Marine Medicine最新文献

{"title":"Gel-ultraphonophoresis for patients with scarring on the skin: results of comparative prospective intervention study","authors":"I. A. Gritskova, I. G. Ponomarenko, G. Ponomarenko, I. V. Cherkashina","doi":"10.22328/2413-5747-2023-9-3-93-101","DOIUrl":"https://doi.org/10.22328/2413-5747-2023-9-3-93-101","url":null,"abstract":"INTRODUCTION. In modern realities of peace and military trauma there are an increasing number of scar skin defects, often accompanied by pronounced subjective sensations and tissue functional limitations. An urgent task is the scientific substantiation of effective methods of their correction. OBJECTIVE. To determine healing effects and safety of using ultraphonophoresis of enzyme gel with high transcutaneous and proteolytic activity in patients with scarring on the skin. MATERIALS AND METHODS. There was examination of 82 patients with emerging (N=21 study group, N=16 comparison group) and mature (N=25 study group, N=20 comparison group) scar skin of different localizations at the rehabilitation stage after various injuries, burns, removal of skin neoplasms. The study applied clinical and functional methods in the assessment of scar tissue, medical and sociological methods in evaluating patients’ quality of life and safety profile. RESULTS. There were improved clinical indicators and functional skin properties in the scar area, a significant regression of subjective sensations, an increased quality of life score, more pronounced in the study groups. Dynamics of clinical indicators is more expressed in group 1 and group 3. Vascularization values before and after treatment in the groups were: in group 1 and 3 before treatment - 6,4±0,93 and 5,8±0,25, after - 3,0±0,24 and 2,7±0,31, respectively; in group 2 the values before and after treatment were 5,6±0,26 и 4,2±0,62, respectively, in group 4 – before treatment 4,9±0,53, after - 4,1±0,48. As a result of dynamics of the quality of life indicators, a more significant improvement was found in the study groups with respect to the comparison groups. In the group with emerging scars the sum of points before treatment was 20,4±0,3, after treatment - 12,4±0,3; in the comparison group - 18,7±0,5 and 13,4±0,5 before and after treatment, respectively; in the group with mature scars: before treatment - 23,6±0,3, after - 13,7±0,4; in the comparison group - 21,3±0,4 и 16,2±0,5 before and after treatment, respectively. A favorable safety profile of treatment was defined: adverse events (tingling, burning) were transient and fully cupped after the procedure. DISCUSSION. Ultraphonophoresis, one of the man methods in the transdermal delivery, contributes to changing the epidermal barrier permeability for molecules of various drugs as well as potentiation for actions of anti-scarring agents at different stages of emerging and existing scar skin defects. CONCLUSION. Ultraphonophoresis of the enzyme gel with a high transcutaneous and proteolytic activity has fibromodulating and sedative curative effects in patients with scarring skin of different genesis and duration.","PeriodicalId":175902,"journal":{"name":"Marine Medicine","volume":"13 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139255459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periodontitis: causes, conditions of occurrence and prevention","authors":"Vladimir F. Chernysh, Alexander M. Kovalevsky, M. A. Bokarev, Stanislav A. Lopatin","doi":"10.22328/2413-5747-2023-9-3-13-23","DOIUrl":"https://doi.org/10.22328/2413-5747-2023-9-3-13-23","url":null,"abstract":"OBJECTIVE. Analyze the causes and conditions for chronic generalized periodontitis, study means of preventive health care through individual oral hygiene. MATERIALS AND METHODS. The study analyzed the scientific literature, devoted to casual factors and conditions of developing chronic generalized periodontitis, its influence on the health of the body and as well as the role of oral hygiene in preventing its onset and progression. Articles in leading domestic dental peer-reviewed publications along with data sources from Pubmed over the past 5 years were analyzed. RESULTS. The literature analysis found that majority of authors acknowledge microbial biofilm microbiota of the oral cavity as the leading etiological factor of periodontitis; such factors as poor oral hygiene, endogenous and exogenous erythrocyte sorption overload, the impact of physical environmental factors – external electromagnetic fields and vibrations affect the progression of the disease. Meanwhile, measures of professional oral hygiene и normalization of individual oral hygiene allows to significantly reduce the risk of emerging and progressing chronic generalized periodontitis. DISCUSSION. By category visits patients, suffering from CGP, were distributed as follows: 61,6 ± 0,7 % people – retirees of Russian Defense Ministry, 16,5 ± 0,5 % people – family members of military men and retired of RDM, 16,3 ± 0,5 % – military men, attached to the dentistry clinic of RDM military units and institutions, 5,7 ± 0,3 % – RMD cadets. Means of individual oral hygiene, relevant for the prevention of periodontitis, include about 15 items. Part of them are classified as traditional, and the proper application of some of them requires additional training, including in the framework of special medical training during hygiene education work and health promotion. The authors came to a conclusion about the expediency of increasing the number of dentists to intensify the prevention of dental caries and periodontal diseases among military men through professionally monitored oral hygiene. CONCLUSION. The high prevalence and intensity of dental system diseases among military men shows the relevance of regular sanitation of their oral cavity. Systematic implementation of individual oral hygiene measures decreases the number of bacteria in the mouth, prevents the development of severe overall body response to inflammation, contributes to a significant reduction in the number of exacerbation of concomitant somatic diseases that improves overall health and people’s quality of life. Professionally monitored oral hygiene, oral hygiene education and motivation for applying modern hygiene products are considered as the basis of oral disease prevention.","PeriodicalId":175902,"journal":{"name":"Marine Medicine","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139257305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute myocardial infarction and pulmonary embolism in a young serviceman with a mutation of the plasminogen activator inhibitor gene type 1","authors":"A. V. Popova, K. Shulenin, D. Cherkashin, S. Shulenin, G. G. Kutelev, D. S. Bogdanov","doi":"10.22328/2413-5747-2023-9-1-87-94","DOIUrl":"https://doi.org/10.22328/2413-5747-2023-9-1-87-94","url":null,"abstract":"The clinical case of acute myocardial infarction and pulmonary embolism in a young soldier with the first occurred protracted attack of angina. The survey found the link between these conditions and gene mutation of type 1 plasminogen activator inhibitor that plays a key role in fibrinolysis by inhibiting the formation of plasmin and leading to slowdown in fibrinolysis processes and a longer-term persistence of blood clot. It is proven that homozygous 4G/4G mutation found in the patient results in the development of arterial and venous thrombosis at a young age and is associated with a tendency to relapse. It clearly shows that hereditary thrombophilia is characterized by the absence of obvious provocative factor and single universal diagnostic algorithm; the diagnosis is based on the comprehensive evaluation of laboratory data.","PeriodicalId":175902,"journal":{"name":"Marine Medicine","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132487872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of diver recompression methods after emergency ascent to prevent decompression sickness: experimental study","authors":"S. L. Levashev, O. Alekseeva","doi":"10.22328/2413-5747-2023-9-1-64-72","DOIUrl":"https://doi.org/10.22328/2413-5747-2023-9-1-64-72","url":null,"abstract":"OBJECTIVE: Based on the analysis of national normative documents and a series of animal experiments to evaluate the effectiveness of a not common method of a diver’s recompression after emergency ascent, skipping all the mandatory decompression stops in order to prevent the development of decompression sickness. MATERIALS AND METHODS: In the study Wister rats (n = 30) were used. The animals were placed in the chamber and there was air compression up to 9 АТА with exposure under pressure within 15 min. Decompression was carried out by pressure release with imitation of emergency ascent. After 5 minutes there was recompression by air up to АТА, isopressure within 10 minutes and elongated decompression. During recompression, further decompression and 2 hours after its completion the animals experienced behavioral response and signs of compression disorder development. RESULTS: The study showed that the test group where the animals’ exposure under 9 ATA completed with the planned decompression on the regime did not experience any behavioral disorder and reflexes of posture during and after decompression. There were also no registered gas bubbles in the brain. Similar results were obtained in the test group with emergency ascent, recompression and further elongated decompression, but not in the group with emergency ascent without recompression. DISCUSSION: The application of the proposed recompression method after imitation of emergency ascent leads to neither visual nor morphologically registered signs of decompression disorders. Along with a shorter period of recompression and decompression as compared with the ones, described in regulatory documents, it allows to adopt the proposed method for reducing the loss of time and resources while maintaining diver’s health and performance after emergency ascent. ","PeriodicalId":175902,"journal":{"name":"Marine Medicine","volume":"226 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123262223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"«Pressure diuresis» phenomenon: mechanisms and physiological significance in diving medical support practice: prospective cohort study","authors":"D. P. Zverev, A. Shitov, A. Myasnikov, A. N. Andrusenko, V. I. Chernov, I. Klenkov, Z. M. Israfilov","doi":"10.22328/2413-5747-2023-9-1-73-86","DOIUrl":"https://doi.org/10.22328/2413-5747-2023-9-1-73-86","url":null,"abstract":"INTRODUCTION: When staying in hyperbaric conditions there is an increase in diuresis, developing a negative water balance, loss of electrolytes and tissue dehydration after diving different in depth, duration, intensity and other parameters, which can be conditionally combined into specific physiological symptom complex – “pressure diuresis” phenomenon (or “diver diuresis”). OBJECTIVE: To investigate the mechanisms of “pressure diuresis” under the action of high gaseous medium pressure and determine the physiological nature of this phenomenon in divers. MATERIALS AND METHODS: 44 men aged 19–23 were examined. In the first study all the subjects had initial sustainability to hyperbaric adverse factors (decompression gas formation – DG, hypoxic hypoxia – HH, nitrogen toxic effect – NTE and oxygen toxic effect – OTE). Hormonal status and body’s osmotic homeostasis rates were defined in all the subjects. The second study evaluated changes of the subjects’ water-electrolyte metabolism, kidney function and osmotic homeostasis during the oral loading renal test with the water load in the baseline and conditions of hyperbaric adverse factor exposure on divers. Statistics: To perform statistical analysis, application packages of Statistica for Windows 10.0 were used. RESULTS: 17 (38,6 %), 29 (65,9 %), 20 (45,5 %) and 35 (79,6 %) subjects had medium and low resistance to DG, HH, OTE and NTE, respectively; 27 (61,4 %), 15 (34,1 %), 24 (54,5 %) and 9 (20,4 %) subjects had high resistance to DG, HH, OTE and NTE. Increase in the concentration of antidiuretic hormone was identified in the diving group with low and medium resistance to NTE, HH, and OTE (by 146,8, 141,1 and 93,2 %, respectively, compared to the results before hyperbaric adverse factor exposure). The highest concentration increase of aldosterone was found among the divers with low and medium resistance to OTE, DG and HH (by 41,5, 39,1 and 36,2 %, respectively). The increase in blood plasma osmolality was observed in the subjects with low and medium resistance to OTE (an increase by 6,6 % compared to the divers with high resistance). A significant reduction in blood plasma osmolality was recorded in the subject group with low and medium resistance to NTE and HH (reduction by 5,2 and 4,2 %, compared to the group with high resistance). The most significant decrease in urine osmolality was identified in the diving group with low and medium resistance to DG and OTE (reduction by 14,5 and 17,7 %, respectively). A significant increase in urine osmolality under the action of hyperbaric factors was defined in the diving group with low and medium resistance to NTE and HH (by 19,8 and 19,3 %). DISCUSSION: The data obtained indicate the emergence of a new body hydration status during person’s staying in hyperbaric conditions. Body hydration status will be connected with its individual resistance to hyperbaric adverse factor effect. Thus, with the development of marked DG iso-osmotic (isotonic) hyperhydration i","PeriodicalId":175902,"journal":{"name":"Marine Medicine","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129606705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of absorbing substance for content of carbon dioxide via calcimeter «Fann»","authors":"S. G. Fokin, S. Bychkov, A. M. Yarkov","doi":"10.22328/2413-5747-2023-9-1-100-103","DOIUrl":"https://doi.org/10.22328/2413-5747-2023-9-1-100-103","url":null,"abstract":"OBJECTIVE: Consider the use of calcimeter “Fann” to analyze the absorbing substance for the content of carbon dioxide. MATERIALS AND METHODS: There was an analysis of the absorbing substance for the content of carbon dioxide by two methods. Their working principle is based on decomposing acid effect on chemical absorber, resulting in a chemical reaction and producing carbon dioxide. RESULTS: Pressure, generated in the reaction process in a closed reactor, is directly proportional to the carbonate content in the sample. The use of calcimeter “Fann” allows to determine the content of carbon dioxide in chemical absorber fast and with high degree of accuracy","PeriodicalId":175902,"journal":{"name":"Marine Medicine","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124426994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rational decompression using computer programs","authors":"A. M. Yarkov, S. Bychkov, S. G. Fokin","doi":"10.22328/2413-5747-2023-9-1-95-99","DOIUrl":"https://doi.org/10.22328/2413-5747-2023-9-1-95-99","url":null,"abstract":"Divers use tables with decompression modes when conducting diving descents. Currently, tables are being replaced by underwater computers, into which modern mathematical models of decompression algorithms are programmed. None of the existing models takes into account the individual characteristics of the organism, the processes occurring in the body under conditions of high pressure of the gas and water environment, and does not describe the real processes well enough. Modern diving computers are able to supply a diver with a large amount of information. Based on data on depth, time, number of dives and time of surface intervals, they help to plan dives, inform when it is necessary to make an ascent, assign, if necessary, safety stops and calculate the time before the flight by plane. Currently, it is safe to say that a computer is simply necessary for a diver. His health, and sometimes his life, depends on it.","PeriodicalId":175902,"journal":{"name":"Marine Medicine","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126476330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficiency of hyperbaric oxygenation in complex rehabilitation of soldiers with traumatic brain injury: prospective study","authors":"A. A. Grintsova, K. O. Karataeva, A. B. Matiytsiv","doi":"10.22328/2413-5747-2023-9-1-58-63","DOIUrl":"https://doi.org/10.22328/2413-5747-2023-9-1-58-63","url":null,"abstract":"OBJECTIVE: Evaluate the effect of hyperbaric oxygenation course on indicators of central hemodynamics, heart-rate variability and ability to concentrate and switch attention in soldiers with traumatic brain injury. MATERIALS AND METHODS: The main group contained 50 patients with combat traumatic brain injury, aged 25-45, whose comprehensive treatment course included hyperbaric oxygenation. The control group consisted of 20 patients, treated with medical therapy under the clinical protocol. Hyperbaric oxygenation treatment was carried out in BLKS-303 MK pressure apparatuses in the 0.3–0.7 ati mode with an isopression exposure of 40 min. The course of hyperbaric oxygenation included 10±2 sessions per day. The indicators of heart-rate variability and central hemodynamics were measured. Bourdon proofreading sample was used to assess alertness and ability to switch attention. Statistics. Statistical analysis of data was performed using “Statistica for Windows 6.5” program. Comparisons are shown as median values (Me) and quartile range (LQ÷UQ) (25% and 75% percentile). Criteria of significance was considered p<0,05. the Mann-Whitney test was used to compare quantitative indicators in the main and control groups, the Wilcoxon T test was applied when studying the dynamics of change in indicators in the study groups. RESULTS: Including hyperbaric oxygenation in the complex therapy of patients with combat traumatic brain injury led to significant reduction in indicators of sympathetic activity - mode amplitude - up to 35,7 % (29,5÷48,0), decrease of tension index up to 116,5 %/с2  (99,0÷122,0) and recovery of vegetative equilibrium indicator LF/HF up to 2,8 (2,5÷4,3). Patients with hyperkinetic type of blood circulation in the main group, compared to the control group experienced significant reduction in stroke volume index to 41,8 (40,7÷54,8) ml/m2 cardiac index up to 4,6 (4,4÷5,2) kg*m/min/m2 , decreased energy expenditure for blood moving to 12,3 (12,3÷12,7) Wh/l. improve coordination is observed in 54 % of the main group in comparison with 34 % of the control group, reduced pathological reflexes - in 50 % of the main group, compared to 22 % of the control group, decrease in the severity of deep reflection disorders - in 55 % of the main group versus 28 % of the control group. Conducting Bourdon proofreading sample test after HBO course in the main group, compared to the control group showed significant error reduction from 12,7 (10,2÷14,6) to 4,2 (3,7÷5,2) (р<0,001); reliable error reduction from 11,8 (9,6÷12,8) to 8,4 (6,5÷10,2) (р<0,05) was noted in the control group. DISCUSSION: Early application of hyperbaric oxygenation in the complex therapy of patients with combat traumatic brain injury contributes to rapid normalization of central hemodynamics, decrease in the severity of impact on the sympathetic part of the autonomic nervous system, reduction in the degree of cardiac rhythm management centralization. Reliable regression of focal symptoms in t","PeriodicalId":175902,"journal":{"name":"Marine Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125873633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulating influence of wistar rats’ oxygen status on behavioural manifestations of nitrogen narcosis: experimental study","authors":"A. N. Vjotosh, O. Alekseeva","doi":"10.22328/2413-5747-2023-9-1-52-57","DOIUrl":"https://doi.org/10.22328/2413-5747-2023-9-1-52-57","url":null,"abstract":"OBJECTIVE of the study is to determine the influence of changing oxygen status in the animal’s body on nitrogen toxic effect under pressure. MATERIALS AND METHODS: A hyperbaric chamber was used to create normothermic effect of hyperbaric nitrogen up to 4,1 MPa amid changing oxygen concentration from 0,03 to 0,004 MPa, recording rats’ motor activity and posture reflexes. RESULTS: Oxygen decrease in the respiratory gas medium from 0,021 to 0,004 MPa due to nitrogen compression raised biphasic sensitivity of Wistar rates to nitrogen toxic effect. Yet in the sites of non-compensable hypoxia sensitivity to hyperbaric nitrogen effect increased 4,5 times. Preliminary exposure of pregnant rats in hypoxia led to decrease in the offspring’s sensitivity to toxic effect of hyperbaric nitrogen by 35% on average after reaching puberty. DISCUSSION: The obtained data allows to regard toxic effect of hyperbaric nitrogen as oxygen-dependent process. While hypoxia along with hyperbaric nitrogen effect enhances nitrogen narcosis, hypoxia, prior to nitrogen compression, reduces intoxication of this gas.","PeriodicalId":175902,"journal":{"name":"Marine Medicine","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121507681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral mucosa diseases in seafarers during long voyages, their treatment and prevention : prospective study","authors":"A. Serikov, A. Iordanishvili","doi":"10.22328/2413-5747-2023-9-1-46-51","DOIUrl":"https://doi.org/10.22328/2413-5747-2023-9-1-46-51","url":null,"abstract":"OBJECTIVE: To detect oral mucous membrane disease of the mouth, lips and tongue in seafarers on long voyage, to evaluate preventive measures and treatment effectiveness. MATERIALS AND METHODS: There was a dental examination of 169 men, aged 22-52 on long voyage, who got full treatment and preventive measures of oral rehabilitation in the pre-deployment period in a time manner. The seafarers were divided into 2 groups. The 1st group included 57 seamen, who were part of the crew. The 2nd group consisted of 112 men, who were training and had the first long voyage. The oral mucosa diagnosis was based on a clinic examination. When identifying pathology, treatment was provided and there were anti-relapse measures after its completion, which were possible given the people on board on long voyage. RESULTS: It was found that the structure of oral mucosa is quite different among people of the 1st and 2nd groups. The pathology among the crew occurred more often due to the autoimmune component of pathogenesis in 5,26% and 0,9% cases respectively, while the people in the 2nd group, being on long voyage as part of their training, experienced infectious oral mucosa pathology (12,28% and 15,32% respectively) significantly more often, and also lesions of the lips due to meteorological factors in 8,77% and 10,81% cases accordingly. DISCUSSION: The article discusses the treatment of meteorological cheilitis, the fracture of the vermilion border of the lip, Vincent disease, herpetic fever and chronic recurrent aphthous stomatitis with the use of domestic medicine for topical application. CONCLUSION: On long voyage 26,04% seafarers had cases of oral mucosa, among which most frequently diagnosed ones were infectious diseases, pathology due to meteorological factors, and also diseases with the autoimmune component of pathogenesis. In all cases domestic medicine for topical application was used to reveal pathology of oral mucosa, and further, to prevent its recurrence that allowed to achieve a good therapeutic result and to avoid recurrence of oral mucosa disease, typical for seafarers during a 9-month voyage. ","PeriodicalId":175902,"journal":{"name":"Marine Medicine","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132994716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}