Journal of thoracic disease最新文献

{"title":"Perioperative dynamic changes of systemic inflammatory response, gut injury, and hypoxemia in patients with acute type-A aortic dissection: an observational case-control study.","authors":"Jianrong Li, Xiaolong Wang, Kai Zhu, Xiufeng Jin, Hongjia Zhang","doi":"10.21037/jtd-2025-141","DOIUrl":"10.21037/jtd-2025-141","url":null,"abstract":"<p><strong>Background: </strong>The details regarding the pathogenesis of hypoxemia in the presence of acute type-A aortic dissection (ATAAD) remains to be fully elucidated. In this study, we investigated the dynamic changes in systemic inflammatory response, gut injury, hypoxemia, and succinate levels in patients with ATAAD and their impact on perioperative hypoxemia.</p><p><strong>Methods: </strong>We conducted a single-center, observational, case-control study that enrolled 18 patients with ATAAD who underwent emergency total arch repair (TAR) combined with frozen elephant trunk (FET) procedure under hypothermic lower-body circulatory arrest and antegrade cerebral perfusion. White blood cell (WBC) count, interleukin (IL)6, IL8, tumor necrosis factor α (TNFα), diamine oxidase (DAO), intestinal fatty-acid-binding protein (iFABP), peptidoglycan (PGN), and succinate were assessed preoperatively and 12, 24, and 48 hours after operation. The PaO₂/FiO₂ ratios were evaluated preoperatively and 4, 8, and 12 hours after operation. These variables were compared between different time points. Correlation analyses and multivariate linear regression were performed to evaluate the variables' impact on 12-hour postoperative hypoxemia.</p><p><strong>Results: </strong>Compared to controls, patients with ATAAD had a significantly higher preoperative WBC count [(12.18±4.50)×10⁹/L <i>vs</i>. (3.73±1.05)×10⁹/L; P<0.001], IL6 (129.31±12.86 <i>vs</i>. 114.22±14.11 pg/mL; P=0.002), IL8 (147.57±16.03 <i>vs</i>. 127.56±20.23 pg/mL; P=0.002), TNFα (59.29±6.90 <i>vs</i>. 40.51±7.53 pg/mL; P<0.001), DAO activity (17.94±1.54 <i>vs</i>. 13.32±1.82 U/L; P<0.001), and succinate (235.92±48.09 <i>vs</i>. 106.95±27.63 µM; P<0.001) but a lower PaO₂/FiO₂. In patients with ATAAD, postoperative levels of IL6, IL8, TNFα, DAO, iFABP, and PGN were significantly elevated compared to preoperative levels, while the PaO₂/FiO₂ ratio decreased significantly from the preoperative levels. Succinate levels peaked prior to the operation and remained elevated at both the 12- and 24-hour postoperative time points. PGN, iFABP, succinate, and lowest rectal temperature during cardiopulmonary bypass were the risk factors for hypoxemia at 12 hours' postoperation.</p><p><strong>Conclusions: </strong>Systemic inflammatory response, gut injury, and hypoxemia had already occurred preoperatively in patients with ATAAD and exacerbated postoperatively following TAR combined with FET procedure under hypothermic lower-body circulatory arrest and antegrade cerebral perfusion. Succinate may play a pivotal role in the development of hypoxemia in patients with ATAAD.</p>","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"17 2","pages":"1054-1063"},"PeriodicalIF":2.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11898389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New classification and precise prevention strategies for donor lung injury in lung transplantation.","authors":"Jianxing He, Xin Xu, Chao Yang, Guilin Peng, Jiang Shi, Chunrong Ju, Hui Liu, Lan Lan, Xiaoyou Liu, Ling Sang, Xuesong Liu, Lulin Wang, Hengrui Liang, Danxia Huang, Nanshan Zhong","doi":"10.21037/jtd-24-1320","DOIUrl":"10.21037/jtd-24-1320","url":null,"abstract":"","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"17 2","pages":"1118-1121"},"PeriodicalIF":2.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11898357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive analysis of imaging and pathological features in 20 cases of pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma: a retrospective study.","authors":"Ruifen Zhao, Yan Dong, Jiejun Kong","doi":"10.21037/jtd-24-1066","DOIUrl":"10.21037/jtd-24-1066","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma is a rare, indolent subtype of non-Hodgkin lymphoma with distinct radiological and pathological characteristics. Clinically, patients may present with nonspecific symptoms such as cough or dyspnea, and the disease can mimic other pulmonary conditions. High-resolution computed tomography (HRCT) imaging plays a critical role in identifying characteristic lung patterns, such as nodules, consolidation, or ground-glass opacities, which help in differentiating pulmonary MALT lymphoma from other pulmonary disorders. The study aimed to identify clinical characteristics based on the HRCT imaging features and pathological findings in patients with pulmonary MALT lymphoma.</p><p><strong>Methods: </strong>The retrospective study involved 20 confirmed cases of pulmonary MALT lymphoma from a thoracic specialty hospital. Comprehensive data analysis included HRCT imaging characteristics such as tumor size, location, bronchial changes and peritumoral pulmonary interstitial infiltration, as well as pathological features, including cell type, morphology, and immunohistochemistry.</p><p><strong>Results: </strong>HRCT imaging showed a high prevalence of air bronchogram (100%) and bronchiectasis (85%), with tumors predominantly located in the left upper lobe. Pathologically, tumors predominantly exhibited monocytoid and centrocyte-like cells, minimal atypia, and B-cell markers like CD20 and CD3 expression. Surgical resection was the primary treatment modality in 60% of cases, with the rest receiving chemical treatment.</p><p><strong>Conclusions: </strong>Significant features evident in both HRCT imaging and pathological analysis were identified in pulmonary MALT lymphoma cases. These findings are anticipated to play a crucial role in facilitating early diagnosis and determining optimal treatment strategies.</p>","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"17 2","pages":"969-978"},"PeriodicalIF":2.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11898346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partial pressure of oxygen control versus modified inflation-deflation method in identifying intersegmental plane during anatomical sublobectomy: a prospective, randomized, controlled trial.","authors":"Mingliang Xing, Liping Tong, Hongtao Duan, Dennis Aliev, Xiaoping Dong, Yong Zhang, Huifeng Liu, Xiaolong Yan","doi":"10.21037/jtd-2025-45","DOIUrl":"10.21037/jtd-2025-45","url":null,"abstract":"<p><strong>Background: </strong>With increasing early-stage non-small cell lung cancer (NSCLC) diagnoses, sublobar resections including segmentectomy and wedge resection have become commonly used in clinical settings. The success of lung segment surgery hinges on the accurate identification of intersegmental planes (ISPs), which is typically achieved by the modified inflation-deflation method; however, this technique is associated with a prolonged duration for identifying ISP. The \"partial pressure of oxygen control method\" represents an optimization of the inflation-deflation technique, designed to facilitate rapid identification of ISP during surgical procedures. The present study was designed to assess the safety and effectiveness of the partial pressure of oxygen (PaO₂) control method for ISP identification in thoracoscopic anatomical sublobectomy, in comparison to the modified inflation-deflation method.</p><p><strong>Methods: </strong>A total of 60 patients scheduled for thoracoscopic anatomical sublobectomy were randomly allocated into two groups: the intervention group (using the PaO₂ control method; n=30) and the control group (using the modified inflation-deflation method; n=30). The time to ISP appearance (T_ISP) was compared between these two groups. Arterial blood gas (ABG) levels were recorded at the following time points: prior to entry to operating room, during one-lung ventilation (OLV), upon completion of lung inflation, 3 minutes post-lung inflation, and 6 minutes post-lung inflation. Statistical analyses were conducted to evaluate the differences in operative time, intraoperative blood loss, incidence of postoperative complications, and average postoperative hospital stay.</p><p><strong>Results: </strong>The T_ISP was significantly shorter in the intervention group than in the control group (307.0±108.3 <i>vs.</i> 496.7±154.0 seconds; P<0.001). Furthermore, the PaO₂ in the intervention group was significantly lower compared to the control group at 3 minutes following 100% oxygen administration (156.6±76.5 <i>vs.</i> 114.1±47.5 mmHg; P=0.01).</p><p><strong>Conclusions: </strong>The PaO₂ control method facilitates more rapid acquisition of ISP compared to the modified inflation-deflation method, and it is deemed a safe and effective technique in thoracoscopic anatomical sublobectomy.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov NCT06644066.</p>","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"17 2","pages":"1042-1053"},"PeriodicalIF":2.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11898333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging trends and hotspots in animal experimental research on lung transplantation from 2004 to 2023: a bibliometric analysis.","authors":"Chen Xie, Mingyi Piao, Liwang Zhou, Xinchen Tao, Yuanyuan Yao, Baochun Jiang, Xinqiang Wang, Min Yan","doi":"10.21037/jtd-24-1451","DOIUrl":"10.21037/jtd-24-1451","url":null,"abstract":"<p><strong>Background: </strong>Lung transplantation is the only viable option for end-stage respiratory diseases, with the global prevalence of this procedure on the rise in recent years. However, it is still plagued by various complications, for which no satisfactory therapy has yet been identified. Understanding the mechanisms underlying these post-transplant complications may be beneficial to enhance patient outcomes. This study utilized bibliometric analysis to assess present publication trends and focal points in the field of animal experimental studies on lung transplantation, aiming to provide insights into potential areas for future research.</p><p><strong>Methods: </strong>Utilizing CiteSpace software, the Online Analysis Platform of Literature Metrology, R package bibliometrix and VOSviewer, an analysis of current publication trends and hotspots in the area of animal experimental research for lung transplantation was carried out for the period spanning from 2004 to 2023. The English articles were searched in the Science Citation Index-Expanded (SCI-E) of Web of Science Core Collection (WoSCC).</p><p><strong>Results: </strong>A total of 995 articles on animal experimental research on lung transplantation over the past two decades were retrieved. Rats, mice and swine were the most commonly used animal models, with orthotopic lung transplantation, ischemia-reperfusion (IR), and ex vivo lung perfusion (EVLP) being the most frequently employed model of lung transplantation in animals. The leading contributed countries in this area were USA, Canada, Japan and China. Washington University and Shaf Keshavjee were acknowledged as the most influential institute and scholar, respectively. The top 10 main clusters identified through co-occurrence cluster analysis included, <i>ex-vivo</i> lung perfusion, EVLP, obliterative bronchiolitis, necroptosis, bronchiolitis obliterans, non-heart-beating donor, donation after circulatory death, xenotransplantation, hydrogen sulfide and alveolar macrophage. Current research focused on lung IR injury, lung transplant, hypoxia, and differentiation, as revealed by keyword burst detection.</p><p><strong>Conclusions: </strong>Over the past 20 years, global publications on animal experimental research for lung transplantation have grown rapidly. The current research hotspots focus on lung IR injury, hypoxia and differentiation during lung transplantation. Exploring the potential synergistic effects of EVLP and necroptosis inhibition in more depth could offer valuable information for improving lung transplant outcomes. Our analysis presents a detailed overview of the current state of animal experimental research in lung transplantation, evaluating current publication trends and focal points and providing significant insights for future research efforts.</p>","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"17 2","pages":"796-815"},"PeriodicalIF":2.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11898359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommended optimal range for the count of examined lymph nodes and lymph node ratio for postoperative adjuvant radiotherapy in patients with pN2 non-small cell lung cancer: a multicenter retrospective cohort investigation.","authors":"Qiming Huang, Xiang Weng, Yiliang Hu, Zhenjie Li, Longren Wu, Zijian Hu, Dongliang Yu, Linmin Xiong","doi":"10.21037/jtd-24-1573","DOIUrl":"10.21037/jtd-24-1573","url":null,"abstract":"<p><strong>Background: </strong>Recent evidence suggests that postoperative adjuvant radiotherapy (PORT) may enhance survival outcomes in patients with pN2 non-small cell lung cancer (NSCLC), particularly when evaluating through examined lymph nodes (ELNs) and lymph node ratio (LNR). This study aims to explore the impact of ELNs and LNR on the efficacy of postoperative radiotherapy in pN2 stage NSCLC patients through a multicenter retrospective cohort analysis, providing valuable insights for clinical treatment decisions.</p><p><strong>Methods: </strong>Data were meticulously extracted from the Surveillance, Epidemiology, and End Results (SEER) 17 registry spanning 2015 to 2019. The study specifically targeted pN2 stage NSCLC patients who underwent surgical intervention and lymph node biopsy, involving an analysis of 1,875 patients while excluding those with incomplete data. The impact of PORT on overall survival (OS) was assessed, stratified by ELNs and LNR. Statistical analyses employed X-tile software to categorize LNR into three distinct groups, and Cox proportional hazard models were utilized to evaluate the influence of various factors on OS.</p><p><strong>Results: </strong>The Cox proportional hazards model revealed a significant survival advantage associated with PORT, demonstrating a 22% higher mortality rate in the non-PORT group [hazard ratio (HR) =1.22, 95% confidence interval (CI): 1.02-1.46, P=0.03] and up to 31% higher in the fully adjusted model (HR =1.31, 95% CI: 1.09-1.58, P=0.004). PORT notably improved survival in patients with ELNs <10, particularly when LNR ≤0.2 (HR =4.15, P=0.03) and LNR ≥0.53 (HR =1.83, P=0.01). Kaplan-Meier survival curves corroborated these findings.</p><p><strong>Conclusions: </strong>Our findings indicate that the number of ELNs and the LNR could serve as valuable criteria for selecting pN2 NSCLC patients who may benefit from PORT. PORT has been linked to improved survival outcomes in pN2 stage NSCLC, with a particular emphasis on its efficacy in patients with ELNs <10 and an LNR of ≤0.2.</p>","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"17 2","pages":"784-795"},"PeriodicalIF":2.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11898341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continued implications of the COVID-19 pandemic environment on non-small cell lung cancer characteristics and treatment in the United States.","authors":"Christina M Stuart, Nicole M Mott, Michael R Bronsert, Adam R Dyas, Salvador Rodriguez Franco, Ana L Gleisner, Simran K Randhawa, Elizabeth A David, John D Mitchell, Robert A Meguid","doi":"10.21037/jtd-24-1334","DOIUrl":"10.21037/jtd-24-1334","url":null,"abstract":"<p><strong>Background: </strong>Given the continued disruption of the coronavirus disease 2019 (COVID-19) pandemic throughout 2021, we aimed to assess for continued implications of the altered healthcare landscape on non-small cell lung cancer (NSCLC) presentation and treatment in the second year of the pandemic.</p><p><strong>Methods: </strong>This was a retrospective cohort study using the United States National Cancer Database (2019-2021). Demographic, cancer-related, and treatment variables were compared between patients diagnosed in the pre-pandemic year [2019], pandemic-year-one [2020], and pandemic-year-two [2021]. Multivariate logistic regression was performed to control for the impact of demographics on oncologic variables, and then for the impact of oncologic variables on treatment modalities and outcomes.</p><p><strong>Results: </strong>Of 376,193 NSCLC cases, 135,649 (36.1%) were pre-pandemic, 119,338 (31.7%) were pandemic-year-one, and 121,206 (32.2%) were pandemic-year-two. Compared to the pre-pandemic year, patients diagnosed in pandemic-year-two had risk-adjusted increases in clinical T stage [odds ratio (OR) =1.017; 95% confidence-interval (CI): 1.003-1.031], N stage (OR =1.048; 95% CI: 1.033-1.063), M stage (OR =1.044; 95% CI: 1.028-1.060), and overall stage (OR =1.038; 95% CI: 1.023-1.052). Additionally, compared to the pre-pandemic year, patients diagnosed in pandemic-year-two continue to see risk-adjusted increases in time from diagnosis to staging (OR =1.044; 95% CI: 1.017-1.072), to first treatment (OR =1.143; 95% CI: 1.133-1.154), to surgery (OR =1.117; 95% CI: 1.093-1.141) and to systemic therapy (OR =1.021; 95% CI: 1.924-1.039).</p><p><strong>Conclusions: </strong>Compared to the pre-pandemic year, patients diagnosed with NSCLC in the United States during pandemic-year-two continue to present at later clinical stage and experience delays to treatment. The oncologic and treatment characteristics of NSCLC have not returned to pre-pandemic baseline in the United States, possibly due to compounding delays to diagnosis and treatment and a growing back log of cases.</p>","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"17 1","pages":"150-160"},"PeriodicalIF":2.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil-to-lymphocyte ratio and its correlation with tuberculosis infection: a cross-sectional survey based on the NHANES database.","authors":"Yunfeng Sheng, Haibo Hua, Yanfei Cui, Yaping Sun","doi":"10.21037/jtd-24-750","DOIUrl":"10.21037/jtd-24-750","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis infection (TBI) is a major challenge to global public health. Early detection and treatment of TBI are crucial in preventing tuberculosis (TB). Although inflammation is closely linked to the pathogenesis of TBI, the neutrophil-to-lymphocyte ratio (NLR), as a new inflammatory marker, has been less studied with TBI risk. This study was based on the National Health and Nutrition Examination Survey (NHANES) database. We utilized a cross-sectional research method to explore the association between NLR and the risk of adult TBI, aiming to fill the blank in the studying relationship between NLR and TBI risk. Our findings may contribute to providing new biomarkers for the diagnosis and treatment of TBI.</p><p><strong>Methods: </strong>In this cross-sectional research, data from the NHANES database for the periods 1999-2000 and 2011-2012 were pooled for the study, with TBI as the dependent variable and NLR as the independent variable. A total of 2,433 participants were enrolled, including 391 TBI patients and 2,042 non-TBI patients. The inclusion criteria included information from complete blood testing and TBI status assessment. We evaluated demographic characteristics and clinical factors such as body mass index (BMI), smoking, drinking, NLR, and TBI risk. We employed weighted logistic regression to set up a relationship model between NLR and TBI and dissected the association between them through stratified analysis and subgroup analysis with confounding factors adjusted. We also utilized restricted cubic spline (RCS) and Kaplan-Meier (K-M) survival curves to investigate the nonlinear relationship between NLR and TBI, as well as their relationship with survival rates.</p><p><strong>Results: </strong>A total of 2,433 samples were included in this project, with 391 TBI patients and 2,042 non-TBI patients. In the multivariable weighted logistic regression model, an obvious negative association was observed between NLR and TBI risk [odds ratio (OR) <1, P<0.05], and it was substantially influenced by diabetes (P for interaction =0.049). The negative association between NLR and TBI risk was particularly remarkable (P<0.05) in male and hypertensive patients. The RCS curve indicated a potential linear relationship between NLR and TBI risk (P-non-linear =0.9561), with NLR >1.899, OR <1, being a protective factor. The K-M survival curve revealed an obvious linkage between high NLR (>2.328) and increased death risk in TBI patients.</p><p><strong>Conclusions: </strong>NLR is remarkably negatively linked with TBI risk. Patients with excessively high NLR have worse outcomes.</p>","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"17 1","pages":"70-81"},"PeriodicalIF":2.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology dynamic of common respiratory virus in spring, 2018-2023 in Guangdong Province, China.","authors":"Yangqianxi Wang, Yong Liu, Jingyi Liang, Jiaxi Sun, Minyi Zhang, Zichen Chang, Yinqiu Guo, Wenting Zeng, Tie Liu, Zhiqi Zeng, Chitin Hon, Zifeng Yang","doi":"10.21037/jtd-23-1638","DOIUrl":"10.21037/jtd-23-1638","url":null,"abstract":"","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"17 1","pages":"518-521"},"PeriodicalIF":2.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preserved ratio impaired spirometry: clinical, imaging and artificial intelligence perspective.","authors":"Qianxi Jin, Ziwei Zhang, Taohu Zhou, Xiuxiu Zhou, Xin'ang Jiang, Yi Xia, Yu Guan, Shiyuan Liu, Li Fan","doi":"10.21037/jtd-24-1582","DOIUrl":"10.21037/jtd-24-1582","url":null,"abstract":"<p><p>Preserved ratio impaired spirometry (PRISm) is a pulmonary function pattern characterized by a forced expiratory volume in one second (FEV1) to forced vital capacity ratio greater than 0.70, with an FEV1 that is below 80% of the predicted value, even after the use of bronchodilators. PRISm is considered a form of \"Pre-Chronic Obstructive Pulmonary Disease (Pre-COPD)\" within the broader scope of COPD. Clinically, it presents with respiratory symptoms and is more commonly observed in individuals with high body mass index, females, and those who are current smokers. Additionally, it is frequently associated with metabolic disorders and cardiovascular diseases. Regarding prognosis, PRISm shows considerable variation, ranging from improvement in lung function to the development of COPD. In this article, we review the epidemiology, comorbidities, and clinical outcomes of PRISm, with a particular emphasis on the crucial role of imaging assessments, especially computed tomography scans and magnetic resonance imaging (MRI) technology, in diagnosing, evaluating, and predicting the prognosis of PRISm. Comprehensive imaging provides a quantitative evaluation of lung volume, density, airways, and vasculature, while MRI technology can directly quantify ventilation function and pulmonary blood flow. We also emphasize the future potential of X-ray technology in this field. Moreover, the article discusses the application of artificial intelligence, including its role in predicting PRISm subtypes and modeling ventilation function.</p>","PeriodicalId":17542,"journal":{"name":"Journal of thoracic disease","volume":"17 1","pages":"450-460"},"PeriodicalIF":2.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}