Kazanskiy meditsinskiy zhurnal最新文献

{"title":"Analysis of the intestinal microbiome in colorectal cancer","authors":"B. I. Gataullin, I. Gataullin, N. Nga, A. Kolpakov, O. Ilinskaya","doi":"10.17816/KMJ2021-185","DOIUrl":"https://doi.org/10.17816/KMJ2021-185","url":null,"abstract":"Aim. To conduct a comparative analysis of the microbiome of biopsies of a tumor and normal intestinal epithelium of patients diagnosed with colorectal cancer and to identify of functional activities of the obtained bacterial isolates that affect the development of the tumor. \u0000Methods. The study included 50 patients with malignant neoplasms of the colon: 36 men and 24 women. The mean age of the patients was 64.110.2 years. To analyze the microbiota of the biopsies, DNA samples were obtained from the tissue of the unaffected colon mucosa and tumor of the patients. Bacterial 16S rRNA genes fragments were amplified using bar-coded primer bakt_341f. Metagenomic next-generation sequencing was performed using the MiSeq platform (Illumina, USA). The obtained data were processed by bioinformatic methods using the QIIME package. Recognition of microorganisms depending on the morphotype and gram staining of the microflora was carried out using combination differential media and biochemical tests. Statistical analysis was carried out using Microsoft Excel, Service Pack 2 for Office XP, Statistica 6.0 (StatSoft). A comparative analysis was performed with the Student's t-test and the MannWhitney test in case of unmet conditions of validity. Alpha diversity of bacterial communities was quantified by the Shannon diversity index and the UniFrac distance for beta diversity analysis. \u0000Results. In patients with colorectal cancer, 5 bacterial phyla were isolated, the predominant of which were Firmicutes and Bacteroidetes, while the content of Actinobacteria was low. In addition, a higher number of representatives of Fusobacteria was observed in the tumor tissue compared to the tissue of a healthy mucosa, at a distance of 5 centimeters proximal to the tumor. The results of this study indicate that the microbiome of a tumor and a healthy mucosa fundamentally differ from each other not only in morphotype and gram staining but also in antagonistic, hemolytic and ribonucleolytic activities. \u0000Conclusion. Colonization of the tumor by dominant aggressive Gram-negative bacteria leads to significant changes in the tumor microbiome composition compared with normal mucosa, whose representatives are displaced from the damaged epithelium by more aggressive strains.","PeriodicalId":17798,"journal":{"name":"Kazanskiy meditsinskiy zhurnal","volume":"38 1","pages":"185-191"},"PeriodicalIF":0.0,"publicationDate":"2021-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87379600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative and qualitative changes in blood cells associated with COVID-19","authors":"N. Evtugina, S. S. Sannikova, A. Peshkova, S. Safiullina, I. Andrianova, G. R. Tarasova, R. R. Khismatullin, S. M. Abdullaeva, R. Litvinov","doi":"10.17816/KMJ2021-141","DOIUrl":"https://doi.org/10.17816/KMJ2021-141","url":null,"abstract":"Aim To establish the relationship of hematological disorders with the pathogenesis, course and outcomes of COVID-19 Methods We examined 235 hospitalized patients with moderate and severe forms of acute COVID-19 receiving anticoagulants and immunosuppressive drugs We studied the full blood cell counts and morphology along with the platelet function by flow cytometry in comparison with the clinical features and synthesis of inflammatory markers To assess platelet contractility, blood clot contraction (retraction) kinetics was used in combination with scanning electron microscopy of platelets and blood clots Results Hemolytic anemia, neutrophilia and lymphopenia were associated with immature erythrocytes and leukocytes, indicating activation of hematopoiesis Contraction of blood clots in COVID-19 was impaired, especially in severe and lethal cases, as well as in the presence of comorbidities, including myeloproliferative and coronary heart diseases and acute cerebrovascular disease In male patients, the changes in clot contraction were more pronounced Suppression of clot contraction correlated directly with anemia and coagulopathy, including a high D-dimer level, which confirms the pathogenetic significance of blood clot contraction in COVID-19 A decrease in platelet contractility was due to moderate thrombocytopenia in combination with chronic platelet activation and secondary platelet dysfunction The structure and cellular composition of blood clots depended on the extent of contraction;clots with impaired contraction were porous, had a low content of deformed polyhedral erythrocytes (polyhedrocytes) and an even distribution of fibrin Conclusion Blood cells undergoing both quantitative and qualitative changes are involved in the pathogenesis of COVID-19;the suppressed platelet-driven contraction of intravital blood clots may be a part of the prothrombotic mechanisms © 2021 The Author(s) This is an open-access article distributed under the terms of the Creative Commons Attribution 4 0 International License (CC-BY 4 0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited See http://creativecommons org/ licenses/by/4 0/","PeriodicalId":17798,"journal":{"name":"Kazanskiy meditsinskiy zhurnal","volume":"26 1","pages":"141-155"},"PeriodicalIF":0.0,"publicationDate":"2021-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72723537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficiency of wound dressing made of powder cotton cellulose","authors":"S. Ksembaev, Ксембаев Саид Сальменович, O. V. Nesterov, Нестеров Олег Викторович, L. N. Khafizova, Хафизова Лилия Наилевна","doi":"10.17816/KMJ2021-12","DOIUrl":"https://doi.org/10.17816/KMJ2021-12","url":null,"abstract":"Aim. To study the effectiveness of a wound dressing made of powdered cotton cellulose for open surgical wounds in the oral cavity. Methods. The effectiveness of a wound dressing made of powdered cotton cellulose during vestibuloplasty was assessed based on clinical indicators. The study included 197 children aged 8–12 years (boys — 91, girls — 106), divided into 2 groups — the main group (100 children treated with powdered cotton cellulose wound dressing) and the comparison group (97 children, treated with a surgical gauze dressing). The number of children in clinical groups was determined by the “copy-pair” method. The dynamics of the postoperative period was assessed according to traditional clinical indicators (the presence of pain, inflammatory edema, hematomas, healing time, etc.). The severity of general and local clinical signs was determined by using the system of its assessment in points developed by us. Differences were considered significant at p <0.05. Results. In the postoperative period, the patients of the main group had no complications — in contrast to the patients of the comparison group, who had pronounced edema and hematomas of the soft tissues of the chin, edema and hyperemia of the displaced flap. Changes in clinical signs severity in points also prevailed in the comparison group (p <0.001). The surgical wound showed complete epithelialization after 11.4±0.7 days in the main group and after 13.5±0.9 days in the comparison group. The reduction in the duration of treatment was 2.1±0.8 days. Conclusion. When using a wound dressing made of powdered cotton cellulose, the wound is protected from the aggressive environment of the mouth, including microflora, food debris, etc., which excludes the possibility of its se­condary infection; there is no pain, postoperative inflammatory edema and hematomas; the surgical wound healing time is reduced; there are no contraindications, no side and allergic reactions.","PeriodicalId":17798,"journal":{"name":"Kazanskiy meditsinskiy zhurnal","volume":"44 1","pages":"12-18"},"PeriodicalIF":0.0,"publicationDate":"2021-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82843932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern methods of surgical treatment of staghorn nephrolithiasis","authors":"M. E. Sitdykova, Ситдыкова Марина Эдуардовна, E. A. Viktorov, Викторов Егор Александрович, A. Zubkov, Зубков Алексей Юрьевич","doi":"10.17816/KMJ2021-60","DOIUrl":"https://doi.org/10.17816/KMJ2021-60","url":null,"abstract":"Staghorn nephrolithiasis is a form of urolithiasis characterized by kidney stones formation that partially or completely fills the collecting system. Staghorn nephrolithiasis has a malignant course, accompanied by collecting system retention and impaired renal function. This pathology is a common cause of disability, which is particularly importance in the context of its prevalence among people of working age. The review systematizes the currently relevant data on surgery of staghorn nephrolithiasis, presents methods of surgical treatment, defines the selection options within them, their advantages and disadvantages, indications, contraindications and complications. This information can help in making an informed decision and increase the effectiveness of treatment for patients with that disease. At the moment, there is an arsenal of treatment options for staghorn nephrolithiasis, among them mi¬nimally invasive high-tech operations are the most advanced and recognized as the methods of choice. The modernization of existing technologies increases their efficiency and safety, but their high cost and the impossibility of using in some cases often make one prefer more traumatic radical interventions. Traditional surgery remains a reliable method of treatment, allowing simultaneous operations and treatment of complex cases of the disease. The possibility of combining existing methods allows for the effective removal of staghorn stones in different groups of patients. Thus, a careful and differentiated approach to the methods of surgical treatment of staghorn nephrolithiasis, their use in combination allows ensuring high efficiency of surgical treatment of this pathology.","PeriodicalId":17798,"journal":{"name":"Kazanskiy meditsinskiy zhurnal","volume":"79 1","pages":"60-73"},"PeriodicalIF":0.0,"publicationDate":"2021-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79692070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Results of orthodontic treatment of a child with asymmetrical micrognathia and the congenital mandibular condylar hyperplasia","authors":"F. Ayupova, R. A. Khotko, E. L. Vinichenko, V. Lovlin","doi":"10.17816/KMJ2021-92","DOIUrl":"https://doi.org/10.17816/KMJ2021-92","url":null,"abstract":"Aim. To analyze the results of orthodontic treatment of a child with asymmetrical micrognathia and mandiblar condylar hyperplasia. Methods. The configuration of a face in the photos was evaluated and diagnostic models of the jaws were analyzed by using the Pont’s and Korkhaus methods in treatment dynamics. The physiological status of bone tissue, temporomandibular joints and teeth was studied by using orthopantomography and computed tomography. Functional disorders were detected by using special tests, including Eschler–Bittner's test and Ilyina-Markosyan’s test. Orthodontic treatment and stimulation of mandibular growth in the mixed dentition stage were undertaken with the single jaw removable appliances and the appliance improved by us for correction of the distal occlusion. The Damon Q bra­cket system with archwires was used in permanent dentition period. Results. The child's convex facial profile was typical for distal occlusion and micrognathia. The facial asymmetry, increasing with mouth opening, and a decrease in mandibular range of motion indicated lesion of the right temporomandibular joint. The right condyle was enlarged on the orthopantomogram. The computed tomography showed that it was asymmetrically enlarged and had a cellular structure. There was detected asymmetric micrognathia. The comprehensive rehabilitation plan included orthodontic treatment, myotherapy, speech therapy, mechanotherapy. The use of removable orthodontic appliances led to the normal size of the dentition and their relation, significantly reduced functional disorders and improved facial aesthetics. Five years after completion of orthodontic treatment, the physiological occlusion and amplitude of the mandibular movements remained, but the right mandibular angle was flattened. Conclusion. The comprehensive rehabilitation of a child with asymmetrical micrognathia and mandibular condylar hyperplasia started in mixed dentition stage provided conditions for the formation of normal permanent dentition and the improvement of functional disorders and facial aesthetics; our results allow us to suggest the positive effect of our tactics for treatment of the patient.","PeriodicalId":17798,"journal":{"name":"Kazanskiy meditsinskiy zhurnal","volume":"43 1","pages":"92-99"},"PeriodicalIF":0.0,"publicationDate":"2021-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91486477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related characteristic of human intervertebral discs from normal anatomy’s point of view","authors":"V. Makarova, Макарова Виктория Владиславовна, M. V. Volchihin, Волчихин Максим Валерьевич","doi":"10.17816/KMJ2021-30","DOIUrl":"https://doi.org/10.17816/KMJ2021-30","url":null,"abstract":"Aim. To compare morphological characteristics between anterior and posterior parts of human intervertebral discs, taking into account age. Methods. Fragments of 36 intervertebral discs C5C6, D5D6, L5S1 anterior parts taken from deceased persons aged 34 to 94 years, median age 61.0 (50.5; 71.8) years were examined. The comparison group consists of histopathological material obtained from 12 patients with radicular syndrome during planned L5S1 microdiscectomies aged 35–77 years, median age 48.5 (43.0; 58.8) years. There were no statistically significant differences in age between the studied groups (p=0.126023). All materials were divided into subgroups depending on the age of the deceased/operated: 34–52 and 60–94 years for material obtained from the deceased; 35–51 and 58–77 years — for material obtained after surgery. The differences between the three groups were examined by the Kruskal–Wallis test, and quantitative indicators in the two groups were compared by Mann–Whitney U-test. Results. In the anterior part of the intervertebral discs, signs of degenerative-dystrophic changes were noted in all studied samples. All samples of nucleus pulposus and annulus fibrosus were fibrocartilage with no inflammation. Statistically significant differences (р=0.0283) were obtained in the number of isogenous groups of chondrocytes in intervertebral discs C5C6 anterior part compared with D5D6, L5S1 in individuals aged 34–52. Age subgroups (34–52 and 60–94 years old) differed significantly (р=0.0219) in the number of single chondrocytes according to results of morphometry of anterior part of intervertebral discs L5S1. Anterior and posterior parts of intervertebral discs L5S1 differed statistically significant in the number of isogenous groups of chondrocytes when comparing the subgroup of operated patients aged 35–51 years (р=0.008475) with the subgroup of deceased persons aged 34–52 years and the subgroup of operated patients aged 58–77 years (р=0.033753) with the subgroup of deceased aged 60–94 years. Conclusion. Anterior and posterior part of intervertebral discs L5S1 had similar qualitative histological characteristics; however, the number of isogenous groups of chondrocytes in the posterior part of intervertebral discs L5S1 samples indicated a greater effect of compression loading compared to anterior part of the same spinal motion segment.","PeriodicalId":17798,"journal":{"name":"Kazanskiy meditsinskiy zhurnal","volume":"4 1","pages":"30-38"},"PeriodicalIF":0.0,"publicationDate":"2021-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85313723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid approach of arterial allograft application in reconstructive surgery of the great arteries","authors":"R. Kalinin, Калинин Роман Евгеньевич, I. Suchkov, Сучков Игорь Александрович, V. Karpov, Карпов Вячеслав Владимирович, N. A. Solianik, Соляник Никита Андреевич, A. Pshennikov, Пшенников Александр Сергеевич, A. Egorov, Егоров Андрей Александрович","doi":"10.17816/KMJ2021-104","DOIUrl":"https://doi.org/10.17816/KMJ2021-104","url":null,"abstract":"The article presents a case of a hybrid intervention using an arterial allograft on the great arteries of the lower extremities in a patient with chronic limb threatening ischemia and prosthetic infection. The patient has a history of repeated operations using synthetic polytetrafluoroethylene and dacron prostheses. In the early postoperative period, a clinical presentation of the prosthesis bed suppuration developed. The article shows the main phases of patient treatment: removal of synthetic prostheses, transplantation of the donor femoral artery, and balloon angioplasty of the popliteal and anterolateral arteries. In the postoperative period, blood circulation in the lower limb is fully compensated, and the dorsal pedis artery pulse is determined. Wounds were healed by primary intention. At the control visit after 6 months, no adverse events were revealed; according to the data of duplex scanning, the main blood flow in the arteries of the leg was recorded, the blood circulation was fully compensated. Thus, hybrid intervention using arterial allograft and balloon angioplasty of the popliteal and anterolateral tibial arteries proved to be an effective method of treatment in the current clinical situation.","PeriodicalId":17798,"journal":{"name":"Kazanskiy meditsinskiy zhurnal","volume":"96 1","pages":"104-109"},"PeriodicalIF":0.0,"publicationDate":"2021-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91356562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Academician Andrei Dmitrievich Ado and the Kazan Scientific Research Institute of Epidemiology and Microbiology","authors":"I. Reshetnikova, Решетникова Ирина Дмитриевна, P. Dunaev, Дунаев Павел Дмитриевич","doi":"10.17816/KMJ2021-115","DOIUrl":"https://doi.org/10.17816/KMJ2021-115","url":null,"abstract":"The article was prepared for the 120th anniversary of the Kazan Scientific — Research Institute of Epidemio¬logy and Microbiology and the 110th anniversary of the birth of the academician, laureate of the USSR State Prize, the author of fundamental guidelines on allergology and pathological physiology, an honorary member of scienti¬fic ¬societies of many countries Andrei Dmitrievich Ado who is a representative of the famous dynasty of scientists and doctors of Mislawski-Ado. The paper presents materials about the dynasty — A.A. Mislavsky, N.A. Mislavsky, A.N. Mislavsky and others; information about the Kazan period of A.D. Ado between 1938 and 1952 during his work at Kazan Scientific — Research Institute of Epidemiology and Microbiology (Kazan Institute of Epidemio¬logy and Microbiology until 1942). The article was prepared using documents from the archives of Kazan Scienti¬fic — Research Institute of Epidemiology, Microbiology, Kazan Medical University, memoirs of their colleagues.","PeriodicalId":17798,"journal":{"name":"Kazanskiy meditsinskiy zhurnal","volume":"48 3.4","pages":"115-122"},"PeriodicalIF":0.0,"publicationDate":"2021-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72571883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possibilities for diagnosis and prediction of preterm labor at the present stage","authors":"V. Mudrov, Мудров Виктор Андреевич, A. M. Ziganshin, Зиганшин Айдар Миндиярович, A. Yashchuk, Ящук Альфия Галимовна, L. A. Dautova, Даутова Лилиана Анасовна, R. S. Badranova, Бадранова Регина Шамилевна","doi":"10.17816/KMJ2021-47","DOIUrl":"https://doi.org/10.17816/KMJ2021-47","url":null,"abstract":"Preterm birth is one of the main causes of perinatal morbidity and mortality, which does not tend to decrease in rate. The risk of death in premature babies is 25–35 times higher than that of full-term babies, and stillbirths are registered 8–13 times more often than in timely delivery. To date, there are no effective ways to prevent preterm birth. Therefore, the timeliness of therapy, which largely determines the outcome of pregnancy in general, depends on the effectiveness of assessing the likelihood of their development. At the International Federation of Gynecology and Obstetrics (FIGO) Congress (2018), preterm birth is identified as a problem that has not yet been solved at the current stage of science and technology development. The result of the unsolved problems is a situation wherein the modern world over the past 60 years there has been no decrease in the premature birth rate, which is 9.5% of births and annually ends with the birth of 15,000,000 premature babies. The study aimed to research modern methods of diagnosis and prediction of spontaneous preterm birth. An analytical method was used in the study: a detailed systematic analysis of modern domestic and foreign literature on the diagnosis and prognosis of preterm birth. We used eLibrary, Scopus, PubMed, MEDLINE, ScienceDirect, Cochrane Library bibliographic databases (until August 2020). The article deals with the diagnosis and prediction of preterm birth probability, which will optimize the management of patients from the risk group and, in the future, will reduce the rate of perinatal morbidity and mortality of premature babies. Despite a significant number of researches devoted to the study of possibilities for diagnosing and predicting spontaneous preterm birth, currently, there are no methods with absolute diagnostic value. Most -existing studies indicate that when assessing the probability of preterm birth, a comprehensive approach should be preferred taking into account the results of several main and additional methods.","PeriodicalId":17798,"journal":{"name":"Kazanskiy meditsinskiy zhurnal","volume":"58 1","pages":"47-59"},"PeriodicalIF":0.0,"publicationDate":"2021-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80969686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of free radical stress correction on corticoid signaling in the kidney of rat with different resistance to hypoxia after systemic circulation arrest","authors":"G. Bayburina, Байбурина Гульнар Анузовна, A. Samigullina, Самигуллина Айгуль Фидратовна, G. Drozdova, Дроздова Галина Александровна","doi":"10.17816/KMJ2021-19","DOIUrl":"https://doi.org/10.17816/KMJ2021-19","url":null,"abstract":"Aim. To assess the influence of the pathogenetic action of the succinate-containing drug on corticosteroid regulation in the kidney of rats with different resistance to hypoxia during recovery after systemic circulation arrest. Methods. The object of the study was male non-inbred white rats weighing 200–220 g. A week after testing for resistance to hypoxia, a 5-minute systemic circulation arrest was simulated by intrathoracic clamping of the vascular bundle of the heart, followed by resuscitation. In the postresuscitation period, the experimental rats were once daily injected with a solution containing inosine + nicotinamide + riboflavin + succinic acid, and the control rats — 0.9% Sodium Chloride solution. The observation period was 35 days. We studied the content of corticosterone, aldosterone in blood plasma, gluco- and mineralocorticoid receptors, carbonylated proteins, dityrosine, and products that react with thiobarbituric acid in homogenates of the kidneys. Statistical data were presented as mean and standard deviation M±σ. Nonparametric Kruskal–Wallis (N) and Mann–Whitney (U) tests followed by Dunn test, Spearman correlation analysis were used. Differences were considered statistically significant at p ≤0.05. Results. The use of succinate-containing preparation reduced the intensity of free radical processes in both groups of animals. Against this background, in low-resistance rats, on the 1st day, the concentration of glucocorticoid receptors statistically significantly increased to 117% (p <0.05), and then was comparable to the control; the greatest statistically significant changes in the level of mineralocorticoid receptors occurred on the 1st day (increase by 25%, p <0.001) and at 21–35th days (decrease by 22–30%, p <0.001). In highly resistant rats, the correction led to a shift in the maximum content of glucocorticoid receptors from the last day (134% of the control level, p <0.01 without therapy) to the 1st (123%, p <0.05 with succinate-containing therapy) and maintaining the receptors level comparable to the initial, in the future. The level of mineralocorticoid receptors in highly resistant rats was lower than in low resistant rats, both in the group without correction and with correction. Conclusion. Correction of the course of the postresuscitation period with a succinate-containing drug in animals with a low resistance to hypoxia against the background of a decrease in the intensity of carbonyl stress and restoration of feedback mechanisms causes stabilization of glucocorticoid receptors level and a decrease in mineralocorticoid receptors to control values by the end of the experiment; in organisms highly resistant to hypoxia, against the background of correction, the activity of lipid peroxidation decreases and the level of both types of receptors are restored.","PeriodicalId":17798,"journal":{"name":"Kazanskiy meditsinskiy zhurnal","volume":"42 1","pages":"19-29"},"PeriodicalIF":0.0,"publicationDate":"2021-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74260208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}