Journal of Translational Medicine最新文献

{"title":"The differential expression of MAGI2 in glomerulopathies and its application as a molecular discriminator of podocytopathies.","authors":"Florian Siegerist, Eleonora Hay, Elke Hammer, Anna Iervolino, Claudia Weber, Juan Saydou Dikou, Eleni Stamellou, Linus Butt, Thomas Benzing, Thorsten Wiech, Paul T Brinkötter, Uwe Zimmerman, Giovambattista Capasso, Christos Chatziantoniou, Christos E Chadjichristos, Tobias B Huber, Uwe Völker, Maximilian Schindler, Nicole Endlich","doi":"10.1186/s12967-025-06696-9","DOIUrl":"10.1186/s12967-025-06696-9","url":null,"abstract":"<p><strong>Background: </strong>Podocyte dysfunction is central to various glomerular diseases, necessitating reliable biomarkers for early detection and diagnosis. This study investigates the regulatory mechanisms of membrane-associated guanylate kinase inverted 2 (MAGI2) and its potential as a biomarker for podocytopathies.</p><p><strong>Methods: </strong>Using fluorescence confocal laser scanning microscopy and super-resolution structured illumination microscopy of immunostained tissue sections of murine, human, and zebrafish tissue we investigated the subcellular location of MAGI2 in the kidney. We assessed the differential regulation of MAGI2 in glomerular disease animal models, and isolated glomerular dedifferentiation using immunostainings and LC-MS/MS tandem mass spectrometry. With CRISPR-Cas9, we generated zebrafish F0 generation mutants lacking either the zebrafish orthologue magi2a or nphs1.</p><p><strong>Results: </strong>The expression of the gene coding for the scaffolding protein MAGI2 was examined across four species and demonstrated to be conserved within the podocyte filtration slit. In vitro and in vivo studies using isolated glomeruli and mammalian animal models of glomerular disease, including DOCA-salt hypertension, nephrotoxic serum nephritis, and puromycin aminonucleoside nephropathy, demonstrated significant downregulation of MAGI2 in injured podocytes. This downregulation was also conserved in a zebrafish model of focal and segmental glomerulosclerosis (FSGS), and the podocyte-specific MAGI2 ortholog Magi2a was reduced post podocyte injury. CRISPR/Cas9-generated zebrafish mutants for magi2a exhibited marked glomerular filtration barrier defects and downregulation of nephrin, underscoring MAGI2's critical role in podocyte function. Human biopsy analyses revealed differential MAGI2 expression: it was increased in minimal change disease (MCD) patients but significantly decreased in primary, but not secondary FSGS cases. As MAGI2 localization did not change in disease states it is an alternative marker for super-resolution microscopy-based morphometry of the filtration slit, correlating with nephrin-based measurements.</p><p><strong>Conclusions: </strong>These findings highlight the potential of MAGI2 as a sensitive biomarker for podocyte injury and its diagnostic utility as a molecular discriminator in differentiating between primary FSGS and MCD in kidney biopsies.</p>","PeriodicalId":17458,"journal":{"name":"Journal of Translational Medicine","volume":"23 1","pages":"701"},"PeriodicalIF":6.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Expression of Concern: Abroma Augusta L. (Malvaceae) leaf extract attenuates diabetes induced nephropathy and cardiomyopathy via Inhibition of oxidative stress and inflammatory response.","authors":"Ritu Khanra, Saikat Dewanjee, Tarun K Dua, Ranabir Sahu, Moumita Gangopadhyay, Vincenzo De Feo, Muhammad Zia-Ul-Haq","doi":"10.1186/s12967-025-06779-7","DOIUrl":"10.1186/s12967-025-06779-7","url":null,"abstract":"","PeriodicalId":17458,"journal":{"name":"Journal of Translational Medicine","volume":"23 1","pages":"700"},"PeriodicalIF":6.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A call to reignite the revolutionary spirit of scientific discovery.","authors":"Ali Asadi, Francesco M Marincola","doi":"10.1186/s12967-025-06669-y","DOIUrl":"10.1186/s12967-025-06669-y","url":null,"abstract":"","PeriodicalId":17458,"journal":{"name":"Journal of Translational Medicine","volume":"23 1","pages":"699"},"PeriodicalIF":6.1,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12186445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Danshenol B alleviates central post-stroke pain by regulating the PIK3CG/NLRP3 signaling pathway.","authors":"Panyang Li, Linna Yu, Jinzhong Yao, Tingting Zhao, Sen Zhao","doi":"10.1186/s12967-025-06719-5","DOIUrl":"10.1186/s12967-025-06719-5","url":null,"abstract":"","PeriodicalId":17458,"journal":{"name":"Journal of Translational Medicine","volume":"23 1","pages":"696"},"PeriodicalIF":6.1,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pyrimidine metabolism-related gene signature for prognosis prediction and immune microenvironment description of breast cancer.","authors":"Han Wang, Ziling Zhou, Hanyi Zhong, Shoutang Wang, Kunwei Shen, Renhong Huang, Ruo Wang, Zheng Wang","doi":"10.1186/s12967-025-06700-2","DOIUrl":"10.1186/s12967-025-06700-2","url":null,"abstract":"<p><strong>Background: </strong>Metabolic reprogramming is a hallmark in cancer. Pyrimidine metabolism (PM), a part of nucleotide metabolism, has been shown to be associated with the progression of various cancers, and the prognostic predictive ability of pyrimidine metabolism-related genes (PMG) in breast cancer has not been elucidated. This paper was designed to identify pyrimidine metabolism-related prognostic marker of breast cancer and potential targeted therapeutic options.</p><p><strong>Methods: </strong>The cohort in the TCGA-BRCA dataset was used for patient information, and 108 pyrimidine metabolism-related genes were identified from the MSigDB KEGG pathways. We identified PM clusters in breast cancer and established a PM risk score model based on 10 pyrimidine metabolism-related genes. The status of immune infiltration was assessed in different groups. Further we identified the relevant hub gene and analyzed its significance for breast cancer metastasis and explored patterns of combination therapy.</p><p><strong>Results: </strong>We identified three types of PM clusters in breast cancer and clarified that PM cluster C with inferior prognosis possessed activation of tumor proliferation-associated pathways. The high-risk group in PM risk score model was found to be characterized by an immunosuppressive microenvironment. The hub gene POLR2C (RNA polymerase II subunit C) was further identified and verified as a potential prognostic marker. Furthermore, targeting POLR2C in combination with anti-PD-1 and anti-angiogenic therapies demonstrated a promising tumor suppression effect, suggesting a potential therapeutic direction.</p><p><strong>Conclusions: </strong>These findings provide additional insights into the link between breast cancer and PMG, offering potential strategies for breast cancer management and treatment.</p>","PeriodicalId":17458,"journal":{"name":"Journal of Translational Medicine","volume":"23 1","pages":"698"},"PeriodicalIF":6.1,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12186316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paracrine signaling in cancer-associated fibroblasts: central regulators of the tumor immune microenvironment.","authors":"Ye Li, Longyun Wang, Wenzhe Ma, Jibiao Wu, Qibiao Wu, Changgang Sun","doi":"10.1186/s12967-025-06744-4","DOIUrl":"10.1186/s12967-025-06744-4","url":null,"abstract":"<p><p>Despite groundbreaking advances in cancer immunotherapy, clinical efficacy remains constrained by the immunosuppressive tumor microenvironment (TME). As key stromal components within this TME, cancer-associated fibroblasts (CAFs) emerge as pivotal regulators of drug resistance and immune evasion. Beyond establishing physical barriers that exclude cytotoxic T cells from tumor nests, that is creating an immune \"desert\", CAFs dynamically reprogram the TME through multifaceted paracrine signaling, orchestrating crosstalk among tumor cells, stromal components, and immune cells. The complex paracrine signaling network jointly promotes the recruitment of immunosuppressive cells, alters the dynamics of immune cells, remodels the extracellular matrix, and ultimately establishes the immunosuppressive TME. Emerging strategies aimed at undermining the paracrine signaling Network of CAF-TME have shown potential in clinical studies to enhance the response to immunotherapy. Natural compounds such as curcumin and Baicalein and their derivatives have further expanded therapeutic approaches by regulating the paracrine phenotype of CAF due to their inherent multi-target intervention advantages. This review describes CAF and its paracrine effect as the central regulators of TME immunosuppression, emphasizing its key role in the immunotherapy response and providing new possibilities for clinical treatment strategies to restore CAFs paracrine-mediated immunosuppression and improve the efficacy of immunotherapy.</p>","PeriodicalId":17458,"journal":{"name":"Journal of Translational Medicine","volume":"23 1","pages":"697"},"PeriodicalIF":6.1,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12186372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Notch3 enhances the synergistic effect of all-trans retinoic acid and calcipotriol in pancreatic stellate cell activation.","authors":"Zheng Lian, Wei-Hong Du, Paizi-Guli Tusup-Han, Yu-Xiang Zhang","doi":"10.1186/s12967-025-06666-1","DOIUrl":"10.1186/s12967-025-06666-1","url":null,"abstract":"<p><strong>Background: </strong>Chronic pancreatitis (CP) is characterized by progressive fibrosis and the activation of pancreatic stellate cells (PSCs). As major producers of collagen-I and fibronectin, PSCs play important roles in pancreatic fibrosis, but few studies have explored methods to target activated PSCs. Notch3, a receptor in the Notch signaling pathway, is highly expressed in activated PSCs, but its specific effect on PSC activation needs to be confirmed. All-trans retinoic acid (ATRA) and the vitamin D analog calcipotriol were able to influence the activation of PSCs, but the relationship between ATRA, calcipotriol and Notch3 has not yet been clarified, and the effects of ATRA and calcipotriol on PSC activation need to be further enhanced.</p><p><strong>Methods: </strong>The impact of Notch3 on pancreatic stellate cell (PSC) activation was evaluated by knocking down Notch3 in PSCs. PSCs were incubated with ATRA and calcipotriol individually or in combination to explore their effects on PSC activation. Notch3-knockdown PSCs were treated with ATRA or calcipotriol under various conditions in vitro to assess their effects on activation. Nuclear receptor inhibition was used to dissect the interplay between Notch3 signaling and ATRA/calcipotriol pathways. The roles of Notch3, ATRA, and calcipotriol were investigated in vivo using a chronic pancreatitis model. Different combinations of these interventions were tested in the chronic pancreatitis model to evaluate their in vivo efficacy.</p><p><strong>Results: </strong>In this study, we confirmed the important role of Notch3 in PSC activation and found that ATRA and calcipotriol could regulate Notch3 expression. Furthermore, that ATRA and calcipotriol can synergistically prevent and reverse PSC activation, whereas knockdown of Notch3 can enhanced this synergistic effect. In CP model, we verified the effect of targeting Notch3 in combination with ATRA and calcipotriol. At last, we found that ATRA and calcipotriol do not regulate Notch3 through the nuclear receptors RARβ and VDR, but ATRA and calcipotriol depend on Notch3 to regulate PSC activation.</p><p><strong>Conclusions: </strong>Notch3 is a target for inhibiting PSC activation, ATRA and calcipotriol regulate Notch3 expression in PSCs, and targeting Notch3 in combination with ATRA and calcipotriol against PSC activation holds promise as a novel therapeutic approach for treating pancreatic fibrosis in CP.</p>","PeriodicalId":17458,"journal":{"name":"Journal of Translational Medicine","volume":"23 1","pages":"694"},"PeriodicalIF":6.1,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OncoE25: an AI model for predicting postoperative prognosis in early-onset stage I-III colon and rectal cancer-a population-based study using SEER with dual-center cohort validation.","authors":"Luyun Yuan, Liyu Wang, Jiamin Gao, Xin Chen, Haoyue Wang, Wei Shan Tan, Kexiang Sun, Yabin Gong, Wanli Deng","doi":"10.1186/s12967-025-06663-4","DOIUrl":"10.1186/s12967-025-06663-4","url":null,"abstract":"<p><strong>Background: </strong>Although CRC incidence is declining overall, early-onset colorectal cancers are increasing. No prognostic models currently exist for predicting postoperative survival in Stage I-III early-onset colon or rectal cancer. Such tools are urgently needed to enable individualized risk assessment.</p><p><strong>Methods: </strong>We identified patients with early onset (EO) and late-onset (LO) colon or rectal cancer from the SEER database and randomly split them into training and test cohorts (7:3). External cohorts of early-onset colon and rectal cancer were collected from two Chinese hospitals. After LASSO-Cox feature selection, six models-RSF, LASSO-Cox, S-SVM, XGBSE, GBSA, and DeepSurv-were developed to predict cancer-specific survival (CSS). Performance was assessed using the C-index, Brier score, time-dependent AUC, calibration, and decision curves. SHAP was used for model interpretation. A risk stratification system and an online calculator were constructed based on the best-performing model.</p><p><strong>Results: </strong>A total of 3,997 EO colon cancer, 2,016 EO rectal cancer, 30,621 LO colon cancer, and 8,667 LO rectal cancer patients from SEER, along with 205 EO colon cancer and 153 EO rectal cancer patients from Chinese institutions, were included in the study. Based on comprehensive evaluation across multiple datasets and metrics, the RSF model demonstrated the best and most stable performance, outperforming not only other machine learning models but also the traditional TNM staging system. In EO colon cancer, the RSF model achieved C-indices of 0.738 (test cohort) and 0.829 (external validation), mean AUCs of 0.765 and 0.889, and integrated Brier scores of 0.084 and 0.077, respectively. For EO rectal cancer, C-indices were 0.728 and 0.722, mean AUCs were 0.753 and 0.900, and integrated Brier scores were 0.106 and 0.095, respectively. The calibration and decision curves further confirmed the RSF model's good calibration and clinical net benefit. The RSF model also showed robust performance in LOCRC cohorts. SHAP analysis was used to quantify the marginal contribution of each predictor within each cancer subtype. Based on the RSF model, we developed a CSS-based risk stratification framework and deployed an online prediction tool.</p><p><strong>Conclusions: </strong>In summary, we selected the RSF model for its outstanding predictive performance, naming it OncoE25, to support personalized health management for EO colon and rectal patients.</p>","PeriodicalId":17458,"journal":{"name":"Journal of Translational Medicine","volume":"23 1","pages":"695"},"PeriodicalIF":6.1,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated peripheral blood multi-omics profiling identifies immune signatures predictive of neoadjuvant PD-1 blockade efficacy in head and neck squamous cell carcinoma.","authors":"Hao Zhang, Wenjie Wu, Meng Wang, Jie Zhang, Chuanbin Guo, Guojun Han, Lin Wang","doi":"10.1186/s12967-025-06770-2","DOIUrl":"10.1186/s12967-025-06770-2","url":null,"abstract":"<p><strong>Background: </strong>Neoadjuvant PD-1 inhibitor therapy has shown promise in locally advanced head and neck squamous cell carcinoma (HNSCC), but only a subset of patients achieves major pathological responses. Liquid biopsy, the analysis of tumor-derived biomarkers in readily accessible bodily fluids (primarily blood), offers significant advantages over traditional tissue biopsies for predicting cancer treatment outcomes. The aim of this study is to develop a predictive model for neoadjuvant PD-1 therapy response in HNSCC patients using exclusively liquid biopsy approaches-namely, peripheral blood immune profiling (CyTOF) and plasma cytokine panels (Olink).</p><p><strong>Methods: </strong>In a prospective trial involving 50 HNSCC patients treated with neoadjuvant tislelizumab plus chemotherapy, peripheral blood samples were collected pre- and post-treatment. Immune cell subsets were analyzed by mass cytometry (CyTOF), and circulating protein markers were quantified via a 92-plex targeted proteomics panel (Olink). Multimodal features were integrated into a predictive model using logistic regression.</p><p><strong>Results: </strong>Baseline immune profiles differed significantly between responder (RD) and non-responder (NRD): RD showed higher frequencies of CD103^-CD8⁺ central memory T cells (Tcm, c03) and elevated plasma interleukins (IL-5, IL-13), whereas NRD had more CD28^-TIGIT^highcPARP^-CD8⁺ terminally differentiated effector memory CD45RA⁺ T cells (Temra, c17) and higher levels of chemokines (CCL3, CCL4) and MMP7. Neoadjuvant therapy reactivated both subsets, evidenced by downregulation of PD-1 and increased expression of activation markers (e.g., CD38) and cytotoxic mediators (e.g., granzyme B and interferon γ). A multimodal predictive model incorporating CD8⁺T cell subsets (c03, c17) and plasma biomarkers (IL-5, MMP7) demonstrated superior predictive accuracy (AUC = 0.9219).</p><p><strong>Conclusions: </strong>Integrated peripheral immune profiling enables robust, noninvasive prediction of neoadjuvant PD-1 blockade efficacy in HNSCC. The identified immune cell subsets and plasma biomarkers provide a clinically applicable framework for early response stratification and personalized immunotherapy, supporting liquid biopsy as a viable platform for clinical decision-making. Trial registration Chinese Clinical Trial Registry, clinical trial number CHiCTR2200056354, 04 February 2022, https://www.chictr.org.cn/showproj.html?proj=151364 .</p>","PeriodicalId":17458,"journal":{"name":"Journal of Translational Medicine","volume":"23 1","pages":"693"},"PeriodicalIF":6.1,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heterogeneous tissue-specific macrophages orchestrate metastatic organotropism of breast cancer: implications for promising therapeutics.","authors":"Cenzhu Wang, Pinchao Fan, Yu Zhou, Meican Ma, Haowei Zhong, Lei Liu, Qin Chen, Kun Xu","doi":"10.1186/s12967-025-06660-7","DOIUrl":"10.1186/s12967-025-06660-7","url":null,"abstract":"<p><p>Compelling evidences have manifested that breast cancer cells prefer to metastasize to certain distant organs, including brain, lung, bone and liver. According to the canonical \"seed and soil\" theory, this prominent biological behavior, termed as metastatic organotropism, involves intricate interactions between breast cancer cells (the \"seeds\") and specific residents in the tumor microenvironment (the \"soil\"), initiating from pre-metastatic niche formation to metastatic outgrowth. Recently, multifaceted heterogeneity of tissue-specific macrophages (TSMs) and their roles played in organotropic metastases of breast cancer are incrementally unveiled. Herein, we decipher multiple diversities of TSMs, including evolvement, profiles, functions and metabolic characteristics under different polarization states. Further, we elaborate on bidirectional effects of TSMs on metastatic organotropism of breast cancer (both to the \"seeds\" and \"soil\"), and unearth underlying signaling pathways based on updated mechanistic researches. Lastly, we compile a series of clinical trials, hoping to illuminate promising TSM-targeting therapies against breast cancer organotropic metastases.</p>","PeriodicalId":17458,"journal":{"name":"Journal of Translational Medicine","volume":"23 1","pages":"692"},"PeriodicalIF":6.1,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}