Langenbecks Archiv fur Chirurgie最新文献_第8页

[111-indium DTPA octreotide scintigraphy in colorectal liver metastases]. [111-铟DTPA奥曲肽显像在结直肠肝转移中的应用]。

Langenbecks Archiv fur Chirurgie Pub Date : 1997-01-01

J K Seifert, R Görges, A Bockisch, T Junginger

{"title":"[111-indium DTPA octreotide scintigraphy in colorectal liver metastases].","authors":"J K Seifert, R Görges, A Bockisch, T Junginger","doi":"","DOIUrl":"","url":null,"abstract":"The somatostatin analogue octreotide is effective in the treatment of neuroendocrine and other tumours. 111-In-labelled DTPA-octreotide scintigraphy is successful in localizing primary neuroendocrine tumours and metastases and other tumours containing somatostatin receptors. An antiproliferative effect of octreotide was also demonstrated for colorectal carcinoma. Since only about 40% of colorectal carcinomas express somatostatin receptors, we tried to establish whether 111-In-labelled DTPA-octreotide scintigraphy is able to reveal the receptor status of liver metastases in patients with colorectal liver metastases. This would be useful in selecting patients for adjuvant therapy studies with octreotide. We performed 111-In-labelled DTPA-octreotide scintigraphy in ten patients with nonresectable liver metasoffes of colorectal origin and curatively resected primary. In nine of ten patients the liver metastases were somatostatin receptor negative, in one patient somatostatin receptor positive. In the patient with somatostatin receptor-positive liver metastases after resection of a rectal carcinoma, the histological examination of the biopsies from the liver metastases showed a solid tumour of neuroendocrinal differentiation. In the repeated histological examination of the specimen of the rectal primary, a small solid tumour with neuroendocrinal differentiation was found between formations of adenocarcinoma (adenoendocrine carcinoma). In our study 111-In-labelled DTPA-octreotide scintigraphy did not indicate the receptor status of liver metastases from colorectal carcinoma and was not useful in the planning of therapeutic regimens. For the diagnosis of the receptor status of colorectal liver metastases autoradiographic investigation on tissue biopsies are still necessary. In patients with adenoendocrine carcinomas 111-In-labelled DTPA-octreotide scintigraphy may help to histologically differentiate the metastases.","PeriodicalId":17985,"journal":{"name":"Langenbecks Archiv fur Chirurgie","volume":"382 6","pages":"332-6"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20422335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survival in primary soft tissue sarcoma of the extremities and trunk. 四肢和躯干原发性软组织肉瘤的存活率。

Langenbecks Archiv fur Chirurgie Pub Date : 1997-01-01 DOI: 10.1007/BF02391867

M Peiper, D Zurakowski, C Zornig

{"title":"Survival in primary soft tissue sarcoma of the extremities and trunk.","authors":"M Peiper, D Zurakowski, C Zornig","doi":"10.1007/BF02391867","DOIUrl":"https://doi.org/10.1007/BF02391867","url":null,"abstract":"Background: Soft tissue sarcomas (STS) of the extremities are rare. The purpose of this study was to identify prognostic risk factors associated with survival in patients with primary extremity and truncal STS.Methods: Patient, tumor, and pathologic data from 149 consecutive patients with localized primary STS of the extremities and trunk were analyzed using Kaplan-Meier and Cox regression techniques to identify univariate and multivariate risk factors. A subgroup analysis was performed to compare factors predictive of survival in patients who received treatment before (n = 50) and after (n = 99) treatment was standardized in 1988.Results: The 5-year survival rate was 76.5% with an average follow-up of 6 years. Local recurrence occurred in 23% of all patients, 40% before 1988 and 15% after 1988 (P < 0.0001). Risk factors associated with survival included resection quality (R0 vs. R1; P < 0.0001), era of operation (P = 0.002), local recurrence (P < 0.001), UICC stage (P < 0.0001), tumor size (P < 0.001), tumor depth (P = 0.002), regional lymph nodes (P < 0.0001), and histology (P < 0.0001). Multivariate analysis revealed that tumor size, tumor depth, and resection quality were independent risk factors of survival.Conclusions: These results indicate that management of STS in a specialized institution improves overall survival. Resection quality is the most important risk factor of survival. Therefore, effort should be made during primary treatment of STS to achieve wide, tumor-free resection margins.","PeriodicalId":17985,"journal":{"name":"Langenbecks Archiv fur Chirurgie","volume":"382 4","pages":"203-8"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02391867","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20324883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Preservation of pig liver allografts after warm ischemia: normothermic perfusion versus cold storage. 猪同种异体肝脏热缺血后的保存:常温灌注与冷藏。

Langenbecks Archiv fur Chirurgie Pub Date : 1997-01-01 DOI: 10.1007/BF02391863

A Hellinger, R Fiegen, R Lange, U Rauen, U Schmidt, H Hirche, S Kaiser, H de Groot, J Erhard, F W Eigler

{"title":"Preservation of pig liver allografts after warm ischemia: normothermic perfusion versus cold storage.","authors":"A Hellinger, R Fiegen, R Lange, U Rauen, U Schmidt, H Hirche, S Kaiser, H de Groot, J Erhard, F W Eigler","doi":"10.1007/BF02391863","DOIUrl":"https://doi.org/10.1007/BF02391863","url":null,"abstract":"Warm ischemia is known to induce substantial damage to the liver parenchyma. With respect to clinical liver transplantation, the tolerance of the liver to warm ischemia and the preservation of these organs have not been studied in detail. In isolated reperfused pig livers we proceeded according to the following concept: Livers were subjected to 1 or 3 h of warm ischemia. Subsequently, these organs were preserved by either normothermic perfusion or cold storage (histidine-tryptophan-alpha-ketoglutarate, HTK) for 3 h each. After storage, liver function was assessed in a reperfusion circuit for another 3 h. Parameters under evaluation were bile flow, perfusion flow, oxygen consumption, enzyme release into the perfusate (creatine kinase, glutamic oxaloacetic transaminase (GOT), lactic dehydrogenase, and glutamic pyruvic transaminase), and histomorphology. Damage to the liver was lowest after warm ischemia of 1 h. The results after cold storage were superior to those after normothermic perfusion (GOT: 3.2 +/- 0.3 and 2.6 +/- 0.2 U/g liver; cumulative bile production: 14.7 +/- 2.1 and 9.4 +/- 1 ml, respectively; P < 0.05). In contrast, we found substantial damage at the end of reperfusion in livers undergoing 3 h of warm ischemia under both preservation techniques with severe hepatocellular pyknoses and essentially altered nonparenchymal cells. The results suggest that pig livers undergoing 1 h of warm ischemia and cold storage for 3 h with HTK solution may lead to functioning after transplantation.","PeriodicalId":17985,"journal":{"name":"Langenbecks Archiv fur Chirurgie","volume":"382 4","pages":"175-84"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02391863","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20324882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

[A break or bend in the unreamed tibial intramedullary nail. Experimental study]. [未扩孔的胫骨髓内钉的断裂或弯曲]实验研究)。

Langenbecks Archiv fur Chirurgie Pub Date : 1997-01-01

E Wallenböck, G Koch

{"title":"[A break or bend in the unreamed tibial intramedullary nail. Experimental study].","authors":"E Wallenböck, G Koch","doi":"","DOIUrl":"","url":null,"abstract":"The intramedullary tibial nail with a proximal angle according to Herzog was developed in order to facilitate implantation. However, the modified technique of unreamed nailing also required a shift of the point of insertion; as a consequence the proximal angle required a considerable increase in the force necessary to introduce the nail. In a study using-four cadaver bones and five commercially available unreamed femoral and tibial nails, the authors demonstrate this considerable increase in insertion force and the development of pressure in the medullary cavity. The measurements made with our experimental setup clearly show that the proximal angle of the unreamed tibial nails available for our series does not have a favourable influence on insertion behaviour. As it appears, it results in an increase in the force required for insertion of the nail, thus also causing a greater strain on the bone and an increase in pressure in the medullary cavity. In contrast, the continuous bend of the nail results in a much smoother course of pressure development in the medullary cavity, which does not reach the same high values as with the unreamed tibial nails, despite the fact that less time is required for insertion of the nail. In our opinion, modification of the axial shape of the nail would result both in better implantability and easier removal. We therefore advocate such a modification of the axial shape of intramedullary tibia nails.","PeriodicalId":17985,"journal":{"name":"Langenbecks Archiv fur Chirurgie","volume":"382 5","pages":"257-65"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20339177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Long-term results of abdominal surgery interventions. Different evaluation from the viewpoint of the patient, the surgeon and the public health office]. 腹部手术干预的长期结果。从病人、外科医生和公共卫生办公室的角度进行不同的评价]。

Langenbecks Archiv fur Chirurgie Pub Date : 1997-01-01 DOI: 10.1007/BF02539303

P Scherwitz, S P Mönig, T Schmitz-Rixen, M Raab

{"title":"[Long-term results of abdominal surgery interventions. Different evaluation from the viewpoint of the patient, the surgeon and the public health office].","authors":"P Scherwitz, S P Mönig, T Schmitz-Rixen, M Raab","doi":"10.1007/BF02539303","DOIUrl":"10.1007/BF02539303","url":null,"abstract":"The patient, the surgeon and the public health officer (Versorgungsamt) assess the long-term results of abdominal operations differently. We tried to objectivize these different assessments. The clinical data were collected retrospectively. Data on postoperative subjective state and degree of handicap were obtained in a written patient survey (March 1995). Two groups with benign diseases and one group with malignant disease were examined: 59 patients who had undergone sigmoidectomy for diverticulitis (30 female and 29 male patients, median age: 61.5 years), 347 patients subjected to proximal gastric vagotomy for duodenal ulcers (72 female and 275 male patients, median age: 46 years) and 158 patients who had undergone gastrectomy for gastric carcinoma (56 patients female, 102 patients male, median age: 61 years). The public health officer, classed 35.6% of the patients who had undergone sigmoidectomy and 34.6% of the patients who underwent vagotomy as officially handicapped with a stated grade of disablement, 77.2% of the patients with gastrectomy were officially classed as handicapped. When other diseases were taken into account in addition, 27.1% of the patients who had undergone sigmoidectomy, 27.4% of those who had undergone vagotomy and 75.9% of the patients with gastrectomy had received passes officially identifying them as severely handicapped persons. In the vast majority of cases, the combination of several different ailments had resulted in recognition of a graded handicap and severely disabled person's pass, skeletal, cardiac and circulatory ailments being the most frequent. In spite of this, the evaluation of post-operative course by our patients, the surgeon and the public health officer (as reflected in the official state classification) in terms of the degree of handicap clearly differed.","PeriodicalId":17985,"journal":{"name":"Langenbecks Archiv fur Chirurgie","volume":"382 1","pages":"19-24"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20104845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Comparison of local and systemic inflammation after laparotomy or laparoscopy in the rat sepsis model]. [大鼠脓毒症模型剖腹和腹腔镜术后局部和全身炎症的比较]。

Langenbecks Archiv fur Chirurgie Pub Date : 1997-01-01 DOI: 10.1007/pl00014645

C A Jacobi, H U Zieren, R Sabat, W Lorenz, F E Halle, J M Müller

{"title":"[Comparison of local and systemic inflammation after laparotomy or laparoscopy in the rat sepsis model].","authors":"C A Jacobi, H U Zieren, R Sabat, W Lorenz, F E Halle, J M Müller","doi":"10.1007/pl00014645","DOIUrl":"https://doi.org/10.1007/pl00014645","url":null,"abstract":"Background: Laparoscopic techniques are frequently used in patients with peritonitis or intra-abdominal inflammatory diseases although increased intraperitoneal pressure may cause sepsis by promoting bacteraemia and systemic inflammatory response.Methods: This experimental study investigates the influence of laparotomy and laparoscopy on bacteraemia, tumour necrosis factor (TNF)-alpha and endotoxin plasma levels. Standardized foecal inoculum was injected intraperitoneally and rats underwent either laparotomy (n = 20), laparoscopy (n = 20), or no further manipulation in the control group (n = 20).Results: One hour after intervention, bacteraemia was significantly higher in both the laparotomy or laparoscopy groups than in the control group (P = 0.01). Foecal inoculum caused a significant increase in TNF-alpha and endotoxin plasma levels 1 h after intervention with the significantly highest levels after laparotomy (P < 0.05). In addition, the mean number of intraperitoneal abscesses were also significantly higher (P < 0.05) after laparatomy (n = 10) than after laparoscopy (n = 8) or in the control group (n = 5).Conclusions: Laparotomy and laparoscopy increased the incidence of bacteraemia and systemic inflammation compared to control group. However, inflammatory response and intraperitoneal abscess formation were significantly higher in the laparotomy group than in the laparoscopy group.","PeriodicalId":17985,"journal":{"name":"Langenbecks Archiv fur Chirurgie","volume":"382 4 Suppl 1","pages":"S9-13"},"PeriodicalIF":0.0,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/pl00014645","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20267641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

[Morphologic effect of adrenaline and insulin on bone capillaries after receptor blockade. Functional transmission electron microscopy analysis]. 受体阻断后肾上腺素和胰岛素对骨毛细血管的形态学影响。功能透射电镜分析]。

Langenbecks Archiv fur Chirurgie Pub Date : 1997-01-01

J R Döhler, S P Hughes

引用次数: 0

[Primary malignant intraluminal tumor of the aorta]. 原发性主动脉腔内恶性肿瘤。

Langenbecks Archiv fur Chirurgie Pub Date : 1997-01-01

U Settmacher, M Heise, K Dette, U Frei, P Neuhaus

引用次数: 0

Fournier's gangrene: still highly lethal. 富尼耶坏疽：仍然是高度致命的。

Langenbecks Archiv fur Chirurgie Pub Date : 1997-01-01 DOI: 10.1007/BF02539302

A J Papachristodoulou, G N Zografos, G Papastratis, V Papavassiliou, C J Markopoulos, D Mandrekas, J G Gogas