Jurnal Sains Farmasi & Klinis最新文献

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Effect of Eleutherine americana Merr. bulb extract on blood pressure and heart rate in anesthetized hypertensive rats 美国凯瑟琳的作用。球茎提取物对高血压麻醉大鼠血压和心率的影响

Jurnal Sains Farmasi & Klinis Pub Date : 2018-08-31 DOI: 10.25077/JSFK.5.2.119-125.2018

Yori Yuliandra, Rizki Oktarini, A. Armenia

{"title":"Effect of Eleutherine americana Merr. bulb extract on blood pressure and heart rate in anesthetized hypertensive rats","authors":"Yori Yuliandra, Rizki Oktarini, A. Armenia","doi":"10.25077/JSFK.5.2.119-125.2018","DOIUrl":"https://doi.org/10.25077/JSFK.5.2.119-125.2018","url":null,"abstract":"The effect of ethanolic extract of Eleutherine americana Merr. on the blood pressure and heart rate has been investigated. A number of 25 Sprague-Dawley male rats were induced with prednisone 1.5 mg/kg in combination with saline solution 2.5% for 14 days to obtain hypertension model. The rats were anesthetized and prepared for the recording of blood pressure and heart rate. The rats were divided into five groups receiving 100, 200, and 400 mg/kg of the extract, vehicle control, and captopril 30 mg/kg as the reference. The treatment was administered three times with 30 minutes interval. The systolic (SBP), diastolic (DBP), mean arterial pressure (MAP), and heart rate (HR) were recorded. The data were analyzed with two-way analysis of variance (ANOVA) followed by Duncan’s MRT (95% confidence interval). The study revealed that the extract exhibited a blood pressure lowering effect. The best antihypertensive activity of the extract was shown by the dose of 100 mg/kg. Meanwhile, HR was also affected inversely by the treatment, in which the lowest dose caused the highest increase. The study suggests that the extract of Eleutherine americana exhibits antihypertensive activity that may be potential for future development of drugs. ","PeriodicalId":17687,"journal":{"name":"Jurnal Sains Farmasi & Klinis","volume":"330 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83852534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Aktivitas Sitotoksik Ekstrak Etil Asetat Daun Tampa Badak (Voacanga foetida (Bl.)K.Schum) pada Kanker Kolon HTB-38 醋酸盐活性坦帕叶坦帕(Voacanga foetida, Bl. K.Schum)的细胞毒性活性

Jurnal Sains Farmasi & Klinis Pub Date : 2018-08-31 DOI: 10.25077/JSFK.5.2.142-146.2018

Adriani Susanty, Dachriyanus Dachriyanus, Yanwirasti Yanwirasti, Fatma Sri Wahyuni, Haiyul Fadhli, Pedro Anugrah Aswan

{"title":"Aktivitas Sitotoksik Ekstrak Etil Asetat Daun Tampa Badak (Voacanga foetida (Bl.)K.Schum) pada Kanker Kolon HTB-38","authors":"Adriani Susanty, Dachriyanus Dachriyanus, Yanwirasti Yanwirasti, Fatma Sri Wahyuni, Haiyul Fadhli, Pedro Anugrah Aswan","doi":"10.25077/JSFK.5.2.142-146.2018","DOIUrl":"https://doi.org/10.25077/JSFK.5.2.142-146.2018","url":null,"abstract":"Kanker kolon merupakan penyakit yang ditandai oleh perkembangan sel yang tidak terkendali di lapisan epitel pada usus besar. Salah satu tumbuhan yang memiliki aktivitas sebagai antikanker yaitu tumbuhan tampa badak (Voacanga foetida (Bl.) K.Schum). Tumbuhan tampa badak adalah keluarga apocynaceae yang memiliki aktivitas antikanker terhadap sel kanker darah (L1210 dan K256), sel kanker paru (A549) dan sel kanker serviks (HeLa). Penelitian ini bertujuan untuk mengetahui efek sitotoksik ekstrak etil asetat daun tampa badak terhadap sel kanker kolon HTB-38. Metode yang digunakan pada pengujian ini adalah metode MTT Assay pada waktu 24, 48 dan 72 jam. Parameter yang digunakan adalah IC50. Hasil penelitian menujukkan bahwa nilai IC50 ekstrak etil asetat daun tampa badak terhadap sel kanker kolon HTB-38 pada waktu 24, 48 dan 72 jam masing-masing sebesar 0,0287, 0,0776 dan 0.0415 μg/mL. Hasil penelitian ini menunujukkan bahwa ekstrak etil asetat daun tampa badak mempunyai efek sitotoksik kuat terhadap sel kanker kolon HTB-38. Hasil uji ANOVA menyatakan bahwa terdapat perbedaan persen viabilitas antara konsentrasi 0,1 μg/mL, konsentrasi 0,5 μg/mL dan konsentrasi 1 μg/mL (p<0,05) tetapi lama waktu inkubasi tidak memiliki pengaruh terhadap nilai persen viabilitas (p>0,05).","PeriodicalId":17687,"journal":{"name":"Jurnal Sains Farmasi & Klinis","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81580982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Survei Risiko Penyakit Diabetes Melitus Terhadap Masyarakat Kota Padang 巴东市居民的糖尿病风险调查

Jurnal Sains Farmasi & Klinis Pub Date : 2018-08-30 DOI: 10.25077/JSFK.5.2.134-141.2018

Rahmi Yosmar, Dedy Almasdy, Fitri Rahma

引用次数: 21

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