Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants最新文献

Estudio comparativo de la actividad anti-fúngica de extractos secuenciales de Fuchsia lycioides contra Candida sp. 紫红色枸杞提取物对念珠菌抗真菌活性的比较研究。

Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants Pub Date : 2022-01-30 DOI: 10.37360/BLACPMA.22.21.1.08

Marcela Brito, A. Maturana, I. Montenegro, Bastian Said, A. M. V. Morales, Valeska Calderon, S. Flores, Manuel Martínez, Alejandro Madrid

引用次数: 1

Potential antioxidant effect of fruit peels for human use from northern Peru, compared by 5 different methods 秘鲁北部水果果皮的潜在抗氧化作用，通过5种不同的方法进行比较

Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants Pub Date : 2021-08-17 DOI: 10.37360/BLACPMA.21.20.6.44

M. L. Ganoza-Yupanqui, Amner Muñoz-Acevedo, R. Ybañez-Julca, E. Mantilla‐Rodríguez, Ewaldo Zavala, Sandra Gajardo, Miguel Rios, J. Benites, Jose L. Martinez

{"title":"Potential antioxidant effect of fruit peels for human use from northern Peru, compared by 5 different methods","authors":"M. L. Ganoza-Yupanqui, Amner Muñoz-Acevedo, R. Ybañez-Julca, E. Mantilla‐Rodríguez, Ewaldo Zavala, Sandra Gajardo, Miguel Rios, J. Benites, Jose L. Martinez","doi":"10.37360/BLACPMA.21.20.6.44","DOIUrl":"https://doi.org/10.37360/BLACPMA.21.20.6.44","url":null,"abstract":"The objective of the work was to determine the antioxidant potential in vitro of freeze-dried peel extracts of 20 fruits from the northern region of Peru through five tests (Folin-Ciocalteu, DPPH., ABTS+., FRAP and CUPRAC). According to multivariate statistical analyzes, five groups were found: (i.) peel extracts with the highest values of antioxidant capacity (AC) from custard apple, and star fruit; (ii.) rind extracts with high AC values from quince, sweet granadilla, guava, and black grape; (iii.) husk extracts with middle values of AC from passion fruit, and red mombin; (iv.) shell extracts with low AC values from tangerine, mandarine, and bitter orange; and, (v.) coating extracts with the lowest AC values from pawpaw, red pawpaw, muskmelon, dragon fruit, yellow and red indian figs, pear, apple, and green grape. To conclude, the fruit lyophilized-husk extracts of custard apple, star fruit, quince, sweet granadilla, guava, and black grape obtained the best AC.","PeriodicalId":17966,"journal":{"name":"Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80317594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Phytochemical composition and biological screening of two Lophophytum species 两种枇杷属植物的化学成分及生物学筛选

Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants Pub Date : 2021-08-17 DOI: 10.37360/BLACPMA.21.20.6.43

C. Torres, C. Zamora, Héctor A Sato, M. B. Nuñez, Ana Maria Gonzalez

{"title":"Phytochemical composition and biological screening of two Lophophytum species","authors":"C. Torres, C. Zamora, Héctor A Sato, M. B. Nuñez, Ana Maria Gonzalez","doi":"10.37360/BLACPMA.21.20.6.43","DOIUrl":"https://doi.org/10.37360/BLACPMA.21.20.6.43","url":null,"abstract":"Lophophytum species are holoparasites that grow on tree roots. The objectives of the work were to explore the chemical composition of the tubers of two Lophophytum species and to analyze the antioxidant, anti-inflammatory and antilithiatic activity of their extracts using in vitro methods. The chemical composition was determined by histochemical, phytochemical and TLC tests. In addition, the profile of phenolic compounds was determined by HPLC-MS. The presence of secondary metabolites of recognized activity was demonstrated. The results of the HPLC-MS/MS allowed the tentative identification of catechin, luteolin and glycosides of eriodictyol, naringenin and luteolin in the extract of Lophophytum leandri and eriodictyol, naringenin, luteolin and their glycosylated derivatives in Lophophytum mirabile. The extracts showed promising antioxidant (DPPH, ABTS and β-carotene-linoleic acid), anti-inflammatory (inhibition of 5-LOX) and anti-urolytic (by bioautographic TLC) activity. It is noteworthy that these are the first results of the phytochemical composition and biological activity of L. mirabile. However, in vivo studies are required to corroborate these activities.","PeriodicalId":17966,"journal":{"name":"Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73467514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative characterization of cinnamon, cinnamaldehyde and kaempferol for phytochemical, antioxidant and pharmacological properties using acetaminophen-induced oxidative stress mouse model 利用对乙酰氨基酚诱导的氧化应激小鼠模型，比较表征肉桂、肉桂醛和山奈酚的植物化学、抗氧化和药理特性

Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants Pub Date : 2021-07-30 DOI: 10.37360/BLACPMA.21.20.4.25

Zulfia Hussain, Junaid Ali Khan, M. Arshad, F. Muhammad, R. Z. Abbas

{"title":"Comparative characterization of cinnamon, cinnamaldehyde and kaempferol for phytochemical, antioxidant and pharmacological properties using acetaminophen-induced oxidative stress mouse model","authors":"Zulfia Hussain, Junaid Ali Khan, M. Arshad, F. Muhammad, R. Z. Abbas","doi":"10.37360/BLACPMA.21.20.4.25","DOIUrl":"https://doi.org/10.37360/BLACPMA.21.20.4.25","url":null,"abstract":"This study was aimed to explore the comparative efficacy of cinnamon bark extract, cinnamaldehyde and kaempferol against acetaminophen (APAP)-induced oxidative stress. Cinnamon bark extract, cinnamaldehyde and kaempferol were utilized for in-vivo analysis. From the results of in-vitro screening tests, cinnamon ethanolic extract was selected for in-vivo study in mouse model. For this, Balb/c albino mice were treated with cinnamon ethanolic extract (200 mg/kg), cinnamaldehyde (10 mg/kg) and kaempferol (10 mg/kg) orally for 14 days followed by single intraperitoneal administration of APAP during 8 hours. Blood and organ samples were collected for biochemical and histopathological analysis. The results showed that cinnamon bark ethanolic extract, cinnamaldehyde and kaempferol ameliorated APAP-induced oxidative stress and organ toxicity in mice. In conclusion, cinnamaldehyde and kaempferol possess comparable antioxidant potential even at 20-times less dose as compared to cinnamon bark ethanolic extract suggesting therapeutic potential in oxidative stress-related disorders.","PeriodicalId":17966,"journal":{"name":"Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73572389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Foliar morpho-anatomy of Araujia odorata (Apocynaceae - Asclepiadoideae) in an altitudinal gradient. Histochemistry of laticifers 天麻科-天麻科臭麻叶在海拔梯度上的形态解剖。乳汁管的组织化学

Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants Pub Date : 2021-07-30 DOI: 10.37360/BLACPMA.21.20.4.27

M. Alvarez, M. I. Mercado, M. E. Guantay, G. Ponessa

{"title":"Foliar morpho-anatomy of Araujia odorata (Apocynaceae - Asclepiadoideae) in an altitudinal gradient. Histochemistry of laticifers","authors":"M. Alvarez, M. I. Mercado, M. E. Guantay, G. Ponessa","doi":"10.37360/BLACPMA.21.20.4.27","DOIUrl":"https://doi.org/10.37360/BLACPMA.21.20.4.27","url":null,"abstract":"Araujia odorata is a sub-shrub native from Argentina, Brazil, Paraguay and Uruguay, whose latex, roots and leaves are used in traditional medicine. The objective of this work is to study the foliar morpho-anatomy of six populations in an altitudinal gradient (359-2155 m.a.s.l.) of Northwestern Argentine and to determine the nature of the compounds present in the laticiferous of the stems and fruits using conventional techniques for plant anatomy. The populations under study did not show significant morpho-anatomical differences. They presented simple leaves, pinnated brochydodromous venation, amphiestomatic isolateral lamina, brachy, anomo and amphicyclocytic stomata, eglandular trichomes, midvein with bicolateral vascular bundle and non-articulated laticifers continuous in the petiole, stem and fruits. Differences in the quantified foliar parameters are observed, however, only the density of trichomes, stomata and the thickness of the cuticle are positively correlated with the altitudinal gradient, indicating phenotypic plasticity. Histochemical analysis of laticifers and other stem idioblasts of A. odorata was performed for the first time.","PeriodicalId":17966,"journal":{"name":"Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84125846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological properties and phytochemical characterization from Miconia chamissois Naudin aqueous extract 水提物的生物学特性和植物化学性质

Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants Pub Date : 2021-07-30 DOI: 10.37360/BLACPMA.21.20.4.32

L. Gomes, Diegue Henrique Nascimento Martins, Sandra Marcia Mazutti da Silva, Yuri Yabu de Barros, P. M. de Souza, M. D. de Freitas, Cristopher William Fagg, L. A. Simeoni, P. O. Magalhães, D. Silveira, Y. Fonseca-Bazzo

{"title":"Biological properties and phytochemical characterization from Miconia chamissois Naudin aqueous extract","authors":"L. Gomes, Diegue Henrique Nascimento Martins, Sandra Marcia Mazutti da Silva, Yuri Yabu de Barros, P. M. de Souza, M. D. de Freitas, Cristopher William Fagg, L. A. Simeoni, P. O. Magalhães, D. Silveira, Y. Fonseca-Bazzo","doi":"10.37360/BLACPMA.21.20.4.32","DOIUrl":"https://doi.org/10.37360/BLACPMA.21.20.4.32","url":null,"abstract":"The objective of this study was to evaluate biological and phytochemical properties of the aqueous extract from the leaves of Miconia chamissois Naudin (AEMC). Phytochemical properties were assessed by analyzing the chromatographic profile and the polyphenol content of AEMC. Biological properties evaluation was conducted based on cytotoxicity assay and by evaluating the antioxidant, antimicrobial, and enzymatic inhibition activities. Results indicated the presence of phytochemicals in AEMC such as flavonoids and polyphenols, including rutin, isoquercitrin and vitexin derivatives. AEMC showed antioxidant activity, which may be attributed to the high polyphenolic content. Moreover, AEMC demonstrated in vitro enzyme inhibition activity against tyrosinase and alpha-amylase, as well as showed low cytotoxicity. On the other hand, AEMC exhibited weak antimicrobial activity against S. aureus and C. albicans. Thus, AEMC is a promising alternative in search of potential drugs for the treatment of diseases induced by oxidative stress and inflammation, conditions due to hyperpigmentation processes, such as melisma, as well as for diabetes.","PeriodicalId":17966,"journal":{"name":"Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90760779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

In vitro and in vivo antioxidant potentials of the methanolic crude extract from Inula glomerata Oliv. & Hiern (Asteraceae) and Salacia kraussii (Harv.) Harv (Celastraceae) 菊果甲醇粗提物体外和体内抗氧化活性的研究。&海麒麟(菊科)和克拉希亚(哈佛)哈里(卫矛科)

Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants Pub Date : 2021-07-30 DOI: 10.37360/BLACPMA.21.20.4.31

M. Ojo, F. Osunsanmi, N. Cele, G. E. Zharare, R. Mosa, A. Opoku

{"title":"In vitro and in vivo antioxidant potentials of the methanolic crude extract from Inula glomerata Oliv. & Hiern (Asteraceae) and Salacia kraussii (Harv.) Harv (Celastraceae)","authors":"M. Ojo, F. Osunsanmi, N. Cele, G. E. Zharare, R. Mosa, A. Opoku","doi":"10.37360/BLACPMA.21.20.4.31","DOIUrl":"https://doi.org/10.37360/BLACPMA.21.20.4.31","url":null,"abstract":"Reactive oxygen species are implicated in multiple pathological conditions including erectile dysfunction. This study evaluated the in vitro and in vivo antioxidant potential of the methanolic extracts of Inula glomerata and Salacia kraussii. The plant materials were pulverized and extracted with methanol. The phytochemical analysis, ability of the crude extracts to scavenge free radicals (ABTS, DPPH, NO.) in vitro as well as the total phenolic and flavonoid contents was investigated. In vivo, antioxidant potentials of the crude extracts (50/250 mg/kg body weight) were determined in an erectile dysfunction rat model. The phytochemical analysis revealed that both plants contain flavonoids, tannins, terpenoids, and alkaloids. The crude extracts at varying degree of efficiency, scavenged ABTS and DPPH radicals. The crude extracts at low concentrations (50 mg/kg b.w) significantly (p<0.05) diminished the level of malondialdehyde, augmented catalase activities and elevated glutathione levels. However, SOD activities were significantly boosted in a dose-dependent manner by the crude extracts. Therefore, I. glomerata and S. kraussii possess antioxidant properties, hence, can serve as a therapeutic modality in the treatment of oxidative stress-induced erectile dysfunction.","PeriodicalId":17966,"journal":{"name":"Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84564932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Sideritis perfoliata inhibits cell proliferation, induces apoptosis and exhibits cellular antioxidant activity in cervical cancer cells 过叶黄体炎抑制宫颈癌细胞增殖，诱导细胞凋亡，并表现出细胞抗氧化活性

Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants Pub Date : 2021-07-30 DOI: 10.37360/BLACPMA.21.20.4.29

Gizem Cocelli, M. Pehlivan, O. Yumrutas

{"title":"Sideritis perfoliata inhibits cell proliferation, induces apoptosis and exhibits cellular antioxidant activity in cervical cancer cells","authors":"Gizem Cocelli, M. Pehlivan, O. Yumrutas","doi":"10.37360/BLACPMA.21.20.4.29","DOIUrl":"https://doi.org/10.37360/BLACPMA.21.20.4.29","url":null,"abstract":"In this study, it was aimed to determine the antioxidant and anticancer activities of Sideritis perfoliata methanolic extract (SPE) on cervical cancer cells (HeLa). Different doses (25, 50, 100 and 200 µg/mL) of SPE were used to determine proliferation of HeLa cells by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT) staining method. Induction of apoptosis was determined by Annexine-V and propidium iodide staining method. Interleukin (IL) 6-8 levels were measured by ELISA method. Antioxidant activities of SPE were determined by DPPH, DNA (plasmid pBR322) protecting and cellular antioxidant activity tests. Some phytochemicals of SPE were also screened by LC-MS-MS. It was determined that SPE reduced the proliferation of HeLa cells and also induced apoptosis. IL6-8 levels importantly decreased at 200 µg/mL. SPE exhibited moderately antioxidant activities in tests used. Among the phenolics identified, vanillic acid had the highest amount. As a result, it was determined to have the anticancer activity of SPE by decreasing cell proliferation, inducing apoptosis and decreasing IL6-8 in HeLa cells.","PeriodicalId":17966,"journal":{"name":"Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86594161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Pharmacobotanical characterization of Monteverdia ilicifolia (Mart. ex Reiss.) Biral leaves and its adulterants sold as medicinal tea in Brazil: a contribution to quality control 黄花蒙特韦迪亚(Monteverdia ilicifolia)的药理学特征。Reiss交货)。比拉尔叶及其掺假物在巴西作为药用茶出售:有助于质量控制

Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants Pub Date : 2021-07-30 DOI: 10.37360/BLACPMA.21.20.4.28

F. M. do Amaral, S. Monteiro, T. Fernandes, D. F. Teixeira, L. Lucchetti, S. Jacob, S. R. de Paiva, Ana Joffily

{"title":"Pharmacobotanical characterization of Monteverdia ilicifolia (Mart. ex Reiss.) Biral leaves and its adulterants sold as medicinal tea in Brazil: a contribution to quality control","authors":"F. M. do Amaral, S. Monteiro, T. Fernandes, D. F. Teixeira, L. Lucchetti, S. Jacob, S. R. de Paiva, Ana Joffily","doi":"10.37360/BLACPMA.21.20.4.28","DOIUrl":"https://doi.org/10.37360/BLACPMA.21.20.4.28","url":null,"abstract":"Leaves of Monteverdia ilicifolia (“espinheira-santa”) are considered a medicinal tea by the Brazilian Sanitary Surveillance Agency (Anvisa), by their anti-dyspeptic, anti-acid and protective of the gastric mucosa properties. Their spiny margins are similar to those of other botanical species, which may lead to misidentifications. The aim of this work was to evaluate the authenticity of 32 samples of herbal drugs commercialized as “espinheira-santa” in the formal trade in Brazil, by macro and microscopic morphological studies of the leaves. The evaluation of the botanical authenticity was based on leaf venation patterns, shape and anatomy of the petiole and midrib region in cross section, vascular system arrangement and epidermal characters. Analysis of these characters compared to literature data suggests that 34% of the samples are M. ilicifolia and the remaining 66% are Sorocea bonplandii, a species with no clinical studies assuring its effective and safe use, representing thus a potential risk to public health.","PeriodicalId":17966,"journal":{"name":"Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86628854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Investigation of anti-Alzheimer’s activity of aqueous extract of areca nuts (Areca catechu L.): In vitro and in vivo studies 槟榔水提物抗阿尔茨海默病活性的研究:体外和体内研究

Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants Pub Date : 2021-07-30 DOI: 10.37360/BLACPMA.21.20.4.30

M. Bozorgi, Z. Najafi, Sahar Omidpanah, A. Sadri, Z. Narimani, F. Moghadam, Najmeh Edraki, T. Akbarzadeh, Mina Saeedi

{"title":"Investigation of anti-Alzheimer’s activity of aqueous extract of areca nuts (Areca catechu L.): In vitro and in vivo studies","authors":"M. Bozorgi, Z. Najafi, Sahar Omidpanah, A. Sadri, Z. Narimani, F. Moghadam, Najmeh Edraki, T. Akbarzadeh, Mina Saeedi","doi":"10.37360/BLACPMA.21.20.4.30","DOIUrl":"https://doi.org/10.37360/BLACPMA.21.20.4.30","url":null,"abstract":"Alzheimer’s disease (AD) is an age-related neurodegenerative disorder. Sever cognitive and memory impairments, huge increase in the prevalence of the disease, and lacking definite cure have absorbed worldwide efforts to develop therapeutic approaches. Since many drugs have failed in the clinical trials due to multifactorial nature of AD, symptomatic treatments are still in the center attention and now, nootropic medicinal plants have been found as versatile ameliorators to reverse memory disorders. In this work, anti-Alzheimer’s activity of aqueous extract of areca nuts (Areca catechu L.) was investigated via in vitro and in vivo studies. It depicted good amyloid β (Aβ) aggregation inhibitory activity, 82% at 100 µg/mL. In addition, it inhibited beta-secretase 1 (BACE1) with IC50 value of 19.03 µg/mL. Evaluation of neuroprotectivity of the aqueous extract of the plant against H2O2-induced cell death in PC12 neurons revealed 84.5% protection at 1 µg/mL. It should be noted that according to our results obtained from Morris Water Maze (MWM) test, the extract reversed scopolamine-induced memory deficit in rats at concentrations of 1.5 and 3 mg/kg.","PeriodicalId":17966,"journal":{"name":"Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75521261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2