Zhong Guo, Jason H. Whitfield, S. Edwardraja, K. Alexandrov
{"title":"Connecting biochemistry and elelctronics with artifical allosteric protein biosensors","authors":"Zhong Guo, Jason H. Whitfield, S. Edwardraja, K. Alexandrov","doi":"10.1109/LO.2018.8435862","DOIUrl":"https://doi.org/10.1109/LO.2018.8435862","url":null,"abstract":"The idea that biological systems can be built from standard components is the central tenet of Synthetic Biology. Although proteins control most of real time information and energy flow in a cell, our ability to create protein-based switches and thereon based circuits is woefully underdeveloped. We addressed this by developing a generally applicable strategy for converting constitutively active enzymes into allosterically controlled switches. This was achieved by constructing chimeric enzymes where the enzymatically active part is fused with a conformational switch. We demonstrated that such basic signaling units could be compiled into higher order biosensor systems capable of detecting potentially any analyte. Specifically using this approach we constructed electrochemical and optical biosensors specific to ions, small molecule drugs and proteins.","PeriodicalId":175509,"journal":{"name":"2018 International Conference Laser Optics (ICLO)","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125193721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Kopylov, K. Spasibko, G. Leuchs, T. Murzina, M. Chekhova
{"title":"Non-phasematched Sum Frequency Generation from Tightly Focused High Gain Parametric Down Conversion","authors":"D. Kopylov, K. Spasibko, G. Leuchs, T. Murzina, M. Chekhova","doi":"10.1109/LO.2018.8435723","DOIUrl":"https://doi.org/10.1109/LO.2018.8435723","url":null,"abstract":"we study the sum frequency generation from high gain parametric down conversion with broadband spectrum in the absence of the phase matching. In the case of strong focusing, a set of interference spectral peaks in the spectrum of the second harmonic appear without the phase matching. Experimental data supported by theoretical modeling reveal the influence of correlation effects on non-phase matched sum frequency generation.","PeriodicalId":175509,"journal":{"name":"2018 International Conference Laser Optics (ICLO)","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125337553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Valuev, S. Kontorov, V. Kulagin, D. Prokhorov, V. Cherepenin, A. N. Shulunov
{"title":"Microwave photonics frequency conversion of microwave signals","authors":"V. Valuev, S. Kontorov, V. Kulagin, D. Prokhorov, V. Cherepenin, A. N. Shulunov","doi":"10.1109/LO.2018.8435452","DOIUrl":"https://doi.org/10.1109/LO.2018.8435452","url":null,"abstract":"Comparative study of different architectures for microwave photonics frequency converters of microwave signals is presented. Characteristics of the receivers with different architectures are obtained with the help of numerical simulation. Experimental parameters for the prototypes of receivers show good agreement with the results of numerical simulation. It is shown that the signal-to-noise ratio can reach 60–70 for a carrier frequency of tens of gigahertz and a receiving bandwidth of several hundreds of megahertz","PeriodicalId":175509,"journal":{"name":"2018 International Conference Laser Optics (ICLO)","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125416717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Gorodnitskiy, A. Voloshin, N. Kondratiev, I. Bilenko, M. Gorodetsky
{"title":"Electro-optic broadband modulator based on lithium niobate WGM microresonator","authors":"A. Gorodnitskiy, A. Voloshin, N. Kondratiev, I. Bilenko, M. Gorodetsky","doi":"10.1109/LO.2018.8435532","DOIUrl":"https://doi.org/10.1109/LO.2018.8435532","url":null,"abstract":"We report an experimental investigation of electrooptic amplitude modulator based on whispering gallery mode (WGM) optical microresonators. We have analyzed in detail the limits of operating ranges and ways to extend them. The WGM resonator is a polished lithium niobate micro-disk with metal deposited ring RF electrodes. To excite the WGM modes, a coupling prism was used.","PeriodicalId":175509,"journal":{"name":"2018 International Conference Laser Optics (ICLO)","volume":"437 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116146231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Yu, H.-Z. Li, Y. Yin, Z. Sheng, P. McKenna, F. Shao
{"title":"PW laser-driven bright ɣ-ray emission and dense positron production from diamondlike carbon foils","authors":"T. Yu, H.-Z. Li, Y. Yin, Z. Sheng, P. McKenna, F. Shao","doi":"10.1109/LO.2018.8435808","DOIUrl":"https://doi.org/10.1109/LO.2018.8435808","url":null,"abstract":"we propose an all-optical scheme for ultra-bright γ-ray emission and dense positron production with lasers at intensity of 10<sup>22-23</sup> Wcm<sup>-2</sup>. By irradiating two colliding elliptically-polarized lasers onto two diamondlike carbon foils, electrons in the focal region of one foil are rapidly accelerated by the laser radiation pressure and interact with the other intense laser pulse which penetrates through the second foil due to relativistically induced foil transparency. This symmetric configuration enables efficient γ-photon emission with unprecedented brightness of 10<sup>25</sup> photons/s/mm<sup>2</sup>/mrad<sup>2</sup>/0.1%BW at 15 MeV and intensity of 5×10<sup>23</sup> Wcm<sup>-2</sup>. A GeV positron beam with density of 2.5×10<sup>22</sup> cm<sup>-3</sup> and flux of 1.6×10<sup>10</sup>/shot is achieved.","PeriodicalId":175509,"journal":{"name":"2018 International Conference Laser Optics (ICLO)","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116390921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Staliūnas, D. Gailevičius, V. Koliadenko, V. Taranenko, V. Purlys, M. Peckus
{"title":"Photonic Crystal Microchip Laser","authors":"K. Staliūnas, D. Gailevičius, V. Koliadenko, V. Taranenko, V. Purlys, M. Peckus","doi":"10.1109/LO.2018.8435668","DOIUrl":"https://doi.org/10.1109/LO.2018.8435668","url":null,"abstract":"We show, theoretically and experimentally, that photonic crystals with spatial filtering functionality, inside of a microchip laser cavity, can substantially improve spatial characteristics of the emission of microchip laser. The angular divergence of the emitted beam is reduced, and the radiation brightness is increased.","PeriodicalId":175509,"journal":{"name":"2018 International Conference Laser Optics (ICLO)","volume":"109 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116461863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Khramov, N. Ishmametiev, R. Shaidullin, O. Ryabushkin
{"title":"Metal-Coated Fiber Sensor for Laser Radiation Power Measurement","authors":"I. Khramov, N. Ishmametiev, R. Shaidullin, O. Ryabushkin","doi":"10.1109/LO.2018.8435801","DOIUrl":"https://doi.org/10.1109/LO.2018.8435801","url":null,"abstract":"A novel technique for the measurement of highpower radiation of fiber lasers presented. A copper-coated silica fiber was used as a sensor. Optical power transmitting through the sensor is obtained by measuring the change of a metal coating electric resistance induced by its heating due to the absorption of the scattered radiation.","PeriodicalId":175509,"journal":{"name":"2018 International Conference Laser Optics (ICLO)","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114476810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Matveev, V. Demidov, A. Sovetsky, A. Moiseev, A. Matveyev, G. Gelikonov, V. Zaitsev, A. Vitkin
{"title":"OCT-based label-free 3D mapping of lymphatic vessels and transparent interstitial-fluid-filled dislocations","authors":"L. Matveev, V. Demidov, A. Sovetsky, A. Moiseev, A. Matveyev, G. Gelikonov, V. Zaitsev, A. Vitkin","doi":"10.1109/LO.2018.8435727","DOIUrl":"https://doi.org/10.1109/LO.2018.8435727","url":null,"abstract":"Approach to OCT-lymphangiography (OCT-LA) and interstitial-fluid-filled dislocations mapping that complement speckle variance (SV) OCT angiography is presented. OCT-LA can be extracted from the same OCT raw datasets that were acquired for SV OCT angiography. Lymphatic vessels and interstitial dislocations are filled with transparent fluids (e.g. lymph) and can be separated from the blood vessels and tissue. In vivo application of the OCT-LA approach is demonstrated on NRG mouse with grown BX-PC3 tumor (human pancreatic cancer cells).","PeriodicalId":175509,"journal":{"name":"2018 International Conference Laser Optics (ICLO)","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122130011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Laser acceleration of optimized electron and proton beams from low-density targets","authors":"V. Bychenkov","doi":"10.1109/LO.2018.8435574","DOIUrl":"https://doi.org/10.1109/LO.2018.8435574","url":null,"abstract":"Laser-driven charged particle acceleration mechanisms with relativistically intense pulses of ultrashort duration are reviewed for innovative low-density targets of near critical and near relitivistically critical densities. Applications of the generated high-energy electron and proton beams to nuclear and radiation sources are discussed.","PeriodicalId":175509,"journal":{"name":"2018 International Conference Laser Optics (ICLO)","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116850949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Rosenwaks, I. Auslender, E. Yacoby, K. Waichman, B. Barmashenko
{"title":"Basic Processes in DPALs: Experimental and Theoretical Studies","authors":"S. Rosenwaks, I. Auslender, E. Yacoby, K. Waichman, B. Barmashenko","doi":"10.1109/LO.2018.8435497","DOIUrl":"https://doi.org/10.1109/LO.2018.8435497","url":null,"abstract":"Experimental and theoretical parametric studies of the influence of the pump-to-laser beam overlap, the alkali cell length and composition of the buffer gas on the laser power, slope efficiency and the laser beam quality factor M2 of static Cs DPALs is reported.","PeriodicalId":175509,"journal":{"name":"2018 International Conference Laser Optics (ICLO)","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117037055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}