Journal of Skin and Stem Cell最新文献_第9页

Cutaneous Manifestations of COVID-19: A Brief Review of a Possible Diagnostic Tool COVID-19 的皮肤表现：简评一种可能的诊断工具

Journal of Skin and Stem Cell Pub Date : 2021-03-31 DOI: 10.5812/jssc.110666

M. Akbarzadeh, Mahshid Kuchaki Rafsanjani, Mohammad-Salar Hosseini

引用次数: 0

Plantar Papules and Plaques: A Dermoscopic-Histopathological Correlation 足底丘疹和斑块:皮肤镜-组织病理学相关性

Journal of Skin and Stem Cell Pub Date : 2021-03-31 DOI: 10.5812/jssc.116806

B. Ankad, V. Koti, B. Nikam, M. Rangappa

{"title":"Plantar Papules and Plaques: A Dermoscopic-Histopathological Correlation","authors":"B. Ankad, V. Koti, B. Nikam, M. Rangappa","doi":"10.5812/jssc.116806","DOIUrl":"https://doi.org/10.5812/jssc.116806","url":null,"abstract":"Background: Painful lesions affecting the plantar aspect of the foot are routinely encountered in daily practice, and plantar wart, corn, and callus are the most common conditions. Although the clinical examination is sufficient to clinch an accurate diagnosis, atypical presentations indicate the need for invasive investigations like skin biopsy. Here we evaluated dermoscopic patterns of painful lesions affecting the plantar surface. Objectives: The current study aimed to, firstly, investigate the dermoscopic patterns and differentiate between painful papules and plaques on the foot, and, secondly, to analyze the histopathological correlation of these dermoscopic patterns. Methods: Following a cross-sectional design, the current study was carried out on patients with the clinical diagnosis of painful lesions of foot suggestive of plantar wart, corn, and callus referring to a tertiary care center from June 2019 to Jan 2020. Dermoscopy analysis and biopsy were performed for all participants. Results: Among 92 patients with painful plantar lesions, 56, 22, and 15 had a plantar wart, corn, and callus, respectively. Dermoscopy of warts revealed red dots (89.28%) and yellow halo (82.14%). A translucent central core (100%) and whitish ring (81.81%) on dermoscopy of patients with corn. Dermoscopy of callus demonstrated opaque yellow area in all (100%) the patients. Dermatoglyphics were absent in plantar wart in contrast to corn and callus, wherein they were preserved. Conclusions: Dermoscopy can be considered as a rapid, non-invasive, diagnostic tool in the daily practice of a dermatologist. Here, it assisted in distinguishing clinically akin painful plantar papules and plaques. These dermoscopic patterns also were well correlated histopathologically.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"117 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122641755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

General Health Status of Patients with Pemphigus Vulgaris 寻常型天疱疮患者的一般健康状况

Journal of Skin and Stem Cell Pub Date : 2021-03-31 DOI: 10.5812/jssc.110049

N. Alizadeh, A. Darjani, A. Ghanbari, Afsane Hadipour

{"title":"General Health Status of Patients with Pemphigus Vulgaris","authors":"N. Alizadeh, A. Darjani, A. Ghanbari, Afsane Hadipour","doi":"10.5812/jssc.110049","DOIUrl":"https://doi.org/10.5812/jssc.110049","url":null,"abstract":"Background: Pemphigus vulgaris is a severe autoimmune disease that involves skin and mucosal membranes by blistering lesions of varying sizes. Pemphigus is often associated with psychological stress. Objectives: This study aimed to show the status of general health in patients suffering from this disease. Methods: A descriptive study was conducted on 35 new cases of pemphigus vulgaris that were referred to the tertiary level hospital from March 2017 to March 2018. Personal and clinical data were gathered by interviewing. Assessment of severity of the disease was done by the Ikeda index, and GHQ-28 questionnaires were used to measure their general health status. Results: A total of 35 new cases of non-treated pemphigus vulgaris (16 females and 19 males; mean age of 48.3 years, range 25 - 84 years) participated in this study. Median severity score of pemphigus was 4.1. Moreover, GHQ-28 positivity was detected in 65.7%o the patients. Social dysfunction and anxiety/insomnia had higher scores in subscales. There was a reverse relationship between disease severity and GHQ-28 values (P < 0.05). Conclusions: Pemphigus may negatively affect the general health of patients, and this issue should be considered in the treatment of this disease.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114997354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Sporotrichosis: Review of Innate and Acquired Immune Mechanisms 孢子虫病:先天和获得性免疫机制综述

Journal of Skin and Stem Cell Pub Date : 2021-03-27 DOI: 10.5812/JSSC.108996

A. Tirado-Sánchez, A. Bonifaz

{"title":"Sporotrichosis: Review of Innate and Acquired Immune Mechanisms","authors":"A. Tirado-Sánchez, A. Bonifaz","doi":"10.5812/JSSC.108996","DOIUrl":"https://doi.org/10.5812/JSSC.108996","url":null,"abstract":"Context: Different factors such as the site of infection, the etiological agent, and the immune system can modify the antifungal response of the host. Differences in Sporothrix schenckii strains’ virulence and the host’s immune competency may be involved in the development of sporotrichosis. Nevertheless, the mechanisms related to the disease’s development and progression remain not fully elucidated. Nowadays, no model outweighs the usefulness of mice in biological studies. In these models, transient controlled immunity is created by depressed inflammatory cells during the acute phase of the disease. This is also related to nitric oxide-induced T-cell apoptosis and the lack of a mitogen response. Evidence Acquisition: The recognition of the lipid components of S. schenckii can induce and prolong inflammation. This recognition occurs mainly through the Toll-like receptor (TLR)-4 or the inflammasome. At the same time, TLR-2-mediated identification of fungal exoantigen can serve as an immune evasion process, continuing and worsening the infection. Cell-mediated immune mechanisms have a predominant influence on modulating the clinical expression of sporotrichosis, which is mainly related to Th1/Th17 immunity. Conclusions: In this study, we aimed to explore the innate and acquired immune mechanisms involved in sporotrichosis, as well as the most commonly used animal models for experimental studies.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"136 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127400559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hematological Findings in COVID-19 and Insights to Stem Cell Therapy: From Bench to Practice COVID-19的血液学发现和对干细胞治疗的见解:从实验室到实践

Journal of Skin and Stem Cell Pub Date : 2021-02-20 DOI: 10.5812/JSSC.107133

S. Mohamed, G. E. Gohary, F. AlGahtani, Fakher Alayoubi, N. A. El-Aziz

引用次数: 0

Surgical Pearl: Small Suction Syringe for Producing Blister 外科珍珠针用于产生水泡的小型抽吸注射器

Journal of Skin and Stem Cell Pub Date : 2021-02-13 DOI: 10.5812/JSSC.106614

M. Mukhtar

引用次数: 0

Nicolau Syndrome Following Intralesional Sclerotherapy: A Dreaded Complication of a Simple Office Procedure 斑块内硬化治疗后的Nicolau综合征:一种简单手术的可怕并发症

Journal of Skin and Stem Cell Pub Date : 2021-02-13 DOI: 10.5812/JSSC.107198

N. Deshmukh, V. Belgaumkar, R. Chavan, N. Bhatt

{"title":"Nicolau Syndrome Following Intralesional Sclerotherapy: A Dreaded Complication of a Simple Office Procedure","authors":"N. Deshmukh, V. Belgaumkar, R. Chavan, N. Bhatt","doi":"10.5812/JSSC.107198","DOIUrl":"https://doi.org/10.5812/JSSC.107198","url":null,"abstract":"Introduction: Nicolau syndrome is an iatrogenic dreaded adverse skin reaction leading to ischemic necrosis of skin and underlying tissue after parenteral drug injection. The etiopathogenesis is poorly understood. However, inflammation, reflex vasospasm, and thrombo-embolic occlusion of blood vessels, including arterioles and arteries, are suggested as the cause of ischemia. Case Presentation: We report a 12-year-old girl who developed Nicolau syndrome after a simple office procedure of intralesional sclera therapy with sodium tetradecyl sulfate for a apyogenic granuloma on her right index finger. Three days later, she reported complaints of excruciatingly painful swelling with bluish discoloration of the right hand involving the palm, entire index, middle, and ring fingers, and distal part of the little finger. Nicolau syndrome was documented after intramuscular injections of drugs. Nevertheless, there are very few reports of Nicolau syndrome following post intralesional sclerotherapy. Conclusions: Sclerotherapy is a simple office procedure routinely performed by health care professionals (e.g., dermatologists and surgeons), and awareness about its dreaded entity is key. Stringent precautions and prompt management can prevent unfavorable complications. Additionally, prudent patient selection and detailed counseling with explicit informed consent regarding Nicolau syndrome are imperative while planning any parenteral drug injection or intralesional sclerotherapy to avoid litigation.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117244552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Surgical Pearl: Dissecting Forceps with Polytube for Periorbital Senile Comedone Extraction 手术珍珠用于眶周老年性粉刺提取的带聚乙烯管的剥离钳

Journal of Skin and Stem Cell Pub Date : 2021-02-08 DOI: 10.5812/JSSC.104632

M. Mukhtar

引用次数: 1

Dermatological Manifestations of COVID-19 in Children 儿童COVID-19的皮肤病学表现

Journal of Skin and Stem Cell Pub Date : 2020-11-09 DOI: 10.5812/jssc.106890

V. Athwani, S. Gothwal

引用次数: 4

Cutaneous Elastorrhexis; A Heralding Sign of Gronblad-Strandberg Syndrome: A Case Report 皮肤Elastorrhexis;Gronblad-Strandberg综合征的先兆:1例报告

Journal of Skin and Stem Cell Pub Date : 2020-10-26 DOI: 10.5812/jssc.105455

R. Chavan, N. Deshmukh, V. Belgaumkar, V. Raut

{"title":"Cutaneous Elastorrhexis; A Heralding Sign of Gronblad-Strandberg Syndrome: A Case Report","authors":"R. Chavan, N. Deshmukh, V. Belgaumkar, V. Raut","doi":"10.5812/jssc.105455","DOIUrl":"https://doi.org/10.5812/jssc.105455","url":null,"abstract":"Introduction: Pseudoxanthoma Elasticum (PXE), also called Gronblad-Strandberg syndrome, is an autosomal recessive disorder due to mutation in the ABCC6 allele on chromosome 16p. It is characterized by the progressive fragmentation and calcification of elastin fibers of the dermis, blood vessels, and Bruch’s membrane of the eye. In this article, the authors present a case of PXE with cutaneous elastorrhexis. Case Presentation: A 31-year-old female presented with skin changes in the form of yellowish linearly arranged papules over the lateral side of the neck and anterior abdomen since adolescence. Her retinoscopy and cardiovascular examinations were reported as normal. The molecular analysis could not be done due to financial limitations. Based on these findings, the patient was suspected of PXE according to the revised criteria for the diagnosis of PXE. Conclusions: Skin lesions are generally first to appear in adolescence. Ocular findings develop at later ages, i.e., third or fourth decades. Cardiovascular manifestations develop later in life. Hence, skin changes can aid in the early diagnosis of PXE and help clinicians to screen patients for systemic complications. Being a multisystem heritable disorder with morbidity and mortality, there is a need to formulate the clinical criteria for definitive diagnosis in resource-poor settings where molecular assays cannot be performed. The recognition of typical skin lesions can aid in the accurate diagnosis to facilitate the early detection and management of life-threatening systemic complications.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"186 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132587902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0