Journal of Veterinary Science & Medical Diagnosis最新文献

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Activity of Lycii fructus against Colorectal Cancer Based on Network Pharmacology and in Vitro Experiments 基于网络药理学和体外实验的枸杞抗大肠癌活性研究
Journal of Veterinary Science & Medical Diagnosis Pub Date : 2023-01-01 DOI: 10.12677/md.2023.133047
娇秀 樊
{"title":"Activity of Lycii fructus against Colorectal Cancer Based on Network Pharmacology and in Vitro Experiments","authors":"娇秀 樊","doi":"10.12677/md.2023.133047","DOIUrl":"https://doi.org/10.12677/md.2023.133047","url":null,"abstract":"Objective: To study the activity and the molecular mechanism of the active ingredients from Lycii fructus against colorectal cancer based on network pharmacology and in vitro experiments. Me-thods: The active components and corresponding targets of Lycii fructus were predicted by TCMSP; screening colorectal cancer related targets by TTD database, Gene Card database, and DisGeNET database; the common targets of Lycii fructus and colorectal cancer were obtained using Venny2.1 online tool, and PPI (Protein-Protein Interaction) networks analysis was conducted using STRING database; Gene Ontology (GO) enrichment and KEGG pathway enrichment were analyzed by Me-tascape website; MTT assay was used to examine the anticancer activity of the extract from Lycii fructus against colorectal cancer. Results: 35 active ingredients of Lycii fructus were predicted, with 121 potential anti-cancer targets identified. The 5 most promising targets based on PPI analysis were TP53, HSP90AA1, AKT1, MAPK1, and RELA. KEGG enrichment showed that the active ingredients from Lycii fructus mainly functioned via PI3K-Akt signaling pathway, HIF-1 signaling pathway, and relaxin signaling pathway. MTT assay was used to examine the effect of the extract from Lycii fructus on the colorectal cancer cell viability and its antioxidant activity. Conclusion: Based on the network pharmacology and in vitro experiments, the possible antitumor targets of the active ingredients from Lycii fructus were screened and their antitumor activity was verified in vitro , providing a reference for the further study of the anticancer mechanism of Lycii fructus .","PeriodicalId":17544,"journal":{"name":"Journal of Veterinary Science & Medical Diagnosis","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86472729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on Expression of sST2 and IL-33 in Vascular Calcification of Maintenance Hemodialysis Patients 维持性血液透析患者血管钙化中sST2、IL-33表达的研究
Journal of Veterinary Science & Medical Diagnosis Pub Date : 2023-01-01 DOI: 10.12677/md.2023.131003
佳武 李
{"title":"Study on Expression of sST2 and IL-33 in Vascular Calcification of Maintenance Hemodialysis Patients","authors":"佳武 李","doi":"10.12677/md.2023.131003","DOIUrl":"https://doi.org/10.12677/md.2023.131003","url":null,"abstract":"","PeriodicalId":17544,"journal":{"name":"Journal of Veterinary Science & Medical Diagnosis","volume":"371 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77485328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress in Diagnosis and Treatment of Ankylosing Spondylitis 强直性脊柱炎的诊断与治疗进展
Journal of Veterinary Science & Medical Diagnosis Pub Date : 2023-01-01 DOI: 10.12677/md.2023.132019
春丽 卢
{"title":"Progress in Diagnosis and Treatment of Ankylosing Spondylitis","authors":"春丽 卢","doi":"10.12677/md.2023.132019","DOIUrl":"https://doi.org/10.12677/md.2023.132019","url":null,"abstract":"","PeriodicalId":17544,"journal":{"name":"Journal of Veterinary Science & Medical Diagnosis","volume":" 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91549430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress in the Study of Episiotomy and Its Complications 会阴切开术及其并发症的研究进展
Journal of Veterinary Science & Medical Diagnosis Pub Date : 2023-01-01 DOI: 10.12677/md.2023.133048
李 高
{"title":"Progress in the Study of Episiotomy and Its Complications","authors":"李 高","doi":"10.12677/md.2023.133048","DOIUrl":"https://doi.org/10.12677/md.2023.133048","url":null,"abstract":"Childbirth always puts traumatic stress on a woman’s body. To reduce perineal trauma during childbirth, obstetricians use an episiotomy. Despite controversy over its use, episiotomy remains a common practice. Weighing the pros and cons, the scientific literature supports the selective use of episiotomy. With the worldwide trend of decreasing use of episiotomy, several techniques have","PeriodicalId":17544,"journal":{"name":"Journal of Veterinary Science & Medical Diagnosis","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76162633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic Features of Pituitary Stalk Block-ade Syndrome and Review of the Literature 垂体柄阻断综合征的诊断特点及文献复习
Journal of Veterinary Science & Medical Diagnosis Pub Date : 2023-01-01 DOI: 10.12677/md.2023.132029
荣荣 王
{"title":"Diagnostic Features of Pituitary Stalk Block-ade Syndrome and Review of the Literature","authors":"荣荣 王","doi":"10.12677/md.2023.132029","DOIUrl":"https://doi.org/10.12677/md.2023.132029","url":null,"abstract":"","PeriodicalId":17544,"journal":{"name":"Journal of Veterinary Science & Medical Diagnosis","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74669042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Congenital Vaginal Flaw Combined with Double Uterine Initiation Uterus: 1 Case 先天性阴道缺损合并双子宫起始子宫1例
Journal of Veterinary Science & Medical Diagnosis Pub Date : 2023-01-01 DOI: 10.12677/md.2023.133044
伟利 刘
{"title":"Congenital Vaginal Flaw Combined with Double Uterine Initiation Uterus: 1 Case","authors":"伟利 刘","doi":"10.12677/md.2023.133044","DOIUrl":"https://doi.org/10.12677/md.2023.133044","url":null,"abstract":"","PeriodicalId":17544,"journal":{"name":"Journal of Veterinary Science & Medical Diagnosis","volume":"144 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78162603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research Progress of PCSK9 Function in Tu-mor Microenvironment of Breast Cancer PCSK9在乳腺癌肿瘤微环境中的功能研究进展
Journal of Veterinary Science & Medical Diagnosis Pub Date : 2023-01-01 DOI: 10.12677/md.2023.131008
玉东 慕
{"title":"Research Progress of PCSK9 Function in Tu-mor Microenvironment of Breast Cancer","authors":"玉东 慕","doi":"10.12677/md.2023.131008","DOIUrl":"https://doi.org/10.12677/md.2023.131008","url":null,"abstract":"","PeriodicalId":17544,"journal":{"name":"Journal of Veterinary Science & Medical Diagnosis","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91191074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Segmentation Scheme for Ultrasound Images of Thyroid Nodules 甲状腺结节超声图像分割方案
Journal of Veterinary Science & Medical Diagnosis Pub Date : 2023-01-01 DOI: 10.12677/md.2023.132025
乘麟 赵
{"title":"Segmentation Scheme for Ultrasound Images of Thyroid Nodules","authors":"乘麟 赵","doi":"10.12677/md.2023.132025","DOIUrl":"https://doi.org/10.12677/md.2023.132025","url":null,"abstract":"","PeriodicalId":17544,"journal":{"name":"Journal of Veterinary Science & Medical Diagnosis","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84689221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on the Relationship between Hypothyroidism during Pregnancy and Gestational Diabetes Mellitus 妊娠期甲状腺功能减退与妊娠期糖尿病关系的研究
Journal of Veterinary Science & Medical Diagnosis Pub Date : 2023-01-01 DOI: 10.12677/md.2023.133042
可婧 李
{"title":"Study on the Relationship between Hypothyroidism during Pregnancy and Gestational Diabetes Mellitus","authors":"可婧 李","doi":"10.12677/md.2023.133042","DOIUrl":"https://doi.org/10.12677/md.2023.133042","url":null,"abstract":"In recent years, the relationship between gestational hypothyroidism and gestational diabetes has attracted widespread attention. Studies have found that the former can cause insulin","PeriodicalId":17544,"journal":{"name":"Journal of Veterinary Science & Medical Diagnosis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84749554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Observation on the Treatment of Silicosis Remission Stage (Spleen and Kidney Qi Deficiency Syndrome) with Self Drawn Experience Formula for Strengthening the Spleen, Tonifying the Kidney, and Clearing the Lung 自拟健脾补肾清肺经验方治疗矽肺缓解期(脾肾气虚证)临床观察
Journal of Veterinary Science & Medical Diagnosis Pub Date : 2023-01-01 DOI: 10.12677/md.2023.132037
丽娜 陈
{"title":"Clinical Observation on the Treatment of Silicosis Remission Stage (Spleen and Kidney Qi Deficiency Syndrome) with Self Drawn Experience Formula for Strengthening the Spleen, Tonifying the Kidney, and Clearing the Lung","authors":"丽娜 陈","doi":"10.12677/md.2023.132037","DOIUrl":"https://doi.org/10.12677/md.2023.132037","url":null,"abstract":"","PeriodicalId":17544,"journal":{"name":"Journal of Veterinary Science & Medical Diagnosis","volume":"280 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86738091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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