"Florence E. van Lieshout, Roel Klein, Martin Kolk, Kylian van Geijtenbeek, Romy Vos, S. Ruipérez-Campillo, R. Feng, B. Deb, Prasanth Ganesan, R. Knops, I. Išgum, S. Narayan, E. Bekkers, B. D. Vos, F. Tjong
{"title":"Deep Learning for Ventricular Arrhythmia Prediction Using Fibrosis Segmentations on Cardiac MRI Data","authors":"\"Florence E. van Lieshout, Roel Klein, Martin Kolk, Kylian van Geijtenbeek, Romy Vos, S. Ruipérez-Campillo, R. Feng, B. Deb, Prasanth Ganesan, R. Knops, I. Išgum, S. Narayan, E. Bekkers, B. D. Vos, F. Tjong","doi":"10.22489/cinc.2022.191","DOIUrl":"https://doi.org/10.22489/cinc.2022.191","url":null,"abstract":"Many patients at high risk of life-threatening ventricular arrhythmias (VA) and sudden cardiac death (SCD) who received an implantable cardioverter defibrillator (ICD), never receive appropriate device therapy. The presence of fibrosis on LGE CMR imaging is shown to be associated with increased risk of VA. Therefore, there is a strong need for both automatic segmentation and quantification of cardiac fibrosis as well as better risk stratification for SCD. This study first presents a novel two-stage deep learning network for the segmentation of left ventricle myocardium and fibrosis on LGE CMR images. Secondly it aims to effectively predict device therapy in ICD patients by using a graph neural network approach which incorporates both myocardium and fibrosis features as well as the left ventricle geometry. Our segmentation network outperforms previous state-of-the-art methods on 2D CMR data, reaching a Dice score of 0.82 and 0.77 on myocardium and fibrosis segmentation, respectively. The ICD therapy prediction network reaches an AUC of 0.60 while using only CMR data and outperforms baseline methods based on current guideline markers for ICD implantation. This work lays a strong basis for future research on improved risk stratification for VA and SCD","PeriodicalId":176425,"journal":{"name":"International Conference on Computing in Cardiology","volume":"319 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131593606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Wavelet-Based Approach for Automatic Diagnosis of Strict Left Bundle Branch Block","authors":"Alba Martín, J. P. Martínez","doi":"10.22489/CinC.2018.154","DOIUrl":"https://doi.org/10.22489/CinC.2018.154","url":null,"abstract":"Cardiac resynchronization therapy (CRT) is widely used in heart failure patients with left bundle branch block (LBBB). However, the high false-positive rates obtained with the conventional LBBB criteria limit the effectiveness of this therapy. This has yielded to the definition of a new stricter criteria for diagnosis. The aim of this work was to develop and assess a fully-automatic algorithm for strict LBBB diagnosis. Twelve-lead, high-resolution, 10-second ECGs from 602 patients enrolled in the MADIT-CRT trial were available. Data were labelled for strict LBBB by 2 experts and divided into training (n=300) and validation (n=302, blind annotations to the investigators) sets for assessing algorithm performance. After QRS detection, a wavelet-based delineator was used to detect individual Q-R-S waves, QRS onsets and ends, and identify the type of QRS pattern on each standard lead. Then, multilead QRS boundaries were determined in order to compute the QRS width. Finally, an automatic algorithm for notch/slur detection within the QRS complex was applied based on the same wavelet approach used for delineation. In the validation set, LBBB was diagnosed with a sensitivity and specificity of Se=92.9% and Sp=65% (Acc=79%, PPV=73.9% and NPV=89.6%). Results confirmed an accurate diagnosis of strict LBBB based on a fully-automatic extraction of temporal and morphological QRS features.","PeriodicalId":176425,"journal":{"name":"International Conference on Computing in Cardiology","volume":"178 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124419381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Mantilla, J. Paredes, J. Bellanger, J. Betancur, F. Schnell, C. Leclercq, M. Garreau
{"title":"Detection of Fibrosis in LGE-Cardiac MRI using Kernel DL-based Clustering","authors":"J. Mantilla, J. Paredes, J. Bellanger, J. Betancur, F. Schnell, C. Leclercq, M. Garreau","doi":"10.1109/CIC.2015.7408660","DOIUrl":"https://doi.org/10.1109/CIC.2015.7408660","url":null,"abstract":"In this paper we address the problem of fibrosis detection in patients with Hypertrophic cardiomyopathy (HCM) by using a sparse-based clustering approach and Dictionary learning. HCM, as a common cardiovascular disease, is characterized by the abnormal thickening, architectural disorganization and the presence of fibrosis in the left ventricular myocardium. Myocardial fibrosis in HCM leads to both systolic and diastolic dysfunction. It can be detected in Late Gadolinium Enhanced (LGE) cardiac magnetic resonance imaging. We present the use of a Dictionary Learning (DL)-based clustering technique for the detection of fibrosis in LGE-Short axis (SAX) images. The DL-based detection approach consists in two stages: the construction of one dictionary with samples from 2 clusters (LGE and Non-LGE regions) and the use of sparse coefficients of the input data obtained with a kernel-based DL approach to train a K-Nearest Neighbor (K-NN) classifier. The label of a test patch is obtained with its respective sparse coefficients obtained over the learned dictionary and using the trained K-NN classifier. The method has been applied on 11 patients with HCM providing good results.","PeriodicalId":176425,"journal":{"name":"International Conference on Computing in Cardiology","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122951268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Aging Changes in the Regularity of Hemodynamic Parameters during Six-Minute Walk Test","authors":"Marcos Hortelano, R. Reilly, R. Abad","doi":"10.1109/CIC.2015.7411101","DOIUrl":"https://doi.org/10.1109/CIC.2015.7411101","url":null,"abstract":"The objective of this study was to determine the effect of aging on regularity of blood pressure and pulse interval in resting and active conditions. We studied two normotensive subjects groups: young (20 to 40 years, n=23) and elderly people (60 to 80 years, n=23). No differences of gender have been found between young and elderly groups. Beat-to-beat blood pressure was measured by Finapres system during the six-minutes walk distance test. Overall systolic and diastolic blood pressures and pulse intervals regularity were determined. Differences in blood pressure and heart rate regularity were found between age groups. These results show the efficiency of nonlinear methods to characterize cardiac dynamic.","PeriodicalId":176425,"journal":{"name":"International Conference on Computing in Cardiology","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114628860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}