Journal of thoracic disease最新文献

{"title":"The impact of American Society of Anesthesiologists physical status on the feasibility and safety of non-intubated video-assisted thoracoscopic surgery: a retrospective analysis.","authors":"Sira Laohathai, Apichat Tantraworasin, Ratchaya Weerayutwattana, Imran Tahir, Jakraphan Yu","doi":"10.21037/jtd-2026-1446","DOIUrl":"10.21037/jtd-2026-1446","url":null,"abstract":"<p><strong>Background: </strong>Non-intubated video-assisted thoracoscopic surgery (NIVATS) avoids the risks of general anesthesia, one-lung ventilation and tracheal intubation, and has traditionally been reserved for low-risk patients [American Society of Anesthesiologists (ASA) physical status I-II]. Its feasibility and safety in patients with higher ASA physical status remain insufficiently defined. We compared perioperative outcomes between low- and high-ASA patients undergoing NIVATS.</p><p><strong>Methods: </strong>This single-center retrospective cohort study included consecutive patients undergoing elective NIVATS for lung resection between September 2019 and December 2023. Patients were stratified into low-ASA (ASA I-II) and high-ASA (ASA III-IV) groups. Baseline characteristics and perioperative outcomes were compared using the Mann-Whitney U test, Chi-squared test or Fisher exact test. Multivariable Poisson regression adjusted for sex and operation type was used to estimate the independent association of high-ASA status with key outcomes, expressed as the incidence rate ratio (IRR).</p><p><strong>Results: </strong>A total of 663 patients were analyzed (low-ASA, n=517; high-ASA, n=146). High-ASA patients were older (median 66.9 <i>vs.</i> 42.1 years, P<0.001) and had a greater comorbidity burden. Conversion to intubated video-assisted thoracoscopic surgery (VATS) (2.1% <i>vs.</i> 1.4%, P=0.58), operative time (P=0.53) and overall perioperative complications (P=0.52) did not differ between groups. However, the high-ASA group had higher rates of reoperation (3.4% <i>vs.</i> 0.4%, P=0.007), longer hospital stay (P=0.003) and higher mortality (2.1% <i>vs.</i> 0.2%, P=0.03). After adjustment, high-ASA status independently predicted a prolonged hospital stay [IRR 2.18, 95% confidence interval (CI): 2.02-2.34, P<0.001] and markedly higher mortality (IRR 12.21, 95% CI: 1.27-117.51, P=0.03), but not conversion to intubated VATS, ICU admission or postoperative complications.</p><p><strong>Conclusions: </strong>NIVATS is technically feasible and intraoperatively well tolerated in high-ASA patients, with conversion and immediate complication rates comparable to those of low-ASA patients. However, high-ASA status independently predicts prolonged hospitalization and a substantially increased risk of mortality. These findings underscore the importance of careful patient selection and intensive, tailored postoperative care for high-risk patients undergoing NIVATS.</p>","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"18 8","pages":"895"},"PeriodicalIF":2.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148929898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythromycin inhibits the differentiation of NCR^-ILC3s activated by lung dendritic cells in mice exposed to cigarette smoke.","authors":"Yifang Xu, Ying Shen, Lili Mo, Haijuan Tang, Shilin Qiu, Shuangqi Cai, Yi Liang, Xiaoning Zhong","doi":"10.21037/jtd-2026-1251","DOIUrl":"10.21037/jtd-2026-1251","url":null,"abstract":"<p><strong>Background: </strong>Both dendritic cells (DCs) and nature cytotoxicity receptor-negative 3-type innate lymphoid cells (NCR^-ILC3s) have been implicated in chronic lung inflammation in mice with cigarette smoke (CS)-induced chronic obstructive pulmonary disease (COPD). Our study aims to investigate whether erythromycin (EM) can suppress the differentiation of ILC3s into NCR^-ILC3s through restraining DCs activation and therefore attenuate CS-related lung injuries in COPD mice.</p><p><strong>Methods: </strong>Our study comprised both <i>in vivo</i> and <i>in vitro</i> experiments. In the former, lung samples were collected from non-smokers, smokers, patients with stable COPD, as well as mice exposed to air, CS, and CS combined with EM, respectively. In the latter, lung DCs sifted by CD11c magnetic beads from mice exposed to either air or CS were co-cultured with lung CD45⁺Lin^-CD127⁺ILCs sorted from air-exposed mice. EM was added to the co-culture involving DCs from CS-exposed mice. Flow cytometry and other assays were used to examine the quantities of NCR^-ILC3s, DCs, relevant costimulatory molecules and cytokines in human tissues, mice lungs, and cell cultures.</p><p><strong>Results: </strong>Compared to non-smokers, lung NCR^-ILC3s frequencies significantly increased in both smokers and COPD patients, and inversely correlated with forced expiratory volume in 1 second percent predicted (FEV₁% pred) and diffusing capacity for carbon monoxide (P<0.05). CS-exposed mice showed evident emphysema and elevated frequencies of lung NCR^-ILC3s and DCs. In contrast, mice receiving CS and EM displayed attenuated emphysema and reduced levels of NCR^-ILC3s and DCs (P<0.05). In co-culture experiments, NCR^-ILC3s frequencies were markedly higher when DCs were derived from CS-exposed mice than from air-exposed mice. This increase was substantially reversed by the addition of EM (P<0.05).</p><p><strong>Conclusions: </strong>Lung NCR^-ILC3s frequencies escalate consistently in smokers, COPD patients, and CS-exposed mice. In CS-exposed mice, EM can inhibit DC-mediated NCR^-ILC3s activation in the lungs, alleviate CS-related chronic lung inflammation, and ameliorate emphysema.</p>","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"18 8","pages":"861"},"PeriodicalIF":2.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience of biological implants in thoracic surgery for soft tissue and chest wall reconstruction in clean and contaminated environments.","authors":"Hannah Jesani, Veena Surendrakumar, Hasanali Walji, Mostafa Ahmed, Luis Hernandez-Arenas, Laura Socci, Antonio Martin-Ucar","doi":"10.21037/jtd-2026-0955","DOIUrl":"10.21037/jtd-2026-0955","url":null,"abstract":"<p><strong>Background: </strong>Biological mesh has become an integral tool in surgery for reconstructive procedures. Acellular dermal matrices derived from porcine or bovine collagen scaffolds provide a durable implant material for use in reconstruction of the chest wall, and soft tissues including the pericardium and diaphragm. We aimed to present our experience of biological meshes used for thoracic reconstructive procedures for a wide range of clinical indications by a single surgeon, comparing the effect of contaminated and clean surgical environments and implant materials.</p><p><strong>Methods: </strong>We retrospectively reviewed all patients who had undergone thoracic surgery reconstructive procedures under a single surgical team with biological mesh material over a 16-year period from March 2009 to April 2025. Data included indication for surgery, operative procedure, surgical site, biological implant material (cross-linked or non-cross-linked), postoperative infection, in-hospital mortality and reoperation rate. We directly compared the results between patients undergoing the procedure in infected/contaminated versus clean cases.</p><p><strong>Results: </strong>In total 152 consecutive procedures were performed utilising 212 patches. Median age was 65 years (range, 24-84 years) and majority treated were males 104/152 (68%). Indications for surgery included total pleurectomy for mesothelioma (38%), resection of extended thoracic malignancy (33%), surgery for trauma or related complications (19%), and benign conditions including adult congenital abnormalities (10%). Cross-linked biological mesh had a significantly reduced surgical site infection rate compared to non-cross-linked biological mesh (n=6; 7% <i>vs.</i> n=16; 23%, P=0.008). This remained significant following adjustment for key clinical confounding factors [adjusted odds ratio (OR) 0.289, 95% confidence interval (CI): 0.105-0.793, P=0.02]. Direct comparison of contaminated environments versus clean showed surgical site infections postoperatively were not significantly different (24% <i>vs.</i> 12% P=0.09). No biological patch necessitated explantation due to infection. In-hospital mortality and reoperation rates remained low at 4% and 9% respectively.</p><p><strong>Conclusions: </strong>Our study evaluates and supports the continued use of biological patches for thoracic reconstruction of soft tissues and chest wall. Biological patches have a role in a diverse range of surgical indications including extended resection of malignancy and traumatic injuries and can be feasibly used in high risk contaminated surgical fields.</p>","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"18 8","pages":"931"},"PeriodicalIF":2.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a peripheral lung cancer model in rabbits using thoracoscopic-guided bronchoscopic inoculation.","authors":"Taek Yong Ko, Jin Hyuk Choi, Sun-Ju Oh, Dahae Yang, Ju Young Na, Sooyong Lee, Jesang Yu","doi":"10.21037/jtd-2026-1080","DOIUrl":"10.21037/jtd-2026-1080","url":null,"abstract":"<p><strong>Background: </strong>In preclinical research, tumor models are most commonly established by direct inoculation of tumor cell suspensions into the target organ. In the lung, however, precise delivery to a designated site is technically difficult, and leakage of cells into adjacent tissues such as the pleural cavity may cause diffuse spread rather than localized tumor formation. A model that reproducibly forms a tumor at a predetermined peripheral location would provide a useful experimental platform for studies on surgical approaches or stereotactic body radiation therapy (SBRT). This study aimed to develop such a peripheral lung cancer model in rabbits.</p><p><strong>Methods: </strong>New Zealand White rabbits were anesthetized with intramuscular ketamine and xylazine, intubated, and maintained on sevoflurane. A flexible bronchoscope (3.7-mm outer diameter) was advanced to the orifice of the lateral segment of the right lower lobe, and a 1-mm Teflon catheter was passed through its working channel into the segmental bronchus under direct vision. Through a small intercostal incision, a thoracoscope was introduced, and the parenchymal site corresponding to the catheter tip was identified. Under thoracoscopic guidance, a VX2 tumor cell suspension, alone or mixed with lipiodol, was injected through the catheter. Tumor progression was monitored by serial chest radiography at 2 and 4 weeks. At week 5, the animals were euthanized, and the trachea and right lung were resected <i>en bloc</i> for histopathological analysis.</p><p><strong>Results: </strong>Tumor formation was observed in six rabbits. Among animals given the optimized protocol (larger rabbits injected with the VX2-lipiodol mixture), four of five developed pulmonary tumors and three showed tumors localized to the intended peripheral region, whereas tumors induced with VX2 alone grew invasively without peripheral localization. Histopathological examination confirmed malignancy at the target site.</p><p><strong>Conclusions: </strong>Thoracoscopy-guided bronchoscopic inoculation, particularly when combined with lipiodol, enabled localized establishment of peripheral lung tumors in rabbits. The model provides a basis for developing preclinical platforms to evaluate diagnostic modalities and localized therapies such as SBRT, although further refinement and validation are required.</p>","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"18 8","pages":"903"},"PeriodicalIF":2.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a radiomics-habitat model for preoperatively predicting poorly differentiated stage IA lung adenocarcinoma.","authors":"Gang Xiang, Zi Yang, Xiang Wang, Jie Gao, Bin Yang, Qin-Ling Jiang, Yu Ding, Wen-Man Li, Guang-Yan Si","doi":"10.21037/jtd-2026-1254","DOIUrl":"10.21037/jtd-2026-1254","url":null,"abstract":"<p><strong>Background: </strong>Stage IA poorly differentiated lung adenocarcinoma has stronger invasiveness and shorter survival time. Its treatment methods are related to the survival time, and preoperative prediction can assist clinical practice in formulating personalized treatment options. The aim of this study was to develop and validate a computed tomography (CT)-based radiomics-habitat fusion model for preoperative prediction of stage IA poorly differentiated lung adenocarcinoma.</p><p><strong>Methods: </strong>A retrospective dual-center cohort of 507 patients with surgically confirmed stage IA lung adenocarcinoma was enrolled. The 419 patients from The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University (Center 1) were randomly assigned to a training cohort (n=294) and an internal test cohort (n=125), whereas 88 independent patients from Second Affiliated Hospital of Naval Medical University (Center 2) formed the external validation cohort. Tumor pathological differentiation graded by the 2021 World Health Organization (WHO) classification of thoracic tumors was set as the reference standard. Voxel-wise k-means clustering divided intratumoral regions into three distinct habitats (H1-3). Four machine learning algorithms [logistic regression, random forest, ExtraTrees, eXtreme Gradient Boosting (XGBoost)] were separately used to construct whole-tumor radiomics models, habitat subregional models and the final combined model. Model discrimination was comprehensively evaluated via area under the curve (AUC), sensitivity and specificity, etc.; calibration and clinical utility were assessed by calibration curves and decision curve analysis (DCA). SHapley Additive exPlanations (SHAP) analysis was applied to interpret feature contributions of the combined model.</p><p><strong>Results: </strong>Poorly differentiated lesions accounted for 26.2% (133/507) of all participants. In the independent external validation cohort, the combined model demonstrated robust discriminatory performance with an AUC of 0.880 [95% confidence interval (CI): 0.794-0.966], significantly outperforming single models (P<0.05). At the optimized decision threshold, the combined model achieved a sensitivity of 0.84 and a specificity of 0.81. DCA confirmed that the combined model provided substantial net clinical benefit.</p><p><strong>Conclusions: </strong>The developed and externally validated CT-based radiomics-habitat combined model serves as a promising non-invasive tool for preoperatively identifying poorly differentiated stage IA lung adenocarcinoma. Nevertheless, our external validation cohort only included 88 patients from a single independent center, which limits the generalizability of the model; further multi-center validation is warranted prior to clinical use.</p>","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"18 8","pages":"854"},"PeriodicalIF":2.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formononetin ameliorates bleomycin-induced pulmonary fibrosis in mice via targeting USP5.","authors":"Yongping Wang, Xueze Liu, Hao Song, Cheng Yang","doi":"10.21037/jtd-2026-1522","DOIUrl":"10.21037/jtd-2026-1522","url":null,"abstract":"<p><strong>Background: </strong>Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease with limited therapeutic options. Transforming growth factor beta 1 (TGF-β1) is a major profibrotic mediator that promotes fibroblast activation and extracellular matrix (ECM) deposition. This study aimed to evaluate the therapeutic effects of formononetin on bleomycin-induced pulmonary fibrosis (PF) and investigate its underlying mechanism and potential molecular target.</p><p><strong>Methods: </strong>A TGF-β1-responsive luciferase reporter system was used to screen natural compounds that inhibit TGF-β signaling. The effects of formononetin on cell viability, fibroblast activation, and the expression of α-smooth muscle actin (α-SMA), collagen I (Col-1), and fibronectin (Fn) were examined in vitro. Its therapeutic effects were further evaluated in a bleomycin-induced PF model in male C57BL/6 mice. Lung function, histopathological changes, collagen deposition, and inflammatory cells and mediators in bronchoalveolar lavage fluid (BALF) were assessed. Molecular docking and small interfering RNA experiments were performed to investigate ubiquitin-specific peptidase 5 (USP5) as a potential target.</p><p><strong>Results: </strong>Formononetin inhibited TGF-β1-induced reporter activity and significantly reduced the messenger RNA and protein levels of α-SMA, Col-1, and Fn in fibroblasts. In bleomycin-treated mice, formononetin improved lung function, attenuated histopathological fibrosis and collagen deposition, and reduced pulmonary inflammation. Mechanistically, the findings indicated that formononetin inhibited USP5, increased p53 transcription and expression, and subsequently suppressed TGF-β1/Smad signaling and fibroblast activation.</p><p><strong>Conclusions: </strong>Formononetin attenuated bleomycin-induced PF in mice, potentially through the USP5/p53/TGF-β1/Smad signaling axis. These findings support further investigation of formononetin as a potential candidate for PF treatment.</p>","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"18 8","pages":"839"},"PeriodicalIF":2.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A frozen prelude and an open challenge.","authors":"Anna H Xue, Subhasis Chatterjee, Joseph S Coselli","doi":"10.21037/jtd-2026-0774","DOIUrl":"10.21037/jtd-2026-0774","url":null,"abstract":"","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"18 8","pages":"987"},"PeriodicalIF":2.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncovering sodium overload-associated gene signatures in chronic obstructive pulmonary disease through integrated bioinformatics and machine learning.","authors":"Zhongzhou Zou, Jietao Chen, Zutong Mai, Ningcheng Wu, Yuxuan Wang, Ruihong Xu, Zhonghui Jiang, Guoyong Chen, Lei Xian","doi":"10.21037/jtd-2026-0843","DOIUrl":"10.21037/jtd-2026-0843","url":null,"abstract":"<p><strong>Background: </strong>Airway epithelial cells depend on tightly regulated ion transport, and disturbed sodium handling has been linked to mucus dehydration, oxidative stress and epithelial injury in obstructive lung disease. How sodium/ion-homeostasis-related transcription is organised in chronic obstructive pulmonary disease (COPD), and whether it converges with the disease's broader expression architecture, has not been systematically examined. This study aimed to identify sodium-overload-associated genes in COPD and evaluate a compact epithelial gene panel across multiple validation platforms.</p><p><strong>Methods: </strong>Two bulk lung-transcriptomic cohorts were integrated and analysed with differential expression, weighted gene co-expression network analysis (WGCNA) and a locked sodium-overload-related gene (SORG) set defined a priori from GeneCards. Candidate genes were characterised by functional enrichment and protein-protein interaction analysis, benchmarked across twelve machine-learning algorithms, and then examined in an independent external cohort, a mucus-score sensitivity analysis, single-cell RNA sequencing and quantitative polymerase chain reaction (qPCR; 13 COPD and 12 non-COPD controls).</p><p><strong>Results: </strong>Seven genes lay at the intersection of differential expression, the COPD-associated co-expression module and the sodium-overload set, enriched for xenobiotic-metabolism and oxidative-stress pathways. A reduced three-gene panel (<i>ALDH3A1</i>, <i>MUC5AC</i> and <i>PHEX</i>) gave moderate but reproducible discrimination [area under the curve (AUC) 0.686], with acceptable calibration and positive net benefit over the threshold range examined, and reached an AUC of 0.809 in the external cohort. The three genes co-varied with multiple immune-cell fractions without implying direction. Single-cell analysis and qPCR localised the changes mainly to airway epithelial cells: <i>ALDH3A1</i> and <i>MUC5AC</i> were consistently higher in COPD across datasets, whereas <i>PHEX</i> showed directional heterogeneity across platforms.</p><p><strong>Conclusions: </strong>Sodium/ion-homeostasis-related transcription is associated with a stressed airway-epithelial state in COPD. The three-gene panel is best read as a compact, biologically interpretable framework-annotation-guided rather than evidence of causal sodium overload, and not a stand-alone diagnostic-that warrants validation in larger, prospectively matched cohorts.</p>","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"18 8","pages":"858"},"PeriodicalIF":2.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-facilitated catheter-directed thrombolysis in acute pulmonary embolism: interpreting survival benefit under low event rates and bleeding trade-offs.","authors":"Yusen Wu, Zhi Yuan","doi":"10.21037/jtd-2026-1547","DOIUrl":"10.21037/jtd-2026-1547","url":null,"abstract":"","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"18 8","pages":"1001"},"PeriodicalIF":2.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A drainage-analgesia integrated chest tube for pain control after thoracoscopic lung resection.","authors":"Junichi Murakami","doi":"10.21037/jtd-2026-2257","DOIUrl":"10.21037/jtd-2026-2257","url":null,"abstract":"","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"18 8","pages":"822"},"PeriodicalIF":2.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}