Journal of Trauma and Acute Care Surgery最新文献

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American Association for the Surgery of Trauma/American College of Surgeons Committee on Trauma clinical protocol for nutrition support in adult trauma. 美国创伤外科协会/美国外科医师学会创伤委员会关于成人创伤营养支持的临床方案。
IF 3.9 2区 医学
Journal of Trauma and Acute Care Surgery Pub Date : 2026-11-01 Epub Date: 2026-08-26 DOI: 10.1097/TA.0000000000005160
Julie Valenzuela, Krista Haines, Gaurav Sachdev, Cassandra White, Thomas Schroeppel, Tanya Anand, Shannon L Castle, Lena M Napolitano
{"title":"American Association for the Surgery of Trauma/American College of Surgeons Committee on Trauma clinical protocol for nutrition support in adult trauma.","authors":"Julie Valenzuela, Krista Haines, Gaurav Sachdev, Cassandra White, Thomas Schroeppel, Tanya Anand, Shannon L Castle, Lena M Napolitano","doi":"10.1097/TA.0000000000005160","DOIUrl":"10.1097/TA.0000000000005160","url":null,"abstract":"<p><strong>Abstract: </strong>The provision of nutrition in adult trauma patients requires a detailed and personalized approach to achieve optimal patient outcomes. Initial assessment for malnutrition is required in all patients, as the hypermetabolic state of acute trauma may exacerbate malnutrition risk during the acute phase. Initial assessment in ICU patients includes determination of nutrition risk (high vs. low) using the modified NUTRIC or NRS scores and evaluation for malnutrition. In critically ill trauma patients, indirect calorimetry is most accurate for determination of calorie/protein requirements. Early enteral nutrition is recommended when resuscitation is complete. Continuous gastric feeds are recommended, with postpyloric jejunal feeding for patients at high risk of aspiration. In patients with enteral feeding intolerance and ileus, prokinetic agents should be implemented first, followed by postpyloric feeding tube if persistent feeding intolerance. Parenteral nutrition should be initiated if enteral nutrition is contraindicated (intestinal obstruction, severe ileus, high-output fistula, ischemia), and in patients who cannot achieve goal enteral nutrition. In patients with shock requiring vasopressors, an individualized approach should evaluate the risks and benefits of early enteral nutrition versus the potential risk of nonocclusive mesenteric ischemia. Critically ill geriatric, obese, and cirrhotic trauma patients warrant specialized nutrition care. Immunonutrition, glutamine, and probiotics/prebiotics are not currently recommended for trauma or burn patients.</p>","PeriodicalId":17453,"journal":{"name":"Journal of Trauma and Acute Care Surgery","volume":" ","pages":"736-750"},"PeriodicalIF":3.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13690351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148829484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trauma, hemorrhage, and the pulmonary hilum: Defining prolonged pulmonary hilar control in a swine model. 创伤、出血和肺门:猪模型中肺门控制延长的定义。
IF 3.9 2区 医学
Journal of Trauma and Acute Care Surgery Pub Date : 2026-11-01 Epub Date: 2026-08-24 DOI: 10.1097/TA.0000000000005060
Thomas M R McKinley, Jonathan B Livezey, Taylor Williams, Andrew Anklowitz, Tiffany Kippenberger, David R Chow, Laura E Riddle, David Mendoza, Marcos C Aranda, Daniel L Miller, Chance Spalding, John P Kuckelman
{"title":"Trauma, hemorrhage, and the pulmonary hilum: Defining prolonged pulmonary hilar control in a swine model.","authors":"Thomas M R McKinley, Jonathan B Livezey, Taylor Williams, Andrew Anklowitz, Tiffany Kippenberger, David R Chow, Laura E Riddle, David Mendoza, Marcos C Aranda, Daniel L Miller, Chance Spalding, John P Kuckelman","doi":"10.1097/TA.0000000000005060","DOIUrl":"10.1097/TA.0000000000005060","url":null,"abstract":"<p><strong>Background: </strong>Surgical clamping of the pulmonary hilum is the preferred method for hilar control in trauma. However, prolonged pulmonary ischemia has not been characterized in the setting of hemorrhagic shock. We sought to characterize the effect of prolonged unilateral pulmonary ischemia after various classes of hemorrhagic shock in an in vivo swine model. We hypothesize that progressive hemorrhagic shock will amplify the physiologic effects and histologic changes that occur due to pulmonary hilar clamping.</p><p><strong>Methods: </strong>The swine underwent a bilateral anterolateral thoracotomy followed by weight-based hemorrhage and left pulmonary hilar occlusion with hilar clamping. Subjects were randomized to one of five groups: control or class I to IV hemorrhagic shock. Hemodynamic data, laboratory values, and length of survival were recorded. Biopsies of the bilateral pulmonary parenchyma were obtained.</p><p><strong>Results: </strong>Twenty-six animals were randomized to control (N=5), Class I (N=6), Class II (N=6), Class III (N=6), and Class IV (N=3) hemorrhage shock. The Class I to III groups demonstrated improved survival compared with the Class IV group ( p <0.01). For the left (clamped) lung, there was significantly increased inflammation immediately after clamping that incrementally increased over 4 hours in all groups ( p <0.01). The right (nonclamped) lung had significantly increased inflammation 15 minutes after clamping that incrementally increased over 4 hours in all groups ( p =0.03). This inflammation was similar between lungs and between groups regardless of the class of shock ( p =0.46).</p><p><strong>Conclusions: </strong>Prolonged pulmonary hilar occlusion in Class I to III hemorrhagic shock does not significantly decrease survival. Severity of inflammation in both the occluded and contralateral lung is only increased by duration of hilar occlusion-not degree of hemorrhage-and consistently increased over the 240 minutes of occlusion. Our description of bilateral pulmonary histopathologic inflammatory changes from unilateral hilar occlusion is a novel finding, as is the minimal effect of hemorrhage on these changes. ( J Trauma Acute Care Surg. 2026;101: 819-826.).</p>","PeriodicalId":17453,"journal":{"name":"Journal of Trauma and Acute Care Surgery","volume":" ","pages":"819-826"},"PeriodicalIF":3.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of a safe volumetric cut-off for observation of traumatic hemothorax: A Western Trauma Association multicenter study. 一项西方创伤协会的多中心研究:用于观察外伤性血胸的安全体积截点的验证。
IF 3.9 2区 医学
Journal of Trauma and Acute Care Surgery Pub Date : 2026-11-01 Epub Date: 2026-04-24 DOI: 10.1097/TA.0000000000004991
Anna Tatakis, Danielle Wilson, Abdul Hafiz Al Tannir, Jason D Sciarretta, Kelsey Cage, John J Kessler, Rosemary A Kozar, Eric O Yeates, Andrew Medvecz, Tammy Kopelman, Andrea Slivinski, Karla Echeverria-Rosario, Ioana B Florea, Jane Cowan, Abby Wong, Daniel Stephens, Mohamad Abou Chaar, Kendal Weger, Grace Chang, Mark Flage, Lilian Von Husen, Allison E Berndtson, Jeffrey Anderson, Paige Newman, Brittany Nowak, Brittany Smoot, Michael Farrell, Kristin Oller, Ananth Murthy, Jayden Moore, Sneha Swaminathan, Christine Cocanour, Elizabeth Kim, Donald LaSeur, Kelly Boyle, Jacqueline Blank, Marc de Moya
{"title":"Validation of a safe volumetric cut-off for observation of traumatic hemothorax: A Western Trauma Association multicenter study.","authors":"Anna Tatakis, Danielle Wilson, Abdul Hafiz Al Tannir, Jason D Sciarretta, Kelsey Cage, John J Kessler, Rosemary A Kozar, Eric O Yeates, Andrew Medvecz, Tammy Kopelman, Andrea Slivinski, Karla Echeverria-Rosario, Ioana B Florea, Jane Cowan, Abby Wong, Daniel Stephens, Mohamad Abou Chaar, Kendal Weger, Grace Chang, Mark Flage, Lilian Von Husen, Allison E Berndtson, Jeffrey Anderson, Paige Newman, Brittany Nowak, Brittany Smoot, Michael Farrell, Kristin Oller, Ananth Murthy, Jayden Moore, Sneha Swaminathan, Christine Cocanour, Elizabeth Kim, Donald LaSeur, Kelly Boyle, Jacqueline Blank, Marc de Moya","doi":"10.1097/TA.0000000000004991","DOIUrl":"10.1097/TA.0000000000004991","url":null,"abstract":"<p><strong>Background: </strong>Traumatic hemothorax (HTX) contributes significantly to trauma morbidity and is frequently managed with tube thoracostomy (TT). However, TT placement has complications and some HTXs can be successfully observed. Optimal observation criteria remain unclear, and management practices vary. This multicenter study aimed to characterize current practices, determine observation failure rates, and identify predictors of safe observation.</p><p><strong>Methods: </strong>We conducted a prospective observational study from July 2023 to June 2025 across 16 trauma centers. Adult patients with computed tomography-confirmed HTX were included. Exclusions included age under 18 years, TT before computed tomography, concurrent pneumothorax >35 mm, death within 48 hours, or observation failure due to operative intervention. HTX volume was calculated using Mergo's formula ( V =d 2 ×L). Each hemithorax was analyzed independently. The primary outcome was observation failure. HTX >300 mL was evaluated as a predictor of failure in a multivariable logistic regression model.</p><p><strong>Results: </strong>Among 962 HTXs in 932 patients, 68% (n=657) were initially observed. The observation group had shorter hospital (7 vs. 9 d) and intensive care unit stays (1 vs. 3 d) compared with immediate TT ( p <0.001). Observation failure rate was 22% (n=141), most commonly from HTX progression (54%). Failed observation patients had longer hospital stays (13 vs. 9 d, p <0.001) but similar complication rates, secondary intervention needs, and 30-day outcomes compared with early TT. HTX volume >300 mL strongly predicted observation failure (adjusted odds ratio, 16.01; 95% confidence interval, 8.25-31.06). Management practices varied: 52% received antibiotics with TT, 16% underwent irrigation, and thoracostomy tube sizes ranged from 8 to 36 Fr.</p><p><strong>Conclusions: </strong>Initial observation of HTX is frequently successful, with HTX volume >300 mL being the strongest predictor of failure. Failed observation patients experience longer stays but similar outcomes to early TT placement. Notable practice variation highlights opportunities for research and standardization through unified practice management guidelines.</p><p><strong>Level of evidence: </strong>Therapeutic/Care Management; Level III.</p>","PeriodicalId":17453,"journal":{"name":"Journal of Trauma and Acute Care Surgery","volume":" ","pages":"797-804"},"PeriodicalIF":3.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Filling gaps or filling wallets? The role of for-profit medicine in the US trauma system. 填补缺口还是填补钱包?营利性医疗在美国创伤系统中的作用。
IF 3.9 2区 医学
Journal of Trauma and Acute Care Surgery Pub Date : 2026-11-01 Epub Date: 2026-04-20 DOI: 10.1097/TA.0000000000005018
Danby Kang, Sophia Smith, Crisanto M Torres, Allyson Hynes, Megan G Janeway, Lisa Allee, Anne K Buck, Sheina Theodore, Mark Seamon, Dane R Scantling
{"title":"Filling gaps or filling wallets? The role of for-profit medicine in the US trauma system.","authors":"Danby Kang, Sophia Smith, Crisanto M Torres, Allyson Hynes, Megan G Janeway, Lisa Allee, Anne K Buck, Sheina Theodore, Mark Seamon, Dane R Scantling","doi":"10.1097/TA.0000000000005018","DOIUrl":"10.1097/TA.0000000000005018","url":null,"abstract":"<p><strong>Background: </strong>After the US trauma system contracted in the 1990s with the loss of financially vulnerable trauma centers (TCs), a subsequent re-expansion took place. Many new trauma centers are for-profit (FPTCs) and may provide redundant care for affluent populations. Little is known about their role in the national trauma system. We hypothesized that FPTC catchments would provide redundant coverage to affluent populations.</p><p><strong>Methods: </strong>Data for the contiguous United States were obtained from the 2020 Decennial Census or American Community Survey. Population-weighted centroids of each census tract, as well as TC locations, were geocoded in ArcGIS Pro. FPTC status was obtained from the Centers for Medicare and Medicaid Services. Road and traffic data were obtained from Esri StreetMaps Premium. The shortest travel time from each population-weighted centroid was calculated to the nearest TC to delineate coverage areas and populations. This analysis was repeated without FPTCs to assess contributions to the trauma system. Data were exported to Stata for further analysis.</p><p><strong>Results: </strong>In total, 83,713 population-weighted centroids and 2,044 TCs were captured. About 11% of tracts were primarily served by 223 FPTCs, representing the closest TC for 43M people. While overall transport times were similar between FPTCs and NPTCs (14.0 vs. 14.2 min, p =ns), the removal of FPTCs did not change national transport times (median 0 min; IQR, 0, 0; range, 0-98). FPTC catchment populations were associated with more urban [odds ratio (OR), 1.02, 95% CI, 1.01-1.02, p <0.001], Hispanic (OR, 1.14, 95% CI, 1.14-1.15, p <0.001), uninsured (OR, 1.65, 95% CI, 1.57-1.73, p <0.001) or Medicare covered (OR, 1.04, 95% CI, 1.02-1.07, p <0.001) populations.</p><p><strong>Conclusions: </strong>Most FPTCs provide redundant care to populations that are often less insured, of similar poverty levels and of different demographics as compared with nonprofit centers. However, a small subset of FPTCs provides access to care for populations who would face long transport times without them. ( J Trauma Acute Care Surg . 2026;101: 886-893.).</p><p><strong>Level of evidence: </strong>Prognostic/Epidemiological; Level III.</p>","PeriodicalId":17453,"journal":{"name":"Journal of Trauma and Acute Care Surgery","volume":" ","pages":"886-893"},"PeriodicalIF":3.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An in vivo assessment of green plasma: The potential hemostatic superiority of a currently discarded blood product. 绿色血浆的体内评估:目前废弃的血液制品的潜在止血优势。
IF 3.9 2区 医学
Journal of Trauma and Acute Care Surgery Pub Date : 2026-11-01 Epub Date: 2026-06-15 DOI: 10.1097/TA.0000000000005071
James M Williams, Samantha C Redden, David J Sun, Yao-Wei W Wang, Michelle K McNutt, Jessica C Cardenas, Scott D Olson, Bryan A Cotton
{"title":"An in vivo assessment of green plasma: The potential hemostatic superiority of a currently discarded blood product.","authors":"James M Williams, Samantha C Redden, David J Sun, Yao-Wei W Wang, Michelle K McNutt, Jessica C Cardenas, Scott D Olson, Bryan A Cotton","doi":"10.1097/TA.0000000000005071","DOIUrl":"10.1097/TA.0000000000005071","url":null,"abstract":"<p><strong>Introduction: </strong>Approximately 5% of donated plasma has a green appearance, due to elevated ceruloplasmin levels from increased estrogen. These products are currently discarded based on color alone. However, studies have shown improved trauma outcomes from female donors. In an ex vivo study, we recently noted accelerated and increased clot production with green plasma. The purpose of this study was to assess whether these findings could be confirmed in an in vivo animal model of severe hemorrhage.</p><p><strong>Methods: </strong>We utilized a well-established rat model of uncontrolled hemorrhage. Following cannulation and anesthesia, 33 rats underwent midline laparotomy followed by excision of 50% of the middle hepatic lobe to induce hemorrhage. After 60 seconds, GREEN (11 rats), standard FEMALE (11), or MALE plasma (11) were infused at a fixed volume of 5 mL. Abdominal cavity blood was collected to evaluate blood loss every 15 minutes for 60 minutes. Deaths occurring before experiment termination were recorded.</p><p><strong>Results: </strong>Rats resuscitated with GREEN plasma had improved shock index compared with FEMALE and MALE at 15 (3.7 vs. 6.2 vs. 10.2; p =0.092), 30 (3.8 vs. 8.2 vs. 6.5; p =0.039), and 60 minutes (3.9 vs. 29.9 vs. 7.1; p =0.015). Mean arterial pressures in GREEN plasma-resuscitated rats were higher at 30 ( p =0.032) and 60 minutes ( p =0.115). Cumulative percent blood volume lost was lower at each time point in those receiving GREEN plasma. Survival to 60 minutes was 100% among GREEN and FEMALE plasma rats but only 64% among MALE resuscitated ones ( p <0.001).</p><p><strong>Conclusions: </strong>Our study demonstrated that green plasma has improved efficacy for reducing bleeding and restoring hemodynamic stability compared with standard plasma in a rodent model of uncontrolled hemorrhage. Combined with our recent ex vivo data noting equivalent (often superior) hemostatic potential compared with standard units, we recommend reintroducing this often-discarded AABB-approved product back into the plasma donor pool.</p>","PeriodicalId":17453,"journal":{"name":"Journal of Trauma and Acute Care Surgery","volume":" ","pages":"784-789"},"PeriodicalIF":3.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of presentations in scientific conferences: Publication and citation rates in trauma surgery. 科学会议上演讲的影响:创伤外科的出版物和引用率。
IF 3.9 2区 医学
Journal of Trauma and Acute Care Surgery Pub Date : 2026-10-23 DOI: 10.1097/TA.0000000000005188
Gavin Touponse, Serena Bidwell, Amei Shank, Jesse Tai, James Poe, Alexander Berg, Hason Khan, Lu Tian, Raul Coimbra, Jeff Choi
{"title":"The impact of presentations in scientific conferences: Publication and citation rates in trauma surgery.","authors":"Gavin Touponse, Serena Bidwell, Amei Shank, Jesse Tai, James Poe, Alexander Berg, Hason Khan, Lu Tian, Raul Coimbra, Jeff Choi","doi":"10.1097/TA.0000000000005188","DOIUrl":"https://doi.org/10.1097/TA.0000000000005188","url":null,"abstract":"<p><strong>Background: </strong>Understanding the publication rates and citation patterns of conference abstracts is critical for program committees and investigators alike. However, the downstream scholarly outcome of conference abstracts remains poorly characterized. We hypothesized that across contemporary US trauma-related scientific meetings, a substantial proportion of conference abstracts would not progress to peer-reviewed publications, and that publication rates and citation patterns would vary by presentation format and conference.</p><p><strong>Methods: </strong>We conducted a cross-sectional study of abstracts presented at four major US trauma surgery conferences from 2017 to 2019. We identified peer-reviewed manuscripts associated with conference abstracts via Google Scholar and PubMed. We collected presentation format, publishing journal, 2024 journal impact factor, and citation count. A cohort of directly submitted peer-reviewed manuscripts was also analyzed. Mixed-effects Poisson regression models assessed the association between presentation and citation counts, adjusting for publication timing.</p><p><strong>Results: </strong>Of 1,157 abstracts, 762 (66%) were published as peer-reviewed manuscripts. Most manuscripts were published in the Journal of Trauma and Acute Care Surgery (JTACS) (55%), with 5 in journals with a higher-impact factor than JTACS. On regression analysis, abstracts presented as oral presentations, and published in journals with an impact factor higher than JTACS, were associated with a greater number of citations. When comparing manuscripts presented as abstracts to directly submitted peer-reviewed manuscripts, abstract presentation was associated with 22% more citations (incidence rate ratio: 1.22; 95% CI [1.16-1.29]; p<0.001).</p><p><strong>Conclusions: </strong>This cross-sectional study of four trauma societies found that approximately a third of presented abstracts did not progress to peer-reviewed publication, with publication rates varying by conference and presentation format. Exploratory analyses found that among those published in JTACS, published manuscripts originating from presented abstracts demonstrated a modestly higher citation count compared with directly submitted manuscripts. Our findings highlight an opportunity to better understand how conference time and investigator effort translate into downstream scholarly output.</p><p><strong>Level of evidence: </strong>Prognostic/Epidemiological; Level IV.</p>","PeriodicalId":17453,"journal":{"name":"Journal of Trauma and Acute Care Surgery","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149245191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
β-Blockade reprograms trauma-induced changes in bone marrow exosomal microRNAs. β-阻断可重编程创伤诱导的骨髓外泌体microrna变化。
IF 3.9 2区 医学
Journal of Trauma and Acute Care Surgery Pub Date : 2026-10-23 DOI: 10.1097/TA.0000000000005221
Athina L Yoham, Letitia E Bible, Kolenkode B Kannan, Agneta F Peethala, Aidan D Garemani, Carmen K Karsonovich, Christine E Rodhouse, Whitman B Wiggins, Miguel Hernandez-Rios, Robert Maile, Philip A Efron, Alicia M Mohr
{"title":"β-Blockade reprograms trauma-induced changes in bone marrow exosomal microRNAs.","authors":"Athina L Yoham, Letitia E Bible, Kolenkode B Kannan, Agneta F Peethala, Aidan D Garemani, Carmen K Karsonovich, Christine E Rodhouse, Whitman B Wiggins, Miguel Hernandez-Rios, Robert Maile, Philip A Efron, Alicia M Mohr","doi":"10.1097/TA.0000000000005221","DOIUrl":"https://doi.org/10.1097/TA.0000000000005221","url":null,"abstract":"<p><strong>Background: </strong>Severe trauma produces sustained sympathetic activation that contributes to bone marrow dysfunction, impaired hematopoiesis, and persistent injury-associated anemia. Although β-adrenergic blockade improves bone marrow recovery after injury, the downstream mechanisms remain incompletely defined. We hypothesized that propranolol reprograms trauma-induced bone marrow extracellular vesicle (EV) microRNA (miRNA) expression toward restoration of hematopoietic homeostasis.</p><p><strong>Methods: </strong>Sprague-Dawley rats were randomized to naïve, polytrauma (PT), PT plus propranolol (PT+BB), PT with chronic restraint stress (PTRS), or PTRS plus propranolol (PTRS+BB) groups (n=6-8 per group). Propranolol (10 mg/kg intraperitoneally) was administered daily. On day 7, complete blood counts were obtained, and bone marrow-derived EV miRNAs were profiled using the NanoString nCounter platform. Differentially expressed miRNAs were identified using an absolute log2 fold change ≥1.5 and p<0.05. Predicted pathways were assessed using Ingenuity Pathway Analysis, and miR-125b-5p was validated by quantitative PCR.</p><p><strong>Results: </strong>PT altered 45 EV miRNAs compared with naïve animals, including suppression of miRNAs involved in hematopoietic stem cell maintenance and erythropoiesis. Chronic restraint stress amplified this response, with 93 differentially expressed miRNAs following PTRS. Propranolol altered 12 miRNAs after PT and 43 after PTRS, increasing hematopoietic regulatory miRNAs, including miR-125b-5p, while suppressing several stress- and inflammation-associated miRNAs. Pathway analysis identified alterations in NOTCH, RUNX1, PTEN, thyroid receptor/retinoid X receptor, and histone modification signaling. Quantitative PCR confirmed a 2.4-fold increase in EV miR-125b-5p following propranolol in PTRS animals (p=0.018).</p><p><strong>Conclusions: </strong>Trauma and persistent adrenergic stress broadly remodel bone marrow EV miRNA signaling. β-Adrenergic blockade selectively reprograms these networks toward pathways associated with hematopoietic recovery, identifying EV miRNAs as potential mediators of posttraumatic bone marrow dysfunction.</p><p><strong>Level of evidence: </strong>Not applicable-Animal research.</p>","PeriodicalId":17453,"journal":{"name":"Journal of Trauma and Acute Care Surgery","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149245194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Authors'reply to Hibberd O, Karageorgos S. Psychological care after pediatric trauma: When, who, and what next? 儿童创伤后的心理护理:何时,谁,下一步是什么?
IF 3.9 2区 医学
Journal of Trauma and Acute Care Surgery Pub Date : 2026-10-23 DOI: 10.1097/TA.0000000000005220
Alexander S Mina, Joshua Pena-Ewers, Lauren Jarr, Kathy Luong, Howard I Pryor, Virginia D Cline
{"title":"Authors'reply to Hibberd O, Karageorgos S. Psychological care after pediatric trauma: When, who, and what next?","authors":"Alexander S Mina, Joshua Pena-Ewers, Lauren Jarr, Kathy Luong, Howard I Pryor, Virginia D Cline","doi":"10.1097/TA.0000000000005220","DOIUrl":"https://doi.org/10.1097/TA.0000000000005220","url":null,"abstract":"","PeriodicalId":17453,"journal":{"name":"Journal of Trauma and Acute Care Surgery","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149245169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TQP mortality reporting system case reports: Palliative care-transfers in with anticipated death. TQP死亡率报告系统病例报告:姑息治疗转移与预期死亡。
IF 3.9 2区 医学
Journal of Trauma and Acute Care Surgery Pub Date : 2026-10-22 DOI: 10.1097/TA.0000000000005184
Julie Y Valenzuela, Kimberly A Davis, Aaron R Jensen, Samuel P Mandell, Shannon L Castle
{"title":"TQP mortality reporting system case reports: Palliative care-transfers in with anticipated death.","authors":"Julie Y Valenzuela, Kimberly A Davis, Aaron R Jensen, Samuel P Mandell, Shannon L Castle","doi":"10.1097/TA.0000000000005184","DOIUrl":"https://doi.org/10.1097/TA.0000000000005184","url":null,"abstract":"","PeriodicalId":17453,"journal":{"name":"Journal of Trauma and Acute Care Surgery","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149245199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trauma Quality Programs Mortality Reporting System Case Reports: Unanticipated Mortality Due to Prolonged Operative Course. 创伤质量计划死亡率报告系统病例报告:手术过程延长导致的意外死亡率。
IF 3.9 2区 医学
Journal of Trauma and Acute Care Surgery Pub Date : 2026-10-19 DOI: 10.1097/TA.0000000000005216
Shailvi Gupta, Richard P Dutton, Aaron R Jensen, Samuel P Mandell, Shannon L Castle
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引用次数: 0
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