Journal of Tropical Pharmacy and Chemistry最新文献_第2页

Molecular Docking and Molecular Dynamics Simulation using Monascus sp. as a Candidate Cervical Cancer Drug 红曲霉作为宫颈癌候选药物的分子对接与分子动力学模拟

Journal of Tropical Pharmacy and Chemistry Pub Date : 2023-06-29 DOI: 10.25026/jtpc.v7i1.432

Anna Yuliana, Ira Rahmiyani, Cindi Kartika

{"title":"Molecular Docking and Molecular Dynamics Simulation using Monascus sp. as a Candidate Cervical Cancer Drug","authors":"Anna Yuliana, Ira Rahmiyani, Cindi Kartika","doi":"10.25026/jtpc.v7i1.432","DOIUrl":"https://doi.org/10.25026/jtpc.v7i1.432","url":null,"abstract":"Cervical cancer is the fourth most common female cancer worldwide and results in over 300000 deaths globally. Given that HPV prophylactic vaccines do not exert a therapeutic effect in individuals previously infected, it is unlikely that HPV-associated cancers will be eradicated in the coming years. Therefore, there is an emerging need for the development of anti-HPV drugs. The purpose of this study is to find out Monascus sp. as cervical anticancer using molecular docking and dynamics methods. The results of docked with AutodockTools were visualized with Pymol, analyzed the effectiveness using the Ramachandran plot. The docking results show that there are 2 pigments that have lower G than raloxifen in estrogen receptor beta with the lowest G indicated by the pigment Monascin and Ankaflavin, which is -6.94 kcal/mol with Ki value of 39.49 nM and -6.22 kcal/mol with Ki value of 27.78 nM. The results of molecular dynamics, Ankaflavin and Monascin have good stability at estrogen receptor beta because the outlier area has a value 11.722% and 10.256%. And the amino acid residues in the most preferred area were 68.864% and 70.330%. In addition, Monascopyridine B and Monascuspiloin pigments showed good and stable results at the EGFR receptor because the outlier areas were 14.692% and 10.623%. And the amino acid residues in the most-favored region were 65.403% and 73.260%. Based on the results of this study, we predict that Ankaflavin, Monascin, Monascopyridine B and Monascuspiloin can be used as new cervical anticancer candidates after validated with in vitro and in vivo tests.","PeriodicalId":17494,"journal":{"name":"Journal of Tropical Pharmacy and Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135155568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Docking Study of Nigella sativa Alkaloid Compounds as the Inhibitor of Papain-Like Protease SARS-CoV-2 黑草生物碱复合物作为木瓜蛋白酶样蛋白酶SARS-CoV-2抑制剂的分子对接研究

Journal of Tropical Pharmacy and Chemistry Pub Date : 2023-06-29 DOI: 10.25026/jtpc.v7i1.420

Gusnia Meilin Gholam, Iman Akhyar Firdausy

{"title":"Molecular Docking Study of Nigella sativa Alkaloid Compounds as the Inhibitor of Papain-Like Protease SARS-CoV-2","authors":"Gusnia Meilin Gholam, Iman Akhyar Firdausy","doi":"10.25026/jtpc.v7i1.420","DOIUrl":"https://doi.org/10.25026/jtpc.v7i1.420","url":null,"abstract":"SARS-CoV-2 causes about 66% of China’s Wuhan market workers to experience fever, dry cough, and fatigue. Black cumin (Nigella sativa) is a plant with many benefits to cure many illnesses like hypertension, headache, infection, and inflammation. This study aimed to investigate the inhibition by compounds belonging to the Alkaloid group from Black Cumin Seed to inhibit PLpro activity as a target for SARS-CoV-2. The study used five alkaloid compounds ((2E,4E)-Decadienal, (2E,4Z)-Decadienal, Nigellicine, Nigellidine, and Nigellimine) from the Black cumin seed and a PLpro SARS-CoV-2 receptor (PDB ID: 6WX4). The methods used are ligand and receptor preparation, grid box validation, molecular docking, 2D and 3D visualisation, and data analysis using Gibbs free energy, type of interaction, and contact of amino acid residues data. This study used YASARA structure and BIOVIA Discovery Studio. The results showed that Nigellidine has the highest Gibbs free energy with a -2.67 kcal/mol score, higher than VIR251. PLpro has a catalytic triad at Cys111, His272, and Asp286 residues, the compound that binds to the active site is Nigellicine found at amino acid Cys111 with Pi-Sulfur.","PeriodicalId":17494,"journal":{"name":"Journal of Tropical Pharmacy and Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135155569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preliminary Phytochemical Screening and Quantitative Analysis of Methanol Leaf Extract of Erlangea tomentosa (Oliv. & Hiern) S.Moore (Asteraceae) 毛毛叶儿甲醇叶提取物的初步筛选及定量分析。&希恩·s·摩尔(菊科)

Journal of Tropical Pharmacy and Chemistry Pub Date : 2023-03-06 DOI: 10.25026/jtpc.v7i1.528

Anselme Mboneye, A. N. Onchweri,, Timothy Neeza, S. Odoma

引用次数: 0

Genipin as a Cross-linker in a Ciprofloxacin Delivery System Containing a Bovine Hydroxyapatite-Collagen Composite for Bone Infections Genipin作为交联剂在含有牛羟基磷灰石-胶原复合物的环丙沙星递送系统中用于骨感染

Journal of Tropical Pharmacy and Chemistry Pub Date : 2023-01-25 DOI: 10.25026/jtpc.v7i1.465

N. Fitriani, A. S. Budiatin, E. Hendradi

{"title":"Genipin as a Cross-linker in a Ciprofloxacin Delivery System Containing a Bovine Hydroxyapatite-Collagen Composite for Bone Infections","authors":"N. Fitriani, A. S. Budiatin, E. Hendradi","doi":"10.25026/jtpc.v7i1.465","DOIUrl":"https://doi.org/10.25026/jtpc.v7i1.465","url":null,"abstract":"The purpose of this research was to design an implant for a ciprofloxacin-based drug delivery system by combining bovine hydroxyapatite and collagen with genipin as the crosslinking agent. The production of ciprofloxacin implants using bovine hydroxyapatite:collagen blend (70:30). In addition, this synthetic preparation was made using three various concentrations of genipin (0.6, 0.8, and 1.0%). The pellets were created by compressing the implants. The tablets are cylindrical with a diameter of 4.0 mm and a weight of 100.0 mg. Ciprofloxacin cultures were characterized for swelling rate, porosity, density, compressive strength, morphology (SEM), dose, and drug release in vitro. The addition of genipin as a crosslinking agent may maintain ciprofloxacin release consistent with in vitro therapeutic levels of ciprofloxacin. These results are supported by compressive strength data, where the addition of genipin concentrations induces higher implant stiffness and scanning electron microscopy photomicrographs reveal small pore sizes and BHA adhere to collagen fibers so that ciprofloxacin is completely dispersed in the implant after cross-linking with genipin. As a drug delivery system for osteomyelitis, it can be concluded that the use of genipin as a cross-linking agent can sustain ciprofloxacin release commensurate with in vitro therapeutic levels of ciprofloxacin for 30 days.","PeriodicalId":17494,"journal":{"name":"Journal of Tropical Pharmacy and Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42366946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic Effect of Pericarp of Mangosteen and Propolis from Stingless Bee Extracts on Nitric Oxide Scavenging Activity 山竹果皮与无刺蜂提取物蜂胶对一氧化氮清除活性的协同作用

Journal of Tropical Pharmacy and Chemistry Pub Date : 2023-01-17 DOI: 10.25026/jtpc.v7i1.458

Imron Meechai, Rokeeyah Suha, Nurihan Daleng, I. Chelong, Acharee Suksuwan

引用次数: 0

Effect of Combination of Dark Chocolate and Herbal Ingredients for Dysmenorrhea in Late Adolescents 黑巧克力加草药治疗青少年晚期痛经的疗效观察

Journal of Tropical Pharmacy and Chemistry Pub Date : 2023-01-17 DOI: 10.25026/jtpc.v7i1.503

Rika Nurlaili Putri Azizah, Putri Anggreini, Fajar Prasetya

{"title":"Effect of Combination of Dark Chocolate and Herbal Ingredients for Dysmenorrhea in Late Adolescents","authors":"Rika Nurlaili Putri Azizah, Putri Anggreini, Fajar Prasetya","doi":"10.25026/jtpc.v7i1.503","DOIUrl":"https://doi.org/10.25026/jtpc.v7i1.503","url":null,"abstract":"About 55% of women experience dysmenorrhea. One of the foods that can reduce menstrual pain is dark chocolate. Other herbal ingredients such as turmeric, red ginger, moringa, sambiloto, and honey are also known to reduce pain. However, research on combination of dark chocolate with herbal ingredients has not been conducted. Therefore, this study aims to determine the effectiveness of dark chocolate with herbs in reducing menstrual pain. This test was conducted on 30 respondents who were divided into three groups, namely the positive control group (K), dark chocolate (C), and a combination of dark chocolate with herbs (C+H). Dark chocolate was combined with herbal ingredients consisting of turmeric, red ginger, moringa, sambiloto extract, and honey as a beverage 250 mL. The study is quantitative research with quasi-experimental method. Pain measurement using the Numeric Rating Scale (NRS) sheet was given before and 2 hours after treatment. The data was analyzed using paired t-test. State the results of the values obtained the combination of dark chocolate and herbs showed a significant reduction in pain before and after treatment (p<0.05). Based on these results, it was concluded that the combination of dark chocolate with herbs could be one of the therapies for dysmenorrhea.","PeriodicalId":17494,"journal":{"name":"Journal of Tropical Pharmacy and Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68939822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and Stability Tests of Hair Tonic from Oil Palm (Elaeis guineensis Jacq.) Leaves Extract and Effectiveness in Protecting Hair 油棕护发液的配方及稳定性试验叶子提取物和有效保护头发

Journal of Tropical Pharmacy and Chemistry Pub Date : 2022-12-31 DOI: 10.25026/jtpc.v6i2.524

Angga Cipta Narsa

{"title":"Formulation and Stability Tests of Hair Tonic from Oil Palm (Elaeis guineensis Jacq.) Leaves Extract and Effectiveness in Protecting Hair","authors":"Angga Cipta Narsa","doi":"10.25026/jtpc.v6i2.524","DOIUrl":"https://doi.org/10.25026/jtpc.v6i2.524","url":null,"abstract":"Hair loss is a condition that unavoidable process, where the hair is detached more than 100 strands per day that occurs continuously. Oil palm leaf with their compounds can be used to treat hair loss and damage. The purpose of this study was to formulate oil palm leaf extract into hair tonic preparations and evaluate the effectiveness in preventing hair damage. Hair tonic formula from oil palm leaf extract contains 96% ethanol, menthol, propylene glycol, phenoxyethanol, and aquades. The evaluation of hair tonic preparations included organoleptic, homogeneity, pH, and viscosity tests, as well as tests of antioxidant activity and effectiveness of hair tonic preparations. The results of the antioxidant activity test of oil palm leaf extract hair tonic showed the IC50 value at room temperature (25°C) indicating an average value of 37.2519±8.535 ppm, warm temperature (50°C) 40.5459±9.086 ppm, and cold temperature (4°C) 36.8257±6.928 ppm, which belongs to the category of very strong antioxidant activity, with the results of the evaluation of the oil palm leaf hair tonic slightly colored. greenish to dark green, has a distinctive menthol aroma, has a pH and viscosity that meets the requirements of a good hair tonic preparation, with pH between 3-7 and viscosity less than 5 cPs. Hair tonic preparations of oil palm leaf extract can prevent hair decolorization due to sun exposure at concentrations of 25 ppm to 200 ppm.","PeriodicalId":17494,"journal":{"name":"Journal of Tropical Pharmacy and Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43750113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antithrombotic and Antioxidant Activities of Binahong [Anredera cordifolia (Ten.) Steenis] Leaf Ethanol Extract and Its Nanoemulsion Preparation in Swiss Webster Mice Binahong[Anredera cordifolia（Ten.）Steenis]叶乙醇提取物及其纳米乳液制剂对瑞士韦氏小鼠的抗血栓和抗氧化活性

Journal of Tropical Pharmacy and Chemistry Pub Date : 2022-12-18 DOI: 10.25026/jtpc.v6i2.516

M. Iwo, Amirah Adlia, Silviyanita Isna Septila, Yennie Agnes Pratama, D. Purkon

{"title":"Antithrombotic and Antioxidant Activities of Binahong [Anredera cordifolia (Ten.) Steenis] Leaf Ethanol Extract and Its Nanoemulsion Preparation in Swiss Webster Mice","authors":"M. Iwo, Amirah Adlia, Silviyanita Isna Septila, Yennie Agnes Pratama, D. Purkon","doi":"10.25026/jtpc.v6i2.516","DOIUrl":"https://doi.org/10.25026/jtpc.v6i2.516","url":null,"abstract":"Platelet aggregation has the potential to form thrombi and result in cardiovascular system diseases such as myocardial infarction and ischemic stroke - one of the leading causes of death globally. Traditionally, people use binahong leaves as blood thinners. Therefore, this study aims to obtain scientific data on the efficacy of binahong leaf as antithrombotic. The efficacy test was carried out on male Swiss-Webster mice. The results showed that the ethanol extract of binahong leaves at doses of 50 (BLEE50) and 100 mg/kg bw (BLEE100) could increase bleeding time on H7 (7.61±1.79% and 3.72±1.76% vs 1.08±0.90%) and H14 (13.81±4.42% and 5.06±2.30% vs 1.66±1.09%) and coagulation time at H7 (5.01±1.36% and 4.18±1.67% vs 1.38±1.08%) and at H14 (7.92±1.97% and 7.19±1.96% vs 1.70±1.10%) significantly (p<0.05). The two doses of BLEE were formulated in the form of nanoemulsions with the Self Nano Emulsifying Drug Delivery System (NBLEE50 and NBLEE100) were also able to prolong bleeding time and coagulation time significantly (p<0.01) but only NBLEE50 prolonged bleeding time (p<0.05) significantly against BLEE50. In the test of the anti-platelet aggregation effect with ADP as an inducer, both doses of BLEE and the nanoemulsion preparation (NBLEE) could significantly (p<0.01) inhibit platelet aggregation with a percentage of inhibition >70% which was not different from the standard (acetylsalicylic acid). In the antioxidant effect test using the DPPH method, BLEE has an IC50 = 66.08?g/mL which is classified as a strong antioxidant. Both doses of BLEE and its NBLEE could significantly (p<0.01) inhibit lipid peroxidation in plasma and liver and NO radicals formation. BLEE50 can significantly (p<0.05) reduce mean platelet volume (6.05±0.24fL vs 6.55±0.34fL) and platelet distribution width (8.52±0.36% vs 9.25±0.42%). Based on those results, BLEE has the potential to be used as an antiplatelet aggregation and antioxidant.","PeriodicalId":17494,"journal":{"name":"Journal of Tropical Pharmacy and Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47535745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genistein Content and Tyrosinase Inhibitory Activity of Edamame (Glycine max) Extracts 大豆提取物中染料木素含量和酪氨酸酶抑制活性

Journal of Tropical Pharmacy and Chemistry Pub Date : 2022-11-28 DOI: 10.25026/jtpc.v6i2.461

I. Y. Ningsih, Lisa Kusuma Wardhani, Annisa Ragdha Eka Nuryuanda, E. Puspitasari, M. A. Hidayat

引用次数: 0

Pharmacologically Active Secondary Metabolites from Psoralea corylifolia 补骨脂的药理活性次级代谢产物

Journal of Tropical Pharmacy and Chemistry Pub Date : 2022-11-28 DOI: 10.25026/jtpc.v6i2.431

N. P. Ariantari, Elizabeth S. P. Ratnasantasyacitta

{"title":"Pharmacologically Active Secondary Metabolites from Psoralea corylifolia","authors":"N. P. Ariantari, Elizabeth S. P. Ratnasantasyacitta","doi":"10.25026/jtpc.v6i2.431","DOIUrl":"https://doi.org/10.25026/jtpc.v6i2.431","url":null,"abstract":"Psoralea corylifolia has gained much attention, particularly in the cosmetic industry for the past few years owing to promising pharmacological activities of its metabolites. Seeds of P. corylifolia are the main source of bakuchiol, a meroterpene compound that is extensively harnessed in numerous skincare products. Furanocoumarins, psoralen and isopsoralen are other metabolites mainly from P. corylifolia seeds and known for their antipsoriatic activity. Moreover, various studies have reported several classes of secondary metabolites from this plant possessing diverse biological activities. This article highlights recent updates on P. corylifolia phytoconstituents and their promising pharmacological activities based on scientific publications during the last 10 years (2011-2021). The literature search was carried out through scientific-based websites and databases such as Google Scholar, NCBI, and PubMed. This paper included sixty-three bioactive metabolites reported in the last 10 years, belonging to the group of flavonoids, meroterpenes, furanocoumarins, coumestans, steroid and phenolic compounds. These phytoconstituents displayed a broad range of bioactivities including anti-inflammatory, antibacterial, antidiabetic, controlling obesity, hepatoprotective and cytotoxicity. \u0000Keywords: Bakuchiol, pharmacological activities, Psoralea corylifolia, bioactive metabolites.","PeriodicalId":17494,"journal":{"name":"Journal of Tropical Pharmacy and Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47535847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1