Liver Transplantation最新文献_第10页

Letter to the Editor: Methodological considerations for predicting HCC recurrence after liver transplantation. 致编辑的信：预测肝移植后HCC复发的方法学考虑。

IF 4.7 2区医学

Liver Transplantation Pub Date : 2025-05-30 DOI: 10.1097/LVT.0000000000000646

Zhongheng Li

引用次数: 0

Living donor liver transplant offers pretransplant and posttransplant pediatric survival advantages. 活体肝移植提供了移植前和移植后的儿童生存优势。

IF 4.7 2区医学

Liver Transplantation Pub Date : 2025-05-30 DOI: 10.1097/LVT.0000000000000649

Amy G Feldman, Megan A Adams

引用次数: 0

From embedded interprofessional clinics to expanded alcohol-associated liver disease programs. 从嵌入的跨专业诊所到扩展的酒精相关肝病项目。

IF 4.7 2区医学

Liver Transplantation Pub Date : 2025-05-13 DOI: 10.1097/LVT.0000000000000638

Gerald Scott Winder, Juan Pablo Arab, Arpita Goswami Banerjee, Kelly Bryce, David C Fipps, Filza Hussain, Gene Im, Lesley Omary, Arpan A Patel, Shivali Patel, Susan Rubman, Marina Serper, Akhil Shenoy, Joji Suzuki, Paula Zimbrean, Kimberly Brown, Marwan Abouljoud, Jessica L Mellinger

{"title":"From embedded interprofessional clinics to expanded alcohol-associated liver disease programs.","authors":"Gerald Scott Winder, Juan Pablo Arab, Arpita Goswami Banerjee, Kelly Bryce, David C Fipps, Filza Hussain, Gene Im, Lesley Omary, Arpan A Patel, Shivali Patel, Susan Rubman, Marina Serper, Akhil Shenoy, Joji Suzuki, Paula Zimbrean, Kimberly Brown, Marwan Abouljoud, Jessica L Mellinger","doi":"10.1097/LVT.0000000000000638","DOIUrl":"10.1097/LVT.0000000000000638","url":null,"abstract":"Hazardous alcohol use remains a major contributor to acute and chronic liver disease, while alcohol-associated liver disease (ALD) is a leading indication for liver transplantation. In recent years, embedded, interprofessional ALD clinics have improved access to alcohol use disorder care within hepatology and liver transplantation, but more work is needed to meet this challenge. The literature is lacking regarding scaling procedures to provide services for increasingly large ill patient populations. This article begins to fill this gap by describing \"expanded ALD care\": broad, innovative, longitudinal, interprofessional care delivery strategies surpassing standalone clinics. Drawing from analogous patient populations served by collaborative models in primary care and comprehensive eating disorder treatment, the expanded ALD care framework proposes practical strategies toward specific innovations: equipoise between biomedical and psychosocial care elements, increased clinician number and reach, long-term patient relationships, harm reduction and palliative care, outreach to external agencies and clinicians, and enhanced support for patients and families. The article also defines attributes of innovative healthcare systems that support expanded ALD care.","PeriodicalId":18072,"journal":{"name":"Liver Transplantation","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and pathological spectrum of disease severity among patients with acute liver failure (ALF) undergoing deceased donor liver transplantation. 急性肝衰竭（ALF）患者接受死亡供肝移植的临床和病理特征

IF 3.9 2区医学

Liver Transplantation Pub Date : 2025-05-06 DOI: 10.1097/LVT.0000000000000634

Shannan R Tujios, Jody A Rule, Norman Sussman, Jorge L Rakela, Daniel Ganger, Nathan Bass, Adrian Reuben, R Todd Stravitz, David Kleiner, Hanlin Wang, Eun-Young K Choi, Lan Peng, Matthew Yeh, Bryce Hatfield, Guang-Yu Yang, Ryan Gill, Robert J Fontana, William M Lee

{"title":"Clinical and pathological spectrum of disease severity among patients with acute liver failure (ALF) undergoing deceased donor liver transplantation.","authors":"Shannan R Tujios, Jody A Rule, Norman Sussman, Jorge L Rakela, Daniel Ganger, Nathan Bass, Adrian Reuben, R Todd Stravitz, David Kleiner, Hanlin Wang, Eun-Young K Choi, Lan Peng, Matthew Yeh, Bryce Hatfield, Guang-Yu Yang, Ryan Gill, Robert J Fontana, William M Lee","doi":"10.1097/LVT.0000000000000634","DOIUrl":"10.1097/LVT.0000000000000634","url":null,"abstract":"Listing and transplanting patients with acute liver failure (ALF) is challenging, requiring rapid assessment of the likelihood of recovery. The availability of a large number of ALF liver explants, along with their clinical data, afforded an opportunity to retrospectively evaluate liver transplantation (LT) decision-making. We hypothesized that, with the benefit of hindsight, a small number of patients might have recovered without LT. Three hundred liver explants from ALF patients of varying etiologies who had undergone LT over 22 years in the Acute Liver Failure Study Group registry were reviewed for histopathological features and degree of necrosis by a committee of 8 hepatopathologists. A second committee of 8 experienced transplant hepatologists independently reviewed clinical data on these same 300 patients and retrospectively scored the likelihood that each patient required transplantation. Only 3 (1%) of those reviewed by the Clinical Committee were considered to \"Definitely\" not require liver grafting, while an additional 10 (3.3%) were deemed to \"Possibly\" not require transplantation (Not Likely Group, N=13). There was no difference in the degree of necrosis in explants in these groups, when compared to the remaining Likely Group, N=287 (95.6%), except in acetaminophen (APAP)-associated ALF, where the degree of necrosis was more uniformly graded as severe, correlating with the need for transplantation. Virtually every patient undergoing LT for ALF retrospectively appeared to need their transplant, based on expert clinical consensus review. Overall, there was poor correlation between clinical severity and apparent degree of necrosis seen in the 300 liver explants, except perhaps for APAP subjects.","PeriodicalId":18072,"journal":{"name":"Liver Transplantation","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12353392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of recipient hypernatremia on pediatric liver transplantation outcomes. 受体高钠血症对小儿肝移植结果的影响。

IF 4.7 2区医学

Liver Transplantation Pub Date : 2025-05-01 Epub Date: 2024-11-08 DOI: 10.1097/LVT.0000000000000528

Zhi Mei Sonia He, Gabriel Reyes, Tommy Liu, Malcolm McDonald, Spoorthi Kamepalli, John A Goss, Nhu Thao Nguyen Galvan, Abbas Rana

{"title":"The impact of recipient hypernatremia on pediatric liver transplantation outcomes.","authors":"Zhi Mei Sonia He, Gabriel Reyes, Tommy Liu, Malcolm McDonald, Spoorthi Kamepalli, John A Goss, Nhu Thao Nguyen Galvan, Abbas Rana","doi":"10.1097/LVT.0000000000000528","DOIUrl":"10.1097/LVT.0000000000000528","url":null,"abstract":"In pediatric liver transplants, dysnatremias have been found to have an impact on pretransplant and posttransplant outcomes. However, much of the current literature has focused on waitlist survival, secondary organ damage, and dysnatremia in donors rather than in recipients. To understand the effect of recipient immediate pretransplant hypernatremia on posttransplant mortality, we conducted a multivariable retrospective review analyzing data from 8011 pediatric patients undergoing liver transplantation provided by the United Network for Organ Sharing (UNOS). Multivariable analysis of hypernatremia showed an increased risk of mortality (OR: 2.49, 95% CI: 1.75, 3.54 for a serum sodium between 150 and 155 mEq/L), while hyponatremia did not show a significant increase in relative risk for mortality (HR: 1.11, 95% CI: 0.75, 1.63 for a serum sodium between 125 and 130 mEq/L). Kaplan-Meier curves stratified by sodium level showed statistically significant differences in outcomes with progressively increasing mortality associated with increasing serum sodium levels. In particular, there is a statistically significant increase in 90-day mortality with serum sodium levels above 150 mEq/L. Hyponatremia had a moderate impact on mortality but was not statistically significant. Our analysis of immediate pretransplantation resolution of hypernatremia also showed improved survival outcomes with a decreased mortality compared to transplant patients with unresolved hypernatremia. In conclusion, immediate pretransplant recipient hypernatremia has a substantial impact on pediatric post-liver transplantation survival. Corrected hypernatremia resulted in decreased mortality compared to uncorrected hypernatremia. Recipient hypernatremia is an important indicator of disease processes and a predictor of poor posttransplantation mortality outcomes.","PeriodicalId":18072,"journal":{"name":"Liver Transplantation","volume":" ","pages":"648-657"},"PeriodicalIF":4.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative outcomes of living donor liver transplantation in elderly recipients: A study on morbidity and survival in 1018 recipients. 老年受者活体肝移植的比较结果：关于 1,018 名受者发病率和存活率的研究。

IF 4.7 2区医学

Liver Transplantation Pub Date : 2025-05-01 Epub Date: 2024-10-25 DOI: 10.1097/LVT.0000000000000518

Fuat H Saner, Dimitri A Raptis, Leen Alchibi, Sami A Kareem, Kris Ann H Marquez, Yasser Elsheikh, Yasir Alnemary, Saleh Alabbad, Markus U Boehnert, Massimo Malago, Dieter C Broering

{"title":"Comparative outcomes of living donor liver transplantation in elderly recipients: A study on morbidity and survival in 1018 recipients.","authors":"Fuat H Saner, Dimitri A Raptis, Leen Alchibi, Sami A Kareem, Kris Ann H Marquez, Yasser Elsheikh, Yasir Alnemary, Saleh Alabbad, Markus U Boehnert, Massimo Malago, Dieter C Broering","doi":"10.1097/LVT.0000000000000518","DOIUrl":"10.1097/LVT.0000000000000518","url":null,"abstract":"Given the increasing demand of patients requiring liver transplants who are 70 years or older and may have health conditions, this study aimed to assess the outcomes of recipients of living donor liver transplants (LDLTs) in this age group. We conducted an analysis using a prospective registry that included all recipients of LDLT from January 2011 to May 2023. Patients were divided into 2 age groups, 18-69 years and 70 years or older, and their short-term and long-term outcomes were compared. We considered complications as major if they were grade ≥3a (Dindo-Clavien). Among 1018 recipients of LDLT, 71 (7%) were aged 70 years or older. The rates of posttransplant complications of any severity were comparable between the younger and older age groups (46.7% vs. 46%, p = 0.983), as were the rates of major complications (25% vs. 25%, p = 0.995) and in-hospital mortality (6% vs. 7%, p = 0.800). The 1-, 3-, and 5-year graft survival rates were 94%, 86%, and 81% in the younger group and 92%, 87%, and 65% in the older group ( p = 0.090). Similarly, the overall 1-, 3-, and 5-year recipient survival rates were 90%, 85%, and 86% in the younger group and 88%, 86%, and 65% in the older group ( p = 0.100). This study suggests that carefully selected elderly patients can undergo LDLT and achieve comparable short-term outcomes to their younger counterparts.","PeriodicalId":18072,"journal":{"name":"Liver Transplantation","volume":" ","pages":"630-636"},"PeriodicalIF":4.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142503168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Less salt and more water for children-not just dietary, but transplant management too. 儿童少吃盐多喝水——不仅仅是饮食，还有移植管理。

IF 4.7 2区医学

Liver Transplantation Pub Date : 2025-05-01 Epub Date: 2025-01-28 DOI: 10.1097/LVT.0000000000000577

M Kyle Jensen, Juan F Gallegos-Orozco

引用次数: 0

Jehovah's Witnesses: Challenges in liver disease management and in liver transplantation. 耶和华见证人：肝病管理和肝移植的挑战。

IF 4.7 2区医学

Liver Transplantation Pub Date : 2025-05-01 Epub Date: 2024-10-16 DOI: 10.1097/LVT.0000000000000514

Jordan S Sack, Sander S Florman, Thomas D Schiano

引用次数: 0

Letter to the Editor: Plasma exchange for alcohol-associated liver disease as a bridge to liver transplantation-A call to expand its adaptation in Japan. 致编辑的信：血浆置换治疗酒精相关肝病，作为肝移植的桥梁：呼吁扩大其在日本的适用范围。

IF 4.7 2区医学

Liver Transplantation Pub Date : 2025-05-01 Epub Date: 2024-12-10 DOI: 10.1097/LVT.0000000000000553

Takeru Yoshimoto, Daisuke Katagiri, Yasuo Tanaka

引用次数: 0

The caveat of biliary pH as biomarker of bile duct viability during normothermic machine perfusion of donor livers. 在供肝常温机器灌注过程中，胆道ph值作为胆管活力的生物标志物。

IF 4.7 2区医学

Liver Transplantation Pub Date : 2025-05-01 Epub Date: 2024-12-16 DOI: 10.1097/LVT.0000000000000538

Bianca Lascaris, Puck C Groen, Silke B Bodewes, Roberto Broere, Otto B van Leeuwen, Jeroen de Jonge, Vincent E de Meijer, Robert J Porte

引用次数: 0