Liver Transplantation最新文献_第10页

Liver transplantation after ex vivo normothermic machine preservation without recooling the graft: A clinical series from a single center. 无再冷却的离体恒温机器保存后的肝移植：来自单一中心的临床系列。

IF 4.7 2区医学

Liver Transplantation Pub Date : 2025-01-13 DOI: 10.1097/LVT.0000000000000564

Salvatore Gruttadauria, Ivan Vella, Sergio Li Petri, Caterina Accardo, Pasquale Bonsignore, Alessandro Tropea, Sergio Calamia, Duilio Pagano, Gaetano Burgio, Rosalia Longo, Fabrizio di Francesco

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Noninvasive assessment of renal dysfunction in patients with end-stage liver disease: New solutions for old problems? 终末期肝病患者肾功能的无创评估：老问题的新解决方案？

IF 4.7 2区医学

Liver Transplantation Pub Date : 2025-01-13 DOI: 10.1097/LVT.0000000000000566

Simone Incicco, Carmine Gambino

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Preoperative assessment of body composition and sarcopenia in candidates for multivisceral transplant . 多脏器移植候选者的体成分和肌肉减少症的术前评估。

IF 4.7 2区医学

Liver Transplantation Pub Date : 2025-01-13 DOI: 10.1097/LVT.0000000000000565

Ruy J Cruz, Hao Liu, Ajai Khanna, Colin Powers, Vikraman Gunabushanam, Andrea DiMartini

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Letter to the Editor: Impact of long-term continuous terlipressin infusion on the liver transplant waitlist in an Australian cohort. 致编辑的信：澳大利亚队列中长期持续输注特利加压素对肝移植等待名单的影响。

IF 4.7 2区医学

Liver Transplantation Pub Date : 2025-01-01 Epub Date: 2024-08-15 DOI: 10.1097/LVT.0000000000000456

Marie Sinclair, Brooke Chapman, Avik Majumdar, Adam Testro

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Introducing the History, Culture, and Liver Disease series. 历史、文化和肝病系列介绍。

IF 4.7 2区医学

Liver Transplantation Pub Date : 2025-01-01 Epub Date: 2024-08-26 DOI: 10.1097/LVT.0000000000000472

Russell Rosenblatt

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Mapping out a Medication Adherence Promotion System (MAPS): Can it reduce graft rejection in pediatric liver transplantation? 绘制药物依从性促进系统 (MAPS)：它能减少小儿肝移植中的移植物排斥反应吗？

IF 4.7 2区医学

Liver Transplantation Pub Date : 2025-01-01 Epub Date: 2024-09-02 DOI: 10.1097/LVT.0000000000000479

Sarah R Lieber, Marina Serper

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Cystatin C in decompensated cirrhosis: Shedding the excess baggage in clinical practice. 失代偿期肝硬化中的胱抑素 C：在临床实践中甩掉多余的包袱。

IF 4.7 2区医学

Liver Transplantation Pub Date : 2025-01-01 Epub Date: 2024-10-22 DOI: 10.1097/LVT.0000000000000516

Erin F Barreto, Olivia C Walker, Sumeet K Asrani

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Transjugular intrahepatic portosystemic shunt for the patients on the liver transplant list. 经颈静脉肝内门静脉分流术在肝移植名单上的应用。

IF 4.7 2区医学

Liver Transplantation Pub Date : 2025-01-01 Epub Date: 2024-09-09 DOI: 10.1097/LVT.0000000000000429

Cristina Ripoll, Falk Rauchfuss, Rene Aschenbach, Utz Settmacher, Alexander Zipprich

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Cystatin C and the difference between cystatin C and serum creatinine: Improved metrics to predict waitlist mortality among patients with decompensated cirrhosis. 胱抑素 C 以及胱抑素 C 与血清肌酐之间的差异：预测失代偿期肝硬化患者候诊死亡率的改进指标。

IF 4.7 2区医学

Liver Transplantation Pub Date : 2025-01-01 Epub Date: 2024-07-24 DOI: 10.1097/LVT.0000000000000439

Giuseppe Cullaro, Andrew S Allegretti, Kavish R Patidar, Elizabeth C Verna, Jennifer C Lai

{"title":"Cystatin C and the difference between cystatin C and serum creatinine: Improved metrics to predict waitlist mortality among patients with decompensated cirrhosis.","authors":"Giuseppe Cullaro, Andrew S Allegretti, Kavish R Patidar, Elizabeth C Verna, Jennifer C Lai","doi":"10.1097/LVT.0000000000000439","DOIUrl":"10.1097/LVT.0000000000000439","url":null,"abstract":"Among patients with decompensated cirrhosis, serum creatinine (sCr) is biased by sex, frailty, and hepatic synthetic function, while Cystatin C (cysC) is not. We found that sCr would better associate with waitlist mortality and that the difference between cysC and sCr (cysCsCr diff ) would quantify this bias and be independently associated with outcomes. We measured cysC levels at ambulatory liver transplant visits among 525 consecutive patients seen at our center. We defined the cysCsCr diff as the difference between cysC minus sCr. We compared demographics and clinical characteristics in patients with low, intermediate, and high cysCsCr diff , divided by tertile. We used Cox regression to compare the association between sCr and cysC and waitlist mortality and demonstrate the independent association between cysCsCr diff and waitlist mortality. In Cox regression, cysC was significantly more associated with waitlist mortality than sCr ( p < 0.001). We found that as compared to those with a low cysCsCr diff , those with an intermediate or high cysCsCr diff were more likely to be female, have ascites, have higher frailty, and have higher MELD 3.0 scores ( p < 0.05 for all). Compared to those with a low cysCsCr diff , we found that those in the intermediate and high groups were more likely to die during follow-up (low: 6% vs. intermediate: 8% vs. high: 11%, p = 0.007). We found that after adjusting for the components of the MELD 3.0 score, each 1-point increase in the cysCsCr diff was associated with 1.72× (1.27-2.32) the hazard of waitlist mortality. Our study demonstrates that not only is cysC more associated with waitlist mortality than sCr, but that cysCsCr diff represents a novel independent metric associated with waitlist mortality.","PeriodicalId":18072,"journal":{"name":"Liver Transplantation","volume":" ","pages":"24-31"},"PeriodicalIF":4.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141748525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implementation of a multicomponent medication adherence promotion system is associated with a decrease in late T-cell-mediated rejection. 多成分用药依从性促进系统的实施与晚期T细胞介导的排斥反应的减少有关。

IF 4.7 2区医学

Liver Transplantation Pub Date : 2025-01-01 Epub Date: 2024-05-31 DOI: 10.1097/LVT.0000000000000413

Julie Bonn, Teresa Ambrosino, Kristin Rich, Amy Taylor, Sharad I Wadhwani

{"title":"Implementation of a multicomponent medication adherence promotion system is associated with a decrease in late T-cell-mediated rejection.","authors":"Julie Bonn, Teresa Ambrosino, Kristin Rich, Amy Taylor, Sharad I Wadhwani","doi":"10.1097/LVT.0000000000000413","DOIUrl":"10.1097/LVT.0000000000000413","url":null,"abstract":"Poor immunosuppression adherence in pediatric recipients of liver transplant (LT) contributes to late T-cell-mediated rejection (TCMR) in ~90% of cases and increases the risk of mortality. A medication adherence promotion system (MAPS) was found to reduce late rejection in pediatric recipients of kidney transplants. Using quality improvement methodology, we adapted and implemented the MAPS in our LT clinic. Our primary outcome was population-level rates of late TCMR, measured as a monthly incident rate. Three-hundred fourteen patients undergoing LT are currently cared for at our institution. One-hundred sixty-two (52%) are females with a median age of 16 years and a median age at LT of 2 years. Preimplementation, monthly rejection rates were 0.84 rejections per 100 patient-months. After iterative implementation of MAPS over 2.3 years, monthly rejection rates decreased to 0.46 rejections per 100 patient-months, a 45% decrease in late TCMR. Implementation of MAPS was associated with a sustained 45% decrease in TCMR at a single center, suggesting that quality improvement tools may help improve clinical outcomes. MAPS may be an important tool to ensure long-term allograft health. Future studies should rigorously test MAPS across a multicenter sample.","PeriodicalId":18072,"journal":{"name":"Liver Transplantation","volume":" ","pages":"85-91"},"PeriodicalIF":4.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0