P. Gurung, Bishal Shrestha, A. Neupane, Pravesh Rajbhandhari
{"title":"Different Trials in Mechanical Thrombectomy for Acute Ischemic Stroke","authors":"P. Gurung, Bishal Shrestha, A. Neupane, Pravesh Rajbhandhari","doi":"10.52910/AJHS.46","DOIUrl":"https://doi.org/10.52910/AJHS.46","url":null,"abstract":"Acute Ischemic Stroke (AIS) is a leading cause of death and disability. It can be treated early with a favorable prognosis if intravenous recombinant tissue plasminogen activator (IV rt-PA) is given to eligible patients within 4.5 hours of its onset. For those patients who do not meet the criteria to undergo intravenous fibrinolysis, mechanical thrombectomy has been shown to be an effective alternative in patients presenting with occlusion of first segment of middle Cerebral artery (MCA) or of internal carotid artery (ICA), provided the intervention is performed within 24 hour according to previous trial. We herein review different randomized controlled trials on AIS undergoing mechanical thrombectomy","PeriodicalId":175886,"journal":{"name":"Annapurna Journal of Health Sciences","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128305615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Use, Abuse, and Associated Impacts of Alcohol on Health and Crimes in Nepal","authors":"L. Gautam, A. Bohara, Jaya Satyal, A. Grela","doi":"10.52910/AJHS.45","DOIUrl":"https://doi.org/10.52910/AJHS.45","url":null,"abstract":"Alcohol is a socially acceptable and widely available drink in most countries. Its excessive consumption is linked to various health issues, increase in crime rate and even loss of life. This puts heavy strain in low-income countries like Nepal where full medical facilities are still out of reach for most of the population. Therefore, in this article, we have provided an overview of (i) the effect of alcohol on public health; (ii) trend data on alcohol seizures; (iii) alcohol (including methanol) positive forensic cases; and (iv) other alcohol associated crimes. Our analysis is drawn from a range of data types and sources, triangulating the collected data with alcohol specific academic and grey literature, a survey with students and insights from stakeholder engagements in Nepal. We have shown that alcohol has been associated with a range of health-related issues and crime types in Nepal. For example, alcohol was the most mentioned compound in the student survey (50.7%; n=418) followed by other drugs in Drugs Facilitated Sexual Assault cases. We have also discussed issues with adulteration, surrogates and sub-standard alcohol, highlighting the need for strict monitoring, regulations and extra vigilance about quality control of alcohol in circulation. This should be supported by public awareness campaigns on the use, abuse and impacts of alcohol.","PeriodicalId":175886,"journal":{"name":"Annapurna Journal of Health Sciences","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127877739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Subash Paudel, A. Chandra, Bhavya Pahwa, Janam Shrestha, D. Shrestha, A. Chandra
{"title":"Central Pontine Myelinolysis in Association with Correction of Hypokalemia with Asymptomatic Case of Gastroesophageal Reflux Disease","authors":"Subash Paudel, A. Chandra, Bhavya Pahwa, Janam Shrestha, D. Shrestha, A. Chandra","doi":"10.52910/AJHS.44","DOIUrl":"https://doi.org/10.52910/AJHS.44","url":null,"abstract":"This case report has described the patient having the central pontine myelinolysis (CPM) associated with hypokalemia correction with asymptomatic history of gastroesophageal reflux disease (GERD). It was suspected that due to GERD and vomiting there might be loss of electrolytes resulting to hypokalemia. The hypokalemia was corrected and patient was discharged from the tertiary neurological center in Nepal.Central Pontine Myelinolysis in Association with Correction of Hypokalemia with Asymptomatic Case of Gastroesophageal Reflux Disease","PeriodicalId":175886,"journal":{"name":"Annapurna Journal of Health Sciences","volume":"71 21","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120934238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sambardhan Dabadi, R. Dhungel, Saugat Acharya, Pratikshya Poudel, A. Jha, J. Shrestha
{"title":"Modes of Non-invasive Respiratory Support Devices and their Significance in the Treatment of COVID-19","authors":"Sambardhan Dabadi, R. Dhungel, Saugat Acharya, Pratikshya Poudel, A. Jha, J. Shrestha","doi":"10.52910/AJHS.47","DOIUrl":"https://doi.org/10.52910/AJHS.47","url":null,"abstract":"The Novel Coronavirus pandemic (COVID-19) is threatening people all over the world. Each country worldwide has been affected by COVID-19 and over 300 million people have lost their lives. Acute Respiratory Failure (ARF) is the main complication for COVID-19 patients.Various oxygen therapy devices such as oxygen concentrator, high flow nasal cannula, positive airway devices like continuous positive airway pressure (CPAP), bilevel positive airway pressure (BiPAP) have much helped the patients to recover from the ARF. The use of these technology made it possible to avoid the severity of the disease and, consequently, the need for invasive ventilation and an intensive care unit (ICU).Different ways and techniques of using such devices and their significance have been mentioned in this study.","PeriodicalId":175886,"journal":{"name":"Annapurna Journal of Health Sciences","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132598786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Gautam, Belinda Lioba L. Mesina-Nepomuceno, Pratiksha Paudel
{"title":"Correlation between Serum Calcium and In-Patient Mortality among Patients with Hemorrhagic and Non-Hemorrhagic Cerebrovascular Disease","authors":"R. Gautam, Belinda Lioba L. Mesina-Nepomuceno, Pratiksha Paudel","doi":"10.52910/AJHS.51","DOIUrl":"https://doi.org/10.52910/AJHS.51","url":null,"abstract":" Introduction: Cerebrovascular disease is the second most frequent cause of death worldwide. This study was designed to access the correlation between ionized calcium and clinical outcomes of Cerebrovascular events.\u0000Methods: The study included 225 cases diagnosed with cerebrovascular disease and undergone a CT scan. Calcium (ionized calcium) was measured within 1-2 hrs. Of sample collection. The time frame of the study was from December 2016 till December 2017.\u0000Result: There were a total of 52 patients admitted as DVT, among which 26(50%) were male and 26(50%) were female. Twenty patients (38.5%) were COVID-19 positive and 32 (61.5%) were COVID-19 negative. Mean age for among those patients was 50.50±4.8 years, average hospital stay was 6.4±0.6 days, after anticoagulation therapy target INR was reached in 3.8±0.17 days and CVI was present in 14(70%) for COVID positive with DVT. Similarly, mean age was 46.80±3.3 years, average hospital stay was 4.6±0.3 days, after anticoagulation therapy target INR was reached in 3.3±0.21 days and CVI was present in 18(56.65%) with COVID negative with DVT.\u0000Conclusion: Serum calcium was found to be associated with clinical outcome among stroke patients found to have infarction. High incidence of favourable clinical outcome among those who have normal level of serum calcium compared to those who have low serum calcium level was found.","PeriodicalId":175886,"journal":{"name":"Annapurna Journal of Health Sciences","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131872984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jaya Satyal, Pradeep Kc, R. Shrestha, Pratima Dhakal
{"title":"Acupuncture as a Rehabilitative Therapy in Patient with Multiple Sclerosis:A case Study","authors":"Jaya Satyal, Pradeep Kc, R. Shrestha, Pratima Dhakal","doi":"10.52910/AJHS.41","DOIUrl":"https://doi.org/10.52910/AJHS.41","url":null,"abstract":"Acupuncture is a branch of TCM (Traditional Chinese Medicine) and has been practiced in China for more than 3000 years. It coordinates conventional Chinese needling strategies with Western clinical information on the cerebral cortex and has been demonstrated to be an extremely compelling method for treating Multiple sclerosis (MS) and other focal sensory system issues. A 42-year-old female patient who was diagnosed with MS was treated with Acupuncture therapy. This case shows that Acupuncture therapy can be complimentary treatment in Multiple Sclerosis. Acupuncture therapy that holds the possibility to extend treatment alternatives for MS in both ordinary and integrative treatments.","PeriodicalId":175886,"journal":{"name":"Annapurna Journal of Health Sciences","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132168063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Rajbhandari, J. Yadav, R. Karn, R. Ojha, B. Gajurel
{"title":"Challenges Faced for Botulinum Toxin Injection in the Treatment of Hemifacial Spasm and Blepharospasm: Our Experience in Tribhuvan University Teaching Hospital during COVID-19 Pandemic","authors":"R. Rajbhandari, J. Yadav, R. Karn, R. Ojha, B. Gajurel","doi":"10.52910/AJHS.36","DOIUrl":"https://doi.org/10.52910/AJHS.36","url":null,"abstract":"Introduction: Hemi facial spasm (HFS) and Blepharospasm (BS) is a chronic distressing condition. Botulinum toxin (BoNT) injection is one of its treatment modality. Acquiring the injection and treating the patients overcoming the lockdown hurdles of COVID pandemic has been a major challenge. \u0000Methods: Patients who were treated at Tribhuvan University Teaching Hospital (TUTH) Outpatient Department (OPD) during the COVID pandemic in 2020 and 2021 were included in this study. \u0000Results: Out of 30 patients, 77% were female. 47% were diagnosed with BS whereas the rest with HFS. About 50% of them have had symptoms for an average of 2-5 years before receiving botulinum toxin injection. The mean Jankovic score for patients before BoNT was 2.31(SD: 0.66 range 1-4). 26 patients experienced a decrease in spasm within one week of BoNT injection and had symptomatic relief. The mean Jankovic score at week 1 was 0.63(SD: 1.09 range 1-3) and the difference was statistically significant (p<0.001). After 2 weeks of BoNT therapy, all patients experienced a decrease in spasm with symptomatic improvement. The mean Jankovic score at week 2 was 0.26(SD: 0.44 range 0-1) and the difference was statistically significant (p<0.001). In terms of side effects, 4 patients experienced paresis while 26 patients experienced no side effects. No other systemic side effects were reported. \u0000Conclusion: BoNT injection has a good outcome for HFS and BS, despite its cost and the need for frequent injection. Importing the BoNT from India during the lockdown period of COVID pandemic and patients travelling within the country were challenges that were faced by the patients and doctors to achieve the result.","PeriodicalId":175886,"journal":{"name":"Annapurna Journal of Health Sciences","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130364065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hari Prasad Devkota, A. Devkota, Atisammodavardhana Kaundinnyayana, D. Bhandari
{"title":"Strengthening Traditional Medicine Systems in Nepal through Chemical and Pharmacological Research","authors":"Hari Prasad Devkota, A. Devkota, Atisammodavardhana Kaundinnyayana, D. Bhandari","doi":"10.52910/AJHS.48","DOIUrl":"https://doi.org/10.52910/AJHS.48","url":null,"abstract":"Medicinal plants are an integral part of traditional medicine systems all over the world. Nepal, rich in biodiversity and ethnic, linguistic, and cultural diversity, possesses different traditional and folk medicinal practices for thousands of years. These systems have been using many locally available medicinal plants as crude drugs, which are not always properly documented. Detailed documentation and research related to the conservation and cultivation of medicinal plants should be carried out. Scientific studies related to chemical analysis, standardization, evaluation of pharmacological activities, and safety should be carried out to strengthen these systems of traditional medicine. Adequately designed clinical studies are necessary to provide evidence for their therapeutic efficacy","PeriodicalId":175886,"journal":{"name":"Annapurna Journal of Health Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131057362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Vaidya, R. Karmacharya, Neetu Bhandari, G. Hada, Shushil Sah, Sahil Bade, Swastika Sedhai
{"title":"Deep Vein Thrombosis : An Unusual Presentation in COVID-19 Patients-Our Experience and Comparison with Non COVID-19 Deep Vein Thrombosis Cases","authors":"S. Vaidya, R. Karmacharya, Neetu Bhandari, G. Hada, Shushil Sah, Sahil Bade, Swastika Sedhai","doi":"10.52910/AJHS.35","DOIUrl":"https://doi.org/10.52910/AJHS.35","url":null,"abstract":"Introduction: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was found in Wuhan China which caused the acute respiratory illness and became the pandemic as declared by World Health Organization on March 11, 2020. Viral inclusion bodies have been identified in endothelial cells in a variety of organs. Deep Vein Thrombosis(DVT) is one atypical presentation which is thought to be triggered by endothelial dysfunction and exacerbated by hypoxia in patients with COVID-19. \u0000Methods: It was a single center retrospective study in Kathmandu University Dhulikhel Hospital. All the data were taken between January, 2020 till May, 2021 who were presented in OPD or inpatient department with symptoms of DVT and required admission. Presence or absence or concomitant COVID-19 was tested by RT-PCR test. \u0000Result: There were a total of 52 patients admitted as DVT, among which 26(50%) were male and 26(50%) were female. Twenty patients (38.5%) were COVID-19 positive and 32 (61.5%) were COVID-19 negative. Mean age for among those patients was 50.50±4.8 years, average hospital stay was 6.4±0.6 days, after anticoagulation therapy target INR was reached in 3.8±0.17 days and CVI was present in 14(70%) for COVID positive with DVT. Similarly, mean age was 46.80±3.3 years, average hospital stay was 4.6±0.3 days, after anticoagulation therapy target INR was reached in 3.3±0.21 days and CVI was present in 18(56.65%) with COVID negative with DVT. \u0000Conclusion: COVID-19 is still the mysterious virus and exact mechanism of this disease is still a debate which may need many years to solve. Sometimes DVT can be the only presentation of this disease","PeriodicalId":175886,"journal":{"name":"Annapurna Journal of Health Sciences","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121850109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Acharya, P. Rajbhandari, R. Shrestha, Sudan Dhakal, P. Shrestha, S. Gajuryal, B. Pant
{"title":"Economic Burden Associated with Neurocysticercosis at a Tertiary Care Neurological Center in Nepal","authors":"S. Acharya, P. Rajbhandari, R. Shrestha, Sudan Dhakal, P. Shrestha, S. Gajuryal, B. Pant","doi":"10.52910/AJHS.40","DOIUrl":"https://doi.org/10.52910/AJHS.40","url":null,"abstract":"Introduction: Neurocysticercosis (NCC) is the most common parasitic disease of the central nervous system and is a major cause of epilepsy and neurological morbidity in humans in endemic areas of the world. This study was conducted to estimate economic burden of the paients due to Neurocysticercosis arriving at Tertiary Neurological center of Kathmandu,Nepal. \u0000Methods: A cross sectional prospective study was conducted for 2 years among the patients with NCC at Tertiary Neurological Center in Kathmandu. Patients treatment plan and followup date were recorded and patient were categorized into four different groups depending on the frequency of followup and completion of treatment. Direct and indirect cost centers were catagorised and calculated accordingly. The cost was estimated in US dollar as of 2020. \u0000Results: Out of 52 patients who were followed up completely for treatment, majority of patient were from age group 21-30 years . The total cost incurred for group 1, group 2, group 3 and group 4 were $468, $714, $ 1054 and $1986 respectively.The average cost per day for a patient with NCC was calculated to be $1.5. \u0000 Conclusion: This study suggests that Neurocysticercosis results in considerable monetary losses to patient in developing country like Nepal. The average loss of each individual accounted for around one half of per day capita income of Nepal. Various programs and poolicies shall be implemented to reduce the burden of NCC so as to reduce the economic burden associated to it.","PeriodicalId":175886,"journal":{"name":"Annapurna Journal of Health Sciences","volume":"07 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114576075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}