The Russian Archives of Internal Medicine最新文献

{"title":"Myocarditis Associated with COVID-19: Review of a Fatal Case Report","authors":"O. V. Soldatova, I. Y. Goryanskaya, L. E. Namazova, O. Y. Muhtarov","doi":"10.20514/2226-6704-2024-14-3-221-227","DOIUrl":"https://doi.org/10.20514/2226-6704-2024-14-3-221-227","url":null,"abstract":"   To date more than 774 million people worldwide were infected with the SARS-CoV-2 virus (data for February 2024), and approximately 7 million people have already died from COVID-19. Since the beginning of the COVID-19 pandemic, there have been many reports and studies on damage involvement of the SARS-CoV-2 virus not only the respiratory but cardiovascular system as well, including myocardial damage, endothelial dysfunction, acute coronary syndromes, arrhythmias, myocarditis, thromboembolism, heart failure, hypotension, cardiogenic shock and even cardiac arrest. In addition, symptomatic COVID-19 infection with a severe course is more common in comorbid patients with a history of hypertension, diabetes, obesity, cancer or chronic obstructive pulmonary disease. According to the latest literature data, the occurrence of myocarditis associated with a new coronavirus infection is more often observed in young males and is associated with a severe or even fatal prognosis, which determines the relevance of a detailed study of the pathogenetic mechanisms and therapeutic possibilities for myocardial damage prophylaxis, relieving the main disease symptoms and unfavorable prognosis prevention. To date, there are also studies indicating that acute myocarditis could be a complication not only of the infection itself, but even one of the severe post-vaccination against SARS-CoV-2complications.   The purpose of this study is to research the lethal clinical case of acute infectious myocarditis complicated the course of a new coronavirus infection.   A retrospective analysis of the patient’s medical history with the final diagnosis: acute coronaviral myocarditis against the background of non-compact left ventricle myocardium was carried out.","PeriodicalId":176104,"journal":{"name":"The Russian Archives of Internal Medicine","volume":"28 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141349842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aneurysmatic Dilation of Autovenous Conduit After Coronary Bypass Graft: Clinical Case","authors":"S. Enginoev, I. V. Popova, I. I. Chernov, E. V. Efremova, V. N. Kolesnikov","doi":"10.20514/2226-6704-2024-14-3-228-234","DOIUrl":"https://doi.org/10.20514/2226-6704-2024-14-3-228-234","url":null,"abstract":"   Considering the prevalence of cardiovascular pathology and the increase in coronary interventions, including coronary artery bypass grafting (CABG), therapeutic observation and assessment of results, as well as possible complications in this cohort of patients is an urgent problem in the clinic of internal medicine. Autovenous conduits, namely the great saphenous vein, is one of the most common conduits during coronary artery bypass grafting. The reported incidence of minor dilation of great saphenous vein grafts used for CABG varies up to 14 %, but significant dilation of the aneurysm is rare. When performing coronary angiography or multispiral computed angiography, it is possible to establish the true size of the aneurysm, but the presence of mural thrombi can distort the true picture. Complications may include compression of the native coronary vessels, distal embolization, myocardial ischemia, compression of the right atrium, or fistula formation and rupture into the right atrium. The article discusses a rare clinical case of aneurysmal dilatation of an autovenous conduit up to 7.3 cm after 23 years of coronary artery bypass grafting. Considering that the development of aneurysms and pseudoaneurysms in the field of coronary bypass surgery can occur both early and late, clinical vigilance is necessary throughout the entire period of follow-up and informing the patient. The article discusses diagnostic and treatment algorithms for identifying aneurysms and pseudoaneurysms.","PeriodicalId":176104,"journal":{"name":"The Russian Archives of Internal Medicine","volume":"29 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141354608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiota and Long-Term Prognosis in Liver Cirrhosis","authors":"E. G. Malaeva, I. Stoma","doi":"10.20514/2226-6704-2024-14-3-213-220","DOIUrl":"https://doi.org/10.20514/2226-6704-2024-14-3-213-220","url":null,"abstract":"   Purpose. To compare the gut microbiota in patients with an anamnesis of liver cirrhosis of less than and more than 10 years.   Materials and methods. A one-stage study and metagenomic fecal sequencing of 40 hospitalized patients with liver cirrhosis were conducted, of which 35 were with a history of cirrhosis of less than 10 years and 5 — more than 10 years. High-throughput sequencing was performed using a MiSeq genetic analyzer (Illumina, USA) and a protocol based on analysis of 16s rRNA gene variable regions. The study was registered in Clinicaltrials.gov (NCT05335213). Data analysis was performed using Kraken2 algorithm. The analysis of the difference in the proportional composition of the microbiome between the groups was carried out using polynomial Dirichlet modeling (Likelihood-Ratio-Test Statistics: Several Sample Dirichlet-Multinomial Test Comparison), the Mann-Whitney test with preliminary data transformation by CLR transformation (Centered log ratio transform), differential analysis of gene expression based on negative binomial distribution (DESeq2). The significance level α assumed to be 0.05.   Results. In patients with liver cirrhosis, the dominant phylotypes of fecal microbiota are Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria, minor components include taxa Aquificae, Coprothermobacterota, Tenericutes, Verrucomicrobia, Chloroflexi, Deinococcus-Thermus, Thermotogae, Chlorobi. Significant differences have been established in the density of dominant and minor philotypes of gut bacteria, such as Actinobacteria, Proteobacteria, Tenericutes, Coprothermobacterota, as well as some classes, genera, bacterial species in patients with different disease duration (p < 0.05).   Conclusion. There is no doubt about the effect of gut microbiota on compensation for liver function. The established differences in the composition of the microbiota in patients with liver cirrhosis depending on survival over 10 years are of scientific and practical importance for the formation of an evidence-based approach to the use of microbiome-associated interventions","PeriodicalId":176104,"journal":{"name":"The Russian Archives of Internal Medicine","volume":"14 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141355262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kounis Syndrome: Myocardial Infarction After Wasp Bites","authors":"E. D. Resnyanskaya, D. S. Evdokimov, V. S. Feoktistova","doi":"10.20514/2226-6704-2024-14-3-235-240","DOIUrl":"https://doi.org/10.20514/2226-6704-2024-14-3-235-240","url":null,"abstract":"   The presented clinical case describes a rather rare type II Kunis syndrome (SC) that occurred in a 69-year-old man with risk factors for coronary heart disease (CHD) after wasp bites and was accompanied by the development of acute myocardial infarction (MI) due to coronary artery thrombosis (CA). The diagnosis of MI was confirmed on the basis of laboratory and instrumental data: an increase in troponin levels (>10000 pg/ml), changes in the electrocardiogram (ECG) (elevation of the ST segment in II, III leads, aVF), revealed violations of the contractility of the left ventricle (LV) according to echocardiography (zone of akinesia of the basal lower segment LV, hypokinesia of the median inferior and anterolateral segments of the LV, the apical-lateral segment of the LV), the results of coronary angiography (acute occlusion with signs of parietal thrombosis in the right coronary artery). The cause of CA thrombosis could be either a pronounced immuno-inflammatory reaction or the administration of adrenaline to stop anaphylactic reaction. Currently, there are no clear criteria for the verification of SC, the diagnosis is confirmed on the basis of a comprehensive examination of a patient with acute coronary syndrome (ACS) and the presence of a pronounced allergic/anaphylactic reaction. Additionally, to confirm the SC, it is proposed to assess the level of histamine and tryptase in the blood, however, these markers are metabolized quite quickly and, in most cases, it is not possible to identify their elevated levels. This case once again underlines the importance of informing doctors about the risk of developing ACS against the background of a pronounced allergic reaction, as well as the need for further study of SC in order to develop tactics for the treatment and prevention of this group of patients.","PeriodicalId":176104,"journal":{"name":"The Russian Archives of Internal Medicine","volume":"21 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141350145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Report of Al-Amyloidosis with «Hepatic Disguise» of Nephrotic Syndrome","authors":"A. A. Kozlova, V. P. Rauzheva, A. R. Yunyaev, V. V. Mayorov, E. V. Manyakina, V. Kokorin, E. S. Stolyarevich, N. G. Poteshkina","doi":"10.20514/2226-6704-2024-14-3-206-212","DOIUrl":"https://doi.org/10.20514/2226-6704-2024-14-3-206-212","url":null,"abstract":"   Amyloidosis is characterized by damage to several organ systems, which leads to diagnostic delays and progression of the pathological process. The described clinical case demonstrates a long diagnostic search in a patient with AL-amyloidosis. According to the literature, the most often described manifestation of the disease is kidney damage that manifests as nephrotic syndrome. This case is interesting because the reason for hospitalization was liver damage. Laboratory tests revealed cholestatic and cytolytic syndromes and dyslipidemia. Differential diagnostic included diseases with liver damage. In the hospital nephrotic syndrome was identifi ed, renal biopsy was performed that proved the diagnosis of AL-amyloidosis with combined damage to the gastrointestinal tract, liver and kidneys.","PeriodicalId":176104,"journal":{"name":"The Russian Archives of Internal Medicine","volume":"10 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141353721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinic-Functional Assessment of Hemoglobin Desaturation by Oxygen in 6-Minute Walk Test Among Patients with Bronchial Asthma","authors":"V. V. Gnoevykh, A. Y. Smirnova, N. G. Chernova, Y. Shorokhova, M. V. Krestyaninov, E. V. Efremova, I. A. Galushina","doi":"10.20514/2226-6704-2024-14-3-190-196","DOIUrl":"https://doi.org/10.20514/2226-6704-2024-14-3-190-196","url":null,"abstract":"   The main purpose of the study is to assess the prevalence and clinical significance of hemoglobin desaturation by oxygen during the 6-minute walk exercise test in patients with bronchial asthma.   Material and methods: 75 patients with exacerbation of mixed (48 %) and allergic (52 %) bronchial asthma were examined. Research explored following methods: collecting complaints and anamnesis, physical examination, spirometry, CO-metry of exhaled air to determine carboxyhemoglobin, transcutaneous 2-wave pulse oximetry (at rest and during 6-minute walk exercise test) with spectral analysis and correction for COHb. 6-minute walk exercise test was performed after relief of asthma exacerbation (before discharge from the hospital), assessing the desaturation-distance ratio (the ratio of the area of oxygen desaturation of hemoglobin to the 6-minute walk exercise test distance), O2-GAP index, the dynamics of fatigue and dyspnea before and after 6-minute walk exercise test. In smoking patients (n = 36, 48 %), the smoker index was calculated. Based on oximetry results during the 6-minute walk exercise test, patients were divided into “desaturators” (n = 28, 37 %) and “non-desaturators” (n = 47, 63 %).   Results. The findings of the research illustrated that hemoglobin desaturation by oxygen, detected by reducing SpO2 to < 90 % during 6-minute walk exercise test, was associated with the severity of this disease exacerbation, more pronounced impairment of pulmonary ventilation and blood oxygenation, and the demand for longer hospitalization. The prevalence of tobacco smoking and the magnitude of the smoker index in both groups were identical but in “desaturators” we found a higher prevalence of the combination of asthma and COPD compared to “non-desaturators.” The “desaturators” had significantly higher level of desaturation-distance ratio and increased demand for additional oxygen flow to maintain SpO2 at ≥ 88 % during a 6-minute walk test, which indicates a higher “oxygen price” of physical activity in this group of patients.   Conclusion. Thus, the high prevalence of the phenomenon of hemoglobin oxygen desaturation during 6-minute walk exercise test in patients with asthma and associated clinic-functional disorders supports the feasibility and clinical significance of conducting a stress test with a 6-minute walk not only in COPD patients, but also in bronchial asthma patients.","PeriodicalId":176104,"journal":{"name":"The Russian Archives of Internal Medicine","volume":"35 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141354088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Significance Vasoendothelial Growth Factor Depending on the Severity and Duration of Atopic Dermatitis, as Well as Taking into Account the Presence of Markers of Herpes Virus Infection","authors":"N. А. Imanverdiyeva, O. Bashkina","doi":"10.20514/2226-6704-2024-14-3-197-205","DOIUrl":"https://doi.org/10.20514/2226-6704-2024-14-3-197-205","url":null,"abstract":"   Currently, the problem of diagnosis and treatment of diseases associated with disorders of the angiogenesis process, as well as regenerative processes, is acute. Factors regulating the processes of angiogenesis in allergic diseases, including atopic dermatitis, play a key role in maintaining chronic inflammation and can have a significant impact on the course of the disease.   Materials and methods: The study is analytical cross-sectional and presented by a comprehensive examination of 140 patients with AtD aged 2 to 12 years (median age 4.2 years), divided into 2 groups: 70 children with an established diagnosis of AtD; 70 children with atopic dermatitis infected with herpes simplex virus (AtD+HVI). The control group consisted of 70 somatically healthy children. A special laboratory examination included the determination of specific IgM and/or IgG class antibodies to herpes simplex virus type 1-2 antigens by enzyme immunoassay (ELISA); determination of the DNA of the studied herpesviruses in blood samples by polymerase chain reaction; determination of vascular endothelial growth factor A (VEGF-A) in the blood plasma of patients by ELISA.   The results of our own research: A statistically significant (p <0.001) increase in the level of vascular endothelial growth factor A in blood serum was found in children with AtD compared with the control group. Against the background of infection with the herpes simplex virus, an increase in the level of vascular endothelial growth factor A in blood serum was revealed compared with patients with atopic dermatitis (p < 0.001). There was also a statistically significant increase in serum VEGF-A levels in patients with AtD (p < 0.001) and AtD+HVI (p < 0.001) with an increase in the severity of AtD. This was confirmed by the results of a correlation analysis that revealed the relationship between the level of VEGF-A and the severity of clinical symptoms of the disease.The addition of herpesvirus infection to AtD worsens the clinical symptoms of this disease.","PeriodicalId":176104,"journal":{"name":"The Russian Archives of Internal Medicine","volume":"143 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141350867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Portal Vein Thrombosis in Liver Cirrhosis. Part 1: Epidemiology, Pathogenesis, Clinic, Diag-nosis, Impact on Prognosis","authors":"A. Yagoda, P. Koroy, L. S. Baisaeva, T. R. Dudov","doi":"10.20514/2226-6704-2024-14-3-165-172","DOIUrl":"https://doi.org/10.20514/2226-6704-2024-14-3-165-172","url":null,"abstract":"   Portal vein thrombosis is the most common thrombotic complication in patients with liver cirrhosis, especially in cases of severe forms. The pathogenesis is multifactorial in nature, it determined by a change in the balance between the coagulation and anticoagulation systems. Thrombosis is often asymptomatic and is accidentally detected, although it can be complicated by varicose bleeding, intestinal ischemia, and portal biliopathy. Ultrasound Doppler examination is a screening method, as an alternative, computed tomography and magnetic resonance imaging are used. The review highlights data on epidemiology, risk factors, clinical features, and diagnosis of portal vein thrombosis in patients with liver cirrhosis. The data on the effect of portal vein thrombosis on the progression of liver cirrhosis and the survival of patients, including after liver transplantation, are presented.","PeriodicalId":176104,"journal":{"name":"The Russian Archives of Internal Medicine","volume":"15 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141356521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of Densitometric Assessment of Bone Tissue in Young Patients with Hodgkin’s Lymphoma","authors":"K. M. Badykova, J.S. Kitaeva, E. A. Praskurnichij","doi":"10.20514/2226-6704-2024-14-3-173-180","DOIUrl":"https://doi.org/10.20514/2226-6704-2024-14-3-173-180","url":null,"abstract":"   Hodgkin’s lymphoma occurs mainly in people aged 15 to 45 years. The use of cytostatic drugs as pathogenetic therapy can cause complications from the musculoskeletal system, such as osteopenia and osteoporosis. To date, the issue of the use of densitometric examination in young patients remains relevant.   The aim of the work. To study the features of densitometric assessment of bone tissue in young patients with Hodgkin’s lymphoma.   Materials and methods. The study included 63 patients with an established diagnosis of Hodgkin’s lymphoma after pathogenetic therapy and 30 people who make up the control group. All patients underwent a study of bone mineral density by means of two-energy absorptiometry in three areas: the proximal femur, femoral neck and lumbar spine. The Z-criterion was also calculated for each patient. In order to identify the optimal areas of densitometric measurement, the method of one-factor regression analysis was applied.   Results. According to the results of densitometry, a decrease in bone mineral density is more common in the study group compared with the control group. At the same time, in patients with Hodgkin’s lymphoma, mineral density decreases equally in the proximal femur and femoral neck. Nevertheless, the manifestations of osteoporosis are more pronounced in the femoral neck, whereas the phenomena of osteopenia prevail in the proximal region. However, a decrease in the Z-criterion in the lumbar spine is observed more often than in the neck and proximal femur.   Conclusion. Early diagnosis opens up the possibility of early prevention of osteoporosis in young patients.","PeriodicalId":176104,"journal":{"name":"The Russian Archives of Internal Medicine","volume":"98 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141359037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the Role of Mast Cells and Their Proteases in the Severe COVID-19","authors":"A. Budnevsky, S. N. Avdeev, E. S. Ovsyannikov, I. Savushkina, O. N. Choporov, V. Shishkina, A. V. Pertsev, I. M. Perveeva, N. Alekseeva","doi":"10.20514/2226-6704-2024-14-3-181-189","DOIUrl":"https://doi.org/10.20514/2226-6704-2024-14-3-181-189","url":null,"abstract":"   During the pandemic of the new coronavirus infection COVID-19 the question about the importance of mast cells and their proteases arose.   The aim of this study is to determine the role of mast cells and their proteases chymase and tryptase in the pathogenesis of severe COVID-19.   Materials and methods. The study included 55 patients: 29 male (52,7 %) and 26 female (47,3 %) aged 67 [62;71] years with severe COVID-19 and fatal outcome. An analysis of postmortem lung biopsies of patients with COVID-19 was carried out, determining the representation of mast cells, protease profile and degranulation activity. A correlation analysis was carried out between mast cell and clinical and laboratory parameters of patients.   Results. Increased number of mast cells and their degranulation activity were found in patients with chronic heart failure, obesity, chronic kidney disease, coronary heart disease and acute cerebrovascular accident. Degranulation of tryptase-positive mast cells are depleted as the duration of the disease increases: the content of single tryptase-positive mast cells (%) negatively correlates with the duration of the disease and hospitalization (p = 0,015, r = -0,327 and p = 0,006, r = -0,368, respectively), the content of tryptase-positive mast cells fragments (%)correlates with the duration of hospitalization (p = 0,007, r = 0,357). Correlations were established between the levels of non-conjugated bilirubin and alanine aminotransferase with the content of single tryptase-positive mast cells (per mm2) (r = 0,340, p < 0,05 and r = 0,307, p < 0,05, respectively), as well as single degranulated tryptase-positive mast cells (per mm2) (r = 0,369, p < 0,05 and r = 0,363, p < 0,01, respectively), and the level of conjugated bilirubin with the content of single tryptase-positive mast cells (%) (r = 0,415, p < 0,05). The blood calcium level correlates with the absolute total content of single tryptase-positive mast cells (p = 0,013, r = 0,457), as well as degranulated (p = 0,017, r = 0,441). A negative correlation was also found between potassium level and the relative content of single non-degranulated tryptase-positive mast cells (p = 0,014, r = -0,352). Correlations were found between the level of total bilirubin at the time of admission and over time with the content of single degranulated chymase-positive mast cells (per mm2) (p = 0,043, r = 0,277 and p = 0,027, r = 0,317, respectively). Urea level upon admission positively correlates with the absolute total content of single chymase-positive mast cells (p = 0,045, r = 0,277), as well as degranulated (p = 0,04, r = 0,283). The potassium level in the blood correlates with the total content of co-adjacent chymase-positive mast cells (p < 0,05, r = 0,388), as well as content of co-adjacent degranulated chymase-positive mast cells (p < 0,05, r = 0,388).   Conclusion. Significant correlations were noted between mast cells parameters and duration of the disease and hospitalization, the presen","PeriodicalId":176104,"journal":{"name":"The Russian Archives of Internal Medicine","volume":"32 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141356873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}