Journal of the Peripheral Nervous System最新文献

{"title":"A Case Series of Unilateral Peripheral Neuropathy","authors":"Caroline Kramarz,&nbsp;Marion Masingue,&nbsp;Françoise Bouhour,&nbsp;Christophe Vial,&nbsp;Philippe Latour,&nbsp;Christophe Vandendries,&nbsp;Thierry Maisonobe,&nbsp;Jan Coebergh,&nbsp;Julian Blake,&nbsp;Mary M. Reilly,&nbsp;Tanya Stojkovic,&nbsp;Alexander M. Rossor","doi":"10.1111/jns.70033","DOIUrl":"https://doi.org/10.1111/jns.70033","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Peripheral neuropathy may present with a variety of phenotypes depending on the pattern of weakness and sensory loss, the neurophysiological characteristics (axonal or demyelinating) and additional features such as involvement of the autonomic nervous system or the cranial nerves. The most common phenotype is a symmetrical length-dependent sensory and motor neuropathy. Other phenotypes include non-length-dependent forms such as chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) or a sensory neuronopathy or ganglionopathy. Asymmetric forms of neuropathy are mostly represented by mononeuritis multiplex and Lewis-Sumner syndrome or focal CIDP. Unilateral weakness or sensory loss respecting the midline is mainly due to pathology in the central nervous system and is unusual in peripheral neuropathy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We evaluated the clinical and genetic features of three unrelated individuals with a peripheral neuropathy affecting one side of the body.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We describe three unrelated patients (two female and one male) with a slowly progressive peripheral neuropathy restricted to one side of the body. Each case is marked by onset in early childhood with the absence of a family history or a structural lesion of the central nervous system. Neurophysiology demonstrated an axonal type of neuropathy in two cases and conduction slowing supportive of a demyelinating neuropathy type in one. Genetic testing was performed in the three cases, specifically looking for variants in genes associated with Charcot-Marie-Tooth disease (CMT) but none were identified in DNA extracted from blood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Interpretation</h3>\u0000 \u0000 <p>A unilateral, slowly progressive peripheral neuropathy is a rare phenomenon, and we propose the cause of this unusual phenotype to be due to a mosaic or chimeric form of Charcot-Marie-Tooth disease (CMT).</p>\u0000 </section>\u0000 </div>","PeriodicalId":17451,"journal":{"name":"Journal of the Peripheral Nervous System","volume":"30 2","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and Responsiveness of Balance Measurements Using Posturography in Patients With Immune-Mediated Neuropathies","authors":"Milou R. Michael,&nbsp;Robin van Veen,&nbsp;Luuk Wieske,&nbsp;Ingemar S. J. Merkies,&nbsp;Ivo N. van Schaik,&nbsp;Filip Eftimov","doi":"10.1111/jns.70031","DOIUrl":"https://doi.org/10.1111/jns.70031","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Validated objective measures for balance in immune mediated neuropathies are lacking. In this study, we investigated the clinimetric properties of posturography using a force platform, a quantitative assessment of postural control.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We assessed patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and IgM-related polyneuropathy (IgM-PNP) using sway parameters (path, area and amplitude) measured at multiple time points. Validity was investigated by assessing differences in sway path between patients with and without reported balance symptoms and by assessing correlations of sway path with (established) impairment measures related to balance, disability and quality of life (QoL). Responsiveness was assessed by means of an anchor-based approach, using a patient anchor and two disability scales.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We included 52 CIDP and 13 IgM-PNP patients. In CIDP, sway path was 25% longer in patients reporting balance symptoms relative to patients without balance symptoms (<i>p</i> = 0.03). There was excellent reliability between consecutive measurements in both CIDP and IgM-PNP. Moderate to good correlations were observed between sway path and an ataxia scale (CIDP: Spearman's <i>ρ</i> = 0.46, 95% CI: 0.2–0.69; IgM-PNP: Spearman's <i>ρ</i> = 0.72, 95% CI: 0.28–0.96) while correlations with related disability measures and QoL were poor. Changes in sway parameters over time were not consistently associated with changes in other outcome measures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Interpretation</h3>\u0000 \u0000 <p>Posturography measurements showed poor validity and responsiveness. Therefore, despite excellent reliability, using a force platform in clinical practice or trials for immune-mediated neuropathies cannot be recommended.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17451,"journal":{"name":"Journal of the Peripheral Nervous System","volume":"30 2","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jns.70031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SLC5A6 Mutations in Axonal Sensorimotor Polyneuropathy Patients Concurrent With Sodium Dependent Multivitamin Transporter Deficiency and Improved Effects by Multivitamin Therapy","authors":"Byung Kwon Pi,&nbsp;Ah. Jin Lee,&nbsp;Soo Hyun Nam,&nbsp;Ki Wha Chung,&nbsp;Byung-Ok Choi","doi":"10.1111/jns.70030","DOIUrl":"https://doi.org/10.1111/jns.70030","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>The <i>SLC5A6</i> gene encodes a transmembrane protein responsible for transporting biotin, pantothenic acid, and lipoic acid. Mutations in <i>SLC5A6</i> have shown a wide spectrum of clinical phenotypes, such as sodium-dependent multivitamin transporter deficiency (SMVTD), childhood-onset biotin-responsive peripheral motor neuropathy (COMNB), and mixed axonal and demyelinating sensory motor neuropathy. The purpose of this study was to identify pathogenic <i>SLC5A6</i> mutations in the Korean CMT cohort.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study performed whole exome sequencing to identify the genetic cause for two independent patients with early onset axonal sensorimotor polyneuropathy and SMVTD. We also examined the therapeutic effects of multivitamin replenishment on a patient with <i>SLC5A6</i> mutations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified compound heterozygous variants of <i>SLC5A6</i> in two patients (p.Arg94X and p.Phe522Ser in patient 1; p.Cys443Tyr and p.Phe513_Lys515delinsLeu in patient 2). In patient 2, an oral regimen comprising biotin, lipoic acid, and pantothenic acid demonstrated significant therapeutic effects, including cessation of cyclic vomiting, resolution of skin lesions on the fingers, and improvements in muscle weakness affecting both the upper and lower extremities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Interpretation</h3>\u0000 \u0000 <p>This study represents the first report of novel heterozygous <i>SLC5A6</i> mutations in patients with axonal CMT and SMVTD, expanding the phenotypic spectrum associated with <i>SLC5A6</i> mutations. Notably, we observed significant therapeutic effects from multivitamin treatment in a patient.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17451,"journal":{"name":"Journal of the Peripheral Nervous System","volume":"30 2","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soleal Sling Syndrome: A Narrative Review","authors":"Laura Hilbig-Vlatten,&nbsp;Jennifer N. Grauberger,&nbsp;Toni F. Engmann,&nbsp;Lilly F. Stadelmeier,&nbsp;Raymond M. Dunn,&nbsp;Ross Mandeville,&nbsp;Jason H. Ko,&nbsp;Pierre D'Hemecourt,&nbsp;Sammy Dowlatshahi","doi":"10.1111/jns.70032","DOIUrl":"https://doi.org/10.1111/jns.70032","url":null,"abstract":"<div>\u0000 \u0000 <p>Soleal sling syndrome is a rare cause of lower extremity neuropathy due to compression of the proximal tibial nerve under the fibromuscular arch of the soleus muscle. It presents with plantar numbness/paresthesias, calf pain, and tenderness over the proximal calf. Chronic compression can lead to toe flexor weakness. This study reviews the clinical presentation, diagnostic workup, and treatment options for soleal sling syndrome. A query of the PubMed database up until August 30, 2022, was conducted to gather relevant clinical, anatomic, and radiographic findings. The literature review identified key features of soleal sling syndrome, highlighting the importance of considering it in patients with calf pain/tenderness and plantar foot neurosensory changes. Diagnosis typically relies on history and physical examination, often with a positive Tinel's sign, though imaging modalities show inconsistent utility. Soleal sling syndrome is underrecognized and overlaps with other syndromes. Radiological imaging modalities can rule out secondary causes of proximal tibial nerve compression but lack consistency for diagnosing idiopathic cases. Surgical decompression of the nerve, via a medial or posterior approach, is the definitive treatment for all causes of tibial nerve compression.</p>\u0000 </div>","PeriodicalId":17451,"journal":{"name":"Journal of the Peripheral Nervous System","volume":"30 2","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility, Validity, and Reliability of the Virtual CMT Infant Toddler Scale (vCMTInfS): A Remote Evaluation of Infants/Toddlers With CMT","authors":"Rosemary Shy,&nbsp;Amanda Dragon,&nbsp;Shawna M. E. Feely,&nbsp;Gabrielle Donlevy,&nbsp;Kayla Cornett,&nbsp;Melissa Mandarakas,&nbsp;Tim Estilow,&nbsp;Joshua Burns,&nbsp;Michael E. Shy","doi":"10.1111/jns.70029","DOIUrl":"https://doi.org/10.1111/jns.70029","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>The CMT Infant Scale (CMTInfS) enables evaluation of infants/toddlers in clinic. Our aim was to evaluate the feasibility, reliability, and validity of a virtual version of the CMTInfS (vCMTInfS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Children aged 55 months or less were evaluated either in clinic using CMTInfS or remotely via telemedicine using the vCMTInfS. A trained clinical evaluator remotely directed activities with assistance from the parent/caregiver. vCMTInfS scores were calculated using the CMTInfS calculator available at www.ClinicalOutcomeMeasures.org. Clinical evaluators also used the Brazelton Neonatal Behavior assessment scale to give insight into the behavior of the child during the exam.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty children (10 males and 10 females) aged 6–55 months with confirmed or at risk for CMT were evaluated. The mean in person (IP) CMT Infant and Toddler Scale (CMTInfS) raw score (4.11, SD = 2.76) was not significantly different from the mean initial virtual (V1) CMTInfS raw score (3.78, SD = 2.59) using a two-tailed test (<i>t</i> = 1.000, <i>p</i> = 0.347). Differences between the first and second (V2) visits as well as between the IP and V2 visits were also nonsignificant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Interpretation</h3>\u0000 \u0000 <p>Our data demonstrate that children aged 55 months or less can be effectively evaluated remotely using the vCMTInfS, which will expand the number of very young children who can be evaluated with rare forms of CMT.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17451,"journal":{"name":"Journal of the Peripheral Nervous System","volume":"30 2","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jns.70029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Results From a Phase 1 Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of ANX005, a C1q Inhibitor, in Patients With Guillain–Barré Syndrome”","authors":"","doi":"10.1111/jns.70024","DOIUrl":"https://doi.org/10.1111/jns.70024","url":null,"abstract":"<p>Q. D. Mohammad, Z. Islam, N., Papri, et al. “Results From a Phase 1 Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of ANX005, a C1q Inhibitor, in Patients With Guillain–Barré Syndrome,” <i>Journal of the Peripheral Nervous System</i> 30 (2025): e70009. https://doi.org/10.1111/jns.70009</p><p>FIGURE 7 | Change in MRC from baseline for ANX005 and placebo (<i>N</i> = 26). MRC, Medical Research Council.</p><p>We apologize for this error.</p>","PeriodicalId":17451,"journal":{"name":"Journal of the Peripheral Nervous System","volume":"30 2","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jns.70024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-Reported Outcome Measures for Assessing Health-Related Quality of Life in Patients With Polyneuropathies, Focusing on Guillain-Barré Syndrome and Chronic Inflammatory Demyelinating Polyneuropathy: A Systematic Review of Measurement Properties","authors":"Farah Pelouto,&nbsp;Adája E. Baars,&nbsp;Nowshin Papri,&nbsp;Juanita A. Haagsma,&nbsp;Bart C. Jacobs,&nbsp;Caroline B. Terwee","doi":"10.1111/jns.70022","DOIUrl":"https://doi.org/10.1111/jns.70022","url":null,"abstract":"<p>Guillain-Barre syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP) are immune-mediated peripheral neuropathies. Despite treatment, patients may report residual deficits, pain, and fatigue with considerable impact on quality of life. A systematic review was conducted of the methodological quality of current patient-reported outcome measures (PROMs) for measuring health-related quality of life (HRQoL) in patients with GBS and CIDP. A literature search was conducted in EMBASE, MEDLINE, Web of Science, and Google Scholar. PROMs developed to measure (aspects of) HRQoL in patients with polyneuropathy were classified using the Wilson and Cleary model. Measurement properties were evaluated in accordance with Consensus-based Standards for selection of health Measurement Instruments (COSMIN) guideline. A total of 57 articles identified 31 unique PROMs that are used for measuring HRQoL in patients with polyneuropathies. Of these, 22 measured symptom status, 19 functional status, and 4 general health perception. Eight PROMs were developed or validated in patients with GBS/CIDP. None of the PROMs demonstrated sufficient content validity for recommendation in this population. Only the Rasch-built Fatigue Severity Scale (R-FSS) performed sufficiently across all other measurement properties. The Inflammatory Rasch-built Overall Disability Scale (I-RODS) and IN-QoL are not recommended for use because of insufficient construct validity. GBS Patient Experience Questionnaire, Chronic Acquired Polyneuropathy Patient-Reported Index (CAP-PRI), Fatigue Severity Scale (FSS), R-FSS, Rotterdam Handicap Scale (RHS) and the 36-Item Short Form Health Survey (SF-36) need further validation. PROMs of good quality assessing all relevant aspects of HRQoL are required for better insight in HRQoL in patients with GBS and CIDP.</p>","PeriodicalId":17451,"journal":{"name":"Journal of the Peripheral Nervous System","volume":"30 2","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jns.70022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Hybrid Closed-Loop Insulin Delivery Is Associated With Improved Glycemic Indicators and Normalization of Small Nerve Fibre Structure in Adults With Type 1 Diabetes","authors":"Hoda Gad,&nbsp;Einas Elgassim,&nbsp;Kawsar Mohamed Ayon Mohamud,&nbsp;Najlaa Sultan Al-Naimi,&nbsp;Hamad Ali Al-Sharshani,&nbsp;Ibrahim Mohammed,&nbsp;Mariam A. Al-Malaheem,&nbsp;Dorothy J. Quadros,&nbsp;Alhanoof AlJalahma,&nbsp;Neila Lamine,&nbsp;Ahmad Yaser Alhaddad,&nbsp;Hussein Ahmed Hussein Zaky Aly,&nbsp;John-John Cabibihan,&nbsp;Abdulaziz Al-Ali,&nbsp;Kishor Kumar Sadasivuni,&nbsp;Ioannis N. Petropoulos,&nbsp;Georgios Ponirakis,&nbsp;Hamda A. Ali,&nbsp;Dabia AlMohanadi,&nbsp;Khaled Baagar,&nbsp;Rayaz A. Malik","doi":"10.1111/jns.70026","DOIUrl":"https://doi.org/10.1111/jns.70026","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hyperglycemia is a major driver of diabetic peripheral neuropathy (DPN) in type 1 diabetes mellitus (T1DM). Advanced hybrid closed-loop (AHCL) technologies improve glycemic control and reduce glycemic variability and may improve DPN.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients with T1DM treated for 9.8 ± 0.32 months with the 780G SmartGuard system (<i>n</i> = 14) were compared with patients with T1DM on MDI (<i>n</i> = 20) and healthy controls (<i>n</i> = 15). Time in range (TIR), time above range (TAR), time below range (TBR), glycemic variability, and HbA_1c were evaluated, and corneal confocal microscopy (CCM) was undertaken to quantify corneal nerve fiber density (CNFD), branch density (CNBD), fiber length (CNFL), and inferior whorl length (IWL).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Participants using the 780G system had a significantly higher TIR (<i>p</i> &lt; 0.001), lower glycemic variability (<i>p</i> = 0.02), and less time in level 2 hyperglycemia (<i>p</i> = 0.01), level 1 hyperglycemia (<i>p</i> = 0.04), and level 2 hypoglycemia (<i>p</i> = 0.008) compared with the MDI group. CNFD (<i>p</i> = 0.02), CNBD (<i>p</i> = 0.04), CNFL (<i>p</i> = 0.04), and IWL (<i>p</i> &lt; 0.001) were significantly higher in the 780G group compared with the MDI group and comparable to healthy controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The MiniMed 780G with SmartGuard improves glycemic control and variability with an improvement in small nerve fiber morphology in patients with DPN.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17451,"journal":{"name":"Journal of the Peripheral Nervous System","volume":"30 2","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Electrophysiological Characterization of Diabetic Neuropathy in a Sub-Saharan African Cohort","authors":"Samuel Eric Chokote,&nbsp;Gaelle Lemdjo,&nbsp;Juan Francisco Idiaquez Rios,&nbsp;Aurelien Tejiozem Anakeu,&nbsp;Leonard Ngarka,&nbsp;Leonard N. Nfor,&nbsp;Michel K. Mengnjo,&nbsp;Wepnyu Y. Njamnshi,&nbsp;Herman Nestor Tsague Kengni,&nbsp;Ruth Joelle Ngongang,&nbsp;Gilles Simeni,&nbsp;Lylian Piameu,&nbsp;Alain Balla Nkonda,&nbsp;Faustin Yepnjio,&nbsp;Godwin Y. Tatah,&nbsp;Umapathi N. Thirugnanam,&nbsp;Alfred Kongnyu Njamnshi","doi":"10.1111/jns.70021","DOIUrl":"https://doi.org/10.1111/jns.70021","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Diabetic neuropathy (DN) is the most frequent complication of diabetes mellitus, contributing to increased morbidity and mortality. Previous clinical studies on DN in sub-Saharan Africa (sSA) have used purely clinical approaches, potentially underestimating the true magnitude of this disease. This study was designed to determine the prevalence of definite diabetic neuropathy and describe the different subtypes using objective small and large fiber function measures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was a hospital-based cross-sectional study that included diabetes and prediabetes patients, followed up at Jordan Medical Services, Yaoundé, Cameroon, between March 2022 and February 2023. The “Toronto Clinical Neuropathy Score” and “Douleur Neuropathique en 4” questionnaires were used for clinical evaluation. Autonomic symptoms were equally recorded. Nerve conduction studies and Sudoscan were used for electrophysiological assessments of large and small fibre functions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eighty-four participants were included; 91.7% had type 2 DM, 2.4% had type 1 DM, and 6% had glucose intolerance. DN was found in 73/84 (86.9%). Diabetic sensorimotor polyneuropathy (DSP) was the most frequent subtype (63.8%), followed by diabetic autonomic neuropathy (40.5%), mononeuropathy (36.9%), asymmetric axonal sensory neuropathy (4.8%) and treatment-induced neuropathy of diabetes (TIND) in 1.2% of patients. The prevalence of large and small fibre neuropathies was 38.1% and 25.0%, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The prevalence of DN and specifically DSP in our study was higher than previously described in African literature. We identified subtypes never before reported in sSA, mainly small fibre neuropathy and TIND. This may have management and policy implications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17451,"journal":{"name":"Journal of the Peripheral Nervous System","volume":"30 2","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jns.70021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143925751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Effects of Visceral and Subcutaneous Adiposity on Peripheral Neuropathy","authors":"Georgios Ponirakis,&nbsp;Leeza Peerzada,&nbsp;Ioannis N. Petropoulos,&nbsp;Hoda Gad,&nbsp;Sidra Abdulshakoor,&nbsp;Jenneth M. Concepcion,&nbsp;Sara H. Khalfalla,&nbsp;Iynas S. A. Elamin,&nbsp;Abeer T. H. AlZawqari,&nbsp;Einas Elgassim,&nbsp;Areej Baraka,&nbsp;Ziyad R. Mahfoud,&nbsp;Marwa A. El Deeb,&nbsp;Nahla Afifi,&nbsp;Rayaz A. Malik","doi":"10.1111/jns.70025","DOIUrl":"https://doi.org/10.1111/jns.70025","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Obesity increases the risk of diabetic neuropathy. This study investigates the impact of visceral (VAT) and subcutaneous adipose tissue (SAT) volume on peripheral neuropathy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 302 adults from the Qatar Biobank (QBB) underwent iDXA to measure VAT and SAT volumes, intima media thickness (IMT), and peripheral neuropathy assessments using corneal confocal microscopy (CCM), vibration perception threshold (VPT), and the DN4 questionnaire.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The QBB cohort was aged 43.9 ± 12.9 years, of whom 43.7% were women, 42.1% had obesity, 17.4% had type 2 diabetes (T2D) and 10.9% had hypertension. VAT was associated with T2D, hypertension, higher HbA1c, diastolic blood pressure, triglycerides, and inflammatory markers, and lower HDL (<i>p</i> &lt; 0.0001). There were no significant associations between SAT and these cardiovascular risk factors. VAT volume was associated with lower corneal nerve inferior whorl length (IWL) (<i>p</i> &lt; 0.05) and higher VPT (<i>p</i> = 0.01), partially mediated by elevated HbA1c (<i>p</i> &lt; 0.05, <i>p</i> = 0.001) and IMT (<i>p</i> &lt; 0.0001), while its association with neuropathic symptoms was fully mediated by systolic blood pressure (<i>p</i> &lt; 0.05), T2D (<i>p</i> &lt; 0.01), and triglycerides (<i>p</i> = 0.05). SAT showed no associations with measures of neuropathy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>VAT but not SAT is associated with peripheral neuropathy. This study underscores the need to target VAT to improve neuropathy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17451,"journal":{"name":"Journal of the Peripheral Nervous System","volume":"30 2","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143925750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}