Marcin Piechocki, Michał Okarski, Kornelia Szkodoń, Katarzyna Lizończyk, Jan Zachara, Marcin Skiba, Tadeusz Przewłocki, Jacek Legutko, Paweł Kleczyński, Anna Kabłak-Ziembicka, Jakub Podolec
{"title":"Preliminary report on depression prevalence in patients with coronary artery disease and severe aortic valve stenosis.","authors":"Marcin Piechocki, Michał Okarski, Kornelia Szkodoń, Katarzyna Lizończyk, Jan Zachara, Marcin Skiba, Tadeusz Przewłocki, Jacek Legutko, Paweł Kleczyński, Anna Kabłak-Ziembicka, Jakub Podolec","doi":"10.33963/v.phj.101939","DOIUrl":"https://doi.org/10.33963/v.phj.101939","url":null,"abstract":"","PeriodicalId":17784,"journal":{"name":"Kardiologia polska","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marta Mazur, Aleksandra Kolarczyk-Haczyk, Łukasz Konarski, Maksymilian Grajek, Mateusz Kachel, Marta Konopko, Aleksander Żurakowski, Mariusz Gąsior, Maciej Rogala, Piotr Jankowski, Paweł Kaźmierczak, Krzysztof P Milewski, Paweł E Buszman, Piotr P Buszman
{"title":"Patients with heart failure and reduced ejection fraction: The sub-analysis from the 3-year Coordinated Myocardial Infarction Care Program (KOS-MI) registry.","authors":"Marta Mazur, Aleksandra Kolarczyk-Haczyk, Łukasz Konarski, Maksymilian Grajek, Mateusz Kachel, Marta Konopko, Aleksander Żurakowski, Mariusz Gąsior, Maciej Rogala, Piotr Jankowski, Paweł Kaźmierczak, Krzysztof P Milewski, Paweł E Buszman, Piotr P Buszman","doi":"10.33963/v.phj.101841","DOIUrl":"https://doi.org/10.33963/v.phj.101841","url":null,"abstract":"","PeriodicalId":17784,"journal":{"name":"Kardiologia polska","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Udaya S Tantry, Sahib Singh, Lekshmi Narayan Raghavakurup, Kevin P Bliden, Paul A Gurbel
{"title":"Can CYP2C19 genotyping improve antiplatelet therapy efficacy in real-life practice? Recent advances.","authors":"Udaya S Tantry, Sahib Singh, Lekshmi Narayan Raghavakurup, Kevin P Bliden, Paul A Gurbel","doi":"10.33963/v.phj.101890","DOIUrl":"https://doi.org/10.33963/v.phj.101890","url":null,"abstract":"<p><p>Clopidogrel remains the most widely used P2Y₁₂ receptor inhibitor worldwide and is often used in combination with aspirin for secondary prevention in patients with arterial disease. The drug is associated with a wide response variability with one on three patients exhibiting little or no inhibition of adenosine diphosphate-induced platelet aggregation. It is a prodrug that is mainly metabolized by hepatic cytochrome P450 (CYP) 2C19. Patients who carry a CYP2C19 loss-of-function (LoF) allele have reduced metabolism of clopidogrel that is associated with reduced platelet inhibition compared to non-carriers that is associated with increased risk for thrombotic event occurrences, particularly, stent thrombosis. The United States Food and Drug Administration (US FDA) issued a black box warning in the clopidogrel label highlighting the importance of presence of CYP2C19 LOF allele during the insufficient metabolism of clopidogrel and availability of other potent P2Y₁₂ inhibitor for the treatment in CYP2C19 poor metabolizers. Clinical trials have conclusively demonstrated greater anti-ischemic benefits of prasugrel/ticagrelor in the treatment of patients carrying the CYP2C19 LoF allele. However, uniform use of these more potent P2Y₁₂ inhibitors has been associated with greater bleeding and cost, and lower adherence. The latter information provides a strong rationale for personalizing P2Y₁₂ inhibitor therapy based on the laboratory determination of CYP2C19 genotype. However, cardiologists have been slow to take up pharmacogenetic testing possibly due to lack of provider and patient education, clear cardiology guidelines and, and lack of positive results from adequately sized randomized clinical trials. However, current evidence strongly supports genotyping of patients who are candidates for clopidogrel. Physicians should strongly consider performing genetic tests to identify LoF carriers and treat these patients with more pharmacodynamically predictable P2Y₁₂ inhibitors than clopidogrel.</p>","PeriodicalId":17784,"journal":{"name":"Kardiologia polska","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Miroslav Hudec, Jan Chovancik, Otakar Jiravsky, Roman Miklik, Valerie Vondalova, Ivan Ranic, Jan Hecko, Martina Palickova Mikolasova, Radek Neuwirth, Libor Sknouril
{"title":"Complex left atrial appendage closure in a multimorbid patient using AVP II occluder: A case report.","authors":"Miroslav Hudec, Jan Chovancik, Otakar Jiravsky, Roman Miklik, Valerie Vondalova, Ivan Ranic, Jan Hecko, Martina Palickova Mikolasova, Radek Neuwirth, Libor Sknouril","doi":"10.33963/v.phj.101804","DOIUrl":"https://doi.org/10.33963/v.phj.101804","url":null,"abstract":"","PeriodicalId":17784,"journal":{"name":"Kardiologia polska","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Catheter hemodynamics and pulse pressure in patent ductus arteriosus: Back to the basics.","authors":"Fadi Bitar, Ziad Bulbul","doi":"10.33963/v.phj.101809","DOIUrl":"https://doi.org/10.33963/v.phj.101809","url":null,"abstract":"","PeriodicalId":17784,"journal":{"name":"Kardiologia polska","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mateusz Barycki, Piotr Rola, Adrian Włodarczak, Szymon Włodarczak, Maciej Pęcherzewski, Piotr Włodarczak, Artur Jastrzębski, Łukasz Furtan, Andrzej Giniewicz, Adrian Doroszko, Maciej Lesiak
{"title":"One-year comparative outcomes of DK culotte and culotte techniques in left main bifurcation in acute coronary syndrome: Sub-study of the Lower Silesia culotte Bifurcation Registry.","authors":"Mateusz Barycki, Piotr Rola, Adrian Włodarczak, Szymon Włodarczak, Maciej Pęcherzewski, Piotr Włodarczak, Artur Jastrzębski, Łukasz Furtan, Andrzej Giniewicz, Adrian Doroszko, Maciej Lesiak","doi":"10.33963/v.phj.102075","DOIUrl":"https://doi.org/10.33963/v.phj.102075","url":null,"abstract":"","PeriodicalId":17784,"journal":{"name":"Kardiologia polska","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Agnieszka Styczeń, Maryla Kuczyńska, Bartosz Kijewski, Michał Tomaszewski, Anna Drelich-Zbroja, Tomasz Zapolski
{"title":"The diagnostic and therapeutic challenges in identifying rare pulmonary arterial hypertension variant associated with portal hypertension and multiple abdominal vascular malformations.","authors":"Agnieszka Styczeń, Maryla Kuczyńska, Bartosz Kijewski, Michał Tomaszewski, Anna Drelich-Zbroja, Tomasz Zapolski","doi":"10.33963/v.phj.101801","DOIUrl":"https://doi.org/10.33963/v.phj.101801","url":null,"abstract":"","PeriodicalId":17784,"journal":{"name":"Kardiologia polska","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Justyna Mączyńska, Piotr Suwalski, Krzysztof Jaworski, Bohdan Firek, Weronika Kunikowska, Ilona Michałowska, Magdalena Marczak, Rafał Dąbrowski
{"title":"Papillary fibroelastoma as a rare cause of recurrent strokes and myocardial infarction.","authors":"Justyna Mączyńska, Piotr Suwalski, Krzysztof Jaworski, Bohdan Firek, Weronika Kunikowska, Ilona Michałowska, Magdalena Marczak, Rafał Dąbrowski","doi":"10.33963/v.phj.101665","DOIUrl":"https://doi.org/10.33963/v.phj.101665","url":null,"abstract":"","PeriodicalId":17784,"journal":{"name":"Kardiologia polska","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luiza Bulak, Michał Furdal, Artur Telichowski, Natalia Świątoniowska-Lonc, Adrian Doroszko, Waldemar Banasiak, Krzysztof Ściborski
{"title":"Sky is the limit - multivessel PCI with mechanical left ventricular support and simultaneous 10 stent deployment.","authors":"Luiza Bulak, Michał Furdal, Artur Telichowski, Natalia Świątoniowska-Lonc, Adrian Doroszko, Waldemar Banasiak, Krzysztof Ściborski","doi":"10.33963/v.phj.101606","DOIUrl":"https://doi.org/10.33963/v.phj.101606","url":null,"abstract":"","PeriodicalId":17784,"journal":{"name":"Kardiologia polska","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}