Macroheterocycles最新文献

{"title":"Assignment of the Vibrations of Unsubstituted BODIPY and Aza-BODIPY","authors":"A. E. Pogonin, Darya A. Postnikova, Artyom Y. Shagurin, Danila V. Belov, S. Usoltsev, Y. Marfin","doi":"10.6060/mhc213973p","DOIUrl":"https://doi.org/10.6060/mhc213973p","url":null,"abstract":"","PeriodicalId":18090,"journal":{"name":"Macroheterocycles","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71167309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and Synchrotron X-Ray Structure of an Apically- and Ribbed-Functionalized Iron(II) Clathrochelate Decorated with Six Methoxyl and Two Carboxyl Terminal Groups","authors":"I. P. Limarev, G. E. Zelinskii, A. Vologzhanina, Y. Zubavichus, Y. Voloshin","doi":"10.6060/mhc210843z","DOIUrl":"https://doi.org/10.6060/mhc210843z","url":null,"abstract":"","PeriodicalId":18090,"journal":{"name":"Macroheterocycles","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71167434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectral Сharacterization of Сomplexes of Tetra- and Tricationic Porphyrins with DNA Duplex","authors":"N. Lebedeva, E. S. Yurina, M. A. Lebedev, A. N. Kiselev, S. Syrbu, Yury A. Gubarev","doi":"10.6060/mhc214031g","DOIUrl":"https://doi.org/10.6060/mhc214031g","url":null,"abstract":"","PeriodicalId":18090,"journal":{"name":"Macroheterocycles","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71167659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction of Cob(III)alamins with Hypothiocyanite. Evidence for the Formation of Hypothiocyanitocobalamin","authors":"Ilia A. Dereven’kov, V. S. Osokin","doi":"10.6060/mhc201128d","DOIUrl":"https://doi.org/10.6060/mhc201128d","url":null,"abstract":"Here, we report the results of investigation of the reactions between cobalamins (Cbls) and hypothiocyanite (OSCN – ), a product of thiocyanate oxidation by hydrogen peroxide in the presence of lactoperoxidase. In the case of aquacobalamin, the product, the UV-vis spectrum of which differs from the UV-vis spectra of Cbl(III)-complexes with SCN – , SO 3 2- , OCN – and CN – anions, is formed and attributed to hypothiocyanitocobalamin. This complex reacts with selenomethionine at substantially lower rate than the free OSCN – . Cyano- and methyl-Cbls are relatively stable in the presence of OSCN – . Glutathionylcobalamin is transformed to hypothiocyanitocobalamin in the presence of OSCN – excess via the oxidation of glutathionyl-ligand and subsequent binding of OSCN – by Cbl(III).","PeriodicalId":18090,"journal":{"name":"Macroheterocycles","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71166398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triacetate of Benzoazacrown Compound as a Chelator for Lead Cations Promising for Targeted Radiopharmaceuticals","authors":"B. Egorova, L. Zamurueva, A. Zubenko, A. V. Pashanova, Z. S. Pillai, O. Fedorova, S. Kalmykov","doi":"10.6060/mhc210440e","DOIUrl":"https://doi.org/10.6060/mhc210440e","url":null,"abstract":"Triacetate of 15-benzoazacrown-5 compound (H 3 BA3A) is a new ligand that has shown advantages towards chelation of some cations. In this paper H 3 BA3A was consequently studied for binding of lead cation. With respect to nuclear properties of 212 Pb radioisotope it can be used for therapy of various oncological diseases mainly due to alpha-emitting daughter radionuclide 212 Bi. Complexes of such radionuclides are considered as parts of targeted radiopharmaceuticals that can be conjugated with biomolecules to provide address delivery to cancerous tissues. Medical radionuclides are commonly short-lived and biomolecules are often heat-sensitive. That is why fast and stable complexation of trace amounts of lead cations in biologically relevant media without additional heating higher than 37 °C is important and challenging task. At the beginning we determined complexation constants in wide pH range including different protonated and hydrolyzed complex species via potentiometric titration technique. The obtained values are high enough for lead chelates logβ(BA3APb – ) = 17.2 (1). Structural features of complex in aqueous solution were established due to 1 H and 13 C NMR spectroscopy. High resolution of obtained spectra and comparison with spectrum of deprotonated ligand shows presence of one rigid conformer of complexed form in the aqueous solution with C s symmetry. In order to study labelled compounds we used longer lived isotope of lead 210 Pb isolated from solution of 226 Ra. Using thin layer chromatography and gamma-spectrometry it was found that 100 μM of ligand is enough to completely chelate 210 Pb in the tracer concentration related to radiopharmaceutical concentration of 212 Pb. According to pH speciation obtained in complexation constant determination, pH 5.5–6 was selected for labelling experiments. Noteworthy, the labeled compound was obtained within 1–5 minutes at room temperature as well as upon heating at 90 o C. Macrocyclic H 3 BA3A demonstrates fast complexation apparently due to larger crown cavity compared to cyclen cavity in H 4 DOTA. This was indirectly shown in potentiometric titration where waiting time for curve’s points was no longer than 5 minutes indicating that equilibrium was achieved within 5 minutes. In order to evaluate possible trans-chelation and trans-metallation of complex in living organism we performed challenging experiments in static conditions: in presence of nine-fold excess of serum proteins, biologically relevant cations 5 mM Ca 2+ , 5 mM Mg 2+ , 0.1 mM Zn 2+ , 0.1 mM Cu 2+ , 0.1 mM Fe 3+ and isotonic solution of 0.15 M NaCl. It was shown that the 100 % intactness of complex can be kept for up to two days of incubation in competing media. Summarizing, the H 3 BA3A forms highly stable complex with lead cation not only in model solution, but also in presence of challenging agents. This stability is provided by high stability constants and rigid structure in solution. 2 O solution using combined glass/AgCl ele","PeriodicalId":18090,"journal":{"name":"Macroheterocycles","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71167094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benzoannelated A3B-Phthalocyanines with Diethyleneglycol Substituents: Synthesis and Control of Aggregation","authors":"A. Yagodin, A. Martynov, Yulia G. Gorbunova, A. Tsivadze","doi":"10.6060/mhc210541m","DOIUrl":"https://doi.org/10.6060/mhc210541m","url":null,"abstract":"New benzoannelated phthalocyanine H 2 A 3 B has been synthesized by cross-condensation of 4,5-dibutoxyphthalonitrile A and naphthalonitrile B bearing two diethyleneglycol substituents. UV-Vis and 1 H NMR measurements performed for H 2 A 3 B showed that the presence of free OH-groups in H 2 A 3 B enhances its aggregation in solution in comparison with its O-tetrahydropyranyl derivative H 2 A 3 Bt , which can be considered as a way to control the physicochemical properties of asymmetric phthalocyanines.","PeriodicalId":18090,"journal":{"name":"Macroheterocycles","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71167161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vibrational Spectra of 5,10,15,20-Tetraphenylporphyrin (H2TPP) and Platinum(II) 5,10,15,20-Tetra(phenyl/pentafluorophenyl)porphyrins (PtTPP and PtTF5PP)","authors":"Ivan Yu Kurochkin, V. A. Olshevskaya, A. Zaitsev, Nina I. Girichevac, G. V. Girichev","doi":"10.6060/mhc224109g","DOIUrl":"https://doi.org/10.6060/mhc224109g","url":null,"abstract":"","PeriodicalId":18090,"journal":{"name":"Macroheterocycles","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71167692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Porphyrin Chemical Dimers to Complex Multicomponent Nanoassemblies: Some Rare Phenomena and Relaxation Processes","authors":"E. Zenkevich, D. Zahn, C. von Borczyskowski","doi":"10.6060/mhc214085z","DOIUrl":"https://doi.org/10.6060/mhc214085z","url":null,"abstract":"","PeriodicalId":18090,"journal":{"name":"Macroheterocycles","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71167923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ammonium Imidazoporphyrin – a Newborn in a Family of Porphyrins for Hybrid Materials","authors":"V. O. Nikulin, K. P. Birin, Yulia G. Gorbunova, A. Tsivadze","doi":"10.6060/mhc224231b","DOIUrl":"https://doi.org/10.6060/mhc224231b","url":null,"abstract":"","PeriodicalId":18090,"journal":{"name":"Macroheterocycles","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71168018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First Tetradentate Diamidophosphite Based on [5,10,15,20-Tetrakis(4-hydroxyphenyl)porphyrinato]zinc: Synthesis, Spectral Features, Coordination, and Application in Asymmetric Pd-Catalyzed Reactions","authors":"I. S. Mikhel, K. Gavrilov, S. Zheglov, Ivan M. Novikov, K. P. Birin, A. Chernyadyev, V. Tyurin","doi":"10.6060/mhc200918g","DOIUrl":"https://doi.org/10.6060/mhc200918g","url":null,"abstract":"The synthesis of the tetradentate diamidophosphite ( L ) containing four 1,3,2-diazaphospholidine rings and a porphyrin moiety, its characterization and application in asymmetric Pd-catalyzed reactions are reported. The best results (up to 63 % ee) were obtained for the Pd-catalyzed allylic alkylation of (E)-1,3-diphenylallyl acetate with dimethylmalonate. The complex L [Ru(p-cymene)Cl 2 ] 4 was synthesized in situ and characterized by spectroscopic data. The structure of the compounds obtained is discussed based on 1 H, 13 C, 13 C DEPT, 31 P, 1 H- 13 C HSQC, 1 H- 13 C HMBC, 1 H- 1 H COSY, 1 H- 1 H ROESY NMR spectroscopy, as well as UV-Vis and fluorescence spectroscopy.","PeriodicalId":18090,"journal":{"name":"Macroheterocycles","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71166496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}