The Lancet最新文献

{"title":"Foodborne disease outbreaks in the USA and the need for prevention.","authors":"Shannon E Majowicz, Lucy J Robertson, Martyn D Kirk","doi":"10.1016/S0140-6736(26)02048-9","DOIUrl":"https://doi.org/10.1016/S0140-6736(26)02048-9","url":null,"abstract":"","PeriodicalId":18014,"journal":{"name":"The Lancet","volume":" ","pages":""},"PeriodicalIF":109.0,"publicationDate":"2026-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149322715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes after percutaneous coronary intervention with drug-eluting stents versus coronary artery bypass grafting for left main coronary artery disease: a prospective analysis of the multicentre IRIS-MAIN registry.","authors":"Seong-Bong Wee, Do-Yoon Kang, Jung-Min Ahn, Ju Hyeon Kim, Min-Ju Kim, Seung-Woon Rha, Sung-Ho Her, Hyo-Soo Kim, Hanbit Park, Chang-Wook Nam, Upendra Kaul, Won-Yong Shin, Jay-Young Rhew, June-Hong Kim, Jang Young Kim, Teguh Santoso, Woo-Young Chung, Youngkeun Ahn, Bong-Ki Lee, Jei Keon Chae, Jin-Bae Lee, Soon Jun Hong, Jin-Ok Jeong, Kyu-Rok Han, Alan Fong, Rakesh Sapra, Dong-Bin Kim, Ho Jin Kim, Kitae Kim, Joon Bum Kim, Jae Suk Yoo, Cheol Hyun Chung, Seung-Jung Park, Duk-Woo Park","doi":"10.1016/S0140-6736(26)02104-5","DOIUrl":"https://doi.org/10.1016/S0140-6736(26)02104-5","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous coronary intervention (PCI) with drug-eluting stents has been widely used to treat patients with left main coronary artery disease; however, long-term comparative outcomes versus coronary artery bypass grafting (CABG) in real-world populations remain poorly characterised. We aimed to compare long-term all-cause mortality after PCI or CABG in Asian patients with unprotected left main coronary artery disease.</p><p><strong>Methods: </strong>We analysed prospectively collected data from the multicentre IRIS-MAIN registry, conducted at 46 hospitals in South Korea, India, Japan, Indonesia, and Malaysia. The registry enrolled adults aged 18 years or older with unprotected left main coronary artery disease (defined as a stenosis diameter of ≥50% as visually estimated on angiography), who had been treated with PCI, CABG, or medical therapy alone. The primary outcome was all-cause mortality. We used a target trial emulation framework to compare the long-term risk of all-cause mortality between PCI with drug-eluting stents and isolated CABG. We used propensity-score overlap weighting to adjust for measured baseline covariates. The IRIS-MAIN Registry study is registered with ClinicalTrials.gov (NCT01341327).</p><p><strong>Findings: </strong>Between Jan 1, 2003, and Dec 31, 2024, 6900 patients were enrolled in the IRIS-MAIN registry, of whom 5379 (78·0%) underwent coronary revascularisation through either PCI with drug-eluting stents (3836 [71·3%]) or CABG (1543 [28·7%]) and were included in the analysis. The median duration of follow-up for all patients was 10·0 years (IQR 5·0-16·7). In the overlap-weighted population, no statistically detectable difference in 10-year weighted Kaplan-Meier rates of all-cause mortality was observed between PCI and CABG (24·0% vs 22·9%; overlap-weighted hazard ratio 1·00 [95% CI 0·87-1·14]; p=0·99). The confidence interval does not exclude a mortality benefit or harm with either strategy.</p><p><strong>Interpretation: </strong>In this non-randomised registry analysis of patients with left main coronary artery disease, there was no statistically detectable difference in all-cause mortality between PCI and CABG. For patients considered suitable for either strategy, multidisciplinary Heart Team discussion might help patients and clinicians weigh potential trade-offs in the choice between PCI and CABG. These findings are observational and cannot establish causal treatment effects or equivalence in survival.</p><p><strong>Funding: </strong>The CardioVascular Research Foundation (South Korea).</p>","PeriodicalId":18014,"journal":{"name":"The Lancet","volume":" ","pages":""},"PeriodicalIF":109.0,"publicationDate":"2026-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149322716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From PROSpect to the bedside: contextual and pathophysiological considerations.","authors":"Jeremy M Loberger, Robinder G Khemani","doi":"10.1016/S0140-6736(26)02054-4","DOIUrl":"https://doi.org/10.1016/S0140-6736(26)02054-4","url":null,"abstract":"","PeriodicalId":18014,"journal":{"name":"The Lancet","volume":"408 10566","pages":"1788-1789"},"PeriodicalIF":109.0,"publicationDate":"2026-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149298697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving men's health in a changing world.","authors":"The Lancet","doi":"10.1016/S0140-6736(26)02190-2","DOIUrl":"https://doi.org/10.1016/S0140-6736(26)02190-2","url":null,"abstract":"","PeriodicalId":18014,"journal":{"name":"The Lancet","volume":"408 10566","pages":"1787"},"PeriodicalIF":109.0,"publicationDate":"2026-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149298726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Men's health: recognising and responding to the problems.","authors":"Raewyn Connell, Toni Schofield","doi":"10.1016/S0140-6736(26)02098-2","DOIUrl":"https://doi.org/10.1016/S0140-6736(26)02098-2","url":null,"abstract":"","PeriodicalId":18014,"journal":{"name":"The Lancet","volume":"408 10566","pages":"1796-1798"},"PeriodicalIF":109.0,"publicationDate":"2026-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149298729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Department of Error.","authors":"","doi":"10.1016/S0140-6736(26)02105-7","DOIUrl":"10.1016/S0140-6736(26)02105-7","url":null,"abstract":"","PeriodicalId":18014,"journal":{"name":"The Lancet","volume":" ","pages":"1814"},"PeriodicalIF":109.0,"publicationDate":"2026-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149207269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whose vitiligo goes untreated?","authors":"Magrietha Swart, Zunaid Ahmed, Willem I Visser","doi":"10.1016/S0140-6736(26)02090-8","DOIUrl":"https://doi.org/10.1016/S0140-6736(26)02090-8","url":null,"abstract":"","PeriodicalId":18014,"journal":{"name":"The Lancet","volume":"408 10566","pages":"1812"},"PeriodicalIF":109.0,"publicationDate":"2026-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149298716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What kind of leader does WHO need?","authors":"Tikki Pangestu","doi":"10.1016/S0140-6736(26)02092-1","DOIUrl":"https://doi.org/10.1016/S0140-6736(26)02092-1","url":null,"abstract":"","PeriodicalId":18014,"journal":{"name":"The Lancet","volume":"408 10566","pages":"1813-1814"},"PeriodicalIF":109.0,"publicationDate":"2026-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149298706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-invasive tests in MASH: clinical practice versus trials.","authors":"Lise Lotte Gluud, Nina Kimer","doi":"10.1016/S0140-6736(26)01144-X","DOIUrl":"https://doi.org/10.1016/S0140-6736(26)01144-X","url":null,"abstract":"","PeriodicalId":18014,"journal":{"name":"The Lancet","volume":"408 10566","pages":"1794-1796"},"PeriodicalIF":109.0,"publicationDate":"2026-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149298688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reframing the manosphere: a public health response to a commercial ecosystem.","authors":"Sarah J Hawkes, Kent Buse","doi":"10.1016/S0140-6736(26)02027-1","DOIUrl":"https://doi.org/10.1016/S0140-6736(26)02027-1","url":null,"abstract":"<p><p>The manosphere, a diffuse commercial ecosystem and loose collection of online communities united by shared beliefs about masculinity, misogyny, and male victimisation, is an under-recognised determinant of health harms. This network has been implicated in considerable health harms: widespread mental health impacts, especially in young people; violence against women, girls, and gender minorities; and delegitimising help-seeking in boys and men. In this Viewpoint, we argue that the manosphere is best understood and addressed as a public health problem.</p>","PeriodicalId":18014,"journal":{"name":"The Lancet","volume":"408 10566","pages":"1912-1916"},"PeriodicalIF":109.0,"publicationDate":"2026-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149298751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}