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Journal of Zhejiang University-SCIENCE B最新文献

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Neuropeptide Y receptor Y8b (npy8br) regulates feeding and digestion in Japanese medaka (Oryzias latipes) larvae: evidence from gene knockout 神经肽Y受体Y8b（nyy8br）调节日本青鳉（Oryzias latipes）幼体的摄食和消化：基因敲除的证据
Journal of Zhejiang University-SCIENCE B Pub Date : 2024-06-05 DOI: 10.1631/jzus.b2300312
Xiaodan Jia, Ke Lu, Xu-Fang Liang
{"title":"Neuropeptide Y receptor Y8b (npy8br) regulates feeding and digestion in Japanese medaka (Oryzias latipes) larvae: evidence from gene knockout","authors":"Xiaodan Jia, Ke Lu, Xu-Fang Liang","doi":"10.1631/jzus.b2300312","DOIUrl":"https://doi.org/10.1631/jzus.b2300312","url":null,"abstract":"","PeriodicalId":17648,"journal":{"name":"Journal of Zhejiang University-SCIENCE B","volume":"55 43","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141383847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
磁共振金角径向采样动态增强成像预测胃癌患者腹腔游离癌细胞 磁共振金角径向采样动态增强成像预测胃癌患者腹腔游离癌细胞
Journal of Zhejiang University-SCIENCE B Pub Date : 2024-06-05 DOI: 10.1631/jzus.b2300929
Xueqing Yin, Xinzhong Ruan, Yongmeng Zhu, Yongfang Yin, Rui Huang, C. Liang
{"title":"磁共振金角径向采样动态增强成像预测胃癌患者腹腔游离癌细胞","authors":"Xueqing Yin, Xinzhong Ruan, Yongmeng Zhu, Yongfang Yin, Rui Huang, C. Liang","doi":"10.1631/jzus.b2300929","DOIUrl":"https://doi.org/10.1631/jzus.b2300929","url":null,"abstract":"","PeriodicalId":17648,"journal":{"name":"Journal of Zhejiang University-SCIENCE B","volume":"329 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141386332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
通过机械力刺激乙型肝炎病毒X基因(HBX)转染的肝星状细胞制备血液透析用双层仿生血管 通过机械力刺激乙型肝炎病毒X基因(HBX)转染的肝星状细胞制备血液透析用双层仿生血管
Journal of Zhejiang University-SCIENCE B Pub Date : 2024-06-01 DOI: 10.1631/jzus.b2300479
Hongyi Liu, Yuanyuan Zhou, Peng Guo, Xiongwei Zheng, Weibin Chen, Shichao Zhang, Yu Fu, Xu Zhou, Zheng Wan, Bin Zhao, Yilin Zhao
{"title":"通过机械力刺激乙型肝炎病毒X基因(HBX)转染的肝星状细胞制备血液透析用双层仿生血管","authors":"Hongyi Liu, Yuanyuan Zhou, Peng Guo, Xiongwei Zheng, Weibin Chen, Shichao Zhang, Yu Fu, Xu Zhou, Zheng Wan, Bin Zhao, Yilin Zhao","doi":"10.1631/jzus.b2300479","DOIUrl":"https://doi.org/10.1631/jzus.b2300479","url":null,"abstract":"","PeriodicalId":17648,"journal":{"name":"Journal of Zhejiang University-SCIENCE B","volume":"47 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141275613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
宏基因组二代测序技术(mNGS)在感染性疾病中的临床应用 宏基因组二代测序技术(mNGS)在感染性疾病中的临床应用
Journal of Zhejiang University-SCIENCE B Pub Date : 2024-05-17 DOI: 10.1631/jzus.b2300029
Ying Liu, Yongjun Ma
{"title":"宏基因组二代测序技术(mNGS)在感染性疾病中的临床应用","authors":"Ying Liu, Yongjun Ma","doi":"10.1631/jzus.b2300029","DOIUrl":"https://doi.org/10.1631/jzus.b2300029","url":null,"abstract":"","PeriodicalId":17648,"journal":{"name":"Journal of Zhejiang University-SCIENCE B","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140963791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MiR-4465修饰的间质干细胞来源的小细胞外囊泡通过靶向LOXL2表达抑制肝纤维化的进展 MiR-4465修饰的间质干细胞来源的小细胞外囊泡通过靶向LOXL2表达抑制肝纤维化的进展
Journal of Zhejiang University-SCIENCE B Pub Date : 2024-05-17 DOI: 10.1631/jzus.b2300305
Yanjin Wang, Yifei Chen, Fuji Yang, Xiaolong Yu, Ying Chu, Jing Zhou, Yongmin Yan, Jianbo Xi
{"title":"MiR-4465修饰的间质干细胞来源的小细胞外囊泡通过靶向LOXL2表达抑制肝纤维化的进展","authors":"Yanjin Wang, Yifei Chen, Fuji Yang, Xiaolong Yu, Ying Chu, Jing Zhou, Yongmin Yan, Jianbo Xi","doi":"10.1631/jzus.b2300305","DOIUrl":"https://doi.org/10.1631/jzus.b2300305","url":null,"abstract":"","PeriodicalId":17648,"journal":{"name":"Journal of Zhejiang University-SCIENCE B","volume":"47 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140966031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sialyltransferase ST3GAL6 silencing reduces α2,3-sialylated glycans to regulate autophagy by decreasing HSPB8-BAG3 in the brain with hepatic encephalopathy 沉默硅氨酰基转移酶ST3GAL6可减少肝性脑病患者脑中的α2,3-硅氨酰化聚糖，从而通过减少HSPB8-BAG3来调节自噬作用
Journal of Zhejiang University-SCIENCE B Pub Date : 2024-05-15 DOI: 10.1631/jzus.b2300917
Xiaocheng Li, Yaqing Xiao, Pengfei Li, Yayun Zhu, Yonghong Guo, Huijie Bian, Zheng Li
{"title":"Sialyltransferase ST3GAL6 silencing reduces α2,3-sialylated glycans to regulate autophagy by decreasing HSPB8-BAG3 in the brain with hepatic encephalopathy","authors":"Xiaocheng Li, Yaqing Xiao, Pengfei Li, Yayun Zhu, Yonghong Guo, Huijie Bian, Zheng Li","doi":"10.1631/jzus.b2300917","DOIUrl":"https://doi.org/10.1631/jzus.b2300917","url":null,"abstract":"","PeriodicalId":17648,"journal":{"name":"Journal of Zhejiang University-SCIENCE B","volume":"22 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140975468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seizure as the main presenting manifestation of three patients with acute glufosinate-ammonium poisoning 以癫痫发作为主要表现的三名急性草铵膦中毒患者
Journal of Zhejiang University-SCIENCE B Pub Date : 2024-04-01 DOI: 10.1631/jzus.B2300469
Ping Wang, Congying Song, Xuan Lu, Yuanqiang Lu
{"title":"Seizure as the main presenting manifestation of three patients with acute glufosinate-ammonium poisoning","authors":"Ping Wang, Congying Song, Xuan Lu, Yuanqiang Lu","doi":"10.1631/jzus.B2300469","DOIUrl":"https://doi.org/10.1631/jzus.B2300469","url":null,"abstract":"草铵膦作为谷氨酸(Glu)的结构类似物,可以不可逆地抑制植物中谷氨酰胺合成酶(GS)和谷氨酸脱羧酶活性,从而阻止谷氨酰胺(Gln)生成,最终导致植物因氮代谢紊乱和细胞内氨积累而死亡。人误服草胺磷后也会出现相应的中毒症状,包括胃肠道症状和神经毒性。草铵膦作为最常见的致癫痫类除草剂,且无特定解毒剂,因此支持性治疗至关重要。在临床诊治过程中,如何及时有效识别草铵膦除草剂引起的神经毒性并提供适当治疗尤为关键。本文介绍了我院三名草铵膦中毒患者的主要症状,其中癫痫是主要的神经表现。随后,通过查阅相关文献,对草铵膦引发神经毒性的相关机制进行了总结,并讨论了神经毒性的预测和检测方法。","PeriodicalId":17648,"journal":{"name":"Journal of Zhejiang University-SCIENCE B","volume":"8 1","pages":"354-358"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140755920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to: Molecular dynamics simulation reveals DNA-specific recognition mechanism via c-Myb in pseudo-palindromic consensus of mim-1 promoter 勘误：分子动力学模拟揭示了通过c-Myb在mim-1启动子伪髓鞘共识中的DNA特异性识别机制
Journal of Zhejiang University-SCIENCE B Pub Date : 2024-04-01 DOI: 10.1631/jzus.B22e0634
Jinru Weng, Shuo Yang, Jinkang Shen, Hongsen Liu, Yuzi Xu, Dongyun Hao, Shan Wang
{"title":"Erratum to: Molecular dynamics simulation reveals DNA-specific recognition mechanism via c-Myb in pseudo-palindromic consensus of mim-1 promoter","authors":"Jinru Weng, Shuo Yang, Jinkang Shen, Hongsen Liu, Yuzi Xu, Dongyun Hao, Shan Wang","doi":"10.1631/jzus.B22e0634","DOIUrl":"https://doi.org/10.1631/jzus.B22e0634","url":null,"abstract":"The original version of this article (Weng et al., 2023) unfortunately contained a mistake. In Acknowledgments, the number (No. 226-2022-00213) of the Fundamental Research Funds for the Central Universities is wrong. The correct number should be No. 2022FZZX01-33.","PeriodicalId":17648,"journal":{"name":"Journal of Zhejiang University-SCIENCE B","volume":"119 ","pages":"360"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140762184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ELABELA-derived peptide ELA13 attenuates kidney fibrosis by inhibiting the Smad and ERK signaling pathways ELABELA衍生肽ELA13通过抑制Smad和ERK信号通路减轻肾脏纤维化
Journal of Zhejiang University-SCIENCE B Pub Date : 2024-04-01 DOI: 10.1631/jzus.B2300033
Zhibin Yan, Ying Shi, Runling Yang, Jijun Xue, Caiyun Fu
{"title":"ELABELA-derived peptide ELA13 attenuates kidney fibrosis by inhibiting the Smad and ERK signaling pathways","authors":"Zhibin Yan, Ying Shi, Runling Yang, Jijun Xue, Caiyun Fu","doi":"10.1631/jzus.B2300033","DOIUrl":"https://doi.org/10.1631/jzus.B2300033","url":null,"abstract":"肾脏纤维化是各种慢性肾脏疾病发展为终末期肾病的关键过程。目前尚无针对肾纤维化的特异性治疗方法。ELA13(氨基酸序列:RRCMPLHSRVPFP)是ELABELA在所有脊椎动物中的保守片段,目前对其生物学活性的研究 却很少。本研究评估了ELA13对转化生长因子β1(TGF-β1)处理的NRK-52E细胞和单侧输尿管闭塞(UUO)小鼠的作用效果。首先,体外实验表明在TGF-β1诱导的NRK-52E细胞中,ELA13可以降低纤维化标志物I型胶原 (Collagen I)、纤连蛋白(fibronectin)和α-平滑肌肌动蛋白(α-SMA)的表达水平。随后,在UUO诱导的小鼠肾纤维化模型中,我们发现ELA13可以通过降低血清中肌酐和尿素氮的含量来改善肾功能,并通过Masson染色、免疫组 织化学、实时定量聚合酶链式反应(RT-PCR)和蛋白质印迹(western blot)的结果证实纤维化标志物和炎症标志物的表达降低了。进一步机制研究发现,ELA13处理可抑制Smad和细胞外调节蛋白激酶(ERK)信号通路。综上所述,ELA13通过抑制Smad和ERK信号通路发挥抗肾纤维化的作用,有望成为抗肾纤维化治疗的候选分子。 Kidney fibrosis is an inevitable result of various chronic kidney diseases (CKDs) and significantly contributes to end-stage renal failure. Currently, there is no specific treatment available for renal fibrosis. ELA13 (amino acid sequence: RRCMPLHSRVPFP) is a conserved region of ELABELA in all vertebrates; however, its biological activity has been very little studied. In the present study, we evaluated the therapeutic effect of ELA13 on transforming growth factor-β1 (TGF-β1)-treated NRK-52E cells and unilateral ureteral occlusion (UUO) mice. Our results demonstrated that ELA13 could improve renal function by reducing creatinine and urea nitrogen content in serum, and reduce the expression of fibrosis biomarkers confirmed by Masson staining, immunohistochemistry, real-time polymerase chain reaction (RT-PCR), and western blot. Inflammation biomarkers were increased after UUO and decreased by administration of ELA13. Furthermore, we found that the levels of essential molecules in the mothers against decapentaplegic (Smad) and extracellular signal-regulated kinase (ERK) pathways were reduced by ELA13 treatment in vivo and in vitro. In conclusion, ELA13 protected against kidney fibrosis through inhibiting the Smad and ERK signaling pathways and could thus be a promising candidate for anti-renal fibrosis treatment.","PeriodicalId":17648,"journal":{"name":"Journal of Zhejiang University-SCIENCE B","volume":"103 ","pages":"341-353"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140767535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Defense and anti-defense mechanisms of bacteria and bacteriophages 细菌和噬菌体的防御和反防御机制
Journal of Zhejiang University-SCIENCE B Pub Date : 2024-02-14 DOI: 10.1631/jzus.b2300101
Xiaoqing Wang, S. Leptihn
{"title":"Defense and anti-defense mechanisms of bacteria and bacteriophages","authors":"Xiaoqing Wang, S. Leptihn","doi":"10.1631/jzus.b2300101","DOIUrl":"https://doi.org/10.1631/jzus.b2300101","url":null,"abstract":"","PeriodicalId":17648,"journal":{"name":"Journal of Zhejiang University-SCIENCE B","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139779456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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