Macroheterocycles最新文献_第4页

Dark and Photoinduced Cytotoxicity of Chlorophyll a Derivatives and Their Analogues towards HeLa Cells: Some Structure - Activity Relationships 叶绿素a衍生物及其类似物对HeLa细胞的暗和光致细胞毒性:一些结构-活性关系

IF 1.4 4区化学

Macroheterocycles Pub Date : 2022-01-01 DOI: 10.6060/mhc224176b

Y. Pylina, I. Khudyaeva, D. V. Belykh

引用次数: 1

Vitamin B12 as a Vector for the Transport of Drugs to the Tumor 维生素B12作为药物运输到肿瘤的载体

IF 1.4 4区化学

Macroheterocycles Pub Date : 2022-01-01 DOI: 10.6060/mhc224244k

D. V. Beigulenko, N. Shepeta, K. Kochetkov, S. Gelperina

{"title":"Vitamin B12 as a Vector for the Transport of Drugs to the Tumor","authors":"D. V. Beigulenko, N. Shepeta, K. Kochetkov, S. Gelperina","doi":"10.6060/mhc224244k","DOIUrl":"https://doi.org/10.6060/mhc224244k","url":null,"abstract":"Studies of various aspects of the action of vitamin B 12 bring interesting, often unexpected, results and open up new prospects for their practical application. The review focuses on recent advances in the use of natural cobalamins and their synthetic analogues in medical practice as vectors for targeted drug delivery to tumors. Particular attention is paid to the rationale for the use of corrinoids in this area in terms of their biodistribution and metabolism in the hu-man body. The most common in nature cobalamins and a number of the most important synthetic derivatives of vitamin B 12 , the absorption and distribution of cobalamins, the main functions of vitamin B 12 in the cell, general ap-proaches to bioorthogonal (i.e., preserving the biological functions of the molecule) modification, as well as consid-eration of sites in the structure of this compound, which are most suitable for conjugation, are successively discussed. The use of corrinoids for the diagnosis of tumors and drug delivery is considered separately. Examples of the synthesis of conjugates of cobalamins and various low molecular weight drugs, as well as proteins and oligonucleotides and targeted transport of the resulting compounds in tumors are analyzed. In conclusion, examples of the use of cobalamins as promising vectors for various colloidal delivery systems, including micro and nanoparticles, are given. The obtained results testify to the prospects of this direction. Of particular importance to the authors is the develop-ment of cobalamin-vectored drug delivery vehicles for chemotherapy of tumors, for which an increased expression of vitamin B 12 transport proteins is observed.","PeriodicalId":18090,"journal":{"name":"Macroheterocycles","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71168820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical study of the lanthanide complexes of tetra(1,2,5-thiadiazolo)porphyrazine, [TSDPzLn(acac)] (Ln = SmIII, EuIII, DyIII, ErIII, LuIII) 四（1,2,5-噻二唑）卟啉镧系配合物[TSDPzLn（acac）]（Ln=SmIII，EuIII，DyIII，ErIII，LuIII）的电化学研究

IF 1.4 4区化学

Macroheterocycles Pub Date : 2022-01-01 DOI: 10.6060/mhc224831s

Mahmoud Hamdoush, Sergey Sigunov, I. Skvortsov, Ekaterina N Tarakanova, P. Stuzhin

引用次数: 0

Preparation of a Hybrid Сeramic-Based Material with Immobilized Dicarboxyl-Terminated Ruthenium(II) Clathrochelate and Its Catalytic Activity in Methane Oxidative Conversion 固定化端羧基螯合钌(II)杂化Сeramic-Based材料的制备及其对甲烷氧化转化的催化活性

IF 1.4 4区化学

Macroheterocycles Pub Date : 2022-01-01 DOI: 10.6060/mhc224374z

A. S. Chuprin, A. Vologzhanina, A. Loktev, M. G. Bugaenko, Y. Voloshin, V. Buznik, A. Dedov

引用次数: 0

Design, Synthesis and Molecular Docking Studies of Indolo[2,3-a]Acridinol Derivatives 吲哚[2,3-a]吖啶醇衍生物的设计、合成及分子对接研究