JPGN Reports最新文献

Co‐occurrence of collagenous gastrointestinal disease in siblings in early childhood: New insight into a rare condition 幼儿期兄弟姐妹同时患胶原性胃肠病：对罕见疾病的新认识

JPGN Reports Pub Date : 2024-06-14 DOI: 10.1002/jpr3.12097

Taryn L. Luitingh, Jessica Ng, K. McGrath

引用次数: 0

Pediatric eosinophilic gastritis treated with benralizumab: A case report 使用苯拉利珠单抗治疗小儿嗜酸性粒细胞性胃炎：病例报告

JPGN Reports Pub Date : 2024-06-14 DOI: 10.1002/jpr3.12088

D. Cheung, Dawn Ebach, Benjamin Davis

引用次数: 0

B cell depletion for autoimmune liver diseases: A retrospective review of indications and outcomes B 细胞耗竭治疗自身免疫性肝病：适应症和结果的回顾性分析

JPGN Reports Pub Date : 2024-06-14 DOI: 10.1002/jpr3.12098

Guillermo A. Costaguta, Fernando Álvarez

{"title":"B cell depletion for autoimmune liver diseases: A retrospective review of indications and outcomes","authors":"Guillermo A. Costaguta, Fernando Álvarez","doi":"10.1002/jpr3.12098","DOIUrl":"https://doi.org/10.1002/jpr3.12098","url":null,"abstract":"Pediatric autoimmune hepatitis has an incidence of 0.23/100.000 children in North America, with a bleak prognosis if left untreated. Steroids are the therapy of choice but are not always effective. B cell depletion is a safe and effective therapy that allows for a steroid‐sparing protocol, especially in patients who do not tolerate side effects.We retrospectively reviewed rituximab‐treated patients between 2017 and 2022. Demographics, previous treatments, reasons for B cell depletion, response, and adverse effects were noted.Six patients with a mean age of 10.2 years were included. All patients had comorbidities that rendered treatment with steroids unsuccessful or undesirable. Rituximab was started at a mean follow‐up of 8 months. After 6 months, the mean alanine transaminase and aspartate transaminase levels decreased from 575 IU/L and 342 IU/L, respectively, to 28 IU/L (p = 0.02) and 36 IU/L (p = 0.008), respectively. Mean γGT decreased from 105 to 25 IU/L (p = 0.01). Immunoglobulin G levels were normalized in all patients (p = 0.01). No severe adverse events were observed. One patient had persistent hypogammaglobulinemia, and another had lymphopenia.B‐cell depletion is an effective and safe treatment for autoimmune liver diseases and should be included as an option, particularly for relapsing patients in whom steroids are undesirable or have shown nonadherence.","PeriodicalId":17618,"journal":{"name":"JPGN Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141344502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

‘You can be as vigilant as you can, yet they make their way in’: A descriptive study of parent and caregiver perspectives towards keeping children safe from button batteries 你可以尽量提高警惕，但它们还是会乘虚而入"：关于家长和看护人如何保护儿童免受纽扣电池伤害的描述性研究

JPGN Reports Pub Date : 2024-06-14 DOI: 10.1002/jpr3.12096

Anna M. Girardi, David N. Long, Gavin Austin

{"title":"‘You can be as vigilant as you can, yet they make their way in’: A descriptive study of parent and caregiver perspectives towards keeping children safe from button batteries","authors":"Anna M. Girardi, David N. Long, Gavin Austin","doi":"10.1002/jpr3.12096","DOIUrl":"https://doi.org/10.1002/jpr3.12096","url":null,"abstract":"Button batteries pose a significant threat to young children, and parents and caregivers play an important role in keeping children safe from button batteries, especially in the home environment. However, little is known regarding parent or caregiver perspectives on button battery safety, in particular, the threat they pose to children. The aim of this study was to examine perspectives on button battery safety to enable tailored prevention strategies and to examine parent and caregiver perspectives on button battery safety in the home.One‐hundred and seventy‐four parents and caregivers of children aged 0–5 completed a cross‐sectional online survey. Distribution occurred via social media. The survey contained multiple‐choice questions pertaining to button battery knowledge and attitudes.Most respondents recognised the dangers of button battery ingestion, yet only 37% knew of button battery ingestion symptoms. While 68% knew of household items containing button batteries, 21% were aware of product‐recall information sources. Approximately 64% understood immediate post‐ingestion steps, but only 31% were familiar with first‐aid procedures. From an attitudinal standpoint, 95% understood the importance of child supervision around button batteries, 78% prioritised battery safety in toy purchases, and 17% found current safety labels unsatisfactory. This study provides a foundation for ongoing investigation of parent and caregiver perspectives on button battery home safety.Ongoing, comprehensive education and public‐safety campaigns are needed to rectify gaps in knowledge regarding button battery safety, and to reduce the risk of button battery ingestion in children.","PeriodicalId":17618,"journal":{"name":"JPGN Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141339100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of gender, race, and age of onset on the phenotype and comorbidities of pediatric eosinophilic esophagitis 性别、种族和发病年龄对小儿嗜酸性粒细胞食管炎表型和合并症的影响

JPGN Reports Pub Date : 2024-06-14 DOI: 10.1002/jpr3.12093

Kyle McKeown, Justin Pritchett, Annette Carlisle, Jie Zhang, Jay Lieberman, Dong Xi

{"title":"Impact of gender, race, and age of onset on the phenotype and comorbidities of pediatric eosinophilic esophagitis","authors":"Kyle McKeown, Justin Pritchett, Annette Carlisle, Jie Zhang, Jay Lieberman, Dong Xi","doi":"10.1002/jpr3.12093","DOIUrl":"https://doi.org/10.1002/jpr3.12093","url":null,"abstract":"To investigate differences in symptoms, allergy comorbidities, and eosinophilic inflammation at the time of diagnosis for patients with eosinophilic esophagitis (EoE) based on gender, race, and age of onset.A retrospective study was conducted at a multidisciplinary EoE clinic; the correlation between histological findings, previously identified symptoms, associated comorbidities, and demographics including gender, race, as well as age of onset was examined. Chi‐squared and Student's T‐tests were utilized for statistical analysis.A total of 91 patients were enrolled in this study, with 70% being male and 67% identifying as White. Among the patients, 45% had an early onset of EoE (defined as ≤6 years old). We revealed that White patients and females were significantly more likely to report dysphagia, while non‐White patients experienced significantly more vomiting symptoms and had a higher prevalence of asthma as a comorbidity. Early‐onset patients exhibited a significantly higher rate of vomiting and had elevated eosinophilic counts compared to patients with EoE onset at a regular age. We also revealed that abdominal pain is associated with a lower average proximal eosinophilic counts.Our study revealed the significant impact of gender, race, and age of onset on the phenotype and comorbidities of EoE, suggesting these factors should be considered when caring for these patients.","PeriodicalId":17618,"journal":{"name":"JPGN Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141341696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric colonic adenocarcinoma: A deceptive case of gastroenteritis and constipation 小儿结肠腺癌：肠胃炎和便秘的骗局

JPGN Reports Pub Date : 2024-05-15 DOI: 10.1002/jpr3.12080

Jack J. Hachem, Sara Javadi, Milissa McKee, James Noel, Robert A. Noel

引用次数: 0

Constipation: On knife edge 便秘：刀锋边缘

JPGN Reports Pub Date : 2024-05-14 DOI: 10.1002/jpr3.12079

Michelle M. Corrado, Melissa Wong, Laura Z. Fenton, Steven Moulton, Alexandra L. Kilgore

引用次数: 0

Evaluation and novel treatment in a case of refractory small bowel‐small bowel intussusception 对一例难治性小肠-小肠肠套叠病例的评估和新疗法

JPGN Reports Pub Date : 2024-05-07 DOI: 10.1002/jpr3.12078

Danielle G. Rabinowitz, Paul A. Rufo