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Journal of toxicology. Clinical toxicology最新文献

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Paroxetine use throughout pregnancy: does it pose any risk to the neonate? 在怀孕期间使用帕罗西汀:它对新生儿有任何风险吗?
Journal of toxicology. Clinical toxicology Pub Date : 2004-01-01 DOI: 10.1081/clt-120028753
I Morag, D Batash, R Keidar, M Bulkowstein, E Heyman
{"title":"Paroxetine use throughout pregnancy: does it pose any risk to the neonate?","authors":"I Morag,&nbsp;D Batash,&nbsp;R Keidar,&nbsp;M Bulkowstein,&nbsp;E Heyman","doi":"10.1081/clt-120028753","DOIUrl":"https://doi.org/10.1081/clt-120028753","url":null,"abstract":"<p><p>A newborn of a SSRI-treated mother presented with lethargy, no crying, and no response to tactile stimulation. EEG findings were abnormal. Laboratory and clinical evaluations were normal. He recovered at the age of two weeks. Serotonin is a neurotransmitter that has an important roll in pain modulation during fetal neurodevelopment. We suspect these symptoms are attributed to the intrauterine exposure to paroxetine, through modulation of pain signals.</p>","PeriodicalId":17447,"journal":{"name":"Journal of toxicology. Clinical toxicology","volume":"42 1","pages":"97-100"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1081/clt-120028753","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24467190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Short-term elemental mercury exposures at three Arizona schools: public health lessons learned. 亚利桑那州三所学校的短期元素汞暴露:公共卫生经验教训。
Journal of toxicology. Clinical toxicology Pub Date : 2004-01-01 DOI: 10.1081/clt-120030944
Assaf T Gordon
{"title":"Short-term elemental mercury exposures at three Arizona schools: public health lessons learned.","authors":"Assaf T Gordon","doi":"10.1081/clt-120030944","DOIUrl":"https://doi.org/10.1081/clt-120030944","url":null,"abstract":"<p><p>Acute exposure of schoolchildren to elemental mercury continues to produce public health crises that drain available health and environmental resources. In this retrospective study, we report three incidents of limited exposure to elemental mercury in Arizona schoolchildren. Health workers screened 347 students, family, and staff by history and physical exam for exposure level and symptomatology. Urine and blood mercury testing further evaluated at-risk individuals. Environmental contamination was also assessed. Despite up to 28% of patients reporting symptoms, no individual was found to have elevated serum or urinary mercury levels requiring treatment. Elevated airborne mercury levels were demonstrated in the classrooms, dormitories, buses, and student homes and appropriate clean-up measures were instituted. Previous studies of multiple exposures to elemental mercury either focus on significant patient morbidity or lack biological data. In contrast, this study reports biological and environmental data demonstrating no clinical toxicity following acute exposure in a large sample. Confirmatory studies are necessary to develop cost-effective guidelines for the appropriate management of these public health crises.</p>","PeriodicalId":17447,"journal":{"name":"Journal of toxicology. Clinical toxicology","volume":"42 2","pages":"179-87"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1081/clt-120030944","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24581174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Health effects of mycotoxins: a toxicological overview. 真菌毒素对健康的影响:毒理学综述。
Journal of toxicology. Clinical toxicology Pub Date : 2004-01-01 DOI: 10.1081/clt-120030947
Frederick Fung, Richard F Clark
{"title":"Health effects of mycotoxins: a toxicological overview.","authors":"Frederick Fung,&nbsp;Richard F Clark","doi":"10.1081/clt-120030947","DOIUrl":"https://doi.org/10.1081/clt-120030947","url":null,"abstract":"<p><p>Diseases caused by fungi are spread by direct implantation or inhalation of spores. Fungi can cause adverse human health effects to many organ systems. In addition to infection and allergy, fungi can produce mycotoxins and organic chemicals that are responsible for various toxicologic effects. We reviewed the published literature on important mycotoxins and systemic effects of mycotoxins. Scientific literature revealed a linkage between ingesting mycotoxin contaminated food and illness, especially hepatic, gastrointestinal, and carcinogenic diseases. Issues related to mycotoxin exposure, specific diseases, and management are discussed. Although there is agreement that diet is the main source of mycotoxin exposure, specific health effects and risk assessment from indoor nonagricultural exposure are limited by the paucity of scientific evidence currently available. Further research on the health effects of inhaling mycotoxins in indoor settings is needed.</p>","PeriodicalId":17447,"journal":{"name":"Journal of toxicology. Clinical toxicology","volume":"42 2","pages":"217-34"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1081/clt-120030947","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24581180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 257
Nephrotoxic effects of X-ray contrast media. x射线造影剂的肾毒性作用。
Journal of toxicology. Clinical toxicology Pub Date : 2004-01-01 DOI: 10.1081/clt-120037430
Erik Andrew, Knut J Berg
{"title":"Nephrotoxic effects of X-ray contrast media.","authors":"Erik Andrew,&nbsp;Knut J Berg","doi":"10.1081/clt-120037430","DOIUrl":"https://doi.org/10.1081/clt-120037430","url":null,"abstract":"<p><p>The annual sale of x-ray contrast media (CM) now represents 60 million doses, and contrast nephropathy (CN) has been the third-leading cause of hospital-acquired acute renal failure. In this review article, physicochemical, pharmacokinetic, and pharmacodynamic properties of CM are surveyed. The definition of CN is presented, as well as the mechanisms involved in the pathogenesis. Low osmolar monomeric CM (LOCM) are less nephrotoxic than the older ionic high osmolar CM (HOCM), but in risk patients the incidence of CN is still high after intravascular administration of LOCM. Non-ionic dimeric CM are iso-osmolar to plasma (IOCM), and they have reduced the nephrotoxicity even more than LOCM. The most important risk factors for CN are diabetes mellitus and impaired renal function. Selection of patients, hydration, and type of CM are essential for prevention and prophylaxis of CN. We do not recommend routine prophylaxis with N-acetylcysteine (NAC) during CM investigations, but its use in high-risk patients should be considered.</p>","PeriodicalId":17447,"journal":{"name":"Journal of toxicology. Clinical toxicology","volume":"42 3","pages":"325-32"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1081/clt-120037430","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24677443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
The benign clinical course following a large pediatric montelukast ingestion. 儿童大量摄取孟鲁司特后的良性临床过程。
Journal of toxicology. Clinical toxicology Pub Date : 2004-01-01 DOI: 10.1081/clt-120037436
F Lee Cantrell, Mary Farson-Collier
{"title":"The benign clinical course following a large pediatric montelukast ingestion.","authors":"F Lee Cantrell,&nbsp;Mary Farson-Collier","doi":"10.1081/clt-120037436","DOIUrl":"https://doi.org/10.1081/clt-120037436","url":null,"abstract":"","PeriodicalId":17447,"journal":{"name":"Journal of toxicology. Clinical toxicology","volume":"42 3","pages":"333-4"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1081/clt-120037436","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24677444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Successful use of hemodialysis in acute valproic acid intoxication. 血液透析在急性丙戊酸中毒中的成功应用。
Journal of toxicology. Clinical toxicology Pub Date : 2004-01-01 DOI: 10.1081/clt-120037437
C P E Guillaume, L Stolk, T F Dejagere, J P Kooman
{"title":"Successful use of hemodialysis in acute valproic acid intoxication.","authors":"C P E Guillaume,&nbsp;L Stolk,&nbsp;T F Dejagere,&nbsp;J P Kooman","doi":"10.1081/clt-120037437","DOIUrl":"https://doi.org/10.1081/clt-120037437","url":null,"abstract":"","PeriodicalId":17447,"journal":{"name":"Journal of toxicology. Clinical toxicology","volume":"42 3","pages":"335-6"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1081/clt-120037437","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24677445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Aphrodisiac drug-induced hemolysis. 壮阳药引起的溶血。
Journal of toxicology. Clinical toxicology Pub Date : 2004-01-01 DOI: 10.1081/clt-120037435
Ruth Stalnikowicz, Yona Amitai, Yedidia Bentur
{"title":"Aphrodisiac drug-induced hemolysis.","authors":"Ruth Stalnikowicz,&nbsp;Yona Amitai,&nbsp;Yedidia Bentur","doi":"10.1081/clt-120037435","DOIUrl":"https://doi.org/10.1081/clt-120037435","url":null,"abstract":"<p><p>Volatile alkyl nitrites have been used during the past decades for \"recreational purposes,\" and for intensifying sexual experience. Their use has been associated with methemoglobinemia and hemolysis. We report three patients who presented over the past year with acute hemolysis after inhalation of butyl nitrite, two of them had glucose-6-phosphate dehydrogenase (G6PD) deficiency.</p>","PeriodicalId":17447,"journal":{"name":"Journal of toxicology. Clinical toxicology","volume":"42 3","pages":"313-6"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1081/clt-120037435","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24678094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
High-potassium haemodialysis in barium poisoning. 高钾血液透析治疗钡中毒。
Journal of toxicology. Clinical toxicology Pub Date : 2004-01-01
Janusz Szajewski
{"title":"High-potassium haemodialysis in barium poisoning.","authors":"Janusz Szajewski","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":17447,"journal":{"name":"Journal of toxicology. Clinical toxicology","volume":"42 1","pages":"117"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24467193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accidental dermal and inhalation exposure with fipronil--a case report. 氟虫腈意外皮肤及吸入接触- 1例报告。
Journal of toxicology. Clinical toxicology Pub Date : 2004-01-01 DOI: 10.1081/clt-120030948
Zygmunt Chodorowski, Jacek Sein Anand
{"title":"Accidental dermal and inhalation exposure with fipronil--a case report.","authors":"Zygmunt Chodorowski,&nbsp;Jacek Sein Anand","doi":"10.1081/clt-120030948","DOIUrl":"https://doi.org/10.1081/clt-120030948","url":null,"abstract":"<p><strong>Background: </strong>Fipronil which has initiated the new generation of insecticides and possesses greater affinity at GABA receptors in insects than humans is supposed to be safer than the old generation of insecticides. Dermal and inhalation exposure to fipronil has not been reported in the literature.</p><p><strong>Case report: </strong>A 50-year-old male was admitted to the Clinic after 5h of spraying his field with the solution of fipronil. The patient was fully conscious with the BP and HR within normal range. There were no seizures, other neurological deficits, signs of conjunctivitis or skin irritation. Physical examinations and biochemical results were normal. The patient complained of a headache, nausea, vertigo and weakness. All symptoms resolved spontaneously after about 5h. During hospitalization and the follow up after three weeks he was asymptomatic.</p><p><strong>Conclusions: </strong>Further investigations should be carried on to evaluate the risk of fipronil in humans. The benzodiazepines are drugs of choice during seizures, B1 agonists and steroids may be useful during severe inhalation exposure.</p>","PeriodicalId":17447,"journal":{"name":"Journal of toxicology. Clinical toxicology","volume":"42 2","pages":"189-90"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1081/clt-120030948","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24581175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 33
Ricin: mechanism of toxicity, clinical manifestations, and vaccine development. A review. 蓖麻毒素:毒性机制、临床表现及疫苗研制。复习一下。
Journal of toxicology. Clinical toxicology Pub Date : 2004-01-01 DOI: 10.1081/clt-120030945
Leah G Doan
{"title":"Ricin: mechanism of toxicity, clinical manifestations, and vaccine development. A review.","authors":"Leah G Doan","doi":"10.1081/clt-120030945","DOIUrl":"https://doi.org/10.1081/clt-120030945","url":null,"abstract":"<p><p>Ricin is one of the most potent plant toxins known, and the castor plant from which it is derived, Ricinus communis, is ubiquitous. The harvesting of castor beans exceeds one million tons annually, and ricin is easier to produce than either anthrax or botulinum. As a result, ricin is a convenient, potent, and available toxin for terrorist acts. This paper will review the mechanism of toxicity, major clinical manifestations, treatment, current methods of detection, and vaccine development.</p>","PeriodicalId":17447,"journal":{"name":"Journal of toxicology. Clinical toxicology","volume":"42 2","pages":"201-8"},"PeriodicalIF":0.0,"publicationDate":"2004-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1081/clt-120030945","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24581178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 118
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