a positive significant association between thigh muscle area and MASLD (OR = 1.29, 95% CI 1.02, 1.62, <i>p</i> = 0.033), and a negative association with hepatic radiodensity (<i>B</i> = −0.76, 95% CI −1.19, −0.34, <i>p</i> = 0.001), independent of muscle radiodensity. Additionally, a significant association was observed between muscle radiodensity and hepatic radiodensity (<i>B</i> = 0.37, 95% 0.09, 0.64, <i>p</i> = 0.008). Finally, sex differences were notable in the association between thigh muscle area and MASLD (<i>F</i>-test = 0.10). Specifically, we observed statistically significant associations between thigh muscle features and liver density/MASLD in men, but not in women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Conclusively, increased thigh muscle volume was associated with greater odds of MASLD and hepatic steatosis, independent of muscle radiodensity. Yet, greater thigh muscle radiodensity was associated with decreased odds of hepatic steatosis, regardless of the muscle volume. Furthermore, a sex difference was observed in our study, underscoring the importance of considering sex-specific factors on the development of MASLD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18101,"journal":{"name":"Liver International","volume":"45 8","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/liv.70239","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The MAGIC-D Prognostic Score: Another Small Step in the Direction of Precision Oncology in Advanced Biliary Tract Cancer","authors":"Octave Letissier,&nbsp;Julien Edeline","doi":"10.1111/liv.70243","DOIUrl":"https://doi.org/10.1111/liv.70243","url":null,"abstract":"&lt;p&gt;In this issue of &lt;i&gt;Liver International&lt;/i&gt;, Persona et al. defined and validated a new prognostic score for advanced biliary tract cancer (BTC) treated with the current first-line standard of care, cisplatin-gemcitabine-durvalumab, the MAGIC-D score [&lt;span&gt;1&lt;/span&gt;]. The addition of immunotherapy to chemotherapy has been shown to improve Overall Survival (OS) over chemotherapy alone in two large phase 3 trials, with durvalumab in the TOPAZ-1 trial, or with pembrolizumab in the KEYNOTE-966 trial [&lt;span&gt;2, 3&lt;/span&gt;]. While the improvement could be seen as modest at the median, it is confirmed as persisting at long-term follow-up, and was able to preserve quality-of-life [&lt;span&gt;4, 5&lt;/span&gt;]. With this new standard of care, it is important to refine our prognostication of patients, as there are no widely accepted prognostic classifications of advanced BTC. A better prognostication might help us to more precisely personalise treatment.&lt;/p&gt;&lt;p&gt;Persona and colleagues made a huge effort by pooling a large multicentre global database of 618 patients treated with this new regimen. They developed a simple prognostic score, showing independent prognostic value of widely available variables (metastatic disease, carcinoembryonic antigen, albumin, gamma-glutamyl transferase, neutrophils-to-lymphocyte ratio), combining them in a score which was able to classify patients in 3 groups with clearly different outcomes (median OS and progression-free survival (PFS) of 18.4 and 11.7 in low-risk, 15.9 and 8.7 in intermediate-risk, and 7.8 and 5.4 months in high-risk groups, respectively). This was validated in a small confirmatory cohort (&lt;i&gt;n&lt;/i&gt; = 79, median OS and PFS of not reached and 12.8 months in the low-risk, 19.6 and 8.5 months in the intermediate-risk, and 12.2 and 5.0 in the high-risk groups, respectively).&lt;/p&gt;&lt;p&gt;This work has several strengths: it was developed in a large series, with patients from different regions of the globe, improving generalizability of the results; the use of real-world data is important because the patients included are less selected than in prospective clinical trials; the score is very simple, easy to calculate and despite this can provide important prognostic information. The work has also some limitations: the follow-up was quite short, less than 1 year, and the evaluation of long-term survival might be less precise, especially taking into account that the benefit of immunotherapy is maintained at long term; the authors pooled together perihilar cholangiocarcinoma, distal cholangiocarcinoma and gallbladder carcinoma in an “other primary sites” category, while each of them might have differences in prognosis, gallbladder cancer having potentially a worse prognosis [&lt;span&gt;6&lt;/span&gt;]; only 319 patients who had all variables available were included in the final multivariable model and 79 patients in the validation cohort; there was no molecular data available, while some data suggest differences in prognosis depending on molecular","PeriodicalId":18101,"journal":{"name":"Liver International","volume":"45 8","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/liv.70243","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the Bile Acid–Neutrophil Axis: Gut Microbiome and Sex-Dimorphism in Post-Cholecystectomy MAFLD","authors":"Haodong Wu,&nbsp;Hailiang Xie,&nbsp;Linghui Tao","doi":"10.1111/liv.70236","DOIUrl":"https://doi.org/10.1111/liv.70236","url":null,"abstract":"","PeriodicalId":18101,"journal":{"name":"Liver International","volume":"45 8","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Disparity in Major Adverse Liver Outcome and Major Adverse Cardiac Event in Alcohol-Associated Liver Disease","authors":"Pojsakorn Danpanichkul,&nbsp;Donghee Kim,&nbsp;Karn Wijarnpreecha,&nbsp;Mark D. Muthiah,&nbsp;Suthat Liangpunsakul","doi":"10.1111/liv.70245","DOIUrl":"https://doi.org/10.1111/liv.70245","url":null,"abstract":"","PeriodicalId":18101,"journal":{"name":"Liver International","volume":"45 8","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-Pathway Targeting in Liver Fibrosis: Exploring the Metabolic Implications of HSC Reprogramming","authors":"Yuan Lei,&nbsp;Hailiang Xie,&nbsp;Mingxian Chen","doi":"10.1111/liv.70237","DOIUrl":"https://doi.org/10.1111/liv.70237","url":null,"abstract":"","PeriodicalId":18101,"journal":{"name":"Liver International","volume":"45 8","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response: Methodological Considerations for Assessing the Long-Term Impact of Maternal MASLD on Offspring Health","authors":"Carole A. Marxer,&nbsp;Jonas F. Ludvigsson","doi":"10.1111/liv.70233","DOIUrl":"https://doi.org/10.1111/liv.70233","url":null,"abstract":"","PeriodicalId":18101,"journal":{"name":"Liver International","volume":"45 8","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenesis, Non-Invasive Assessments and Treatment of Hepatic Fibrosis in Autoimmune Liver Diseases","authors":"Ellina Lytvyak,&nbsp;Gideon Hirschfield,&nbsp;Devika Shreekumar,&nbsp;Yu Jun Wong,&nbsp;Aldo J. Montano-Loza","doi":"10.1111/liv.70190","DOIUrl":"https://doi.org/10.1111/liv.70190","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Autoimmune liver diseases (AILD), including autoimmune hepatitis (AIH), primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), can lead to progressive liver fibrosis, development of cirrhosis, decompensation, hepatocellular carcinoma (HCC), and need for liver transplantation (LT).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This review aims to provide a comprehensive overview of the mechanisms of liver fibrogenesis, non-invasive methods to assess hepatic fibrosis and potential anti-fibrotic interventions in AILD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results and Conclusions</h3>\u0000 \u0000 <p>Current management for AILD should incorporate non-invasive methods to evaluate changes in hepatic fibrosis and consider potential interventions aiming at controlling the progression of the disease, interruption and, potentially, reversal of liver fibrosis. Several laboratory tests can help distinguish patients with advanced fibrosis or cirrhosis but their utility in discriminating earlier histological stages of fibrosis is unclear. A current shift toward non-invasive radiological methods, such as vibration-controlled transient elastography, shear wave elastography, acoustic radiation force impulse imaging and magnetic resonance elastography, opens promising avenues for their wide application; however, their performances may be compromised by hepatic inflammation, ascites, biliary obstruction, or concomitant obesity and metabolic dysfunction-associated steatotic liver disease. Corticosteroids and immunomodulators have been shown to regress fibrosis in AIH patients. In PBC, treatment with either synthetic bile acids, farnesoid X receptor agonists or peroxisome proliferator-activated receptor agonist leads to the improvement or stabilization in the fibrosis stage. There is an urgent need for effective medical treatment in PSC, and available evidence of antifibrotic treatment is particularly limited. Promising anti-fibrotic interventions in AILD encompass conventional pharmacological agents as well as potential new treatments, such as fibrates, monoclonal antibodies, and site- and organelle-specific agents.</p>\u0000 </section>\u0000 </div>","PeriodicalId":18101,"journal":{"name":"Liver International","volume":"45 8","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/liv.70190","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ursodeoxycholic Acid: Not Just a Marker, but a Therapeutic Opportunity in Cholestatic CHILI","authors":"Lina Hountondji,&nbsp;Lucy Meunier","doi":"10.1111/liv.70234","DOIUrl":"https://doi.org/10.1111/liv.70234","url":null,"abstract":"","PeriodicalId":18101,"journal":{"name":"Liver International","volume":"45 8","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: Refining HCC Risk Stratification in CHB: Evaluating Predictive Model Applicability in Diverse Populations","authors":"Thisuri Jayawardena,&nbsp;Gerry MacQuillan,&nbsp;Tim Mitchell","doi":"10.1111/liv.70228","DOIUrl":"https://doi.org/10.1111/liv.70228","url":null,"abstract":"","PeriodicalId":18101,"journal":{"name":"Liver International","volume":"45 8","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}