L'union medicale du Canada最新文献_第9页

[The stress gene in hypertension]. [高血压的应激基因]。

L'union medicale du Canada Pub Date : 1993-11-01

P Hamet, J Tremblay, Y L Sun, M Pravenec, J Kunes, V Kren

{"title":"[The stress gene in hypertension].","authors":"P Hamet, J Tremblay, Y L Sun, M Pravenec, J Kunes, V Kren","doi":"","DOIUrl":"","url":null,"abstract":"Thermosensitivity has been demonstrated in hypertensive rats and mice, and hypertension is frequent in hyperthermia-susceptible pigs. We have demonstrated that thermosensitivity segregates with hypertension in mice as a recessive trait in a single locus termed Tms. Since thermosensitivity can be demonstrated in cells obtained from neonatal hypertensive animals and persists after several passages in culture, it was of interest to study its cellular determinants. We undertook studies of candidate genes of cellular thermosensitivity, hsp70 being the major heat stress gene. First, we have observed an enhanced hsp70 mRNA accumulation in the hypertensive rat, mouse and human after heat shock of the whole animal, of its isolated organs or cultured cells. This increased accumulation of hsp70 mRNA in hypertension is due to its increased transcriptional rate. A restriction fragment length polymorphism (RFLP) of hsp70 was documented in hypertensive rats, which allowed the study of the segregation of this locus with hypertension in recombinant inbred strains of rats. At least one copy of hsp70 has been localized in RT1, the major histocompatibility complex of the rat, with polymorphism demonstrated with BamHI outside of the coding region of hsp70. This polymorphism segregates with 15 mmHg of systolic blood pressure. More recently, our studies led us to identify a polymorphism in another heat stress gene, hsp27. This polymorphism has been identified by PCR SSCP and is located in the 3' region, close to the termination translation codon.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":18049,"journal":{"name":"L'union medicale du Canada","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18904732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Profile of Chlamydia test utilization by the physicians of Laval]. [拉瓦尔州医生衣原体检测使用概况]。

L'union medicale du Canada Pub Date : 1993-11-01

L Arcand, H Arruda

{"title":"[Profile of Chlamydia test utilization by the physicians of Laval].","authors":"L Arcand, H Arruda","doi":"","DOIUrl":"","url":null,"abstract":"Before recommending systematic screening for Chlamydia trachomatis in young sexually-active women in its population, the Laval Community Health Department set out to document current practices in chlamydia testing. The objective of the study was to determine for whom these tests were prescribed, by whom and why. Data were obtained from a representative sample of 413 medical records. The greatest proportion of tests were prescribed for young women between the ages of 15-24 years. More than 85% of the tests were ordered by general practitioners, most of whom practiced in both hospital setting and private clinics. More than half of the tests were administered to obtain a diagnosis; approximately 42% were done for screening purposes. The study revealed a failure to document the sexual history of patients. It was estimated that between 30 and 40% of Chlamydia tests were not justified in being prescribed (according to the recommendations in the literature). It is possible that the criteria in the medical literature are too complex for use in everyday practice. The authors recommend the creation of specific tools adapted to physicians' needs, and the development of a screening program based on a systematic, step-by-step approach to determine whether or not a test is warranted.","PeriodicalId":18049,"journal":{"name":"L'union medicale du Canada","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19291890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[1992 update on the periodic medical examination. 4. Prophylaxis of gonococcal and Chlamydia ophthalmia in the newborn. Canadian study group on the periodic medical examination]. [1992年关于定期体格检查的最新情况。4. 新生儿淋球菌性和衣原体性眼炎的预防。加拿大定期体格检查研究小组]。

L'union medicale du Canada Pub Date : 1993-11-01

引用次数: 0

[Oncology at the Hotel-Dieu in Montreal]. [蒙特利尔上帝酒店肿瘤学]。

L'union medicale du Canada Pub Date : 1993-11-01

J Latreille

引用次数: 0

[The treatment of Cushing's disease]. [库欣病的治疗]。

L'union medicale du Canada Pub Date : 1993-11-01

M Somma, E Rasio, H Beauregard, O Serri, R Comtois, N Aris-Jilwan, A Boucher, J Hardy

引用次数: 0

[Hyperactivity in children: a valid diagnosis?]. 儿童多动症:一个有效的诊断?

L'union medicale du Canada Pub Date : 1993-11-01

R Dubé

引用次数: 0

[When medicine conceives its proper ingenuity... Interview by Robert Henry]. [当医学有了适当的独创性…[罗伯特·亨利采访]。

L'union medicale du Canada Pub Date : 1993-11-01

C Bertrand

引用次数: 0

[Heterogeneity of cognitive profiles in dementias of the Alzheimer type: theoretical aspects and clinical consequences]. [阿尔茨海默型痴呆认知特征的异质性:理论方面和临床后果]。

L'union medicale du Canada Pub Date : 1993-11-01

Y Joanette, L Melançon, B Ska, A R Lecours

{"title":"[Heterogeneity of cognitive profiles in dementias of the Alzheimer type: theoretical aspects and clinical consequences].","authors":"Y Joanette, L Melançon, B Ska, A R Lecours","doi":"","DOIUrl":"","url":null,"abstract":"Presently, Alzheimer's disease can only be diagnosed with the coexistence of clinical symptoms and the presence of neuropathological alterations. Thus, in the absence of pre mortem biological markers, cognitive deficits form the starting point and the basis of inclusion criteria on which the clinician relies in order to make a putative diagnose of dementia of the Alzheimer type (DTA). Cognitive deficits should thus be accurately described through neuropsychological testing since it is essential to identify the cognitive deterioration patterns of the patients--in terms of selective impairment of cognitive functions--as well as the evolution of these patterns. Regarding this issue, the classical teaching of the Geneva school has proposed a homogeneous deterioration of the aphasic-apraxicagnosic syndrome into four stages. However, recent work does not support this hypothesis. On the contrary, these studies tend to show the presence of heterogeneity in neuropsychological manifestations of the disease. The aim of the present paper is to provide a critical review of this topic through a brief survey of the classical work and research that have recently been conducted. An analysis of the possible candidates responsible for the existence of this heterogeneity of cognitive profiles is presented. Finally, theoretical implications and clinical repercussions are discussed.","PeriodicalId":18049,"journal":{"name":"L'union medicale du Canada","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19291937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Muscular weakness in a young woman]. [年轻女子的肌肉无力]。

L'union medicale du Canada Pub Date : 1993-11-01

G Cormier, H Masson, P P Turgeon, H Beauregard

引用次数: 0

[Pathologies of the musculo-skeletal system in musicians]. [音乐家肌肉骨骼系统的病理]。

L'union medicale du Canada Pub Date : 1993-11-01

M Dupuis

引用次数: 0