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In-vitro wound healing potential of Ziziphus oenoplia (L.) Miller 紫竹体外创面愈合潜力的研究米勒
IF 0.5 4区 综合性期刊
Journal of the National Science Foundation of Sri Lanka Pub Date : 2023-06-30 DOI: 10.4038/jnsfsr.v51i2.11232
W. Samarasinghe, K. H. Jayawardena, C. Ranasinghe, S. Somaratne, G. Gunaherath
{"title":"In-vitro wound healing potential of Ziziphus oenoplia (L.) Miller","authors":"W. Samarasinghe, K. H. Jayawardena, C. Ranasinghe, S. Somaratne, G. Gunaherath","doi":"10.4038/jnsfsr.v51i2.11232","DOIUrl":"https://doi.org/10.4038/jnsfsr.v51i2.11232","url":null,"abstract":"\u0000Non-healing wounds are a global health problem. Substances that enhance cell proliferation, angiogenesis, and prevention of bacterial infections accelerate the wound healing process. In this study, the wound healing potential of Ziziphus oenoplia, is investigated for its ability in cell proliferation, angiogenesis, and antibacterial potential. The potential of cell proliferation enhancement (mean percent wound closure) and angiogenic response (mean vascular index) of hexanes, dichloromethane, ethyl acetate, and methanol extracts of leaf and bark of Z. oenoplia were evaluated by scratch wound assay (SWA) using Madin-Darby Canine Kidney (MDCK) cells and chick chorioallantoic membrane (CAM) assay, respectively. The antibacterial activity of these extracts was evaluated against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa by disc diffusion method. Enhanced cell proliferation was shown by the hexanes, dichloromethane, and ethyl acetate extracts of leaf and the hexanes extract of bark. An enhanced angiogenic response was shown by the methanol and ethyl acetate extracts of leaves and the methanol and hexanes extracts of bark. Dichloromethane extract of both leaf and bark showed considerable antibacterial activity against P. aeruginosa which is less susceptible to common antibiotics. SWA-directed fractionation of the hexanes extract of the leaf has resulted in the isolation and identification of an active fraction showing mean percent wound closure of 86.4% (positive control 90.2%) and mean vascular index of 34.5 (positive control 48.6). This fraction contained lupeol, α-amyrin, β-amyrin, hexacosanol, and octacosanol. The present study provides supportive evidence for the potential of wound healing enhancement of leaf and bark extracts of Z. oenoplia.","PeriodicalId":17429,"journal":{"name":"Journal of the National Science Foundation of Sri Lanka","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48328070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Natural α-glucosidase inhibitors from selected medicinal plants in Malaysia 天然α-葡萄糖苷酶抑制剂从马来西亚选定的药用植物
IF 0.5 4区 综合性期刊
Journal of the National Science Foundation of Sri Lanka Pub Date : 2023-06-30 DOI: 10.4038/jnsfsr.v51i2.11177
S. Y. Liew, Y. Sivasothy, N. N. Shaikh, K. Javaid, DM Isa, V. Lee, M. Choudhary, K. Awang
{"title":"Natural α-glucosidase inhibitors from selected medicinal plants in Malaysia","authors":"S. Y. Liew, Y. Sivasothy, N. N. Shaikh, K. Javaid, DM Isa, V. Lee, M. Choudhary, K. Awang","doi":"10.4038/jnsfsr.v51i2.11177","DOIUrl":"https://doi.org/10.4038/jnsfsr.v51i2.11177","url":null,"abstract":"\u0000The most prevalent subtype of diabetes is Type 2 Diabetes Mellitus which results from an abnormal postprandial increase in blood glucose. Inhibition of the carbohydrate-hydrolysing enzymes (alpha-glucosidase and alpha-amylase) in the human digestive organs can control blood glucose levels, making it an important strategy in the management of Type 2 Diabetes Mellitus. A majority of the oral synthetic drugs which have been developed to treat Type 2 Diabetes Mellitus are expensive and have undesirable side effects. As a result, plant-derived remedies have become preferred alternatives as they are easily available, affordable and less harmful. Angustine (1) the major constituent in Nauclea subdita (Korth.) Steud., and (E)-labda-8(17),12-dien-15,16-dial (2) and zerumin A (3) of Alpinia pahangensis Ridley were evaluated for their α-glucosidase inhibitory activity. (E)-Labda-8(17),12-dien-15,16-dial (2) (IC50 = 39.7 μM) was identified as the most potent inhibitor among all three, followed by angustine (1) (IC50 = 48.1 μM) and zerumin A (3) (IC50 = 53.3 μM). Enzyme kinetic studies indicated that angustine (1) was a mixed-type inhibitor, while (E)-labda-8(17),12-dien-15,16-dial (2), and zerumin A (3) were non-competitive inhibitors. Molecular docking and molecular dynamics (MD) simulation studies were performed to predict the key interactions between the ligands and the target protein, 1AGM (complex of acarbose with glucoamylase from Aspergillus awamori). The results of the study of binding interaction energy suggested that angustine (1) has the potential to be used as a natural drug lead in the treatment of type 2 diabetes mellitus.","PeriodicalId":17429,"journal":{"name":"Journal of the National Science Foundation of Sri Lanka","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45805696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficiency boost of inverted polymer solar cells using electrodeposited n-type Cu2O electrons selective transport layers (ESTLs) 使用电沉积n型Cu2O电子选择性传输层（ESTL）的倒置聚合物太阳能电池的效率提高
IF 0.5 4区 综合性期刊
Journal of the National Science Foundation of Sri Lanka Pub Date : 2023-06-30 DOI: 10.4038/jnsfsr.v51i2.11230
W. Wanninayake, D. Namawardana, R. Wanigasekara, K. Jayathilaka, R. P. Wijesundera, W. Siripala, M. I. Malik
{"title":"Efficiency boost of inverted polymer solar cells using electrodeposited n-type Cu2O electrons selective transport layers (ESTLs)","authors":"W. Wanninayake, D. Namawardana, R. Wanigasekara, K. Jayathilaka, R. P. Wijesundera, W. Siripala, M. I. Malik","doi":"10.4038/jnsfsr.v51i2.11230","DOIUrl":"https://doi.org/10.4038/jnsfsr.v51i2.11230","url":null,"abstract":"\u0000Polymer solar cells (PSCs) have attracted tremendous interest as suitable candidates for harnessing solar energy in the recent years. The inherent optoelectronic properties of the inorganic transition metal oxide, negative type cuprous oxide (n-Cu2O), makes it an attractive candidate to improve the performance of PSCs when incorporated as the electron selective transport layers (ESTLs) in the device. In this study, inverted PSCs were fabricated on stainless steel (SS) substrates with n-Cu2O as the ESTL. The n-Cu2O films were prepared by electrodeposition method, followed by annealing under ambient conditions. The active layer material was prepared as bulk heterojunction blend using regioregular poly(3-hexylthiophene) (P3HT) and phenyl-C61-butyric acid methyl ester (PCBM). Poly-(4,3-ethylene dioxythiophene):poly(styrenesulphonate) (PEDOT:PSS) was used as the hole transport layer (HTL) and the final device structure was SS/n-Cu2O/P3HT:PCBM/PEDOT:PSS/Au. Annealing of the n-Cu2O ESTL in air was optimized observing the photoactive performance of the device. Optoelectronic performance of the devices was characterized using spectral response and dark and light current-voltage (I-V) measurements. n-Cu2O ESTL- incorporated devices have absorbed more photons in the short wavelength region of 450‒600 nm with the annealing of n-Cu2O ESTL due to the reduction of electron-hole recombination. The performance of the devices was significantly increased after incorporating pre-annealed n-Cu2O ESTL at 175 °C for 30 min in air. The maximum power conversion efficiency (PCE) was 0.35%.","PeriodicalId":17429,"journal":{"name":"Journal of the National Science Foundation of Sri Lanka","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41776535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of submergence stress responses and mining allelic variations of submergence tolerance gene Sub1A in Sri Lankan rice germplasm 斯里兰卡水稻种质耐淹水基因Sub1A的淹水胁迫反应评估及等位基因变异挖掘
IF 0.5 4区 综合性期刊
Journal of the National Science Foundation of Sri Lanka Pub Date : 2023-04-11 DOI: 10.4038/jnsfsr.v51i1.11121
T. Kariyawasam, D. Nanayakkara, A. Sumanarathna, D. Weerasinghe, L. Suriyagoda, D. Jayatilake
{"title":"Assessment of submergence stress responses and mining allelic variations of submergence tolerance gene Sub1A in Sri Lankan rice germplasm","authors":"T. Kariyawasam, D. Nanayakkara, A. Sumanarathna, D. Weerasinghe, L. Suriyagoda, D. Jayatilake","doi":"10.4038/jnsfsr.v51i1.11121","DOIUrl":"https://doi.org/10.4038/jnsfsr.v51i1.11121","url":null,"abstract":"","PeriodicalId":17429,"journal":{"name":"Journal of the National Science Foundation of Sri Lanka","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45510264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of transverse thermal conductivity of coir fibre using experimental, analytical, and numerical methods 用实验、分析和数值方法评估椰子纤维的横向热导率
IF 0.5 4区 综合性期刊
Journal of the National Science Foundation of Sri Lanka Pub Date : 2023-04-10 DOI: 10.4038/jnsfsr.v51i1.10870
L. Chamath, L. Srimal, G. Sewvandi
{"title":"Assessment of transverse thermal conductivity of coir fibre using experimental, analytical, and numerical methods","authors":"L. Chamath, L. Srimal, G. Sewvandi","doi":"10.4038/jnsfsr.v51i1.10870","DOIUrl":"https://doi.org/10.4038/jnsfsr.v51i1.10870","url":null,"abstract":"","PeriodicalId":17429,"journal":{"name":"Journal of the National Science Foundation of Sri Lanka","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43939100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Temperature control in an exothermic continuous stirred tank reactor 放热连续搅拌釜反应器的温度控制
IF 0.5 4区 综合性期刊
Journal of the National Science Foundation of Sri Lanka Pub Date : 2023-04-10 DOI: 10.4038/jnsfsr.v51i1.10844
V. A. Rani, G. Guna, D. Prabhakaran, M. Thirumarimurugan
{"title":"Temperature control in an exothermic continuous stirred tank reactor","authors":"V. A. Rani, G. Guna, D. Prabhakaran, M. Thirumarimurugan","doi":"10.4038/jnsfsr.v51i1.10844","DOIUrl":"https://doi.org/10.4038/jnsfsr.v51i1.10844","url":null,"abstract":"","PeriodicalId":17429,"journal":{"name":"Journal of the National Science Foundation of Sri Lanka","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46218304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On recurrence relations for moments of dual generalized order statistics for a general transmuted power function distributions with characterizations 具有表征的一般变换幂函数分布对偶广义阶统计量矩的递推关系
IF 0.5 4区 综合性期刊
Journal of the National Science Foundation of Sri Lanka Pub Date : 2023-04-10 DOI: 10.4038/jnsfsr.v51i1.10469
{"title":"On recurrence relations for moments of dual generalized order statistics for a general transmuted power function distributions with characterizations","authors":"","doi":"10.4038/jnsfsr.v51i1.10469","DOIUrl":"https://doi.org/10.4038/jnsfsr.v51i1.10469","url":null,"abstract":"","PeriodicalId":17429,"journal":{"name":"Journal of the National Science Foundation of Sri Lanka","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46766483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predatory Journals; be aware of the spectrum! 掠夺性期刊；注意频谱！
IF 0.5 4区 综合性期刊
Journal of the National Science Foundation of Sri Lanka Pub Date : 2023-04-10 DOI: 10.4038/jnsfsr.v51i1.11667
{"title":"Predatory Journals; be aware of the spectrum!","authors":"","doi":"10.4038/jnsfsr.v51i1.11667","DOIUrl":"https://doi.org/10.4038/jnsfsr.v51i1.11667","url":null,"abstract":"","PeriodicalId":17429,"journal":{"name":"Journal of the National Science Foundation of Sri Lanka","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47513277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Mechanically exfoliated graphene from Sri Lankan vein graphite for field effect transistor application 从斯里兰卡矿脉石墨中机械剥离石墨烯，用于场效应晶体管应用
IF 0.5 4区 综合性期刊
Journal of the National Science Foundation of Sri Lanka Pub Date : 2023-04-10 DOI: 10.4038/jnsfsr.v51i1.10752
{"title":"Mechanically exfoliated graphene from Sri Lankan vein graphite for field effect transistor application","authors":"","doi":"10.4038/jnsfsr.v51i1.10752","DOIUrl":"https://doi.org/10.4038/jnsfsr.v51i1.10752","url":null,"abstract":"","PeriodicalId":17429,"journal":{"name":"Journal of the National Science Foundation of Sri Lanka","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48238349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comparison of model parameter estimation methods for complex survey survival data 复杂调查生存数据模型参数估计方法的比较
IF 0.5 4区 综合性期刊
Journal of the National Science Foundation of Sri Lanka Pub Date : 2023-04-10 DOI: 10.4038/jnsfsr.v51i1.10730
{"title":"A comparison of model parameter estimation methods for complex survey survival data","authors":"","doi":"10.4038/jnsfsr.v51i1.10730","DOIUrl":"https://doi.org/10.4038/jnsfsr.v51i1.10730","url":null,"abstract":"","PeriodicalId":17429,"journal":{"name":"Journal of the National Science Foundation of Sri Lanka","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42866237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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